neonatal resuscitation2
TRANSCRIPT
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European Resuscitation CouncilEuropean Resuscitation Council
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The term “newly born” refers specifically to the neonate in the first minutes to hours following birth
Definition
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International guidelines for neonatal resuscitation
International Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: a Consensus on Science
Resuscitation 2000; 46:3-430
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5 to 10% of newly born infants have difficulty during the transition phase and may require some form of assistance at birth
Ideally, at least one person trained in newborn resuscitation should attend every delivery
Introduction
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Key point
The most important and effective action in neonatal resuscitation is:
Ventilation with oxygenVentilation with oxygen
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Most term newborns do not require any resuscitative intervention at birth
Few essential steps are generally followed in every setting:
Evaluation of the newly born
Warm and dry the babyWarm and dry the baby
Clear the airwayClear the airway
Warm and dry the babyWarm and dry the baby
Clear the airwayClear the airway
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Haemodynamic adaptation may be delayed or reversed by a number of antepartum or intrapartum factors, which may cause asphyxia
The newly born may present apnoeic, hypotonic and cyanotic and may require immediate resuscitative efforts
Asphyxia at birth
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Chestcompressions
DrugsRare
Establish adequate ventilationBMV
Endotracheal intubation
Frequent Oxygen
Dry, Warm, Position, Suction, Stimulate
Resuscitation of the newly born
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The Apgar score after 1 and 5 minutes remains the most widely accepted method of neonatal assessment at birth
Not useful in deciding the need for cardiopulmonary support
Evaluation of the newly born
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Clear of meconiumSpontaneously breathing or cryingGood muscle toneSkin colour pinkTerm gestation
Visual inspection of the newly born
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Evaluation of the newly born
The need for life support interventions will be indicated by the simultaneous evaluation of:
•RespirationRespiration•Heart rateHeart rate
•ColourColour
•RespirationRespiration•Heart rateHeart rate
•ColourColour
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RespirationGood spontaneous respiratory activity may
manifest as vigorous crying or adequate breaths
IMPORTANT: if apnoea or gasping persist after few seconds of tactile stimulation:
Start positive pressure Start positive pressure ventilation immediately ventilation immediately Start positive pressure Start positive pressure ventilation immediately ventilation immediately
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Heart rate
The heart rate may be evaluated with a stethoscope or by palpation of the pulse at the base of the umbilical cord
Umbilical pulse is readily accessible and it does not require interruption of ventilation such as during auscultation
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Heart rate
If the heart rate is below 100 beats per minute, even if the newly born is breathing:
Positive pressure ventilationPositive pressure ventilation with 100% oxygenwith 100% oxygen
Positive pressure ventilationPositive pressure ventilation with 100% oxygenwith 100% oxygen
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Colour
Colour at birth may vary from normal acrocyanosis to pallor to central cyanosis
Pallor may indicate a low cardiac output, severe anemia, hypovolemia or acidosis
Central cyanosis (face, trunk and mucous membranes) indicates hypoxaemia
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Colour
If central cyanosis is present in the spontaneously breathing newborn
100% free-flow O2100% free-flow O2
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PrematurityIncreased likelihood of need for resuscitation
Asphyxia is much more frequent than the term neonate
Major risk of heat loss, respiratory distress and intraventricular haemorrhage
Minimising heat loss in preterm infants improves survival
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Positioning of the infant and removal of secretions as needed
Secretions should be cleared first from the mouth and then from the nose
Neutral or slightly extended position by placing a towel under the infant's shoulders
A- AIRWAY Clearing the airway
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B - BREATHING & STIMULATION
Routine drying and suctioningAlternative methods:
rubbing the back flicking the soles of the feet
If no response to tactile stimulation occurs within few seconds:
Bag and mask ventilation Bag and mask ventilation with 100% oxygenwith 100% oxygen
Bag and mask ventilation Bag and mask ventilation with 100% oxygenwith 100% oxygen
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B - BREATHINGMeconium
Meconium staining of the amniotic fluid 10 to 15% of all pregnancies
About 5% of newborns with meconium in the amniotic fluid may suffer mild tachypnoea to severe pneumonitis and persistent pulmonary hypertension
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Meconium
Efforts to remove meconium from the oropharynx and trachea must precede any other intervention when assisting a depressed newly born
•absent or inadequate respirationabsent or inadequate respiration•heart rate < 100 bpmheart rate < 100 bpm•poor muscle tonepoor muscle tone
•absent or inadequate respirationabsent or inadequate respiration•heart rate < 100 bpmheart rate < 100 bpm•poor muscle tonepoor muscle tone
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Meconium
Suctioning of the hypopharynx under direct vision
Repeated tracheal intubation and direct suction via the endotracheal tube
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Meconium
Key pointKey pointThe infant's level of activity, rather than the consistency of meconium, indicates the need for direct tracheal suctioning
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B - BREATHINGOxygen
The optimal concentration of oxygen for neonatal resuscitation is still uncertain
Increasing data on the use of room air during positive pressure ventilation as an alternative to 100% O2
Further work is needed before making new recommendations
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•Apnoea or gasping breathApnoea or gasping breath•Heart rate <100 bpmHeart rate <100 bpm•Persistent central cyanosisPersistent central cyanosis
•Apnoea or gasping breathApnoea or gasping breath•Heart rate <100 bpmHeart rate <100 bpm•Persistent central cyanosisPersistent central cyanosis
B - BREATHINGPositive Pressure Ventilation
Adequate expansion of the lung is often the only and most important measure needed for successful resuscitation
