neoplasia Robbins pictures

For the lab questions

Doctor 2016

Colonic polyp/ adenoma

• The picture in the previous slide shows a polyp from the colon.

• A polyp is a mass projecting above a mucosal surface.

• This particular polyp in the picture is a benign adenoma of the colon.

• Adenoma= benign lesion that is either originating from glandular tissue or forming glands.

Pleomorphic adenoma from salivary gland

• The pic in the previous slide is a pleomorphic adenoma

• This is a benign tumor affecting salivary glands, mainly parotid

• It is an example of mixed tumor : that contained epithelial and stromal elements

• The epithelial elements are the glandular structures

• The stromal elements are the myxoid stroma that resemble cartilage.

Well differentiated squamous cell carcinoma (SCC)

• The pic in the previous slide shows SCC

• In this example it is well differentiated

• Differentiation means how much the tumor mimics its cell of origin both structurally and functionally

• The differentiation is reported as the grade of the tumor.

• Tumor stage on the other hand is the extent the tumor has spread in the body

• Stage is more important than grade in determining the outcome ( clinical behavior of the tumor)

anaplasia

• Anaplasia means dedifferentiation or lack of differentiation

• It s a histologic hallmark of malignancy

• Characterized by: marked cellular atypia, nuclear pleomorphism , hyperchromasia and tumor giant cells

Atypical mitosis

• Abnormal mitosis is seen in malignant tumors

• Not seen in benign tumors

Carcinoma in situ 1

Carcinoma in situ 2

• Carcinoma in situ is full thickness atypia= severe dysplasia involving the whole thickness of the epithelium

• is a pre invasive stage of cancer

Fibroadenoma of the breast

• Fibroadenoma is benign

• In the pic you notice the well circumscribed, encapsulated lesion

Breast carcinoma:

• Previous pic: lesion is infiltrative and lacks a capsule. These are features of malignancy

Liver with metastatic carcinoma

• The pic in the previous slide is for a liver. You see several nodules within it

• Usually multiple nodules are metastatic

Love is wise … Hatred is foolish