new frontiers for the treatment of solid and liquid tumors...

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The Medical Educator Consortium

Florida Society of Clinical Oncology

Oncology LatinAmerican Association

April 27-29, 2018Conrad Hilton Hotel

Miami, Florida

Luis E. Raez, M.D., FACP, FCCPChief of Hematology-Oncology &

Medical DirectorMemorial Cancer Institute

Memorial Health Care SystemClinical Professor of Medicine

Herbert Wertheim College of MedicineFlorida International University

Miami, Florida

PROGRAM DIRECTORS:Caio Max S. Rocha Lima, M.D.

Hematology and OncologyAssociate Cancer Center Director for

Translational Research Gibbs Cancer Center & Research Institute

CMO Guardian Research Network Spartanburg Healthcare System

Spartanburg, SC

Edgardo S. Santos Castillero, M.D., FACPMedical Director of Cancer Research

Thoracic and Head and Neck Cancer ProgramsEugene & Christine Lynn Cancer Institute

Associate Professor of Clinical Biomedical Science Charles E. Schmidt College of Medicine

Florida Atlantic UniversityBoca Raton, FL

Sponsored by:In Collaboration with:

15th ANNUAL MIAMI CANCER MEETING (MCM)

New Frontiers for the Treatment of Solid and Liquid Tumors: Delivering Precision Medicine

PROOF

Sikander Ailawadhi, M.D.Associate ProfessorVice Chair, Clinical PracticeDirector, Outreach ServicesDivision of Hematology/OncologyDepartment of MedicineMayo Clinic FloridaJacksonville, FL

Jorge Alatorre, M.D.Medical OncologistHospital Angeles LomasHuixquilucan, Edo. de Mexico

Scott Antonia, M.D., Ph.D.Chair, Department ofThoracic Oncology H. Lee Moffitt Cancer CenterTampa, FL

Jumana Ashy, M.S., Pharm.D.Clinical PharmacistAlex’s Place, Pediatric Hematology-Oncology Clinic and Infusion Center University of Miami, Miller School of MedicineMiami, FL

Marcelo Blaya, M.D.Memorial Cancer InsittuteMemorial Health Care SystemHollywood, FL

Aurelio Castrellon, M.D.Breast Cancer ProgramMemorial Cancer InstituteMemorial Health Cancer SystemHollywood, FL

Christian Rolfo Cervetto, M.D., Ph.D.Head of Unit Phase I - Early Clinical Trials; Director of Clinical Trial Management Program; Oncology Department University Hospital Antwerp, Belgium

Gerado Colon-Otero, M.D.Associate Professor of MedicineMayo Clinic School of Medicine - Mayo ClinicJacksonville, FL

Luis Corrales-Rodriguez, M.D.Medical Oncologist at CIMCA, Bíblica, and CCSS, Costa Rica Atención sanitaria y hospitalariaCosta Rica

Dina Dumercy, Pharm.D., BCOP, BCPSClinical Manager-Hematology OncologyDirector-Oncology Pharmacy PGY2 Residency ProgramMemorial Cancer InstituteMemorial Healthcare SystemHollywood, FL

Hugo Fernandez, M.D.Director, Hematology Malignancies & Bone Marrow TransplantLee Moffit Cancer Center at Memorial Health Care SystemHollywood, FL

Mayer N. Fishman, M.D., Ph.D.Professor, Departments of Oncologic Sciences and of Internal MedicineUniversity of South Florida Morsani College of Medicine Medical Oncologist in Genitourinary Oncology, Member of the Chemical Biology and Molecular Medicine Program of the Immunotherapy and Experimental Therapeutics ProgramsMoffitt Cancer Center. Tampa, FL

Jorge Garcia, Pharm.D.Pharmacy Director Memorial Cancer InstituteMemorial Healthcare SystemHollywood, FL

Thomas Herzog, M.D.Clinical Director of the UC Cancer Institute; Professor, Division of Gynecologic OncologyCincinnati, OH

Brian Hunis, M.D.Director of Head & Neck Cancer and Quality, Memorial Cancer InstituteClinical Assistant Professor of MedicineHerbert Wertheim College of MedicineFlorida International UniversityHollywood, FL

