next steps after ics/laba: the case for omalizumab€¦ · next steps after ics/laba: the case for...
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![Page 1: Next Steps After ICS/LABA: The Case For Omalizumab€¦ · Next Steps After ICS/LABA: The Case For Omalizumab Thomas B Casale, MD Executive VP, AAAAI Professor Of Medicine University](https://reader033.vdocuments.us/reader033/viewer/2022051607/602cea03e20e5e6b9513346f/html5/thumbnails/1.jpg)
Next Steps After ICS/LABA: The Case For Omalizumab
Thomas B Casale, MD Executive VP, AAAAI
Professor Of Medicine University Of South Florida
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Disclosures
• Consultant: Cytos
• Advisory Boards:
– Teva
– Novartis
– Genentech
– Boehringer Ingelhein Corp
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Uncontrolled Asthma
Asthma which, despite high dose ICS/LABA therapy, remains “uncontrolled”:
• Poor symptom control: ACQ consistently >1.5 (or “not well controlled” by NAEPP guidelines)
• Frequent exacerbations: 2 or more bursts of systemic CSs (>3 days each) in previous year
• Severe exacerbations: at least 1 hospitalization, ICU stay or mechanical ventilation in previous yr
• Persistent airflow limitation: pre-short and long acting bronchodilator FEV1< 80% predicted (in the face of reduced FEV1/FVC)
2009 ATS/ERS Task Force On Severe Asthma Definition
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Effects Of Omalizumab
i airway eosinophils, mast cells, basophils, T +
B lymphocytes
i IgE+, FceRI+, IL-4+cells in bronchial
epithelium
i response to allergen
skin test
i eNO
Lung Ag Challenge
i free IgE, IgE bound to FceRI, and FceRI expression on mast cells, basophils, dendritic cells,monocytes
i IgE synthesis (?)
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Effects Of Omalizumab On Airway Inflammation
In Mild Atopic Asthmatics
5-center, double blind , placebo-controlled, parallel-group, 16-week study (n=44) :
•Reduction in submucosal eos: 8.0 to 1.5
•10-fold reduction in IgE+cells
- Decreases in FCeRI cells
•Decreases in B cells, and CD3+, CD4+, and
CD8+ cells ……
•implies that IgE plays an important role in airway inflammation in asthma
R Djukanovic, et al, AJRCCM,170:583,2004
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Effects Of Omalizumab on Eos & FEV1 In
Severe (Step 4/5) Asthma
1.2
1.25
1.3
1.35
1.4
1.45
1.5
1.55
Omal Placebo
Before Rx
After Rx
Hoshino & Ohtawa, Respiration: 01/12
FEV1
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Changes In Airway Measurements After 16
Weeks Of Treatment In Severe Asthma
Hoshino & Ohtawa, Respiration: 01/12
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Clinical Effects Of Omalizumab:
Pooled data from 7 trials
In patients on ICS alone, or in combination with other agents, addition of omalizumab:
Reduced number of exacerbations (OR=0.57)
Reduced symptom scores
Reduced need for inhaled corticosteroids
Reduced use of rescue medication
Improved asthma-related quality of life
Consider using in patients with poor control despite optimal care
1Busse W et al. J Allergy CLin Immunol 2001;108:184-90. 2Soler M et al. Eur Respir J 2001;18:254-61. 3Humbert M, et al. Allergy 2005;60:309-16. 4 Rodrigo G, et al, Chest, 2010
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Effects Of Omalizumab on Secondary Endpoints
G Rodrigo et al, Chest, 2010
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Omalizumab vs. Placebo in Moderate-severe Asthma
Normansell et al, Cochrane review, 2014
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Omalizumab effect was independent of:
Duration of treatment
Age
Severity of asthma
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Asthma Exacerbations Over 48 Weeks In
EPR3 Step 5/6
0
10
20
30
40
50
60
70
0 1 2 3 > 4
Omalizumb
Placebo
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
Rate /Pt
Omalizumab
Placebo
Number Exacerbations
%
25% reduction
Hanania et al, Ann Int Med ,2011
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Omalizumab In
Children 6 - 11
Lanier et al. JACI.2009;124:1210-6
Avg FP dose 515 mcg
2/3 on LABA
1/3 on LTRA
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Omalizumab and Seasonal Asthma
Exacerbations In 6 to 20 y/o
NEJM, 3/11
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Endotyping: Th2-Hi Asthma
Atopy/IgE (probably worst indicator)
Early age at onset
Blood/Lung eosinophilia
Exhaled NO (FeNO)
Mast cells
Gene profiles/biomarkers (periostin)
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Omalizumab Effects Based on Biomarkers
Hanania et al, AJRCCM, 2013
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Omalizumab and Asthma Summary
• Omalizumab is effective in children and adults in
reducing exacerbations and steroid requirements
– Also positive effects on SABA use, QOL, Sxs
and PFTs (minor)
• Omalizumab has anti-inflammatory effects
• If not effective by 4-6 months, probably will not
be effective
– Predictors of who will respond are unclear, but
may be similar as other Th2 blockers