T H E I N T E N S I V E C L I N I C A L C O U R S E

April 6th - 8th, 2017 New Brunswick, New Jersey, USA

Includes: Extensive Biomedical Manual, research, systematic clinical protocols, medical forms, patient dietary and supplement support, books and supplies

Nutrient dense food provided throughout the conference

NONDISCLOSURE REQUIRED – LIMITED REGISTRATION SPACE AVAILABLE

NeuroLipidr e s e a r c hf o u n d at io n

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t Clinical Therapeutics Towards Correction of Epigenetic Insult, Mitochondrial and Peroxisomal Dysfunction in Neurological Disorders

t Forget the Guilty Genes, It’s all About the Lipid Membrane

t Clinical Strategies for Mitochondrial Respiration with Cardiolipin, Phospholipids; Primary Disease / Secondary Mitochondrial Dysfunction

t Microbiome Interrupted: The Vagal System at the Center of the Storm

t Rescue of the Brain on Fire through Lipid Mediators/ Resolvins & Protectins, Bioactive Lipids and control of PLA2

t Optimizing Cell Membranes, Organelles and Neurometabolism with Phospholipids and Bioactive Lipids in neuro involvement

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Membrane Medicine Academic SymposiumApril 6 – 7, 2017 • NJ Institute of Food, Nutrition and Heath61 Dudley Road • New Brunswick, NJ 08901

MEMBRANE MEDICINE ACADEMIC DAY ONE –THURSDAY, APRIL 6, 2017

8:00 am 9:00 am Registration and Power Breakfast 9:00 am 10:30 am Membrane Medicine: A Phospholipid Approach to Illness – Patricia Kane, PhD 10:30 am 12:00 pm Dancing on the Membrane – Edward Kane 12:00 pm 12:45 pm Membrane Stabilizing Lunch 12:45 pm 2:00 pm Membrane Medicine Clinical Intro - Patricia Kane, PhD Membrane Medicine Clinical Euro - Katrin Bieber, MD Membrane Medicine Clinical American - Sheryl Leventhal, MD 2:00 pm 3:15 pm Epigenetics, Neurotoxicity, Clinical Strategies for the Brain on Fire – Damien Downing, MD 3:15 pm 3:35 pm Power Break, Let Them Eat Cake viva Paleo 3:35 pm 5:00 pm Alzheimer’s as a NeuroMetabolic Model – Patricia Kane, PhD

MEMBRANE MEDICINE ACADEMIC DAY TWO – FRIDAY, APRIL 7, 2017

8:30 am 9:00 am Power Breakfast 9:00 am 10:00 am Autoimmune Inflammatory Mediated Neurological Disorders – Yehuda Shoenfeld, MD 10:00 am 10:15 am Phospholipids and Refractory Seizure Disorders – Carolyn Matzinger, MD 10:15 am 12:00 pm Neurometabolic Disease: MS, ALS, Parkinson’s, Stroke, Autism, Seizures – Patricia Kane, PhD 12:00 am 12:30 pm Lipid Whiskers, Cardiolipin, Gene Expression and Membrane Dynamics – Edward Kane 12:30 pm 1:15 pm Membrane Stabilizing Lunch 1:15 pm 2:15 pm Disturbed Methylation, Reversing Epigenetics – Patricia Kane, PhD 2:15 pm 3:30 pm The Bidirectional Microbiome from Mainframe Brain to Second Brain – Kristine Gedroic, MD 3:30 pm 3:50 pm Power Break, Feed Your Mitochondria and Microbiome 3:50 pm 5:00 pm Case Studies: Innovative Evaluation and the Consortium Approach in Membrane Medicine

Membrane Medicine Clinical CoursesApril 8, 2017 • Gedroic Medical Institute1200 Mt. Kemble Avenue • Harding Plaza, Suite 350 • Morristown, NJ 07960

