neurological disease ontology alexander diehl university at buffalo october 5, 2011
TRANSCRIPT
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Neurological Disease Ontology
Alexander DiehlUniversity at Buffalo
October 5, 2011
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Ontologies for Neuroscience and Neurology
• The Neurological Disease Ontology (ND)– Based on the Ontology for General Medical
Sciences– Incorporates parts of NIF-Dysfunction and the
Disease Ontology– Three initial areas of focus• Dementia, in particular Alzheimers• Multiple Sclerosis• Stroke, Cerebralvascular events
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Ontology Development
• Based on published existing ontologies as well as the scientific literature, including original articles, reviews, and text books
• Ontology terms (classes) are given both textual and logical definitions. Logical definitions relate the term to terms in other ontologies.
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Ontology Development
• Top-Down and Bottom-Up Approaches Utilized.
• Top-Down starts with high level categories and fills in more specialized classes.
• Bottom-Up looks at specific literature and sees what classes are needed to represent a domain.
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The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.
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The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.
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Bottom-Up (Annotation-Driven) Ontology Development
Lancet (1998) 352:1498
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Bottom-Up (Annotation-Driven) Ontology Development
Lancet (1998) 352:1498
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Bottom-Up (Annotation-Driven) Ontology Development
Journal of Neuroimmunology (2007) 188:167
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Bottom-Up (Annotation-Driven) Ontology Development
Journal of Neuroimmunology (2007) 188:167
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Bottom-Up (Annotation-Driven) Ontology Development
Nature Genetics (2010) 42(6):495
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Bottom-Up (Annotation-Driven) Ontology Development
Nature Genetics (2010) 42(6):495
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A Proto-MS Ontology
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Alexander [email protected]
Neurological Disease Ontology(MS, Dementia, Stroke)
Mark Jensen, Alexander Cox, Bianca Weinstock-Guttman, Kinga Szigiti, Alan Ruttenberg, Barry Smith