Neurology Oftlclal Journal of the Amerlcan Academy of Neurology JUNE 1976 VOLUME 26, NUMBER 6 - PART 2

United States - Japan Conference on Multiple Sclerosis

A conference sponsored by the National Science Foundation and the Japan Society for the Promotion of Science, under the United States-Japan Cooperative Science Program, and by The Kroc foundation for the Advancement of Medical Science.

February 25 - 27, 1976

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US-Japan Conference on Multiple Sclerosis 1

C. W. M. Adams, M.D. Guy's Hospital Medical School London, England

SPEAKERS John Sever, M.D., Ph.D. National Institutes of Health Bethesda

Milton Alter, M.D., Ph.D. Veterans Administration Hospital Minneapolis

Yoshigoro Kuroiwa, M.D. Ky us hu University Fukuoka, Japan

Hiroshi Shibasaki, M.D. Kyushu University Fukuoka, Japan

Richard Carp, Ph.D. New York State Institute for Basic Research on Mental Retardation Staten Island

Nelson L. Levy, Ph.D., M.D. Duke University Medical Center Durham

Akira Shishido, M.D. National Institute of Health of Japan Tokyo, Japan

Donald Silberberg, M.D. Hospital of the University of Pennsylvania Philadelphia

Ryoichi Mori, M.D. Kyushu University Fukuoka, Japan

Floyd A. Davis, M.D. Rush-Presbyterian-St. Luke's Medical Center Chicago

Lawrence Myers, M.D. University of California Los Angeles

Paul Terasaki, Ph.D. University of California Los Angeles

Roger Detels, M.D. University of California Los Angeles

Yoshitaka Nagai, Ph.D. Tokyo Metropolitan Institute of Gerontology Tokyo, Japan

Wallace W. Tourtellotte, M.D., Ph.D. Veterans Adminstration Wadsworth Hospital Center Los Angeles

Peter Dowling, M.D. Veterans Administration Hospital East Orange

David Poskanzer, M.D. Massachusetts General Hospital Boston

Hilde E. Hirsch, Ph.D. University of California Los Angeles

Yasuo Toyokura, M.D. University of Tokyo Tokyo, Japan

John Prineas, M.D. Veterans Administration Hospital East Orange

Fusahiro Ikuta, M.D. Niigata University Niigata, Japan

Tadao Tsubaki, M.D. Niigata University Niigata, Japan

Augustus S. Rose, M.D. University of California Los Angeles

Frederick Wolfgram, Ph.D. University of California Los Angeles

Hiroshi Iwashita, M.D. Kyushu University Fukuoka, Japan

Eijiro Satoyoshi, M.D. Toho University Tokyo, Japan

Hilary Koprowski, M.D. The Wistar Institute Philadelphia

Takeshi Yonezawa, M.D. Kyoto Prefectural University Kyoto, Japan

2 Neurology, June 1976 - Part 2

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Neurology Official Journal of the American Academy of Neurology JUNE 1976 VOLUME 26-NUMBER 6 PART 2

TABLE OF CONTENTS

Abstract No. Abstract No.

1. Epidemiologic and clinical studies of multiple sclerosis 11. Clinical and immunologic studies on multiple sclerosis in Japan Tadao Tsubaki, Yo Horikawa, lhoko Iwata, and Yoshigoro Kuroiwa and Hiroshi Shibasaki Nobutada Arnaya

2. Relationship of environment, ethnicity, and migration 12. Comparative studies of cerebrospinal fluid proteins of to multiple sclerosis multiple sclerosis patients in Japan and Germany R. Detels, B. Visscher, A. Coulson, R. Malrngren, and Hiroshi Iwashita, Helmut Bauer, and Yoshigoro J. Dudley Kuroiwa

3. Multiple sclerosis among Caucasians and Orientals in Hawaii Hiroshi Shibasaki, Michael M. Okihiro, and Yoshigoro Kuroiwa

4. Studies in the epidemiology of multiple sclerosis in the Orkney and Shetland Islands David C. Poskanzer, Alexander M. Walker, Joanne Yon Kondy, and Jean L. Sheridan

5. Painful tonic seizures in multiple sclerosis Yasuo Toyokura, Manabu Sakuta, and Takao Nakanishi

6. Criteria for the clinical diagnosis of multiple sclerosis Augustus S. Rose, George W. Ellison, Lawrence W. Myers, and Wallace W. Tourtellotte

7. Clinical manifestations and the diagnostic problems of multiple sclerosis in Japan Eijiro Satoyoshi, Akira Saku, Nobuhiko Sunohara, and Masao Kinoshita

13. The role of acid hydrolases in demyelination Hilde E. Hirsch

14. Demyelinating pattern with EAE and EAN antisera studies in vitro: Time lapse cinematographic analysis Takeshi Yonezawa, Takahiko Saida, and Michinori Hasegawa