SESSION I: ADVANCED MEMBRANE MEDICINE

9:00 am 9:30 am Power Breakfast 9:30 am 11:00 am Membrane Medicine Clinical Biomedical Approach 11:00 am 12:00 pm Membrane Medicine Hospital Biomedical Approach 12:00 pm 12:30 pm PK Membrane Stabilizing Demonstration 12:30 pm 1:00 pm Membrane Stabilizing Lunch

TRACK ONE – ADVANCED MEMBRANE MEDICINE THERAPEUTICS 1:00 pm 3:00 pm Clinical application of intravenous therapies

The Second Brain: Revitalizing the Microbiome and the Biomedical Colonic Targeted medical evaluation

TRACK TWO – MERGING ACADEMICS WITH CLINICAL APPLICATION IN MEMBRANE MEDICINE 1:00 pm 3:00 pm Research: Studying a Study, Testing a Test

Membranes and Phospholipid evaluation as a clinical application Beyond Genetics, Membranes and Lipids Epigenetic evaluation via the Acumen Overriding Epigenetics with BioMedical Detoxx Primary Disease often has Secondary Mitochondrial Dysfunction, Lock-Step Epigenetics Brain on Fire, Neurometabolic Psychiatry

SESSION II: MEMBRANE MEDICINE TESTING, EVALUATION AND TREATMENT IN CLINICAL PRACTICE

3:00 pm 4:30 pm Clinical Case Studies: Oral and Intravenous Protocols Case Review of Neurotoxicity, Post Stroke, Autism, Parkinson’s, CFS, NeuroLyme, PANDAS/PANS Seizure disorders, Alzheimer’s, Motor Neuron disorders, Mold Neurotoxicity, Multiple Sclerosis

Our Researchers and Clinicians

Kristine Gedroic, MDMorristown, NJ

Thomas Wnorowski, PhDMillville, NJ

Meinrad Milz, MDGermany

Sheryl Leventhal, MDValley College, NY

Annette Cartaxo, MD Morristown, NJ

Neal Speight, MDCharlotte, NC

Professor Yehuda Shoenfeld, MDIsrael

Patricia Kane, PhDMillville, NJ

Carolyn Matzinger, MDLas Vegas, NV

Virginia Marston, MD Galeana, Mexico

Edward KaneMillville, NJ

Katrin Bieber, MDGermany

Shideh Pouria, MDUnited Kingdom

Damien Downing, MDUnited Kingdom

John McLaren-Howard, PhD United Kingdom

Carrie Loughran, RD, LDPortland, OR

Normalization of Phospholipid Membrane with Oral Phosphatidylcholine

Normalization of Phospholipid Membrane with IV Phosphatidylcholine

Five year old female with an undiagnosed neuromuscular disorder presented with a gross distortion of her phospholipid architecture with abnormal lipid binding in June 2010. After 4 months (Oct 2010) of oral phosphatidylcholine imaging of her lipid membrane shows marked improvement along with normalization of her mitochondria (an immune–viral complex was isolated on the mitochondria). Patient is now able to walk with assistance, marked improvement in coordination and muscle tone, and increased growth and development.

Male patient, age 82, with a history of prostate cancer. Initial pictures reveal gross oxidative damage to the cell membrane surface, phospholipid membrane and mitochondria after invasive radiation therapy. PSA levels spiked and patient was in extreme spinal pain. Patient received intravenous IV PK Protocol (Phenylbutyrate, Essentiale, Glutathione) and high dose oral lipids for 2 months prior to visiting oncologist Meinrad Milz in Germany. Pain was diminished 50% and patient was able to comfortably travel to Germany for hyperthermia and IV PK Protocol therapy for 2 weeks. Pain was completely eradicated on the first visit in May 2011 and PSA normalized. Patient continued IV and Oral PK Protocol therapy at home and returned for a check up in Germany December 2011. Patient’s condition is stable and he is enjoying his renewed life.

