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NEWS 2012

01

High Speed X-ray TDI CameraC12200-321

SYSTEMS PRODUCTS PAGE 30

Thermopile Detectors for Energy Saving and Security

SOLID STATE PRODUCTS PAGE 12

New H11706 and H12056 PMT Modules with Internal Shutters

ELECTRON TUBE PRODUCTS PAGE 25

SYSTEMS PRODUCTS PAGE 28

World's first Gen. II sCMOS Camera: Hamamatsu presents ORCA-Flash4.0

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Content04 Company News

07 Application Reports

SOLID STATE PRODUCTS

12 Thermopile Detectors T1126X, T11722 series

13 Compact Silicon APD S11670-01

14 CCD Linear Image Sensor S11151-2048

15 CMOS Linear Image Sensor S11106, S11107

16 CMOS Linear Image Sensor S11638

17 InGaAs Linear Image Sensor G12230-512DB

18 Si/InGaAs Linear Image Sensor G12231-1024DF

19 InGaAs Area Image Sensor G12242-0707W

20 Large Area Flat Panel Sensor C11700DK-40,

C11701DK-40

21 Radiation Detector Module C12137

ELECTRON TUBE PRODUCTS

22 Cooled Side-On Photomultiplier Tube

R11715 series

23 Cooled 16-Channel PMT Module H11836

24 Immunochromato Reader C10066-10

25 PMT Modules with Internal Shutters

H11706, H12056

26 USB Controlled PMT Module H11890 series

27 UV-LED Curing System LC-L1V3

SYSTEMS PRODUCTS

28 ORCA-Flash4.0

30 X-ray TDI Camera C12200-321

SERVICE

33 Fax reply

34 Exhibitions 2012

35 Hamamatsu Photonics Europe

Highlights

News 2012 Vol. 12

ELECTRON TUBE PRODUCTS 25 New PMT Modules H11706 and H12056

SOLID STATE PRODUCTS 12 Thermopile Detectors T1126X and T11722 series

SYSTEMS PRODUCTS 30 X-ray TDI Camera C12200-321

� High sensitivity � Compact package � Excellent noise performance � Wide spectral response range

Thermopile DetectorsSensors for energy saving and security

SOLID STATE PRODUCTS PAGE 12

3News 2012 Vol. 1

Hamamatsu celebrates three anniversaries

News 2012 Vol. 14

Company News

Hamamatsu Photonics Deutschland GmbH celebrated its 25th Anniversary

Hamamatsu Television Europe GmbH (HTV) was officially founded in 1973 as a 100% affiliate of Hamamatsu Photonics K.K. In 1986, the company changed its name to Hamamatsu Photonics Deutschland GmbH and relocated the office to Herrsching at Lake Ammersee.

Rapid technical progress opens new applications and undreamed of possibilities. HPD meets the challenge and has laid the cornerstone for further expansion and best possible customer service by building a new company site in 2005. HPD has about 80 employees with a sales office in Geldern (1996) and representative offices in the Netherlands (1993), Denmark (1989) and Poland (2000). HPD supports the majority of German-speaking countries (except Switzerland), as well as Hungary, Bulgaria, Romania, Greece, Turkey, the Czech Republic and Slovakia.

HPD 25th Anniversary

Many of our customers use Hamamatsu optoelectronic components in applications such as analysis, medical, industrial, automotive, academic and basic research, X-ray engineering and, since 9/11, security equipment. For all these fields of activity it is crucial to push the limits of detection and we support our customers by providing consistently high quality detectors with superior sensitivity.

Dr. Peter Eggl, Managing Director, Hamamatsu Photonics Deutschland GmbH wishes to thank their customers for their business and support over the past 25 years. The HPD team will continue to provide the highest levels of customer service for many years to come.

News 2012 Vol. 1 5

companies. We are moving from understanding products to understanding technology. This is the nice challenge we take today. We want to thank our customers, especially those loyal customers that understand the importance of building long-term relationships with our company. Having such strong relationships allows us to develop long term projects that help both companies to grow.

Mr. David Castrillo, Area Manager, Spain/Portugal, would like to thank his team for the great job they are doing and to the French office team for their support.

HPBE 20th Anniversary

Hamamatsu Photonics Spanish Office celebrated its 20th Anniversary

In 1991, Hamamatsu Photonics France decided to establish a subsidiary in the city of Rubi, Spain. We started with one engineer and shared an assistant with another company. A couple of years later we moved to the Technological Park and started to serve Portugal. Originally, we covered Portuguese business from our office in Spain. We then tried to improve our understanding of the Portuguese market needs by appointing a dealer. Today, however, we have our own engineer based locally in Portugal who understands the specific needs of the Portuguese market and provides local-level support.

We have now grown to a team of 7 people and we use the logistics and support of Hamamatsu Photonics France.

During the last 20 years we have seen a lot of changes in our countries. Applications have moved from low cost to high end and there are many new and exciting companies in our territories, some exporting technology to USA, Germany and Japan. The future is bright as photonics is a highly developing technology, also in Spain and Portugal.

Our job has also evolved. At the beginning, we were selling standard products mainly to academia. Today, we propose custom products to industrial

HPI 20th Anniversary

Hamamatsu Photonics Italy celebrated its 20th

Anniversary

In 1991, Hamamatsu Photonics K.K., decided to establish a new European subsidiary in Arese (Milan) to increase business and provide locally based relationships and support to customers. Since then, business has continuously increased and Hamamatsu Products gained market shares in many different application fields. In 1998, the South Office was established in Roma with a goal to expand business in the South of Italy.

HPI contributed to establish HPEU which will help all of us in Europe to face future business challenges with more efficiency and competitiveness.

Mr. Umberto Maerna, Managing Director of HPI, would like to thank HPK Management and employees for their continuous support, trust and help toward growing HPI business and increasing the market share.

He also wants to thank all HPI staff, present and past, for their efforts and commitment to drive HPI forward to future growth and success.

Hamamatsu 8th FDSS Users Meeting

Hamamatsu Norden have moved

News 2012 Vol. 16

Company News

The 8th FDSS Users Meeting will be held on the 14th June near Paris, France and we are delighted that Sanofi have agreed to host the event.

Drug discovery is evolving very fast in pharmaceutical companies and new players have entered this field from both Biotech and Academia. The Users Meeting represents a unique opportunity for all our collaborators to share their experiences, impressions and questions not only with Hamamatsu, but more importantly among themselves. We are honoured to be joined by guest speakers who will present a wide range of topics from iPS derived cardiomyocytes to GPCR multiplexing in luminescence.

A website detailing venue, accommodation and a preliminary program will soon be online. For more information, please contact Jean Marc D’Angelo ([email protected]) or Christelle Catone ([email protected]).

