neurofibromatosis 1 design project
DESCRIPTION
Neurofibromatosis 1 Design Project. Varahi Trivedi. Background Info of the Disease. Genetic disorder of the nervous system Results in tumor growth Three types (NF1, NF2,, and Schwannomatosis ). Existing Treatment and Research. No existing treatment to physically stop it - PowerPoint PPT PresentationTRANSCRIPT
Neurofibromatosis 1 Design
Project
Neurofibromatosis 1 Design
Project
Varahi TrivediVarahi Trivedi
Background Info of the Disease
Background Info of the Disease
Genetic disorder of the nervous system
Results in tumor growth
Three types (NF1, NF2,, and Schwannomatosis)
Existing Treatment and Research
Existing Treatment and Research
No existing treatment to physically stop it
Prenatal testing and tumor removal
Research done by Children’s Tumor Foundation
Genetic Origin of Disease
Genetic Origin of DiseaseLocated on NF 1 gene of Chromosome
17
Mutations are common on this gene
Two major proteins: Neurofibromin and Ras
Mutation leads to uncontrolled cell division
How A Mutated Cell Functions
How A Mutated Cell FunctionsShape of Neurofibromin will become
altered
Unable to bind with Ras
Cell division unregulated and uncontrolled
Tumor growth
Proposed DesignProposed DesignStep by Step:
1.) Injection of bacteria containing mitochondria into bloodstream and travel to NF1 gene
2.) Bacteria will bind to NF protein and combine the mitochondria with the protein
3.) Bacteria will alter protein shape and mitochondria will retain shape
Expected ResultsExpected ResultsNF protein is vulnerable due to location
Mutation’s intentions would become useless because NF protein shape would be restored
Inhibit tumor growth
Engineered Bacteria Binding to Neurofibromin
Expression of Tumors (unregulated Ras protein)
0 1
1 0
Comparison to Other Treatments
Comparison to Other Treatments
Prenatal testing is unreliable in spotting mutations
Tumor removal is ineffective because tumors can grow back
**Bacteria insertion is promising because it solves the problem at the root**
References/Sources
References/SourcesSources;
__http://wsnfsupport.org/about-neurofibromatosis-2/facts-statistics/__
__http://learn.genetics.utah.edu/content/disorders/whataregd/nf1/__
http://learn.genetics.utah.edu/content/begin/dna/neurofibromin/
__http://emedicine.medscape.com/article/1177266-treatment__
__http://www.jneurosci.org/content/23/26/8949.full.pdf__
__http://www.ctf.org/category/r4r-blog.html__
__http://ghr.nlm.nih.gov/gene/NF1__
__http://emedicine.medscape.com/article/950151-overview__
__http://www.ncbi.nlm.nih.gov/pubmed/14999847__
__http://www.sciencedirect.com/science/article/pii/S009030199700356X__
__http://www.millipore.com/references/tech1/7yv3f6__
__http://learn.genetics.utah.edu/content/disorders/whataregd/nf1/__