15. Neural blocking activity of multiple sclerosis and EAE sera F.A. Davis and C.L. Schauf

16. Modulation of the immunologic response of myelin basic protein by extrinsic and intrinsic factors Yoshitaka Nagai

17. Selected immunologic parameters of demyelinative diseases Donald H. Silberberg, Robert P. Lisak, and Burton Zweiman

18. HLA studies on multiple sclerosis in Japan S. Saito, S. Naito, S. Kawanami, and Yl Kuroiwa 8. Distribution of plaques in 70,autopsy cases of multiple

sclerosis in the United States Fusahiro lkuta and H.M. Zimmerrnan 19. HLA antigens in multiple sclerosis

Chairn Brautbar, Milton Alter, and Esther Kahana

20. HLA and the immune response to measles in multiple sclerosis Lawrence W. Myers, George W. Ellison, Mona E. Fewster, Paul Terasaki, and Gerhard Opelz

9. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions J.W. Prineas and C.S. Raine

10. The progression of the lesion in multiple sclerosis C.W.M. Adarns

4 Neurology, June 1976 - Part 2

Abstract No. Abstract No.

21.

22.

23.

24.

25.

26.

A single mutation hypothesis for multiple sclerosis based on the HLA system Paul Terasaki and Max R. Mickey

Schemes to eradicate the multiple sclerosis central nervous system immune reaction W.W. Tourtellotte, K. Murthy, D. Brandes, N. Sajben, B. Ma, P. Corniso, A. Potvin, A. Costanza, and J. Korelitz

Spinal fluid from patients with multiple sclerosis contains nucleotide-rich material associated with IgG Nelson L. Levy and Thad M. Schoen

Inhibition of experimental allergic encephalomyelitis in guinea pigs by administration of bacterial lipopolysaccharide Kohei Nagasawa and Ryoichi Mori

Serology of demyelinating disease Peter Dowling, Joseph Menonna, and Stuart Cook

Oemyelinating antibodies in multiple sclerosis Frederick Wolfgram and Pierre Duquette

27.

28.

29.

30.

31.

32.

A small virus-like agent found in association with multiple sclerosis material Richard I. Carp, George S. Merz, and Pamela C. Licursi

Multiple sclerosis: Attempts to demonstrate altered immune responses and viruses John L. Sever, David A. Fuccillo, David L. Madden, and Gabriel A. Castellano

An attempt to isolate viruses from multiple sclerosis and neuro-Behcet disease in Japan Fusahiro Ikuta, Hideyuki Kosaka, lwao Takeshita, Hiroshi Ogawa, Takeshi Sato, and Toshiro Kumanishi

Cytotoxic activity of peripheral blood lymphocytes against HeLa cells persistently infected with measles virus: Depressed capacity in multiple sclerosis Ryoichi Mori, Kohei Nagasawa, Kenichi Umene, Junko Miyazono, Hiroshi Shibasaki, and Yoshigoro Kuroiwa

Search for viruses in multiple sclerosis Hilary Koprowski

Encephalomyelitis induced by paramyxovirus in nonhuman primates with a special reference to possible viral etiology of multiple sclerosis Akira Shishido and Kazuya Yamanouchi

US-Japan Conference on Multiple Sclerosis 5

INTRODUCTION

This special supplement of NEUROLOGY contains extended abstracts of a Conference on Multiple Sclerosis that was held on February 25-27, 1976. The conference was sponsored by the Japan Society for the Promotion of Science, The National Science Foundation of the United States, and The Kroc Foundation for the Advancement of Medical Science. The meeting was held in the Santa Ynez Valley of California at the headquarters of the Kroc Foundation, which is located on the J & R Double Arch Ranch of Mr. Ray A. Kroc.

This is the second conference on multiple sclerosis that has been sponsored by the Kroc Foundation. The first one was held in 1972. At the present conference, many new and interesting findings were reported in epidemiology, neuropathology, immunology and immunogenetics, neurochemistry, and virology. Equally important, the conference provided a forum for a detailed examination of the similarities and differences of multiple sclerosis in Orientals and Caucasians.

We acknowledge with gratitude the support of the Japanese and the United States governments through their Cooperative Science Program. The many new friendships that were made at the conference and the quality of the investigations by the scientists of both countries attest to the value of this binational program.

In a special way we wish to thank Mr. Ray A. Kroc for providing the facilities of the Kroc Foundation and for the publication of this supplement. Dr. Robert Kroc and Dr. Peter Amacher were our kind hosts. Thanks are also due to Miss Elaine Price and Mrs. Setsuko Kashitani for editing and typing the abstracts.

Yoshigoro Kuroiwa, M D Frederick Wolfgram, Ph D

US-Japan Conference on Multiple Sclerosis 7

1976;26;8-84 Neurology 26 (6 Part 2)

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