Indications for positive pressure ventilation:
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B - BREATHINGArtificial Ventilation
Most newborns who require positive-pressure ventilation can be adequately ventilated with a bag and mask
BMV should be mastered by all healthcare
providers who may be asked to deal with an emergency delivery
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Bag and Mask Ventilation
Face masks of various size, with cushioned rims and low dead space
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If the heart rate is less than 60 bpm, chest compressions must be started while continuing assisted ventilation
Progress to endotracheal intubation should be considered
Bag and Mask Ventilation
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Endotracheal intubation
Indications for endotracheal intubation may occur at several points during neonatal resuscitation:
Tracheal suctioning for meconium (depressed baby) BMV ineffective or prolonged Chest compressions needed Tracheal administration of medications Congenital diaphragmatic hernia Extreme prematurity Transport
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A straight blade should be used (size 0 for premature infants, size 1 for term infants)
An estimate for the correct oral insertion distance of the ET tube use the following formula:
Endotracheal intubation
Weight in kilograms + 6 cm =
insertion depth at lip in cm
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After the procedure, check successful intubation and correct positioning of the ET tube by the following:
Normal and symmetric chest wall movements Equal breath sounds (axillae) Absence of breath sounds or distension over the stomach Condensation in the tube during exhalation Improvement in heart rate, colour and spontaneous respirations Exhaled-CO2 monitor
Endotracheal intubation
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Successfully used in the resuscitation of term and near term infants at birth
Little experience in small preterm infants and
in newborns with meconium
May be an alternative in the case of ineffective BMV or failed endotracheal intubation
Laryngeal mask airway
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C - CIRCULATIONChest compressions
0.03 to 0.12% of newly borns require chest compressions
Bradycardia and asystole are virtually always a result of respiratory failure, hypoxaemia and tissue acidosis
Adequate ventilation and oxygenation will be sufficient to restore vital signs in the vast majority of infants
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If the heart rate is less than 60 bpm despite 30 seconds of effective positive pressure ventilation with 100% oxygen:
Chest compressions
Start chest compressionsStart chest compressionsStart chest compressionsStart chest compressions
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Chest compressions performed in conjunction with ventilation with 100% oxygen
(3 to 1 ratio 90 compressions and 30 breaths per minute)
Chest compressions
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Routes of drugs administrationUmbilical vein still widely recommended in the
delivery room
•Umbilical catheterisation may be a challenge for physicians not skilled in neonatal resuscitation
•Tracheal route is a rapid accessible route for drug administration during resuscitation
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Intraosseous accessIf fluids and drugs are required and no vascular access is
obtained, intraosseous lines may be an effective alternative
Intravenous access may be required if: no response to adrenaline via ETT need for volume expansion
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Emergency drugs and fluidsIf heart rate is less than 60 bpm after 30 seconds of adequate ventilation and chest compressions, or in the presence of asystole
AdrenalineAdrenalineAdrenalineAdrenaline
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Emergency drugs and fluidsAdrenaline
Dose (I.V., ET or I.O.):
0.1 to 0.3 mL/kg of a 1:10.000 solution (0.01 to 0.03 mg/kg)
repeat every 3 to 5 minutes as indicated
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Volume expanders
Cristalloids (normal saline or Ringer's lactate) are the fluids of choice for volume expansion
If blood loss is likely, O-negative red blood cells
Emergency drugs and fluids
10 ml/kg i.v. over 5 to 10 minutes
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Algorithm of resuscitation Algorithm of resuscitation at birthat birth
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Initial assessment of the newly born
Clear of meconium
Breathing or crying
Good muscle tone
Pink
Term
Warm and dry
Clear the airway
YES
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Clear of meconium
Breathing or crying
Good muscle tone
Pink
Term
Warm and dry
Position
Clear the airway (*)
Stimulate Give oxygen (if needed)
NO
Initial assessment of the newly born
(*) consider endotracheal intubation
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Respiratory activity
Heart rate
Colour
Breathing
Heart rate > 100
Pink
Continue evaluation
Standard care Apnoea or gasping
Heart rate < 100
•Positive pressure ventilation Positive pressure ventilation (*)(*)
•OxygenOxygen
•Positive pressure ventilation Positive pressure ventilation (*)(*)
•OxygenOxygen
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Ventilating
Heart rate > 100
Pink
Ongoing support
Positive pressure ventilation and oxygen
Heart rate < 60
•Positive pressure ventilation Positive pressure ventilation (*)(*)
•Chest compressionsChest compressions
•Positive pressure ventilation Positive pressure ventilation (*)(*)
•Chest compressionsChest compressions
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•Heart rate > 60 •Positive pressure ventilation(*)
•Oxygen
Positive pressure ventilation and chest compressions
•Heart rate < 60
Adrenaline Adrenaline (*)
(via intravenous, endotracheal, intraosseus)(via intravenous, endotracheal, intraosseus)
Adrenaline Adrenaline (*)
(via intravenous, endotracheal, intraosseus)(via intravenous, endotracheal, intraosseus)
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Transport of the newly bornInfants transferred under controlled conditions with skilled assistance do arrive
at destination in better clinical conditions: warmer less hypotensive less acidotic
With such assistance mortality, morbidity and duration of intensive care stay are reduced
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EthicsIndication for initiation or suspension of resuscitation are debatable in
extremely premature infants severe congenital abnormalities infants who do not respond to prolonged resuscitative efforts
In many countries, non-initiation of resuscitation in the delivery room is appropriate infants with confirmed G.A. <23 weeks or B.W. <400 g anencephaly confirmed trisomy 13 or 18
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Ethics
Discontinuation may be appropriate if resuscitation of an infant does not result in spontaneous circulation within 15 minutes