nevada rural opioid overdose reversal (nroor) program …€¦ · state of the science and best...
TRANSCRIPT
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Chris Marchand, M.P.H.NROOR Program Director/Project ECHO CoordinatorUniversity of Nevada School of [email protected]
5th Annual Rural Preparedness Summit June 22, 2016
Nevada Rural Opioid Overdose Reversal (NROOR) Program Overview and Update
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NROOR PROGRAM OVERVIEW
• HRSA Funding Opportunity Number: HRSA-15-146
• Very Competitive – Only 13 States Funded – 18 Total Programs
• Funding Period: August 31st,2015 to August 31st, 2016
• Program Goal: To reduce the morbidity and mortality of opioid overdoses in Nevada through improved access to naloxone.
• Statewide Partnership:
• Lead Applicant: Desert View Hospital, Pahrump Nevada
• NROOR Program Leadership: University of Nevada School of Medicine
• NROOR Program Evaluation: School of Community Health Sciences, UNR
• EMS Naloxone Training: Nevada State EMS, Nevada Department of Health and Human Services
• Fiscal Management Services: Nevada Rural Hospital Partners
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NROOR PROGRAM COMPONENTS
• Statewide Training for EMS Personnel on the Administration of Naloxone
• Provide Initial Stock of Naloxone to Select EMS Basic Services
• Deliver Prescriber Training via Project ECHO-Nevada Platform
• Provide Nasal Narcan Supply to Participating Rural Hospitals
• NROOR Program Components Integrated with SB459:• Two hours of mandatory CME on the misuse and abuse of prescription
drugs.
• Train EMTs (formerly EMT Basic) on the administration of naloxone based on new legislative authorization.
• Utilize new legislation that authorizes pharmacists to furnish naloxone without a prescription.
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NROOR PROGRESS REPORT
• Nevada State EMS: • Train statewide EMS personnel on administration of naloxone:
COMPLETE
• Administer Pre/Post surveys to naloxone-trained EMTs: Complete
• Order pre-filled naloxone syringes to stock select EMS formularies: COMPLETE
• Order Nasal Narcan for NROOR Program participating hospitals: COMPLETE
• NROOR Program Activities: • Administer prescriber training via Project ECHO: PENDING
• Develop and order educational materials to accompany Nasal Narcankits: PENDING
• Evaluation Activities: • Develop Pre/Post survey for EMT training: COMPLETE
• Analyze survey results: COMPLETE
• Identify State EMS and health outcome data points to measure program impact: COMPLETE
• Collect program impact data for evaluation: PENDING
• Perform analysis of program impact data: PENDING6/22/16 4
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Karla D. Wagner, Ph.D.School of community health sciencesuniversity of Nevada, [email protected]
5th Annual Rural Preparedness Summit June 22, 2016
State of the science and best practices around expanded naloxone access to prevent opioid overdose death
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Learning Objectives
By the end of this presentation, attendees will be able to:
describe national and local trends in opioid overdose death
identify factors that elevate patients’ risk for opioid overdose
understand how overdose education and expanded
naloxone access can impact health outcomes
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Definitions and disclaimers
Naloxone, not suboxone or naltrexone
– Opioid antagonist used to treat opioid overdose
– Safe, effective, routine clinical use since 1970s
Unintentional overdose, not suicide
Opioid overdose, not other drugs
I am a public health scientist with 10 years of
experience doing research in this area, not a lawyer or
a clinician
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Trends in overdose death rates
“More persons died from drug overdoses in the United
States in 2014 than during any previous year on record”
1.5x more drug overdose deaths than motor vehicle
crash deaths
Driven by natural and semi-synthetic opioids
– 9% increase in 2014
Heroin deaths tripled 2010-2014
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6450a3.htm6/22/16 8
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6/22/16 9
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2013 National Vital Statistics data place Nevada in the highest quartile of overdose death rates in the US
Source: CDC MMWR (2015) 64(23)
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Data were obtained from the CDC Wonder database. http://wonder.cdc.gov/cmf-icd10.html Query was selected for all races,
genders, ethnicities, and ages and included ICD-10 codes: X40-44 & Y10-14
8.9
10.6
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11
12.313.3
14.7 14.515.6 15.8
1717.5
19.4
17.5 17.5
0
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18
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100
200
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600
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
Age-A
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rug
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late
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Drug Related Unintentional and Undetermined Intent Deaths Among Nevada Residents,
1999 - 2013
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State EMS naloxone
administration, 2014
Rate per 100,000
Wagner, K.D., *Savell, S., *McDoulett, M., Tafoya, S. (September 2015) Opioid use,
abuse, and overdose in Nevada: Trends and potential public health solutions. Poster
Presentation at the 2015 Annual Conference of the Nevada Public Health
Association, Reno, Nevada.6/22/16 12
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Opioid overdose prevention requires a comprehensive response
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Opioid use for
clinical or non-
clinical purposes
Opioid abuseUnintentional
OverdoseDeath
Overdose prevention Education
Overdose response
education and
naloxone prescription
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What are the models for expanded naloxone access?
