new features and workflow enhancements … features and workflow enhancements empower 3 software ......
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©2011 Waters Corporation 1
New features and Workflow Enhancements
Empower 3 Software
Mogens Hallas
Nordic User Training 2011
Långvik, September 6th to 9th, 2011
©2011 Waters Corporation 2
Empower 3
Architecture and operating systems
Web based licensing
ACQUITY improvements
Fraction Collection
Usability and Workflow
Mass Spectrometry
Method Validation Manager
Automated Software Validation
Fusion Method Development
Designed for the Enterprise
Defect Fixes
©2011 Waters Corporation 3
Empower Software
Productivity and Ease-of-Use
Data Acquisition and Instrument Control
Processing and Reporting Data
Compliance
Administration & Data Management
©2011 Waters Corporation 4
Empower 3 – Enhancements
Versatility
— ACQUITY – eCord information stored in Empower database
— Fraction collection – Fraction table and chromatogram annotation
— Advanced detection – Target Mass and Ion Ratio
Compliant ready
— Pharmacopoeia changes
Usability
— Licensing flexibility
— Process only sample sets
— Method Validation Manager
©2011 Waters Corporation 5
Changes with Empower 3
Discontinued Options
— Pattern Matching
— WebServer
Workgroup Changes
— Removed Node Licenses
— 10 User License limit
Consolidated Licenses
— GPC/SEC Option – Includes GPC, GPC/V & GPC/LS
Software Licensing— Limit the number of online Agilent LC and GC systems to the
number of activated Agilent licenses
— Support multi-database instance named user licenses where one named user license can be installed on up to 10 databases
— Split user license multi-packs across multiple databases
©2011 Waters Corporation 6
Empower 3 Architecture
Technology:
— Oracle 11G R2 Database (64-bit)
— Windows 2008 R2 Server Enterprise (64-bit)
— Windows 7 Professional Operating System (64-bit)
— Windows XP Operating System (32-bit) (clients and
LAC/Es)
— Citrix XenApp Server 6.0 running on Windows Server 2008
R2 Enterprise, 64-bit.
Empower 3 is 32-bit app running
in a 64-bit environment
©2011 Waters Corporation 7
Installation
Operating Systems not supported
— Windows NT
— Windows 2000
— Windows XP 64-bit
— Windows 2000 Server.
Installation will not be allowed on these OS‘s
Windows Vista 32-bit, Vista 64-bit, Windows 7 32-bit and Windows
Server 2003 are not supported; however, installation will be
allowed on these operating systems.
Installation on Oracle < 11.2 will be prevented; higher versions
allowed
LAC/E32 configurations 10 -13 supported
— Config 10 and 11 need additional memory—2 GB minimum
— Config 10 and 11 supported on Windows XP 32-bit only
— Config 13 currently available for both Empower 2 and Empower 3
— Config 14 expected end of 3Q2011, Windows 7 64-bit
©2011 Waters Corporation 8
Server Installation from Previous Versions
Server Installation includes ability to perform a system
object export prior to the removal of the previous version of
software.
Server installation allows you to bring the exported
information into Empower 3.
— no system object export or import offered as part of the
personal installer
©2011 Waters Corporation 9
Installation
Project restore will be supported for projects backed up in
Millennium32 version 2.15 or higher.
Push installations
— Client software
— Instrument control software
— Uses Microsoft PSExec tool to perform the push
— Local + Network log file
o Log file name = ‗computer name‘ + ‗date/time stamp‘
o ‗Err‘ is indicated at beginning of log file name if installation
unsuccessful
©2011 Waters Corporation 10
Software Licensing
Waters License Activation Center – Web
— Used to activate and export licenses selected from order number
— User provides contact information
— User selects desired software serial numbers
— License activation file is
created for download
— User executes License Wizard
to activate license on computer
Splitable user licenses
Multi-database user license
©2011 Waters Corporation 11
Column Usage information
Column Lifetime basis and
Sample Set basis
Column information
associated with injections
Column Name
Serial Number
Injection Count
Maximum Pressure
Maximum Temperature
ACQUITY eCord Information
©2011 Waters Corporation 12
ACQUITY eCord Information
eCord data viewed and managed in
Configuration Manager
— eCord Summary Table
— eCord Sample Sets table
eCords added automatically when data is acquired using
system containing eCord
Enumerated custom fields called Column Name and Column
Serial Number (for non-ACQUITY systems)
©2011 Waters Corporation 13
ACQUITY Injection Modes
Full Loop Mode
— Injection volume field automatically filled in with the loop
volume
— Field not editable
Partial Loop Mode / with Needle Overfill
— Injection volume should be within the recommended volume
range
— Editable field
— If volume is outside of the recommended range, a message
occurs indicating as such, but
the injection is allowed to proceed
using that volume.
©2011 Waters Corporation 14
WFCIII
WFC III control in Empower 2
Enhancements in Empower 3
— Fraction annotations on chromatogram
— Fraction table
— Fraction tab in Project window
©2011 Waters Corporation 15
Navigate from Review to….
Preview
Save and Preview
Alter Sample
Run Samples
Navigate tree using arrow keys
Usability
©2011 Waters Corporation 16
Process Only Sample Sets
©2011 Waters Corporation 17
Process Only Sample Sets
•Imported•Copied•Process only
©2011 Waters Corporation 18
Process Only Sample Sets
Allows combining disparate injections into a sample set post-
acquisition
— Allows flexibility in processing
— Allows combination for use of individual injections in MVM
— Allows combination for use in Dissolution/CU multi-phase studies
Privilege called Manage Process Only Sample Set
Fully audit trailed
Creating and editing as in Alter Sample -is similar to altering a
regular sample set.
