nephron map
DESCRIPTION
Excellent diagram of the nephronTRANSCRIPT
-
Na
Glucose
Na
Amino Acids
Na
Phosphate,
lactate, or
citrate,
Na
H
Na
H
Cl
Formate
ATP
KGlucoseAmino
AcidsPhosphate,Lactate, orcitrate
HCO + H3- +
H CO32
CO + H O22
CO
+ H O2
2
H + HCO3
-
+
carbonicanhydrase II
c.a. IV (blocked by acetazolam
ide)
H C
O3
2
ATP
Na
K
ATPK
ATPNa
K
ATPNa
K
ATP
Na
K
--
Na,Cl
+-
Late Proximal Tubule Isosm. absorption
Early ProximalTubule Isosm. abs.
-Cl
+
+
2 Cl
Na
K
+-
+
25%
of N
a+ a
nd 2
0% o
f K+
reab
sorb
ed (i
f not
blo
cked
)
Furo
sem
ide
(loop
diu
retic
)
b
lock
s
Cl
K+
K+
Na+
K+
+
Na+
K+
-
Cl-
Thick AscendingLimb load-depend. H2O imp. Dilutes
Thin Ascending Limb H2O impermeable
Thiaz
ide diu
retics
blo
ck
-
+
Cl
Na
Early DistalTubule load-depend. H20 imp. Dilutes NaCl abs.
Late DistalTubule & Collecting Duct -Intercalated & Principal Cells H2O imp. w/o ADH H2O permeable with ADH
~ 3% of NA+ reabsorbed - Fine Tuning Site
~ 5% o
f NA+ rea
bsorb
ed
-Intercalated Reabsorb K H excretion Aldost. stimd H PO excret. NH excret.
K+ATP
ATP
H+
H+
Principal Cell Secrete K Add aquaporin2
67% of N
a+ and K+ reabsorbed
+
+
NH
+ H+
3N
H(excreted)
+4K
-sparing diuretics(inhibit aldost. effect)
2 4
4+
-
(HP
O or )4 2-
2(or H
PO
)4 -
HCO + H3-
3-
+
H CO32
CO + H O22
c.a.
NewHCOabsorbed
85%
of r
eabs
orbe
d H
CO
(if
CO
fro
m tu
bule
) N
ew H
CO
(if
NH
ex
cret
ed)
33
2-
-+ 4
Angiotensin II Stimulated
Aldosterone Stimulated
ADH (vasopressin) Stimulated
ANP Stimulated
Sympathetic (Norepi.) Stimulated
Aldosterone increases # of:1. Na channels2. Na -K -ATPase pumps3. K channels+
+ ++
ADH R
Gs
ACATP
cAMP
PKA
phosphoryln
H O2
H O2
Blood Flow
Na
Norepinep
hrine
(Sympathe
tic)
Angiotens
in
II
ANP
P
rost
agla
ndin
& D
opam
ine
Ren
in s
ecre
t.
JGA
AN
P also blocks
blood
Afferent Arteriole
Effe
rent
Arte
riole
Nephron SchematicFind an error?
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Major effectMinor effect insignificant, unless lots o stim.
Vasodilator
Vasoconstrictor