EPIGENETIC INSULT MAY COMPLICATE ORPHAN DISEASE PROGRESSION BUT MEMBRANE FUNCTION MAY BE OPTIMIZED WITH PHOSPHOLIPIDS

Kane PC, Cartaxo AL, Pouria S, Gedroic KL, Leventhal SL, Downing D, Kane E, Wnorowski TM, McLaren-Howard J, Speight MO, Bieber KM, Milz MM

NORD Summit October 21st – 22nd, 2015

Case History: Angelman Syndrome, Refractory Status Epilepticus Seven year old male with diagnosis of Angelman Syndrome and in a state of refractory status epilepticus, grand mal seizures. Patient is unable to walk, poor coordination, tremors, hypotonia, insomnia, non-verbal with severe cognitive impairment. Patient failed all meds and the ketogenic diet.

Red cell fatty acid examination showed gross elevation of very long chain fatty acids indicative of impaired peroxisomal respiration, very low total red cell lipid content – 49% with sharp decrease in omega 6 Linoleic acid (-81%), gamma linolenic (-102%), dihomo gamma linolenic acid (-124%), Adrenic (-54%) complicated with marine oil overdose. Imaging of patient’s cellular phospholipids reveal gross abnormalities with marked oxidative damage on the cell surface with fat soluble chemical complexes attached to the membrane phospholipids. The mitochondria was damaged with high levels of toxic lipids and lipid oxidation products as malondialdehyde and diolein. Cardiolipin levels were adequate but calcium was bound to the cardiolipin synthase binding sites with high levels of malondialdehyde on

the cardiolipin. There were DNA adducts of lamictal and malondialdehyde attached to the genes expressing for carbonic anhydrase and glutamine synthetase. Cellular degeneration indication with sharp elevation of cell free DNA at 16 (n > 9.5). Significant elevation of red cell fructose-6-phosphate at 2.05 mmol/l (n= 0.52 – 1.09) indicative of fructose intolerance and hepatic dysfunction. Application of the Membrane Stabilizing Diet with oral phosphatidylcholine (1 Tablespoons qid), evening primrose oil (2 teaspoon tid), SR3 oil (2 Tablespoons tid), fatty alcohols, B vitamins (biotin, riboflavin, pyridoxine, thiamin, leucovorin, methylcobalamin) balanced electrolytes and trace elements resulted in cessation of seizures in 48 hours.

Over the next six months patient re-gained the ability to walk, tremors ceased, cognitive function improved significantly and began interacting with family. Total cessation of seizure activity. Patient is now 11 years old and uses a communication device to communicate, enjoys school, is interactive with family and friends, loves to swim and play soccer.

Patient with Angelman Syndrome with refractory status epilepticus characteristic of the disorder. Patient failed every anti-convulsant medication and the ketogenic diet.

ESSENTIAL FATTY ACIDSOMEGA 6Linoleic -81.61 LGamma Linolenic -102.38 LDihomo-y Linolenic -124.19 LArachidonic -8.05Adrenic -54.77 L

OMEGA 3Alpha Linolenic -13.77Eicosapentaenoic 114.35 HDocosapentaenoic 2.06Docosahexaenoic 71.72 H

ABERRANT FATTY ACIDSTRANS ISOMERS

SATURATED ODDPentadecanoic 51.85 HHeptadecanoic 95.45 HPentacosanoic 164.00 HTricosanoic 60.78 H

VLCFA'SLignoceric 73.48 HHexacosanoic 99.54 HTriacontanoic 100.00 H

RENEGADESPhytanic 250.00 HPristanic 950.00 H

Patient with Angelman Syndrome four months after membrane stabilizing therapy with phospholipid therapy. Seizure free since initiation of phospholipid therapy.