We look forward to meeting you in France.FDSS 7000EX

Hamamatsu Norden

Hamamatsu Photonics Norden AB (HPN) is supporting customers in the Nordic and CIS countries. During the last few years HPN have had the pleasure of seeing our organization grow and last year we came to the point when we had to look for new premises. In January this year the office moved from its previous location in Solna to Kista , 7 km northwest of Stockholm and 30 km south of Arlanda international airport. The new office will give us the opportunity to continue our growth and to further improve our service and support for existing and future customers.

From the mid 1980's Kista has been known as the largest IT-center of Sweden and became referred to as “Chipsta” or “Swedens’s Silicon Valley” in many magazines. Today the skyline of Kista is dominated by the 32 stories high Kista Science Tower and the even taller hotel building Victoria Tower. Among other large companies Ericsson has had their headquarters in Kista since 2003.

The new address of Hamamatsu Photonics Norden AB is:Torshamnsgatan 35, SE-164 40 Kista, SwedenAll phone numbers remain the same.

The Effects of Camera Specifications on Relative Signal to Noise Ratios (SNR)

Historically, read noise has been the primary camera spec used to define sensitivity. The performance characteristics of the ORCA-Flash4.0 (built around new Gen II sCMOS technology) have given us a great reason to think about sensitivity anew. To have a complete understanding of the topic it is imperative that we consider how quantum efficiency (QE), read noise (Nr), signal photon number (S) and, when present, multiplicative noise (Fn) fundamentally affect SNR – individually and in relationship to each other.

In the graph below the purple line represents the relative SNR for a theoretically perfect camera. The numbers above this line indicate the SNR ratio at a series of intensities and the location where the SNR =1 is indicated by a on each curve. Because this is a “perfect” camera, these SNRs are only limited by photon shot noise (sample intensity) not by camera noise or QE. In other words, since the perfect camera is 100% efficient in its collection of light and has no read noise even the very dimmest of samples is detectable.

Of course the real world is never that simple. Real cameras have limitations caused by the actual QE of the sensor, the effective lowering of QE by Fn (referred to as “effective QE” or eQE) and the effects of Nr. For each of the three real cameras shown on this graph there are bars below that represent important regions of each curve.

At the lowest input light levels, shown in region (A), Nr dominates relative SNR calculations (S< Nr2 /(QE * Fn2) and the crossover into shot noise dominated regions is the upper boundary of this low light region ( , 2.3 photons for the ORCA-Flash4.0 and 50 photons for the CCD).

The (B) region is the intermediate zone, where Nr, eQE and Fn all contribute to the relative SNR. We have defined the upper boundary of this region as the point at which the curve is 95% of the maximum relative SNR for that camera ( , 20 photons for the ORCA-Flash4.0 versus 550 photons for the CCD).

The (C) region is the high light region where eQE is the only camera parameter that matters (SNR loss is shown by vertical brackets). These three regions are easily defined for the ORCA-Flash4.0 and for an interline CCD neither of which have the multiplicative noise found in EM-CCD Cameras. For the ORCA-Flash4.0 and the CCD Fn=1. For an EM-CCD Fn=1.4.

Except at the very lowest light levels, the EM-CCD curve mirrors the shape of the perfect camera almost exactly except that the SNR is reduced to 0.68 of the value of the perfect camera. Thus, it is clear that in spite of low Nr, and high apparent QE it is the eQE which tells the story. The SNR of EM-CCD Cameras is greatly affected by Fn and no matter what the input light level is eQE always dominates.

It is the unique combination of high QE and low read noise in the absence of multiplicative noise which allows the ORCA-Flash4.0 to outperform all other cameras for fluorescence microscopy.

Authors: Stephanie Fullerton, Ph.D., Keith Bennett, Ph.D. (Hamamatsu Corporation), Eiji Toda, Teruo Takahashi (Hamamatsu Photonics K.K.)

The white paper "ORCA-Flash4.0 – Changing the Game" is available to download at www.hamamatsucameras.com/flash4

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Changing the GameExtract from ‘ORCA-Flash4.0 – Changing the Game’ White Paper

7News 2012 Vol. 1

Application Report

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A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides

Cytological screening for cervical pre cancers has led to a reduction of cervical cancer incidence. Worldwide it is a subjective and variable method with low single-test sensitivity. New biomarkers like p16 that specifically highlight abnormal cervical cells can improve cytology performance. Virtual microscopy offers an ideal platform for assisted evaluation and archiving of biomarker-stained slides. Current automated Pap evaluation systems are based on con-ventional microscopes and assist the cytology evaluation process by reducing the number of normal slides to be analyzed. Yet these systems are not suited for generating and archiving virtual slides at a large scale. Expert cytologists and slides need to be at the same physical location and multi-observer evaluations require physical sending of slides. A slide scanner on the other hand, e.g. Hamamatsu NanoZoomer 2.0-HT, is capable of generating digital microscopic images of cytological slides at different focus levels to visualize three-dimensional structures within the cytological sample. After completion of image acquisition, digital images can be studied in seamless levels of magnification. Storage of these digital slides on an image server allows for viewing independent of the physical location of pathologist and sample.

“Based on a NanoZoomer 2.0-HT we developed the prototype of a system capable of scanning cytological slides, automatically separating cell clusters and individual cells, detecting nuclei and cytoplasm, and identifying biomarker-stained cells”, says PD Dr.-Ing. Niels Grabe, Scientific Head of the TIGA center. “We implemented a virtual microscopy system allowing highly efficient automated prescreening and archiving of biomarker-stained slides.”

According to Bernd Lahrmann (PhD student) all slides were scanned with 20× resolution (0.46 µm/pixel) which resulted in image sizes of 65 k x 60 k pixels. For the image database the NDP Serve image server of Hamamatsu Photonics was used. “We developed image processing algorithms capable to detect positive stained cells on the slides, like the one shown in Fig 1” Bernd explained. “After removal of artifacts, based on the specific HSV channel values determined earlier, the algorithm was tested with reference samples and yielded very good agreement with the known manual scoring results. To make it more user friendly we developed a novel web server application (CyTIGA server) which provides a user interface for cytological evaluation as shown in Fig. 2“.

Figure 2: Scoring results of the CyTIGA server

Figure 1: Stained cells, detected by CyTIGA

News 2012 Vol. 18

Application Report

“The CyTIGA server provides one-click diagnostic decision-buttons but also offers virtual slide browsing features. This allows interactive navigation through the slide guided by a pre-computed navigation route visiting all or only biomarker-stained objects. The one-click decision-buttons allow fast and simple scoring of each object by an expert.”

But of course such an automatic evaluation algorithm is only useful for daily diagnosis, if it excels manual scoring, which is always subjective and prone to errors by cells not detected or the fact, that not the whole slide is used for evaluation. First tests were done with positive results in favor of the CyTIGA system. The sensitivity of the algorithm to detect biomarker-stained cells was very high (89.1–100 %) on the full slides and even higher than the manual evaluation (84.4–98.2 %) with specificity above 98.9 % for both manual and automatic analysis. Furthermore CyTIGA stores statistical information such as number of cells, number of positive events etc., information not available for further analysis after manual scoring.