Mohamed Kharfan-Dabaja, M.D.Director, Blood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine Mayo Clinic Florida Jacksonville, FL

Educational Committee • Distinguished Faculty

Jorge Alatorre, M.D. (Mexico) Jumana Ashy, M.S, Pharm.D (USA)Luis A. Corrales, M.D. (Costa Rica)Gerardo Colon-Otero, M.D. (USA)

Dina Dumercy, Pharm.D., BCOP (USA)Hugo Fernandez, M.D. (USA)

Jessica MacIntrye, ARNP, NP-C (USA)Luis E. Raez, M.D., FACP, FCCP (USA)Caio Max S. Rocha Lima, M.D. (USA)

Edgardo S. Santos Castillero, M.D., FACP (USA)Eduardo Sotomayor, M.D. (USA)

Adrienne M. Vazquez, MSN, ACNP-BC, AOCN (USA)

EDUCATIONAL COMMITTEE

DISTINGUISHED FACULTY

PROOF

Educational Committee • Distinguished Faculty

Richard Kim, M.D.Medical Oncologist, Gastrointestinal Oncology Department, Moffitt Cancer Center, Assistant Professor of Oncology, University of South Florida College of Medicine.Tampa, FL

Alan Koletsky, M.D.Affiliate Assistant Professor of Clinical Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Genitourinary Cancer Research Program, Lynn Cancer InstituteBoca Raton, FL

Primo N. Lara, Jr., M.D. Professor of Medicine, UC Davis School of Medicine, Acting Director, UC Davis Comprehensive Cancer CenterSacramento, CA

Jose Lutzky, M.D.Co-Chief, Hematology & OncologyDirector, Mount Sinai Melanoma Program, Mount Sinai Medical Center Miami, FL

Jessica MacIntyre, ARNP, NP-CUM/Sylvester Comprehensive Cancer CenterMiami, FL

Robert E. Marx, D.D.S. Professor of Surgery; Director of Research; Chief, Division of Oral andMaxillofacial Surgery, Department of Surgery, University of Miami Miller School of Medicine Diplomate, American Board of Oral and Maxillofacial SurgeryMiami, FL

Ashwin Mehta, M.D.Medical Director Integrative Medicine Program; Memorial Cancer InstituteMemorial Health Care SystemHollywood, FL

Tarek Mekhail, M.D.Associate Director, Florida Hospital Cancer Institute; President,Cancer Institute of FloridaMedical Director, Thoracic Cancer ProgramAssociate Professor – University of Central FloridaOrlando, FL

Louise Morrell, M.D.Director, Lynn Cancer InstituteBoca Raton, FL

Dov Pickholtz, D.O.Chief Consultant Aysev, Comprehensive Cannabinoid CareDelray Beach, FL

Luis E. Raez, M.D., FACP, FCCPChief of Hematology-Oncology &Medical DirectorMemorial Cancer InstituteMemorial Health Care SystemClinical Professor of MedicineHerbert Wertheim College of MedicineFlorida International UniversityMiami, Florida

Caio Max S. Rocha Lima, M.D. Hematology and OncologyAssociate Cancer Center Director for Translational Research Gibbs Cancer Center & Research Institute, CMO Guardian Research NetworkSpartanburg Healthcare System Spartanburg, SC

Hope Rugo, M.D.Professor of MedicineDirector, Breast Oncology and Clinical Trials Education; University of California San FranciscoHelen Diller Family Comprehensive Cancer CenterSan Francisco, CA

Edgardo S. Santos Castillero, M.D., FACPMedical Director of Cancer ResearchLynn Cancer Institute Thoracic and Head and Neck Cancer Programs; Associate Professor of Clinical Biomedical SciencesFlorida Atlantic UniversityBoca Raton, Florida

Orlando E. Silva M.D.Director; Larkin Cancer CenterMiami, FL

Eduardo Sotomayor, M.D.Director, George Washington University Cancer CenterProfessor of Medicine, George Washington, University School of Medicine & Health SciencesWashington, DC