Community based programs
– Long history (1996)
– Existing models and best practices
Clinical settings
– ED discharge
– Primary care
– Specialty clinics
Criminal justice settings
– Education and naloxone upon release
First responders
– EMTs, law enforcement, etc.6/22/16 14
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Community based programs
First US program: 1996 in Chicago, IL
As of June 2014:
– 644 OEND sites providing naloxone kits to laypeople
– 152,283 laypersons received naloxone kits
– 26,463 overdose reversals reported
Wheeler, E., et al. (2015). Opioid Overdose Prevention Programs Providing Naloxone to
Laypersons - United States, 2014. MMWR. Morbidity and Mortality Weekly Report, 64(23),
631-635. 6/22/16 15
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Source: CDC MMWR (2015) 64(23)
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Effects of Community Based Programs
Wilkes County, North Carolina (2009-2010) – Opioid
overdose death rate dropped from 46.6 per 100K in 2009
to 14.4 per 100K in 2011 after implementation of a
comprehensive overdose prevention program including
naloxone distribution (Albert et al. 2011, Haegerich et al.
2014)
Massachusetts (2004-2006) – Opioid overdose death
rates significantly reduced in communities that distribute
naloxone (Walley et al. 2013)
California (1999-2010) – Rate of increase in overdose
death rates significantly reduced in counties that
distribute naloxone (Davidson & Wagner Under Review)17
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Fundamentals of Overdose Education and Naloxone Distribution
1. Identify patients at risk
2. Educate
3. Prescribe or Dispense
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1. Identify
Known or suspected
history of substance
abuse, dependence, or
non-medical use of
opioids
Taking chronic high doses
of prescription opioids,
particularly for long-term
management of chronic
pain
Receiving rotating opioid
medication regimens (and
thus at risk for incomplete
cross-tolerance)
Discharged from ER
following overdose
Completing mandatory
opioid detox or abstinence
program
Recently released from
incarceration and history
of opioid use
Friend, family member, of
contact of someone who is
at risk
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2. Educate
A. Risk Factors/Prevention:
– Change in dose/tolerance
– Polypharmacy (including other opioids, CNS
depressants, benzodiazepines)
– Alcohol use
– Using alone
B. Recognize:
– Blue/not breathing, difficulty responding
C. Respond:
– Sternum rub
– 911
– Naloxone + rescue breathing/CPR206/22/16
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3. Prescribe or dispense naloxone
Intransal w/
MAD
Intranasal
“branded”
NARCAN
Injectable
generic
Auto injector
“Evzio”
FDA approved No Yes Yes Yes
Strength 2mg/2ml 4mg/0.1ml 0.4mg/ml 0.4mg/0.4ml
Cost $$ $$ $ $$$
21
http://prescribetoprevent.org/wp2015/wp-content/uploads/Naloxone-product-
chart.16_01_21.pdf
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3. Prescribe or dispense naloxone
Intransal +
MAD
Intranasal
“branded”
NARCAN
Injectable
generic
Auto injector
“Evzio”
FDA approved No Yes Yes Yes
Strength 2mg/2ml 4mg/0.1ml 0.4mg/ml 0.4mg/0.4ml
Cost $$ $$ $ $$$
6/22/16 22http://prescribetoprevent.org/wp2015/wp-content/uploads/Naloxone-product-chart.16_01_21.pdf
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Clinical Settings
Referral of overdose patients from ED to case manager for
education/naloxone (e.g., Rhode Island)
Integration into primary care, bill for education under Screening,
Brief Intervention, Referral to Treatment (SBIRT) codes (e.g., San
Francisco)
Group education sessions in Co-Occurring Disorder clinic (e.g., San
Diego)
Integration into substance abuse treatment services (e.g., Veteran’s
Affairs, Massachusetts)
Integration into HIV/STI clinic services (e.g., San Francisco, New
York, Pittsburgh, North Carolina)
Education and naloxone for individuals being discharged from drug
treatment 23
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Criminal justice settings
Opioid users are at elevated risk for overdose death
in the period immediately following release from
incarceration
– Odds are elevated 7x to 13x
In research among 137 long-term opiate users
involved in the Rhode Island criminal justice system
– 53% had overdosed at least once (mean = 4 times)
– 64% had been released from an institutional setting
(incl. prison) within 1 month preceding overdose
Wakeman, S. E., et al. (2009). Preventing death among the recently incarcerated: an argument
for naloxone prescription before release. Journal of Addictive Diseases, 28(2), 124-129. 6/22/16 24
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Criminal Justice Settings
In research with 573 people who inject drugs in San Diego
41.5% ever experienced a heroin/opioid overdose - 45 (8%)
in past 6 months
Being arrested for drug possession was associated with
increased odds of overdose (AdjOR 5.17, 95% CI 2.37-
11,24, p<0.001)
Wagner, K. D. et al. (2015). Association between non-fatal opioid overdose and encounters with
healthcare and criminal justice systems: Identifying opportunities for intervention. Drug &
Alcohol Dependence, 153, 215-220. doi:10.1016/j.drugalcdep.2015.05.0266/22/16 25
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Criminal Justice Settings
People at risk for overdose are coming into contact
with clinical and criminal justice systems
We could use these venues to deliver OEND services
before people die from an overdose
– Since 2009, Scotland has been distributing naloxone to
prisoners upon release
– In 2011, this became Scottish national policy
– Post-release program in Rhode Island since 2013
26
http://www.gov.scot/Resource/0045/00451251.pdf
Green, T.C. et al. (2013). Patient Simulation for Assessment and Reinforcement of Layperson Management of Opioid
Overdose with Intranasal Naloxone in a Recently Released Prison Inmate Cohort (Submission #66). Simulation in Healthcare,
8(6), 538.