NORMALIZING MEMBRANE PHOSPHOLIPID DERANGEMENT FROM EPIGENETIC INSULTS IN NEUROLOGICAL DISEASE WITH LIPIDS AND RESOLVINS

Kane PC, Cartaxo AL, Pouria S, Gedroic KL, Leventhal SL, Downing D, Kane E, Wnorowski TM, McLaren-Howard J, Speight MO, Bieber KM, Milz MM

Lipid Mediators in Health and Disease II: From the Cutting Edge • La Jolla, California, May 19 - 20, 2016

Case History: AutismFive-year old male with diagnosis of autistic spectrum disorder and pervasive developmental delay. Patient presents with limited language,verbal apraxia, limited comprehension, anxiety, rage behavior, insomnia, poor attention, stimming, sound sensitivity, crying, excessive hunger, tan stool, bad breath, chronic cough, impaired enterohepatic circulation. Epigenetic testing revealed antimony and Dimethyl phthalate adducted to glutamine synthetase altering gene expression. Antimony attached to metallothionein, actin in the mitochondria, cardiolipin synthase and on the outer surface of the cell membrane leaflet. Epigenetic insult altered gene expression of phospholipid architecture in that this patient’s cellular phospholipids were flipped over backwards. Red cell fatty acid examination showed elevation of very long chain fatty acids indicative of impaired peroxisomal respiration, blocked conversion of eicosanoids into

prostaglandins, elevation of EPA/DHA due to overdose of marine oil, low structural lipids, electrolyte deficits (Na, K, K, CO2), decreased lymphocytes/neutrophils and a state of mild hyperammonemia. Patient began aggressive regime of both intravenous and oral PC/PE, SR3 oil, butyrate, evening primrose oil, trace minerals, balanced electrolytes and seeds with a membrane stabilizing diet. Within 2 months of initiation of therapy patient had improvement in presentation with increased language, the ability to express his feelings, decrease in emotional outbursts, dark stools, and improved sleep pattern. Patient’s epigenetics were analyzed 6 months after therapy with normalization of membrane phospholipids. Patient also improved both cognitively and emotional stability and was placed in a normal classroom at school.

Imaging Before Lipid Therapy

Imaging After 6 Months of Lipid Therapy

Imaging Before Lipid Therapy

Imaging After 6 Months of Lipid Therapy

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Register Now For Symposium and Clinical SessionsMembrane Medicine Biomedical SymposiumACADEMIC SESSIONS:Thursday, April 6 – Friday, April 7, 2017LOCATION: The NJ Institute For Food, Nutrition and Health • 61 Dudley Road New Brunswick, NJ 08901

q Membrane Medicine Academic Symposium: $900.00 early bird price $1200.00 After March 17, 2017

OPEN TO LICENSED MDs & DOs SIGNED NON-DISCLOSURE IS REQUIRED

CLINICAL SESSIONS: Saturday, April 8, 2017LOCATION: Gedroic Medical Institute 1200 Mt. Kemble Avenue • Harding Plaza, Suite 350 Morristown, NJ 07960

q Membrane Medicine Clinical Courses: $500.00 early bird price $700.00 After March 17, 2017

Please make checks payable to BodyBio No refunds for cancellations made after March 17, 2017

Clinical Sessions Location (All Day Saturday)

Gedroic Medical Institute 1200 Mt. Kemble Avenue | Harding Plaza, Suite 350 Morristown, NJ 07960

AccomodationsCrowne Plaza Edison 2055 Lincoln Highway, Edison, NJ 08814 Hotel Phone: 732-287-3500 - 866-279-4813To receive the discounted rate, be sure to identify as members of NeuroLipid/BodyBio.

Reservations Not Accepted After: March 5th, 2017

Conference Location (All Day Thursday & Friday)

New Jersey Institute for Food, Nutrition, & Health 61 Dudley Road New Brunswick, NJ 08901

Mail or fax your registration today with payment to:

Neurolipid Research Foundation / BodyBio 45 Reese Road • Millville, NJ 08332 856-825-8338 • FAX: 856-825-2143

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