NEUROFIBROMA

Amir YariMashhad University of Medical Sciences

Dentistry Faculty

NEUROFIBROMA The neurofibroma is the most common

type of peripheral nerve neoplasm .

It arises from a mixture of cell types Including Schwann cells and perineural fibroblasts.

CLINICAL FEATURES Neurofibromas can arise as solitary

tumors or be a component of neurofibromatosis.

Tumors are most common in young adults.

They are present as: Slow-growing Soft Painless Vary in size (from small nodules to larger masses.)

CLINICAL FEATURES The skin is the most frequent location

for neurofibromas.

Lesions of the oral cavity are not uncommon.

The tongue and buccal mucosa are the most common intraoral sites.

CLINICAL FEATURES

RADIOGRAPHIC FEATURES On rare occasions the tumor can arise

centrally within bone. where it may produce a welldemarcated

or poorly defined unilocular or multilocular radiolucency.

HISTOPATHOLOGIC FEATURES The solitary neurofibroma often is well

circumscribed.(especially when the proliferation occurs within the perineurium of the involved nerve)

Tumors that proliferate outside of the perineu rium may not appear well demarcated and tend to blend with the adjacent connective tissues.

HISTOPATHOLOGIC FEATURES The tumor is composed of in terlacing

bundles of spindle-shaped cells that often exhibit wavy nuclei.

Mast cells tend to benumerous and can be a helpfull diagnostic feature.

Sparsely distributed small axons usually can be demonstrated within the tumor tissue by using silver stains.

lmmunohistochemically the tumor cells show a scattered positi ve reaction for S-100 protein .

HISTOPATHOLOGIC FEATURES

TREATMENT AND PROGNOSIS The treatment for solitary

neurofibromasis local surgical excision. Recurrence is rare. Any patient with a lesion that is

diagnosed as a neurofibroma should be evaluated clinically for the possibility of neurofibromatosis.

Malignant transformation of solitary neurofibromas can occur(although the risk appears to be remote.)

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Email: amir.yari@hotmail.com