©2011 Waters Corporation 19
Usability
Project integrity errors won‘t stop batch project
backup/restore
— Log file is generated to document errors
— Time zone and database update request also won‘t stop backup
Multiple application windows locked due to timeout
— Unlock once to unlock all
— Does not pertain to 6-button window
Run Samples Control Panel Position saved as preference
©2011 Waters Corporation 20
Usability
View Message Center for All Users privilege
— Allows granularity to specify users that see all messages or
only their own
ApexTrack - Use appropriate peak width for USP Plate Count
USP Resolution and Relative Resolution determination
— Values dependent on inflection points Width@Tangent
— Incorrect peak width parameter could over smooth data in
previous versions
— Software will recalculate peak‘s inflection points using a peak
width that is accurate for the peak instead of the possibly
inappropriate peak width in the method
— Affects BB peaks whose PW is outside of 2X Auto-PeakWidth
range
— No more message regarding ―Inappropriate Peak Width‖
©2011 Waters Corporation 21
EP/JP/USP Signal to Noise
©2011 Waters Corporation 22
EP/JP/USP Signal to Noise
Allows determination of noise within a blank injection
centered on the peak region
Allows user to specify a noise segment based on peak width
at half height:
— USP Half Height Multiplier for Noise Region
— EP Half Height Multiplier for Noise Region
— JP Half Height Multiplier for Noise Region
©2011 Waters Corporation 23
MS Ion Ratios + Acceptance Tolerance
— For defensible compound confirmation
— Area or Height ratio of 10 Channel : 20 Channel (1 – 4) in same injection
— Acceptance tolerance on result as compared to a reference injection
— Failed values are faulted
©2011 Waters Corporation 24
MS Target Masses
Open Access, Run Samples, QuickStart, Alter Sample
Specify up to 5 base monoisotopic masses in sample table
(not processing method)
Possible adducts entered in PM
Obtain Yes/No answer as to
whether the target mass is
present in sample
©2011 Waters Corporation 25
MS Target Masses
Masses specified in Run Samples supersede the one in the
processing method
©2011 Waters Corporation 26
Accuracy Profile Plot
% Relative Error vs. X Value
MVM : SFSTP Calculations
Accuracy Total Error
— Sums intermediate precision
and bias
— % Total Error
— % Relative Error
— % Relative Error Mean
— Tolerance Interval
— Upper/Lower Limit of
Quantitation
©2011 Waters Corporation 27
Linearity of the Response (current) – Response vs.
Amount/Concentration
Linearity of the Method - Calculated value (from linearity of
response) vs. Amount/Concentration
MVM – Linearity of the Method
Linearity of the Response
Linearity of the Method
©2011 Waters Corporation 28
Benefit to the Customers: One Software solution for all
chromatographic systems
— Reduced Training, Validation and Support
Instrument Control Available Today
— 16 Vendors with 235+ Instrument modules
— Major LC and GC Vendors
New Techniques
— Supercritical Fluid Chromatography (SFC)
— Capillary Electrophoresis (CE)
Extended Instrument Control with Empower Software
©2011 Waters Corporation 29
Beckman Coulter CE
Support for MDQ instrument has been completed
— Small molecules, Chiral Analysis and Ion Analysis
— Sample temperature control with UV/Vis and DAD
Support for the PA-800 and PA-800 plus
— Proteins and carbohydrates
— Sample temperature control with UV/Vis and DAD
Support for the LIF (Laser-Induced Fluorescence) detector
©2011 Waters Corporation 30
Designed for the Enterprise
Lowering Total Cost of Ownership
Rapid Deployment
HighAvailability
EnhancedWANCompatibility
©2011 Waters Corporation 31
Post Release Projects
Virtualization is now supported: VMWare vSphere.
Feature Release 1 to follow in Q4 2011 ???
— Oracle Solaris
— Data Guard, RAC & Database logging
— Toolkit web enabled
— 7890 Dual Tower support
— Defect fixes, as necessary
Feature Release 2 - targeted for Q1 2012 ???
— Dissolution, 20 Bath Support and USP Multi-Stage Protocol
— Method Validation Manager
— System Policies based on Project Hierarchy
— Workflow, ease of use enhancements
©2011 Waters Corporation 32
Waters Systems Solutions
Services
BiopharmaceuticalSystem Solution
Chemistries
SystemSolution
CoreCompetencies
Reg BioSystemSolution
LipidomicsSystemSolution
Food SafetySystemSolution
ProteomicsSystemSolution
SystemSolution
SystemSolution
ApplicationExpertise
Instruments
Informatics
©2011 Waters Corporation 33
Empower
MassLynx
NuGenesis SDMS
©2011 Waters Corporation 34
Services as Part of Your Projects
Capabilities— Planning & Consultation
— Implementation Support
— Software Installation
— Validation
— Training
— Maintenance & Support
Enhancing your Investments— Professional resources
— Efficient project management
— Time savings
— Cost effective use of resources
— Partnership for success
©2011 Waters Corporation 35
Join Now at www.waters.com/empowerme
©2011 Waters Corporation 36