STUDY SHEDS LIGHT ON THE ASSEMBLY OF RIBOSOME AND DEMYSTIFYING THE IMMORTALITY OF CANCER

CELLS 

JUAN JOSE CASTRO PALACIOMEDICAL STUDENT

JULY 23 2012

INTRODUCTIONTelomereis the

estructure of the chromosomes more

asociated with cellular aging

The telomerase activity make that the

cell division be uncontroled, and the

cancer appears

A new study by researchers at Brigham and Women's Hospital (BWH) shows that a common form of anxiety, known as phobic anxiety, was associated with shorter telomeres in middle-aged and older women. The study suggests that phobic anxiety is a possible risk factor for accelerated aging.

ANXIETY L INKED TO SHORTENEDTELOMERES, ACCELERATED

AGING:RESEARCH

Telomeres are DNA-protein complexes at the ends of chromosomes

This structure prevents the fusion with others chromosomes

Telomeres are considered markers of biological or cellular aging.

researchers had obtained blood samples from 5,243 women, age 42 to 69 years

Been related the anxiety and the length of the telomeres.

The shortest telomeres are asociated with the anxiety in the persons.

The psicological stress produces an endless of molecular process y the

organism.

The immune cell function, oxidative stress or activity

telomerase, are some impact that the psicological stress

produce in the cell.

OBSERVATION

The psicological stress caused by the anxiety produces many cellular process that can change the course of the aging. In some cases this aging brings the risk of cancer, heart desease, dementia and mortality. This study provides many cuestion about the real process of the shortening of the telomeres and the security measures for the people.

DEMYSTIFYING THE IMMORTALITY OF CANCER CELLS

 

In cancer cells, normal mechanisms governing the cellular life cycle have gone haywire. Cancer cells continue to divide indefinitely, without ever dying off, thus creating rapidly growing tumors. EPFL scientists have discovered a protein complex involved this deregulated process, and hope to be able to exploit it to stop tumor formation in its tracks.

The telomere of the cell play a big role in the division of the cell.This part of the chromosomes defined the lifespand of the cell.

The telomeres are controlled by the telomerase, a enzime charge of the creation of the secuence of ADN in the telomeres.

In most of the cell of the organism the telomerase are inactive to meet with the internal clock, and give to the cell at least 

60 division.

In the cancer the cell have a mutation, because the telomerase are active , and 

regenerates the telomere

In this form the cell can divide indefinitely, in 

others words is inmortal

The scientist found a complex of three proteins that prevents the 

activity of the telomerase, adhering to the telomere

In the cancer this protein complex started his activity very late,  and the 

telomerase acts in the telomere.

OBSERVATIONThe role that play the diferents proteins in the cell shows the complicated proces in the division. Surely in the division are involved many others factors, but we can see that the smallest mutation produces a variety of deseases like the cancer. This kinds of studies give us many tools to combat this pathologies.

MEDICAL UTILITYAnxiety linked to shortened telomeres, accelerated aging: research

• Many people can considerate the anxiety like a form of aging, in this form the health autorities can take action for prevent the shortening of the telomeres

• The diet and somes drugs can be used for reduce the oxidative stress in the cell.

• The profundization of the study of the real asociation between telomeres and anxiety, can tell us if the small telomers its a factor to anxiety or the anxiety make the shortening of this structures

MEDICAL UTILITYAnxiety linked to shortened telomeres, accelerated

aging: research

MEDICAL UTILITYDemystifying the immortality of cancer cells

• The inhibition of the telomerase can be on of the mathods of stop the cellular division, so the cancer process will be controlled 

MEDICAL UTILITYDemystifying the immortality of cancer cells

• Knowing that the protein complex stop the activity of the telomerase, the researchers can synthetize it, and develop a form to transport the complex to te telomeres before the telomerase act in the DNA structure.

BIBLIOGRAPHY• Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow

JD, Gawthon RM. Acelerated telomere shortening in response to life stress. Proc Natl Acad Sci 2004; 101: 17312-17315

• Cooper Geoffrey M, cooper´s celula, tercera edición , Editorial Marban.

 • Anxiety linked to shortened telomeres, accelerated

aging:research. Medical xpress. Published on July 6, 2012

• Demystifying the immortality of cancer cells. Actualités.Published on july 5, 2012

• Martinez S, Lina Maria. Biología Molecular. 5 ed Medellín: UPB. Fac Medicina