natural products-cholesterol synthesis
DESCRIPTION
Cholestrol synthesis with the mechanismsTRANSCRIPT
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Natural Products
Prepared by:
Mr:Mohammed H. Raidah
2008-2009
O
O
MeO+ 100Co
HO
O
MeO
NaOHHCl
O
O
MeOH
LiAlH4
HOH
OH2
MeO
OH2
OHH
H2SO4
OH
O
ZnRed.
NaOMe
EtO2CH
C OOEt
H HC
HO
OH
KOBut
EVKH
O
Et CO
HO
O
KOH
HO
H
CH3C
H
H
OsO4
HO
H
OH
OHMeCOCuSO4H
O
H
O
OH
CO
Me
Me
HO
HO
CO
NHMePh
NaOMe,HCOOEt
CO
OEtH
HO
HO
CO
HC O
HO
HO
CO
H
NMePhHOH
H
O
HO
CO
CHNMePh
CN
OH HH
O
HO
COH2,Pd
COO
H
H
HO
CO
OOH
OH
H
HO
CO
OO
NaOAcMe MgBr
KOH
H
HO
CO
OO
HC
H
HO
CO
OHO
H
H
HO
CO
OHIO4 H
H
O
O
O
H
NH OAc
H
H
O
CHO
Na2CrO7
CH2N2
H
H
O
CO2Me
H2/Pt
CrO3,AcOH H
H
O
CO2Me
H
H
H
NaBH4,KOH
AC2O,SOCl2OC
O
CO Me
Me
With my best wishes
H
H
AcO
C
H
H
H
O
Me
C6H13MgBr
H
H
AcOH
H
H
OH
H2/Pt
Ac2O, AcOH
H
H
HOH
H
H
H
Na2Cr2O7
H
H
OH
H
H
H
Base
Br BrH
H
OH
H
H
Dehydrohalogenation
H
Ac2O
OC
O
CO Me
Me
H
H
AcOH
H
H
H
H
HOH
H
H
NaBH4, MeOH, H2O