The TIGA Center is a cooperative project which started in 2007 at the University Heidelberg with the goal of establishing a bioinformatics platform dedicated to the quantitative analysis and modelling of tissues. A strong emphasis is placed on clinically relevant research projects.

At the heart of the TIGA’s technology platform are automated microscopic scanners for whole slide imaging of glass slides. By integrating such imaging systems in a technical pipeline ranging from organotypic in vitro cell cultures to computational tissue modelling the TIGA generates a wealth of yet unexploited clinically highly relevant tissue data.

PD Dr.-Ing. Niels Grabe is the scientific head of the TIGA center, Dipl.-Bioinf. Bernd Lahrmann is a PhD student in medical informatics at the TIGA center.

For further information see “A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides”, Cellular Oncology 32 (2010) 109-119 and http://tigacenter.bioquant.uni-heidelberg.de/

Author: PD Dr.-Ing. Niels Grabe, Bernd Lahrmann

PD Dr.-Ing. Niels Grabe Bernd Lahrmann

9News 2012 Vol. 1

Streak Camera System Using 2D-Photon Counting

Performance test of a table top picosecond pulsed X-ray and laser Induced fluorescence spectrometer based on a streak camera system using 2D-photon counting

IntroductionThe classic way of scintillator characterization and testing such materials is based on time-correlated single photon counting (TCSPC). A disadvantage of these systems is the difficulty to get spectral information with the measured decay times. Streak camera systems have been a milestone in measuring X-Ray Excited Optical Luminescence (XEOL) because they offer the advantage to measure decay times and emission spectra simultaneously. The system is based on a pulsed laser and a 40 kV pulsed X-ray tube, excited by that laser. This allows us to use either the optical pulses or the X-ray pulses as the excitation source for induced fluorescence. For a performance test well known scintillators and fluorescence materials were measured.

Experimental Set Up and MeasurementsFigure 1 shows the housed laser and X-ray tube N5084 with optics, and the detection system consisting of a spectrograph and a streak system.

The laser beam or the pulsed X-ray radiation excites the sample. The fluorescence light of the sample passes a collecting lens system and then is focused on the spectrograph. The electronics (spectrograph, streak camera, CCD camera) assemble the signal to a streak image (Fig. 2) where emission wavelength is plotted against time. From this image decay time and emission spectra are accessible. All measurements were taken under ambient air conditions and room temperature. The used substances were chemical pure (p.a.). Rhodamine 6G dissolved in MeOH to a concentration of 106 M and measured in a quartz cuvette under pulsed laser excitation (repetition rate 10 MHz; λ = 440 nm). Cesium iodide and anthracene were pressed to pellets under 10 t of pressure. The pellets were measured under pulsed X-ray excitation (40 kV and 1.2 µA).

ResultsCesium iodide (Fig. 3) has its emission maximum at 310 nm. To determine the decay time, a biexponential fit was done which led to τ0 = 1.67 ns and τ1 = 10.21 ns for the two components (χ2 = 1.0880). The emission maximum of anthracene is 450 nm (Tab. 1). The decay time was determined to τ0 = 2.36 ns (single exponential fit, χ2 = 1.1471). Rhodamine 6G (Tab. 1) shows an emission maximum at 560 nm. The decay time is 4.42 ns.

News 2012 Vol. 110

Application Report

Fig. 1: X-ray tube inside a shielded measuring chamber with laser head, optics, spectrograph and streak camera

Fig. 2: Time resolved streak image of pure CsI with an accumulation time of 60 minutes (upper) and rhodamine 6G in methanol (lower) with an accumulation time of 30 minutes (xaxis: wavelength; yaxis: time and intensity is coded in pseudo-colours)

All measuring and fitting results are listed in table 1. The τ and χ2 values are given with and without deconvolution. For decay time determinations the whole fluorescence spectra were used and the decay time fits were performed by Hamamatsu HPD-TA fit software.

Conclusion and OutlookThe described system provides us with decay times and emission spectra which are corresponding to the literature. Therefore, this table top picosecond X-ray and laser induced fluorescence spectroscopy streak system shows a very good performance. Furthermore the easily manageable system offers the opportunity to measure samples with a variable geometry (crystals, powders, pellets, liquids) which is an absolute advantage.

Future works will focus on measuring samples of enhanced and new scintillation / fluorescence materials. For a second performance test scintillators with the fast core-valence emission (CVL) and relatively low light yield will be measured [5]. Additionally, we consider to integrate a pulsed UV-LED as another excitation source.

Authors: Dipl.-Chem. N.-P. Pook, B.Sc. C.-J. Fruhner and Prof. Dr. A. Adam, Institute of Inorganic and Analytical Chemistry, Clausthal University of Technology, Paul-Ernst-Str. 4, D-38678 Clausthal-Zellerfeld, Germany

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References[1] S. Keszthelyilandori, I. Foldvari, R. Voszka, Z. Fodor, Z. Seres, Nucl. Instr. Meth. A 1991, 303, 374. [2] B.C. Grabmaier, IEEE Trans. Nucl. Sci. 1984, 31, 372.[3] H. Odaka, T. Miura, K. Hatanaka, S. Wiebel, H. Fukumura, J. Phys. Chem. C 2009, 113, 11969.[4] W.J. O'Hagan, M. McKenna, D.C. Sherrington, O.J. Rolinski, D.J.S. Birch, Meas. Sci. Technol. 2002, 13, 84.[5] C. van Eijk, Nucl. Tracks Rad. Meas. 1993, 21, 5.

11News 2012 Vol. 1

Fig. 3: Fitting results and emission spectrum of X-ray induced fluorescence of pure CsI as a 150 mg pellet

Tab. 1: Comparison of measured and literature decay times

Material Results [ns] χ2Lit. Decay Time [ns]

λem[nm]

Lit. λem[nm]

Lit.

CsIτ0 = 1.67τ1 = 10.21

1.088010 310 310 [1]

Deconvolutionτ0 = 1.71τ1 = 10.65

1.0841

CsI(Tl) τ0 = 910.4 1.0654980 560 560 [2]

Deconvolution τ0 = 901.6 1.0891

Anthracene τ0 = 2.36 1.14712.08 450 450 [3]


Rhodamine 6G τ0 = 4.42 1.04274.07 560 560 [4]



News 2012 Vol. 112

Thermopile DetectorsT11262, T11722, T11263, T11264

Evaluation module for array typeLeft: Single-element type T11262-01; Second from left: Dual type T11722-01; Second from right: Linear type T11263-16, T11263-32 (identical in shape); Right: Area type T11264-08

T11262-01

The T11262-01 is a single element detector which features high sensitivity making it ideally suited for gas analysis applications through the use of external filters.

