7/31/2019 Nervous Function and Manifestations of Mental Psychology in Patients With Post-stroke Depression of Different Sy

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Yan Donga, , ,

Bo Yanga, Jingling Songa,

Lihua Yub

a Department of Neurology, General Hospital of Fuxin Mining Industry Group, Fuxin 123000,

Liaoning Province, China

b Department of Traditional Chinese Medicine, General Hospital of Fuxin Mining Industry Group,

Fuxin 123000, Liaoning Province, China

Received 2 November 2006. Accepted 20 January 2007. Available online 19 June 2007.

http://dx.doi.org/10.1016/S1673-5374(07)60019-X , How to Cite or Link Using DOI

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Nervous function and manifestations of mental

psychology in patients with post-stroke depression of

different syndrome types of traditional Chinese

medicine

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AbstractBackground

Poly-criteria pathogenesis of patients with stroke causes diversity of syndrome types of traditional

Chinese medicine (TCM); meanwhile, complexity and diversity of pathological mechanism also play a key

role in determining severity so as to induce effects on nervous function and manifestation of mental

psychology in patients with post-stroke depression (PSD).

Objective

To analyze the syndrome types of TCM with nervous function and manifestations of mental psychology

in PSD patients so as to provide evidence for the treatment based on the syndrome differentiation.Design

Contrast observation.

Setting

Departments of Neurology and Traditional Chinese Medicine, General Hospital of Fuxin Mining Industry

Group.

Participants

A total of 469 outpatients or inpatients with stroke were selected from the Department of Neurology,

General Hospital of Fuxin Mining Industry Group from April 2002 to July 2005. All subjects met the

diagnostic criteria of stroke established by the Fourth National Cerebrovascular Disease Academic

Meeting in 1995 and were finally diagnosed with CT and MRI. Totally, 177 PSD patients were involved in

the final analysis and provided the confirmed consent. There were 121 males and 56 females aged from

46 to 79 years.

Methods

All the enrolled subjects were diagnosed for syndrome differentiation by senior TCM physicians within 1

week before discharge based on Diagnostics of Traditional Chinese Medicine, which was classified into 5

types, including sputum-stasis stagnation syndrome,qistagnation and blood stasis, kidney-essence

deficiency, deficiency of the spleen and stomach and phlegm-fire disturbing the heart. In addition, they

were also assessed by neurologic deficit scale (NDS; 45 points in total; the higher the scores were, the

severer the deficit was), Fugl-Meyer assessment, (FMA; 100 points in total, including 66 points of upper

limbs and 34 points of lower limbs; the higher the scores were, the stronger the motor function was),

modified Barthel index [BI; 100 points in total; the higher the scores were, the better the activity of daily

Tuesday, May 15, 2012

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7/31/2019 Nervous Function and Manifestations of Mental Psychology in Patients With Post-stroke Depression of Different Sy

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life (ADL) was], symptom checklist-90 (SCL-90; including total scores, positive scores, mean and average

scores of positive items), Hamilton depression rating scale (HAMD) and Hamilton anxiety rating scale

(HAMA, the higher the scores were, the severer the degree was). Patients were divided into one

symptom type, two symptom types and 3 symptom types; meanwhile, they were also divided into

deficiency symptom, excess symptom and deficiency-excess symptom. Scores among various groups

were compared simultaneously.

Main outcome measures

Comparison of nervous function and mental psychology of PSD patients with various symptoms.

ResultsDifferences of various symptoms: Among 177 patients, there were 43 subjects in the types of sputum-

stasis stagnation, 64 in qistagnation and blood stasis, 21 in kidney-essence deficiency, 33 in def iciency

of the spleen and stomach, and 16 in phlegm-fire disturbing the heart. In the comparison of the scores

of nervous function and psychological tests among different syndrome types, the scores of most motor

functions of upper and lower limbs, total scores of FMA and ADL in PSD patients of sputum-stasis

stagnation,qistagnation and blood stasis, kidney-essence deficiency were obviously lower than those of

the total samples and PSD patients of deficiency of the spleen and stomach and phlegm-fire disturbing

the heart, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive items, average

number of SCL-90 positive items and average score of SCL-90 positive i tems in the former three groups

were all obviously higher than those in the latter three groups (P< 0.050.01). Different number of

syndrome types: In the comparison of the scores of nervous function and psychological tests among the

PSD patients with different number of syndrome types, the scores of most motor functions of upper andlower limbs, total scores of FMA and ADL in PSD patients with one or two syndrome types were

obviously higher than those of the total samples and the PSD patients with three or more syndrome

types, whereas the total scores of NDS, HAMD, HAMA, SCL-90 and SCL-90 positive i tems, averagenumber of SCL-90 positive items and average score of SCL-90 positive i tems were all obviously lower in

the former two than in the latter two (P < 0.050.01). There were no obvious differences in the scores of

most items of nervous function and psychological tests among the PSD patients of deficiency syndrome,

excess syndrome and the deficiency-excess syndrome (P > 0.05).

Conclusion

The damages of nervous function and mental psychology are more serious in PSD patients with the

syndrome types of sputum-stasis stagnation,qistagnation and blood stasis, kidney-essence deficiency,

as well as those with several (three or more) syndrome types, and the conditions may be improved bythe treatment based on TCM syndrome differentiation.

cerebrovascular disorders/complications;

depressive disorder;

Yan Dong, Associate chief physician, Department of Neurology, General Hospital of Fuxin

Mining Industry Group, Fuxin 123000, Liaoning Province, China

Dong Y, Yang B, Song JL, Yu LH. Nervous function and manifestations of mental psychology

in patients with post-stroke depression of different syndrome types of traditional Chinese

medicine.

SYNDROME DIFFER CLASSIFICATION

Corresponding author: Yan Dong, Department of Neurology, General Hospital of Fuxin

Mining Industry Group, Fuxin 123000, Liaoning Province, China

Key words

Copyright 2007 The Editorial Board of Neural Regernation Research. Published by Elsevier (Singapore)

Pte Ltd. All rights reserved.

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