John Strasswimmer M.D., Ph.D.Medical Director, Melanoma & Cutaneous Oncology ProgramLynn Cancer Institute, Boca Raton Regional Hospital; Professor, Affiliate, of Medicine (Dermatology)Professor, Affiliate, of BiochemistryFlorida Atlantic University Boca Raton, FLAssociate Professor, Affiliate, of Dermatology, University of MiamiDelray Beach, FL

Vicente Valero, M.D.Professor, and Deputy Chairman, Breast Medical Oncology DepartmentClinical Director, The Morgan Welch Inflammatory, Breast Cancer Research Program and Clinic, Associate Director, Nellie B. Connally Breast CenterThe University of Texas M. D. Anderson Cancer CenterHouston, TX

Adrienne M. Vazquez, MSN, ACNP-BC, AOCN Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of MedicineMiami, FL

Ahmed Zakari M.D.Associate Professor University of Central Florida, College of MedicineMedical Director, Gastro Intestinal Cancer Program; Florida Hospital Cancer Institute; Section Chair of Hematology, Florida HospitalOrlando, FL

PROOF

CONFERENCE DESCRIPTION This is a 3-day course designed for medical oncologists, hematologists, radiation oncologists, surgical oncologists, physician assistants (PA), advanced registered nurse practitioners (ARNP), oncology nurses, registered pharmacists, pharmacy technicians, and radiation therapists. General practitioners (internal medicine and family medicine) will have the benefit of review standard of care and new developments in cancer management. Residents in training and fellows from these specialties are encouraged to attend.

Topics in solid tumors and hematological malignancies will be reviewed; that will include topics in breast cancer, lung cancer, gastrointestinal (GI) malignancies, gynecologic malignancies, (GU) genitourinary cancers, head and neck cancers, melanoma, and hematological malignancies such as multiple myeloma, CLL and non-Hodgkin’s lymphoma, and myelodysplastic syndrome. There will also be a special session devoted to the area of supportive care in oncology, with emphasis on properties & uses of medical marijuana, bone metastasis, malignant hypercalcemia, and management of chemotherapy, targeted therapy and immunotherapy-related side effects.

The areas of focus for this conference will include the current standards of care in the treatment of all aforementioned malignancies and new developments in these areas of cancer care. There will be much emphasis on molecular diagnosis and individualization of cancer therapy based on molecular profiles. There will be reviews of new chemotherapeutic, antiangiogenic and immunotherapeutic agents.

Presentations from latest national (AACR 2018, ASCO 2017, SABC 2017, and ASH 2017) and international forums (ESMO 2017 and WCLC 2017) meetings will be discussed and guidelines of cancer care will be emphasized. The participants in the meeting will have the opportunity not only to learn, review, and understand the state-of-the-art management in cancer care but also engage in personal interaction with our panel of experts in these subjects during our question and answer sessions.

CONFERENCE OBJECTIVES Upon completion of this course attendees will be able to:

1. Understand the latest advances in chemotherapy, targeted therapy and immunotherapy options available for lung cancer, breast cancer, GI malignancies, GU malignancies, melanoma, head and neck cancer as well as hematological malignancies including multiple myeloma, NHL, MDS, and CLL.

2. Evaluate the current standards of care in the treatment of a variety of solid and hematologic malignancies.

3. Discuss risks and benefits when combined modality of treatment (that includes radiation therapy and surgery) being delivered to patients who have localized malignant processes (i.e., NSCLC, head and neck, prostate cancer, and others).

4. Manage symptoms induced by chemotherapy, immunotherapy or targeted therapy such as nausea, vomiting, auto immune complications and hematologic and metabolic toxicities

ACCREDITATION: The Medical Educator Consortium is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

DESIGNATION STATEMENT: The Medical Educator Consortium, designates this live activity for a maximum of 17.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

15th Annual Miami Cancer Meeting (MCM): New Frontiers for the Treatment of Solid and Liquid Tumors:

Delivering Precision Medicine

PROOF



NURSING CEUThis activity has been approved by the Nurse Practitioner Council of Miami-Dade Inc. for SIXTEEN (16.0) Contact Hours for nurses who attend this program in it’s entirety. Nurse Practitioner Council of Miami-Dade Inc, is accredited as a provider of Continuing Nursing Education by the State of Florida, CE Broker Provider Number 50-15792

PHARMACY CEUThis activity is approved for a total of 16 contact hours of Continuing Education Credit for Pharmacists and Pharmacy Technicians awarded by the University of Miami Sylvester Comprehensive Cancer Center. Participants must attend all day lectures to receive credit for that day. Partial credits are not available. Where credits are approved on a session-by-session basis, participants must attend each session in its entirety to receive complete credit for the session. A certificate of completion will be provided to each participant at the end of the conference. Credit will be entered into CE Broker. UMHC/Sylvester is a approved by the Florida Board of Pharmacy as a provider of continuing pharmacy education.