Features � High sensitivity in the 3 to 5 µm spectral band � Compact package

Applications � Gas analysis

Area Array T11264-08

The T11264-08 features an 8 x 8 element array with preamp in the same package. An evaluation module is available for ease of operation.

Features � 8 x 8 element array � Wide spectral response range � Superior linearity & High sensitivity

Applications � Area temperature detection

Author: Robin Smith, Hamamatsu Photonics UK

T11722-01

The T11722-01 is a dual-element type thermopile specifically designed to detect CO2 concentrations with high accuracy. One element has a 4.3 µm filter to measure the absorption of CO2 whilst the other channel has a filter for 3.9 µm for reference.

Features � Detects CO2 concentrations with high accuracy � Compact package

Applications � CO2 concentration detection

Linear Array T11263-16/32

Hamamatsu provide a 16-element and a 32-element linear array with preamp in the same package, this offers the best noise performance.

Features � 16 or 32 elements � Superior linearity � High sensitivity � Non-cooled � Wide spectral response range

Applications � Temperature profile detection on FA line

Sensors for energy saving and security

PRELIMINARY


13News 2012 Vol. 1

Si APD with 635 nm band-pass filter

The new S11670-01 is mounted in a subminiature surface mount package measuring just 2.0 x 1.3 x 0.8 mm. A band-pass filter for 635 nm light sources is integrated within the package, over the 0.1 mm diameter sensor active area.

The S11670-01 is designed to operate at a low bias voltage, making it suitable for applications such as portable range finders, which commonly operate at 635 nm.

Features � 635 nm band-pass filter attached � Low bias operation � High speed response (cut off frequency: 1 GHz min.)

Applications � Optical rangefinders

Author: Richard Harvey, Hamamatsu Photonics UK

Spectral response (typical example) (Typ. Ta=25 deg. C.)

Compact Silicon APD S11670-01

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News 2012 Vol. 114

UV sensitive front-illuminated CCD

Hamamatsu introduces the S11151-2048 front-illuminated linear CCD. Unlike conventional front-illuminated CCDs, the S11151-2048 features a high UV response from 200 nm. The new array has 2048 pixels with dimensions of 14 µm x 200 µm.

With low dark current and image lag, the S11151-2048 is ideally suited for spectroscopy applications.

Features � High sensitivity in the UV region >200 nm � Low dark current � Low image lag

Applications � Spectrometers


Spectral response (without window, typical example) (Ta=25 deg. C.)

CCD Linear Image SensorS11151-2048

Parameter Specification UnitNumber of pixels 2,048 pixelsPixel pitch 14 µmPixel height 200 µmPhotosensitive area length 28.672 mmData rate 5 max. MHz

Specifications

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15News 2012 Vol. 1

CMOS Linear Image SensorS11106, S11107

Compact size and cost effective performance

Hamamatsu is pleased to introduce the S11106 and S11107 resin-sealed CMOS linear image sensors. Featuring a video data rate of 10 MHz and operating with a minimal current consumption these parts are ideal for high speed portable devices.

The S11106 has 128 pixels with 63.5 µm pitch and 63.5 µm height, whilst the S11107 has 64 pixels with 127 µm pitch and 127 µm height.

Features � Resin-sealed surface mount package � 10 MHz data rate � 3 V or 5 V single power supply operation � Electronic shutter function � Low current consumption

Applications � Position detection � Rotary encoders � Object measurement � Image reading


S11106/S11107

Specifications

Spectral response (Typ. Ta=25 deg. C.)

Parameter S11106 S11107 UnitNumber of pixels 128 64 -

Pixel pitch 63.5 127 µm

Pixel height 63.5 127 µm

Photosensitive area length 8.06 mm

Spectral response range 400 to 1,000 nm

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News 2012 Vol. 116

CMOS Linear Image SensorS11638

Achieves high sensitivity by adding an amplifier to each pixel

Hamamatsu welcomes the S11638 into their already extensive CMOS linear image sensor line-up. The S11638 is a CMOS linear image sensor that achieves high sensitivity through the use of adding an amplifier to each pixel. Compared to previous CMOS models the S11638 offers high sensitivity and high resistance to UV exposure.

The S11638 features 2,048 pixels with 14 µm pixel pitch and 42 µm pixel height, with sensitivity from 200 nm to 1,000 nm.

Features � High sensitivity: 160 V/(lx.s) � Electronic shutter function � 5 V single power supply operation � 10 MHz. max. video data rate

Applications � Position detection � Encoders � Barcode readers � Image reading � Spectrometers


Specifications

Parameter Specification Unit

Number of pixels 2,048 pixels

Pixel pitch 14 µm

Pixel height 42 µm

Photosensitive area length 28.672 mm

Spectral response range 200 to 1,000 nm

S11638


17News 2012 Vol. 1

InGaAs Linear Image SensorG12230-512DB

Hybrid-structure linear image sensor

Hamamatsu introduces the G12230-512DB hybrid InGaAs linear image sensor. The hybrid structure allows for two 256 pixel back-illuminated InGaAs photodiode arrays to be bump-bonded in a dual inline package with a CMOS readout circuit

The arrays have different spectral responses of 0.95 to 1.7 µm and 1.4 to 2.2 µm, giving an overall spectral response range from 0.95 to 2.2 µm.

With low dark current and linearity error, the G12230-512DB is ideal for spectrophotometry applications as well as any analytical system requiring a single sensor for a wide spectral response range.

Features � Very wide spectral response range of 0.95 to 2.2 µm � 250 x 25 µm pixel size � Low dark current � Low linearity error

Applications

� Spectrophotometry � Analysis and measurement


G12230-512DB


Parameter Symbol Min. Typ. Max. UnitSpectral response range λ - 0.95 to 2.2 - µm

Conversion efficiency CE - 16 - nV/e-

Photoresponse nonuniformity PRNU - ±10 - %

Data rate f - 0.5 1 MHz

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News 2012 Vol. 118

Si/InGaAs Linear Image SensorG12231-1024DF

G12231-1024DF


Unique silicon and InGaAs hybrid array

Hamamatsu introduces the G12231-1024DF hybrid Si/InGaAs linear image sensor. The unique structure employed in this image sensor allows a 768 pixel silicon array to be connected to a 256 pixel InGaAs array via flip-chip bonding.

This structure gives an array with a very wide spectral response from 400 nm to 1.7 µm and, allows for continuous spectrum acquisition across this range.

Features � Very wide spectral response range of 400 nm to 1.7 µm � 500 x 25 µm pixel size � Low dark current

Applications � Spectrophotometry � Analysis and measurement


Specifications

Parameter Min. Typ. Max. Unit

Spectral response range - 0.4 to 1.7 - µm

Number of pixels - 1,024 - pixels

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19News 2012 Vol. 1

G12242-0707W

InGaAs Area Image SensorG12242-0707W

High resolution near-infrared image sensor in TO-8 package

The new G12242-0707W InGaAs area image sensor is a 128 x 128 pixel array with 20 µm pitch, bump-bonded to a CMOS readout circuit.