Green, T. C., et al. (2014). Feasibility of prison-based overdose prevention education and prescribed naloxone at release.
Drug & Alcohol Dependence, 140, e74.
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Law Enforcement Officers
As of January 2016, over 669 law enforcement
agencies in 31 states were carrying naloxone
Rationale:
– In some communities, LEOs arrive on scene before
EMS
– LEOs can be partners in public health efforts (Beletsky
et al., 2011; Beletsky et al., 2008; Silverman et al.,
2012), and this might have beneficial effect on
community relations
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Law Enforcement Naloxone Program Pilot Results
81 Deputy Sheriffs trained in 1 week in 2014
Command station selected based on most frequently
reporting arriving on scene before paramedics
State law is similar to NV’s SB459
30 minute training with slides and hands-on practice
during regular shift briefings
Content included:
– Overdose recognition
– Response techniques
– Department protocols
Wagner, K. D., et al.. (2016). Training law enforcement to respond to opioid overdose with naloxone: Impact
on knowledge, attitudes, and interactions with community members. Drug and Alcohol Dependence. 28
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Law Enforcement Naloxone Program Pilot Results
Deputies administered naloxone 11 times in first 4
months
– 9/11 victims survived
– 3/9 attended at least one visit to substance abuse
treatment center as result of Deputy referral
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Law Enforcement Naloxone Program Pilot Results
Mum [of the victim] was surprised at first but when I got
talking to her she was very thankful and very pleased that
we were there and saved her son’s life – she said “thank
you for saving his life”, that’s what she said to me.
In a lot of cases where we’re first at a scene and are
providing first aid we never find out what happens to the
person after EMS or FD [the fire department] cart them
away….Did they die or survive? Did I save that guy’s life
or not? Whereas with naloxone you get to see the result
immediately, and you know what happened to that person.
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EMTs
NROOR funded in 2014
– Purchase naloxone and
train EMTs and BLS
providers in 5 communities
(Esmeralda, Eureka,
Lincoln, Lyon, Mineral,
Nye, White Pine)
– Purchase naloxone for
distribution to overdose
victims upon hospital
discharge
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Information for prescribers, pharmacists, treatment providers, etc.
www.prescribetoprevent.org
32
CEUs
Education
materials
Implementation
toolkits
Naloxone
prescribing and
dispensing
instructions
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SAMHSA Toolkit on Opioid Overdose Prevention
Includes information
for prescribers on:
– Legal and liability
concerns
– Claims coding and
billing
– Additional resources
http://store.samhsa.gov/product/SMA13-47426/22/16 33
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BJA Toolkit for Law Enforcement
https://www.bjatraining.org/tools/naloxone/Naloxone-
Background
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Conclusion
Expanded access to naloxone has the potential to
save lives
Multiple models exist:
– Community based programs
– Clinical practice
– Criminal justice settings
– Uniformed first responders
A comprehensive approach should integrate these
models with other evidence-based prevention
methods and tailor for local capacity and need
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Resources
News + research on overdose
prevention:
Overdosepreventionalliance.org
Opioid overdose prevention education:
Prescribetoprevent.org
Stopoverdose.org
getnaloxonenow.org
Law enforcement-based naloxone
programs:
http://www.nchrc.org/law-
enforcement/us-law-enforcement-who-
carry-naloxone/
Overview of legal reform
https://www.networkforphl.org/resource
s_collection/2015/05/15/396/resource_l
egal_interventions_to_reduce_overdos
e_mortality
Implementation toolkits:
store.samhsa.gov/product/Opioid-
Overdose-Prevention-Toolkit/SMA13-
4742
http://harmreduction.org/issues/overdo
se-prevention/tools-best-
practices/manuals-best-practice/
CEU’s:
web.uri.edu/pharmacy/2014/02/14/opio
dsaddiction
www.opioidprescribing.com/naloxone_
module_1-landing
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Karla D. Wagner, Ph.D.
Assistant Professor
School of Community Health Sciences
University of Nevada, Reno