FACULTY DISCLOSURE STATEMENTThe Medical Educator Consortium (MEC) adheres to the ACCME Standards for Commercial Support. All persons that will be in a position to control the content of the CME Activity are required to disclose all relevant financial relationships. Faculty disclosure forms outlining this information will be made available to all participants prior to educational activity. MEC has also implemented a mechanism to identify and resolve all conflicts of interest prior to the education activity being delivered to learners. The source of all support from commercial interests will also be disclosed to learners prior to the beginning of the educational activity.

PROOF

Friday, april 2712:30 pm – 7:30 pm Registration Open & Visit Exhibits

1:30 pm – 2:30 pm Lunch & Learn Symposium (non CME) 3:00 pm – 3:10 pm Welcome and Introduction Luis E. Raez

3:10 pm – 7:50 pm Supportive & Palliative Care and Management of New Toxicities Chairs: Dina Dumercy & Luis Corrales-Rodriguez

3:10 pm – 3:40 pm What is New in Immunotherapy and Side Effects Christian Rolfo Cervetto

3:40 pm – 4:10 pm Hypermetabolic Syndrome and Cancer Orlando E. Silva

4:10 pm – 4:40 pm Survivorship and Integrative Medicine in Cancer Ashwin Mehta

4:40 pm – 5:10 pm Cancer Treatment Induced Bone Loss (CTIBL): RANK Ligand, Biphosphonate, Antiangiogenesis, and More Robert E. Marx

5:10 pm – 5:40 pm Marijuana Use in Cancer: Myths and Reality Dov Pickholtz

5:40 pm – 6:00 pm Round Table Discussion and Q & A Session Speakers: Mehta, Silva, Rolfo, Marx & Pickholtz

6:00 pm – 6:15 pm Coffee Break and Visit Exhibits

6:15 pm – 7:30 pm Melanoma & Skin Cancers Session Chair: Caio Rocha-Lima & Jorge Alatorre

6:15 pm – 6:45 pm Melanoma: What Else Beyond Checkpoint Inhibitor Pathway? Jose Lutzky

6:45 pm – 7:15 pm Novel Therapies for BCC and SCC of Skin and Merkel Cancer John Strasswimmer

7:15 pm – 7:25 pm Round Table Discussion and Q & A Session Speakers: Lutzky & Strasswimmer 7:35 pm – 8:35 pm Dinner & Learn Symposium (non CME)

PROGRAM AGENDA

15TH ANNUAL MIAMI CANCER MEETING (MCM):

New Frontiers for the Treatment of Solid and Liquid Tumors: Delivering Precision Medicine

PROOF

Saturday, april 287:00 am – 8:00 am Registration Opens & Visit Exhibits

7:00 am – 8:30 am Breakfast & Learn Symposium (non CME)

8:40 am – 10:40 am Immunotherapy Session 1 Chairs: Edgardo S. Santos & Luis E Raez

8:40 am – 9:10 am Immunotherapy in Lung Cancer Scott Antonia 9:10 am – 9:40 am Immunotherapy in Kidney and Bladder Carcinoma Alan J. Koletsky

9:40 am – 10:10 am Immunotherapy in Head and Neck Cancer and the Role of MSI in Solid Tumors Brian Hunis

10:10 am – 10:20 am Round Table Discussion and Q & A Session Speakers: Antonia, Koletsky & Hunis

10:20 am – 10:40 am Coffee Break and Visit Exhibits

10:40 am – 01:00 pm Lung Cancer Session Chair: Jorge Alatorre

10:40 am – 11:10 am EGFR-ALK-ROS1: Where Are We Now? Edgardo S. Santos

11:10 am – 11:40 am Other Driver Mutations: MET, B-RAF, RET, NTRK, HER-2 Luis E. Raez