Featuring high sensitivity in the near-infrared region this sensor is ideal for thermal imaging, non-destructive inspection, laser beam profiling and general near-infrared imaging applications.

The G12242-0707W is hermetically sealed in a two-stage TE cooled TO-8 package. This delivers highly stable, low noise operation.

Features � Spectral response range: 0.95 to 1.7 µm � 128 x 128 pixels with 20 µm pitch � Internal timing generator � Two-stage TE cooled � Simple operation

Applications � Non-destructive inspection � Near infrared imaging � Laser beam profiling � Thermal imaging


Specifications

Parameter Symbol Specification UnitNumber of pixels - 128 x 128 pixels

Pixel pitch - 20 µm

Spectral response range λ 0.95 to 1.7 µm

PRELIMINARY


News 2012 Vol. 120

Large Area Flat Panel SensorC11700DK-40, C11701DK-40

Large photosensitive area with high-speed response for X-ray 3D imaging

The C11700DK-40 and C11701DK-40 are flat panel sensors for X-ray imaging, specially developed for 3D-CT applications. They deliver high speed response whilst maintaining a large photosensitive area. The panels also have comprehensive firmware allowing for multiple scan modes and image processing.

Features � Large photosensitive area � High speed response � High sensitivity � High resolution

Applications � 3D imaging


Left: C11700DK-40, Right: C11701DK-40

Specifications

Parameter C11700DK-40 C11701DK-40 UnitPixel size 120 x 120 µm

Photosensitive area (H x V) 161 x 159 265 x 215 mm

Frame rate* 40 30 frames/s

Sensitivity* 15,000 LSB/mR

Scintillator Directly deposited CsI -

* Fast mode


21News 2012 Vol. 1

Specifications

Compact, high sensitivity radiation detector module

Hamamatsu introduces the C12137 gamma-ray detector module, containing a scintillator and an MPPC (Multi-Pixel Photon Counter) sensor. The scintillator converts incident gamma rays into visible light which the high sensitivity MPPC detects, giving highly accurate measurement of even very low energy gamma rays.

The signal processing circuit and A/D converter necessary for measurement are also integrated in the compact module, which is additionally equipped with a USB interface for connection to a PC (Windows® 7/XP compatible).

The C12137 is supplied as standard with free evaluation software which allows the user to set measurement conditions, acquire and save data and display graphs.

Features � Gamma ray energy discrimination � Design allows for easy integration into existing equipment � Compact and light weight

Applications � Environmental monitoring and mapping � Radiation screening


Radiation Detector ModuleC12137

Parameter Condition SpecificationScintillator CsI(Tl), 13 x 13 x 20 mm

Counting efficiency 137Cs**, 0.01 µSv/h 40 cpm min.

Energy range 30 keV to 2 MeV

Energy resolution 137Cs**, 662 keV 8 %

Measurement range 0.01 µSv/h to 100 µSv/h

Measurement errorExcluding attenuation by shield object and counting fluctuations

±20 %

Sampling time 1 to 60 seconds

InterfaceUSB 2.0 (Full Speed)

compatible with Windows® 7 (32-bit, 64-bit)/XP (32-bit)*

Power supply USB bus power

* Windows is either registered trademark or trademark of Microsoft Corporation in the United States and other countries. ** Cesium 137

C12137


News 2012 Vol. 122

Very low noise bialkali photomultiplier tube

The R11715 is a cooled 28 mm (1-1/8 inch) side-on photomultiplier tube. Unlike conventional tubes that require a bulky cooling system, the R11715 series incorporates a Peltier cooler coupled to an integrated top plate on the tube itself.

This allows for direct cooling of the photocathode giving extremely low dark counts of approximately 2 counts/s.

With a wide spectral response range from 185 to 710 nm, the R11715 series will be particularly suited to any analytical or medical application requiring a detector with excellent dark count characteristics.

Features � Direct photocathode cooling � Extremely low dark counts � Peak sensitivity at 410 nm � Large active area: 8 mm x 24 mm

Applications � Analytical and medical equipment


Cooled Side-On Photomultiplier TubeR11715 series

R11715 series

Cooling characteristics (at ambient temperature 40 deg. C.)

Specifications

Parameter Specification UnitSpectral response range 185 to 710 nm

Peak sensitivity wavelength 410 nm

Effective area 8 x 24 mm

Phot

ocat

hode

tem

pera

ture

(deg

.C)

Dark

cou

nt (s

-1)

Time (s)

50

40

30

20

10

0

200

160

120

80

40

00 40 80 120 160 200 240 280

Photocathode temperature (deg.C) Dark count (s-1)


23News 2012 Vol. 1

H11836

Cooled 16-Channel PMT ModuleH11836

New H11836 cooled PMT module

Hamamatsu is pleased to introduce the H11836 which expands the existing range of multi-anode photomultiplier modules. This 16 channel module uses thermoelectric cooling to offer the best possible dark counts by cooling the photocathode at the best possible position.

The module features an inbuilt thermistor so that the user can monitor photocathode temperature.

Features � Cooled photocathode � 16-channels � Internal voltage divider circuit, amplifier and high voltage power supply

Applications � Biomedical fluorescence detection � Laser scanning detection � Low-light emission measurement



News 2012 Vol. 124

Ideal for R&D immunochromotographic reagents and quality control

Hamamatsu are pleased to introduce the C10066-10, which makes rapid, high sensitivity quantitative measurements of colour intensities for red/blue based immunochromatographic reagents.

Measurement data is saved in CSV file format allowing for easy analysis in spread sheet software.

The unit is compatible with a wide range of reagent housing cartridges and is ideal for the development of immunochromatographic reagents.

Features � High sensitivity and repeatability � Measures red and blue colour lines � Compatible with a wide range of reagent housing cartridges

Applications � Development of immunochromatographic reagents � Quality control


C10066-10

Immunochromato ReaderC10066-10

Specifications

Parameter Specification UnitInput voltage (AC) 100 to 240 V

Power consumption (max.) 3 VA

Interface USB 2.0 (cable supplied) or RS-232C (dedicated cable optional) -

Light source Green LED / Red LED -

Light detection Silicon photodiode -

Measurement object Red-based colour line / Blue-based colour line -

Dimensions (W x H x D) 215 x 92 x 235 (excluding projecting parts) mm

Weight 1.6 kg


25News 2012 Vol. 1

PMT Modules with Internal ShuttersH11706, H12056

New H11706 and H12056 photomultiplier tube modules

Hamamatsu introduces two new photomultiplier tube modules to add to their comprehensive range of existing modules. The new modules include internal shutters to protect the PMT from excessive light input and are available with a range of photocathodes to cover many different applications.

