Scientific Organizers: Jon C. Clardy, Harvard Medical School, USA Yi Tang, University of California, Los Angeles, USA Sean F. Brady, Rockefeller University, USA

Natural products, the structurally diverse family of small molecules produced by living organisms in an idiosyncratic fashion, have provided the basis for the majority of our therapeutic agents used to treat infectious disease, cancer and immune disorders. Whole genome sequencing of producing organisms, especially bacteria and fungi, continues to reveal that we have discovered only a fraction of these genetically encoded small molecules. Closing this gap between our current inventory and the genomic potential has become an important goal for basic and applied science; synthetic biology coupled with bioinformatic analysis has become the primary research tool for this effort. Bioinformatic mining continues to reveal the enzymes and pathways that nature uses, and synthetic biology has begun to reassemble or refactor these pathways to produce known and unknown products in new hosts. This conference brings together researchers in fields ranging from microbiology to botany, bioinformatics to gene synthesis and assembly, and basic research to industrial applications.

Session Topics:• Mining the Human Microbiome • Mining Environmental Genomes • Fungal and Plant I & II• Plant and Other Pathways • Microbial Pathways

Scholarship Application & Discounted Abstract Deadline: September 25, 2017Abstract Deadline: October 23, 2017Discounted Registration Deadline: November 21, 2017

January 21–24, 2018 | Resort at Squaw Creek | Olympic Valley, California | USA

Natural Products and Synthetic Biology: Parts and Pathways

www.keystonesymposia.org/meetings | 1.800.253.0685 | 1.970.262.1230

a 501(c)(3) nonprofit educational organization

Note: Scholarships are available for graduate students and postdoctoral fellows and are awarded based on the abstract submitted. Submitting an abstract is an excellent opportunity to gain exposure for your work. Abstracts submitted by the abstract deadline will also be considered for short talks on the program.Upper image courtesy of the National Eye Institute.

Meeting Hashtag: #KSsynbio www.keystonesymposia.org/18J1

SUNDAY, JANUARY 21Arrival and Registration

MONDAY, JANUARY 22Welcome and Keynote Address *Jon Clardy, Harvard Medical School, USAChaitan Khosla, Stanford University, USAStructure and Mechanism of Assembly Line Polyketide Synthases

Mining the Human Microbiome *Mohamed S. Donia, Princeton University, USAMichael A. Fischbach, Stanford University, USASmall Molecules from the Human MicrobiotaEmily P. Balskus, Harvard University, USADeciphering the Human Microbiota with ChemistryJason M. Crawford, Yale University, USAHarnessing Cellular Stress for Metabolite Discovery in BacterialPathogensDavid Zeevi, Rockefeller University, USAShort Talk: Towards Mining the Gut Microbiome for TherapeuticTargetsYuki Sugimoto, Princeton University, USAShort Talk: Discovery of Drug-Like Molecules from the HumanMicrobiome

Mining Environmental Genomes *Jason M. Crawford, Yale University, USAJon Clardy, Harvard Medical School, USAUnknown UnknownsTadhg Begley, Texas A&M, USAMechanistic Studies on the Futalosine-Dependent MenaquinoneBiosynthetic PathwayBradley Moore, University of California, San Diego, USABiosynthesis in Toxic Marine MicroalgaeJeremy George Owen, Victoria University of Wellington, New ZealandShort Talk: The Natural Products of Mycale hentscheli BacterialSymbionts

Poster Session 1

TUESDAY, JANUARY 23Fungal and Plant I *Anne E. Osbourn, John Innes Centre, UKSarah O’Connor, John Innes Centre, UKBiocatalysts from Alkaloid Producing PlantsElizabeth Sattely, Stanford University, USADiscovery and Engineering of Plant Chemistry for Plant and HumanHealth Reshma Shetty, Ginkgo Bioworks, Inc., USAThe Emerging Organism Engineering IndustryJaclyn Winter, University of Utah, USADeveloping Heterologous Expression Platforms for Elucidating FungalNatural Product Biosynthesis

Sagar Changdev Gore, Leibniz Institute for Natural ProductResearch and Infection Biology, GermanyShort Talk: Phylogenetic and Binding Pocket Analysis of FungalAdenylation DomainsRoland D. Kersten, Massachusetts Institute of Technology, USAShort Talk: Genome Mining of Plant Ribosomal Peptides

Fungal and Plant II *Jaclyn Winter, University of Utah, USAYi Tang, University of California, Los Angeles, USABioactive Natural Product Discovery Using the Self-Resistance Geneas a LeadAdam L. Meadows, Amyris, Inc, USANext-Generation Platforms for Strain Optimization: Reducing the Costand Time for Commercializing Natural ProductsAxel A. Brakhage, Friedrich Schiller University, GermanyActivation of Natural Product Gene Clusters by MicrobialCommunication and Synthetic BiologyBrandon Pfannenstiel, University of Wisconsin-Madison, USA"Reading" the Histone Code of Secondary Metabolism

Poster Session 2

WEDNESDAY, JANUARY 24Plant and Other Pathways *Elizabeth Sattely, Stanford University, USAChristina D. Smolke, Stanford University, USAA Microbial Biomanufacturing Platform for Natural and SemisyntheticOpioidsAnne E. Osbourn, John Innes Centre, UKPlant Metabolic Clusters – From Genetics to GenomicsFrancis Stewart, Technische Universitaet Dresden, GermanyDirect Cloning and Recombineering of Biosynthetic Gene ClustersSibongile Mafu, University of Massachusetts, USAShort Talk: Discovery of Plant Based Natural Phytochemicals throughElicitation of Calli CulturesRadin Sadre, Michigan State University, USAShort Talk: Boosting Terpenoid and Oil Production in PhotosyntheticTissues of Plants

Microbial Pathways *Tadhg Begley, Texas A&M, USASean F. Brady, Rockefeller University, USACulture-Independent Discovery of Natural Products from SoilMetagenomesChristopher Voigt, Massachusetts Institute of Technology, USAHigh-Throughput Mining of Natural ProductsAlessandra S. Eustaquio, University of Illinois, USABacterial Genome Mining and Biosynthetic Engineering for NaturalProduct Drug Discovery and Development

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

* Session Chair † Invited but not yet accepted Program current as of May 19, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Natural Products and Synthetic Biology: Parts and Pathways (J1)January 21-24, 2018 • Resort at Squaw Creek • Olympic Valley, CA, USA

Scientific Organizers: Jon Clardy, Yi Tang and Sean F. BradySponsored by Merck & Co., Inc.

Discounted Abstract & Scholarship Deadline: September 25, 2017 / Abstract Deadline: October 23, 2017 / Discounted Registration Deadline: November 21, 2017

THURSDAY, JANUARY 25Departure

* Session Chair † Invited but not yet accepted Program current as of May 19, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Natural Products and Synthetic Biology: Parts and Pathways (J1)January 21-24, 2018 • Resort at Squaw Creek • Olympic Valley, CA, USA

Scientific Organizers: Jon Clardy, Yi Tang and Sean F. BradySponsored by Merck & Co., Inc.

Discounted Abstract & Scholarship Deadline: September 25, 2017 / Abstract Deadline: October 23, 2017 / Discounted Registration Deadline: November 21, 2017