11:40 am – 12:10 pm Squamous Cell Carcinoma: What Are the Standards and Potential Pathways in Development Luis A. Corrales

12:10 pm – 12:25 pm Round Table Discussion and Q & A Session Speakers: Santos, Raez & Corrales

12:25 pm – 1:25 pm Lunch & Learn Satellite Symposia (non-CME)


Breakout Session 11:40 pm – 3:20pm Genitourinary and Gynecologic Malignancies Session Chair: Luis Corrales

1:40 pm – 2:10 pm Prostate Cancer Management: From Early Chemical Recurrence to HRPC (excluding Immunotherapy) Mayor N. Fishman



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2:10 pm – 2:40 pm Novel Therapies In Metastatic Kidney Cancer Primo N. Lara

2:40 pm – 3:10 pm Targeted Agents and Chemotherapy in Gynecologic Malignancies Gerardo Colon-Otero

3:10 pm – 3:20 pm Round Table Discussion and Q & A Session Speakers: Fishman, Lara & Colon Otero

Breakout Session 21:40pm – 3:40 pm Management of Side Effects and Complications of Modern Cancer Therapy Chair: Jorge Garcia

1:40pm – 2:10 pm Supportive Care: Perception vs. Reality? Jessica MacIntyre

2:10pm – 2:40 pm Toxicity Profile of Tyrosine Kinase Inhibitors and Immunotherapy for Solid Tumors Tarek Mekhail

2:40pm – 3:10 pm Survivorship in Cancer Care: How to Deal with Long Term Toxicities and Quality of Life Adrianne M. Vazquez

3:10pm – 3:20 pm Round Table Discussion and Q&A Session: MacIntyre, Mekhai & Vazquez


3:40 pm – 5:40 pm Immunotherapy Session 2 Chairs: Caio Rocha-Lima & Brian Hunis

3:40 pm – 4:10 pm Immunotherapy in Gynecologic Malignancies Thomas Herzog

4:10 pm – 4:40 pm Immunotherapy in Colorectal Cancer Ahmed Zakari

4:40 pm – 5:10 pm Immunotherapy in Breast Cancer Aurelio Castrellon

5:10 pm – 5:30 pm Round Table Discussion and Q & A Session Speakers: Herzog, Zakari & Castrellon

Sunday, april 297:00 am – 8:00 am Registration Opens & Visit Exhibits

7:00 am – 8:30 am Breakfast & Learn Satellite Symposia (non CME)

8:40 am – 9:50 am Gastrointestinal Malignancy Session Chair : Caio Max Rocha-Lima & Marcelo Blaya



PROOF

8:40 am – 9:10 am Colorectal Cancer: Novel Insights Richard Kim

9:10 am – 9:40 am Pancreas-Biliary Tract and Hepatocellular Carcinoma Caio Max Rocha-Lima

9:40 am – 9:50 am Round Table Discussion and Q & A Session Speakers: Kim & Rocha-Lima

9:50 am – 10:10 am Coffee Break and Visit Exhibits

10:10 am – 12:40 pm Hematology Malignancies Session Chair: Hugo Fernandez

10:10 am – 10:40 am Multiple Myeloma: Transplant and Non-Transplant Modalities Sikander Ailawadhi

10:40 am – 11:10 am B- and T-Cell Non-Hodgkin’s Lymphomas (excluding Hodgkin’s Disease, CLL and Checkpoint Inhibitor Therapies) Eduardo M. Sotomayor

11:10 am – 11:40 am Acute Myeloid and Lymphoid Leukemias Hugo Fernandez

11:40 am – 12:10 pm CLL and CML Mohamed Kharfan-Dabaja

12:10 pm – 12:40 pm Round Table Discussion and Q & A Session Speakers: Ailawadhi, Sotomayor, Fernandez & Kharfan-Dabaja

12:40 pm – 1:40 pm Lunch & Learn Satellite Symposia (non CME)

1:40 pm – 3:15 pm Breast Cancer Session Chairs: Aurelio Castrellon & Vicente Valero