The H11706 features cable output, head on packaging and has a shutter speed of 1 µs to 10 ms via the use of an external signal.

The H12056 features pin output, side on packaging and a shutter speed of 10 ms to DC via the use of an external signal.

Features � High stability � Internal shutter � Range of spectral responses

Applications � LIDAR � Laser induced fluorescence


Photomultiplier Tube Module H11706

Photomultiplier Tube Module H12056

Spectral response (H11706)

Spectral response (H12056)

Type no. Spectral response Feature

H11706-110 230 to 700 nmSuper-bialkali photocathode, visible range

H11706-01 230 to 870 nmMultialkali photocathode, visible to NIR range

H11706-20 230 to 920 nmExtended red multialkali photocathode

H11706P-110 230 to 700 nmSuper-bialkali photocathode, photon counting type

Type no. Spectral response Feature

H12056-110 230 to 700 nmSuper-bialkali photocathode, visible range

H12056-01 230 to 870 nmMultialkali photocathode, visible to NIR range

H12056-20 230 to 920 nmExtended red multialkali photocathode

H12056P-110 230 to 700 nmSuper-bialkali photocathode, photon counting type


News 2012 Vol. 126

USB Controlled Photon Counting HeadH11890 series

New photon counting head H11890 series

Hamamatsu is pleased to introduce the H11890 compact photon counting head. The photon counting head integrates a metal package photomultiplier tube, high voltage power supply, voltage divider circuit, photon counting circuit and USB interface.

This new photon counting head comes with three different photocathodes allowing for adaptation to many different applications. The photon counting circuits have a high count linearity and low noise.

The photon counting head runs off of USB bus power and as such requires no external power supply, ideal for on the move applications. Hamamatsu provides operating software for ease of use.

Features � Runs off USB bus power � Photon counting head � Simple to use software

Applications � Point of Care Testing � Academic studies � Analytical markets � Biological research


Photon Counting Head H11890

Specifications

Parameter H11890-110 H11890-210 H11890-01 Unit

Input voltage USB Bus Power -

Max. input current 50 mA

Spectral response range 230 to 700 230 to 700 230 to 870 nm

Peak sensitivity wavelength 400 nm

Effective area φ8 mm

Count sensitivity at 400 nm (typ.) 4.9 x 10 5 6.1 x 10 5 3.6 x 10 5 s -1·pW -1

Count linearity * 5.0 x 10 6 s -1

Dark count ** (typ.) 50 50 600 s -1

* Random pulse, at 10 % count loss.** After 30 minutes storage in darkness at plateau voltage.


27News 2012 Vol. 1

UV-LED Curing System LC-L1V3L11921/22 series, E11923/24 series

L11921/22 series

Compact, high power UV LED curing system

Hamamatsu introduce a new light source to the existing Lightningcure® series of UV curing systems. Based around the popular LC-L2, the LC-L1V3 combines all the individual driver components into a single compact package. This reduces the space required for operation and results in a lower cost solution.

The LC-L1V3 still offers the same high stability, high output and long service life of other Lighningcure® LED sources. It also requires significantly less power to operate compared to other LED and lamp based systems – just 25W when driving four heads!

For applications requiring a high UV irradiation stability, the LC-L1V3 incorporates a feedback function that minimizes any drift in light output that can occur in the first 30 minutes of operation.

The LC-L1V3 does not require any cooling, so is ideal for curing applications in clean rooms.

Features � 365 nm and 385 nm LED heads � Maximum irradiation intensity of 15,000 mW/cm2

� Low power consumption of just 25 W with four heads � 20,000 hour LED life � Feedback function � Fanless operation

Applications � UV adhesive curing � UV bonding


Specifications

Parameter365 nm

high power type 385 nm

high power typeUnit

UV irradiation intensity 10,500 15,000 mW/cm 2

Peak wavelength 365±5 385±5 nm

LED life 20,000 h

Input voltage (DC) 9±0.5 V

Power consumption (max.) 25 W

Cooling method Air cooling without blower -

Operating temperature range +5 to +35 deg.C

Storage temperature range -10 to +50 deg.C

Operating humidity range 20 to 80 (No condensation) %

Storage humidity range Below 80 (No condensation) %

Control method Manual control / External control -

Dimension (W x D x H) 160 x 104 x 30 mm

Applicable standard EN61010-1:2001, IEC62471:2006 -

SYSTEMS PRODUCTS

News 2012 Vol. 128

ORCA-Flash4.0

High sensitivity (QE: over 70 %) and high-speed (100 frames/s) scientific imaging CMOS Camera

When Hamamatsu Photonics began life as a company in 1948, Japan was just beginning to apply the philosophy of “Kaizen” (“continuous improvement“) to industry. In the subsequent years, Hamamatsu products have changed and our product range expanded, but the company has always been at the forefront of advanced imaging and tries to produce innovative products that improve peoples’ lives through the application of our technology.

This broader interpretation of Kaizen, where continuous improvement in our products brings an improvement in the lives of our customers means Hamamatsu never lose sight of our customers’ needs.

In the 1980’s we enabled better microscopic imaging in lifescience research when the Argus system allowed biological samples to be analysed digitally and since then we have continued to develop imaging systems that allow scientific research to push back the boundaries of knowledge. Video cameras were followed by CCD Cameras (the introduction of the ORCA range) and EM-CCD Cameras (ImagEM series), until the most recent development of First Generation Scientific CMOS (Gen I sCMOS) Cameras in the last two years. This drive has been in response to a need from our customers to image smaller, faster moving and fainter samples than previously was possible.

Launched in December 2011, the ORCA-Flash4.0 is the latest camera in this long history of Hamamatsu innovation. Unlike all other sCMOS Cameras available on the market today, the Flash4.0 is the first sCMOS Camera to challenge the EM-CCD Cameras dominance in high speed, low-light imaging. In recognition of this landmark the ORCA-Flash4.0 has been described as the world’s first Gen II sCMOS Camera, meaning it can out-perform EM-CCD Cameras. All reviews of EM-CCD Camera performance against sCMOS Cameras published before December 2011 were based on Gen I sCMOS.

For the past 10 years, customers trying to image low intensity or fast moving signals have often resorted to using EM-CCD Cameras for the best results (indeed for very low intensity samples an ImagEM would sometimes be the only camera that would get any results). With the arrival of the ORCA-Flash4.0 that situation has now changed and customers have a choice.

For those extreme applications such as luminescence imaging where the sample emits a few photons and the background shows no emission, EM-CCD Cameras will remain the best choice. Hamamatsu continue to improve our ImagEM EM-CCD Camera range to meet that need.

Readout method Number of pixelsReadout speed

at center position (frames/s)Full resolution 2,048 × 2,048 100

Sub-array readout(Typical examples)

2,048 × 1,024 200

2,048 × 512 400

2,048 × 256 800

2,048 × 64 3,200

2,048 × 8 25,600

Low noise and fast readout time simultaneously

TM

SYSTEMS PRODUCTS

29News 2012 Vol. 1

However there is a large and growing need for high speed, high sensitivity and high resolution to be offered simultaneously in order to capture biological structures that cannot be satisfactorily imaged in conventional light microscopy. EM-CCD Cameras can meet some of this need, but the camera’s multiplication process acts not only on the sample signal but on the rest of the image background also. Additionally, there are additional noise sources that are introduced in EM-CCD Cameras (refer to the Hamamatsu white paper “Changing the Game “ for a detailed explanation). This means that overall an EM-CCD Camera can image low-level fluorescence images at speeds similar to CCDs (ie 10’s of frames per second), but the overall sensitivity is not as high as might be anticipated after the effects of excess noise sources and background multiplication are taken into account.

The ORCA-Flash4.0 is ideally suited to capture low-level fluorescence from complex biological processes. It can simultaneously deliver high sensitivity (over 70 % Quantum Efficiency at 600 nm), very low readout noise (1.3 electrons) and very fast frame rates (100 frames / second) at full resolution (4 Megapixel sensor, each pixel = 6.5 µm).

As you would expect from such as significant enabling technology, pioneering research is already being carried out at leading institutes around the world using the ORCA-Flash4.0 and in a matter of weeks the camera has already delivered ground-breaking results in new techniques such as “super-resolution”, where light microscopy is being taken beyond the established barrier of optical resolution. The ORCA-Flash4.0 represents the beginning of a new chapter for Hamamatsu’s digital camera range and an exciting new frontier for our customers.

Author: Jim Owens, Hamamatsu Photonics UK

Imaging example

High speed Ca2+ imaging of cardiomyocyte derived from human iPS cells stained by Fluo8-AM

SYSTEMS PRODUCTS

News 2012 Vol. 130

X-ray TDI CameraC12200-321

High-speed X-ray imaging

With the new X-ray TDI camera C12200-321 Hamamatsu offers a real fast in-line solution for high-throughput applications requiring best resolution and sensitivity. Although there are various kinds of measuring tasks in the field of X-ray in-line inspection, all quality assurance processes have one thing in common. They have to be as fast as possible while acquiring images with highest resolution and contrast. Whereas most sensor types have problems to combine these three key demands the new C12200-321 X-ray TDI camera is able to do it.

The time delay integration technique is transferring the signal charges synchronously with the object movement. As in the C12200-321 a CCD of 128 vertical pixel lines (with 110 active pixel lines) is used and this method increases the collected signal by vertical line times, improving the signal-to-noise ratio by the square root of vertical lines. Despite the small pixel size of just 48 µm the TDI mode features highest sensitivity even under low brightness condition in a high speed in-line application.

The maximum scanning speed of 36.8 m/min (2x2 binning) combined with a detection width of 221 mm (4,608 pixels) makes the new Hamamatsu X-ray TDI camera a product that can significantly increase the throughput of an inspection system compared to the usage of a traditional stop-and-go stage with a conventional 2-D area sensor.

Author: Stefan Kappelsberger, Hamamatsu Photonics Germany

High Speed X-ray TDI Camera C12200-321

By imaging the internal structure of a lithium battery, foreign materials can be detected.

TDI (Time Delay Integration):Time Delay Integration is a technique in which signal charges in each line are vertically transferred during charge readout. By synchronizing the vertical transfer timing with the movement of the object, the signal charges are integrated without smear. As a result, TDI provides higher sensitivity than standard line scan cameras. It is an ideal technology for high-throughput X-ray applications that require high sensitivity and high resolution simultaneously.

SYSTEMS PRODUCTS

31News 2012 Vol. 1

Features � High resolution � High speed � High sensitivity and S/N ratio with 12 bit output � Wide detection width of 221 mm

Applications � Printed circuit board inspection � Surface-mounted component inspection � Battery inspection � High resolution in-line non-destructive inspection � Medicine inspection

Specifications

Type no. C12200-321CCD pixel number 4,608 (H) × 128 (V)

Active CCD pixel number 4,608 (H) × 110 (V)

CCD pixel size 48 µm × 48 µm

X-ray sensitive area 221 mm (H) × 6 mm (V)

Window FOS (Fiber optic plate with scintillator)

X-ray detection range Approx. 25 kV to 130 kV

X-ray tolerance range 130 kV, 80 µA (max.)

CCD pixel clock 5.0 MHz

TDI line rate1 × 1 Max. 8 kHz (23.040 m/min)

binning 2 × 2 Max. 6.4 kHz (36.864 m/min)

A/D converter 12 bit

Data output 12 bit

Interface (Camera Link) Base Configuration

Pixel clock (Camera Link) 40.0 MHz

TDI line rate control * External mode or internal mode

A/D gain value ** 0 dB to 20 dB (64 steps)

Power requirements DC +15 V (±1 V)

Power consumption 40 V⋅A (max.)

* Selectable by serial command** A/D gain value (M8815-01) is optional.

X-ray source

Object

X-ray TDI Camera

TM

News 2012 Vol. 132

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33News 2012 Vol. 1

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News 2012 Vol. 134

Exhibitions 2012

May 2012

LABOTEC Suisse09. - 10. May 2012 - Basel, Switzerland

Sensor & Vision09. - 10. May 2012 - Bruxelles, Belgium

Micronano System Workshop (MSW 2012)09. - 10. May 2012 - Linköping, Sweden

Spring meeting - Pathology09. - 11. May 2012 - Halmstad, Sweden

Science, Technology & Innovation (Rutherford Appleton Laboratory)10. May 2012 - Harwell, England

Bunsentagung17. - 19. May 2012 - Leipzig, Germany

2nd Pannonia Congress of Pathology17. - 20. May 2012 - Siofok, Hungary

XII Pisa meeting on advanced detectors20. - 26. May 2012 - Isola d'Elba/Italy

Synchrotron20. - 25. May 2012 - Crakow, Poland

Sensor + Test22. - 24. May 2012 - Nürnberg, Germany

Optatec22. - 25. May 2012 - Frankfurt, Germany

Bienal Maquina Herramienta28. May - 02. June 2012 - Bilbao, Spain

EACTA 23. - 25. May 2012 - Amsterdam, Netherlands

Screening Europe30. - 31. May 2012 - Hamburg, Germany

4. Woche der Pathologie31. May - 03. June 2012 - Berlin, Germany

10th Nordic Femtochemistry Conference 201231. May - 01. June 2012 - Lund, Sweden

June 2012

European Light Microscopy Initiative Meeting (ELMI)05. - 08. June 2012 - Louvain, Belgium