1:40 pm – 2:10 pm Familial Hereditary Syndromes in High-Risk Breast Cancer Patients: Genetic Counseling Louise Morrell

2:10 pm – 2:40 pm Anti-HER2 Therapies in Breast Cancer: Adjuvant and Neoadjuvant Hope Rugo

2:40 pm – 3:10 pm Chemotherapy and Hormonal Therapy in the Metastatic Setting (Non Her2 therapy) Vicente Valero

3:10 pm – 3:20 pm Round Table Discussion and Q & A Session. Speakers: Morrell, Rugo & Valero

3:20 pm Meeting Adjourn and Closing Remarks



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HOTEL INFORMATION

REGISTRATION FORM

The Conrad Hilton Hotel Miami 1395 Brickell Avenue Miami, FL 33131 Telephone: 305-503-6585 Website: http://conradhotels1.hilton.com

Discover the luxury of the Conrad Miami, the premier hotel in South Florida, combining the ultimate hotel service and the latest technological advancements with the fashion sensibilities of downtown Miami. Located in the innovatively designed structure of concave glass and steel, in the heart of the city’s financial district, the Conrad Miami hotel overlooks Biscayne Bay in Florida. The Conrad Miami has quick and easy access to many attractions in downtown Miami, including South Beach, Coconut Grove and Key Biscayne and is also just 15 minutes from the Miami International Airport.

The hotel is offering special rates during this conference of $239 Deluxe City View; $269 Deluxe Bay View plus tax, European plan (no meals). The cut off date to make reservations is March 24, 2018, after this date reservations are subject to hotel availability.

Make your reservations by calling 1 (800) 774-1500 and identify yourself as attending the “Miami Cancer Meeting” group “MCM”

or using the link https://aws.passkey.com/go/MCM18

Registration fee: Early bird pricing - BEFORE March 15th, 2018 $50 Residents/Fellows - Nurses - Nurse Practitioners - Physician Assistant & other Health Professionals $200 Physicians $250 Industry Professionals

AFTER March 15th, 2018$90 Residents/Fellows, Nurses, Nurse Practitioners, Physician Assistant & other Health Professionals$250 Physicians$300 Industry Professionals

Registration fee includes admissions to scientific presentations. Requests for refunds must be provided in writing prior to March 28, 2018. No Refunds will be provided after deadline. All cancellations must be submitted in writing and will include a $50 administrative charge. Register online at www.meccinc.com

CONFERENCE MANAGEMENT6619 S Dixie Highway #341, Miami, FL 33143Telephone 305/663-1628 Office Fax 305/675-2718Or visit our website at www.meccinc.com

REGISTRATION

15th Annual Miami Cancer Meeting (MCM)New Frontiers for Treatment of Solid and Liquid Tumors: Delivering Precision Medicine

Register online at www.meccinc.com or FAX to 305/675-2718.

Name ________________________________________________________ Degree _________________________

Address ________________________________________________________________________________________

City _______________________________________________ State ________________ Zip __________________

Telephone (_____)__________________________________________ Fax (_____) __________________________

Email address __________________________________________________________________________________

Specialty ______________________________________________________________________________________

Type of Practice: o Private o Academic o Hospital o Resident/Fellow

REGISTRATION FEE: Early bird pricing - BEFORE March 15th, 2018 $50 Residents/Fellows - Nurses - Nurse Practitioners - Physician Assistant & other Health Professionals $200 Physicians $250 Industry Professionals

AFTER March 15th, 2018 $90 Residents/Fellows, Nurses, Nurse Practitioners, Physician Assistant & other Health Professionals $250 Physicians $300 Industry Professionals

Enclosed is my check in the i/a/o of _____ for registration of this course.I authorize MECC to charge my credit card i/a/o $______ for registration of this course using the following credit card.

Name on Card ___________________________________________________ Exp. Date _____________________

Card number ________________________________________________________ CVV _______________

Authorized signer _______________________________________________________________________________

If you require special assistance or have specific dietary requirements, please contact MECC, Inc. no later than March 27, 2018 via email at [email protected].

PROOF

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new frontiers for the treatment of solid and liquid tumors...

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