11th EU Congress on Telepathology 5th Interna-tional Congress on virtual Microscopy06. - 09. June 2012 - Venezia, Italy

Jaszowiec 11. - 15. June 2012 - Poland

PhotoDet 2012 Workshop 13. - 15. June 2012 - Orsay, France

FDSS users meeting 14. June 2012 - Paris, France

Congrès AFH14. - 15. June 2012 - Lyon, France

Cyto23. - 27. June 2012 - Leipzig, Germany

UKRC 25. - 27. June 2012 - Manchester, England

Next Generation Sequencing - Technologies and Future Applications 26. June 2012 - Cambridge, England

July 2012

Iworid01. - 05. July 2012 - Figueira da Foz, Portugal/

OWLS 20124. - 6. July 2012 - Genova, Italy

British Microcirculation Society & The Microcirculatory Society Joint Conference4. - 6. July 2012 - Oxford, England

11th International Conference on Synchrotron Radiation Instrumentation09. - 13. July 2012 - Lyon, France

FENS14. - 18. July 2012 - Barcelona, Spain

ICSNN22. - 27. July 2012 - Dresden, Germany

September 2012

Photon1203. - 05. September 2012 - Durham, England

SINDEX Massgebend ist Technologie04. - 06. September 2012 - Bern, Switzerland

Drug Discovery05. - 06. September 2012 - Manchester, England

24th European Congress of Pathology08. - 12. September 2012 - Prague, Czech Republic

Elektronik11. - 13. September 2012 - Odense, Denmark

10th European Congress of Toxicologic Pathology11. - 14. September 2012 - Stresa (VB), Italy

Meeting Biofisica17. - 20. September 2012 - Manchester, England

European Microscopy Congress17. - 21. September 2012 - Ferrara, Itlay

Het Instrument25. - 28. September 2012 - Amsterdam, Netherlands

European Optical Society (EOS) Annual Meeting25. - 28. September 2012 - Aberdeen, Scotland

October 2012

4th Congress of the European Academy of Paediatric Societies – EAPS06. - 09. October 2012 - Istanbul. Turkey

Biopharmaceutical Flow Cytometry & Imaging10. - 11. October 2012 - Alderley Park, England

Photonex17. - 18. October 2012 - Coventry, England

OPTO23. - 25. October 2012 - Paris, France

EACTS27. - 31. October 2012 - Barcelona, Spain

November 2012

Vision06. - 08. November 2012 - Stuttgart, Germany

Electronica13. - 16. November 2012 - Munich, Germany

Compamed14. - 16. November 2012 - Duesseldorf, Germany

Carrefour Pathologie19. - 23. November 2012 - Paris, France

35News 2012 Vol. 1

Hamamatsu Photonics Europe

Germany: Hamamatsu Photonics Deutschland GmbH Arzbergerstr. 10, D-82211 Herrsching Phone: +49 (0) 8152 375-0 Fax: +49 (0) 8152 2658 E-mail: [email protected] North-West: (for system products) Phone: +49 (0) 2831 94506 Fax: +49 (0) 2831 94507 E-mail: [email protected] www.hamamatsu.de

Denmark: Lautruphøj 1-3DK-2750 BallerupPhone: +45 70 20 93 69Fax: +45 44 20 99 10E-mail: [email protected] Netherlands: Televisieweg 2, NL-1322 AC Almere Phone: +31 (0) 36 5405384 Fax: +31 (0) 36 5244948 E-mail: [email protected]

Poland: RN 240 ul. sw. A. Boboli 8, PL-02525 Warsaw Phone: +48 (0) 22 6460016 Fax: +48 (0) 22 6460018 E-mail: [email protected]

France: Hamamatsu Photonics France S.A.R.L. 19, rue du Saule Trapu Parc du Moulin de Massy F-91882 Massy Cedex Phone: +33 (0) 1 69 53 71 00 Fax: +33 (0) 1 69 53 71 10 E-mail: [email protected] www.hamamatsu.fr

Grenoble: Buro Club Meylan 29 Boulevard des Alpes, 38246 Meylan Cedex Phone: +33 (0) 4 76 6144 50 Fax: +33 (0) 4 76 6144 44 E-mail: [email protected]

Switzerland: Dornacherplatz 7, CH-4500 Solothurn Phone: +41 (0) 32 625 60 60 Fax: +41 (0) 32 625 60 61 E-mail: [email protected] www.hamamatsu.ch

Spain / Portugal: C. Argenters, 4 edif 2Parque Tecnológico del Vallés E-08290 Cerdanyola (Spain) Phone: +34 93 582 44 30 Fax: +34 93 582 44 31 E-mail: [email protected] www.hamamatsu.es

Belgium: Parc Scientifique -7, Rue du Bosquet B-1348 Louvain-la Neuve Phone: +32 (0) 10 45 63 34 Fax: +32 (0) 10 45 63 67 E-mail: [email protected] Italy: Hamamatsu Photonics Italia S.r.l. a socio unico Strada della Moia 1 int. 6, I-20020 Arese (Milano) Phone: +39-02 9358 1733 r.a. Fax: +39-02 9358 1741 E-mail: [email protected] www.hamamatsu.it

South office: Viale Cesare Pavese, 435, I-00144 Roma Phone: +39-06 5051 3454 Fax: +39-06 5051 3460 E-mail: [email protected]

United Kingdom: Hamamatsu Photonics UK Ltd. 2 Howard Court, 10 Tewin Road, Welwyn Garden City Hertfordshire, AL7 1BW, England Phone: +44 (0) 1707 294888 Fax: +44 (0) 1707 325777 E-mail: [email protected] www.hamamatsu.co.uk

South Africa: PO Box 1112, Buccleuch 2066 Johannesburg Republic of South Africa Phone/Fax: +27 (0) 11 802 5505 Cellphone: +27 (0) 83 298 9266 E-mail: [email protected]

Northern Europe: Hamamatsu Photonics Norden AB Torshamnsgatan 35, SE-16440 Kista (Sweden) Phone: +46 (0) 8 50 90 31 00 Fax: +46 (0) 8 50 90 31 01 E-mail: [email protected] www.hamamatsu.se

Russia: Vyatskaya St. 27, bld. 13 RU-127015, Moscow Phone: +7 (495) 258 85 18 Fax: +7 (495) 258 85 19 E-mail: [email protected]

Impressum

Hamamatsu Photonics News

Publisher and copyright:Hamamatsu PhotonicsDeutschland GmbHArzbergerstr. 10, D-82211 Herrsching am Ammersee, GermanyTelephone: (49)8152-375-0Fax: (49)8152-2658

Sitz der Gesellschaft: HerrschingAmtsgericht München HRB 79474Geschäftsführer: Dr. Peter EgglUSt/VAT-Id.: DE128228814http://[email protected]

Editor and responsible for content:Dr. Peter Eggl

Publishing frequency:Bi-annual, Date of this issue April 2012

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