omCIAL PUBUCATION OF

NATURAL FOOD ASSOCIATES, INC.

NATURAL FOOD AND FARMING

MARCH, 1956VOL. 2, NO. 12

NATURAL FOODASSOCIATES

OFFICERS

Pr&itlentDB. JOE D. NICHOLS, M.D.

Atlanta, Texas

Vice·PresidentDa. FBED D. MILLER, D.D.s.

Altoona, Pennsylvania

["I

The Chemical BackgroundOf .The Relation Between·

Malnutrition And HeredityBy ROYAL LEE, D. D. S.

Vice·PresidentERNEST HALBLIERMcNabb, minois

Address Given to 1956 National Convention, Terre Haute, Ind.

Vice·PresidentJ. VERNE SHANCLEMedford, Oregon

E"ecuti"e SecretaryTHOMAS Lnll'lAtlanta, Texas

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It is a well-established fact thatmalnutrition can bring about morpho.logical changes that are transmittedto offspring. This seems to explodethe generally held opinion that al>quired characteristics cannot be trans­mitted to offspring. This has beencovered to BOme extent in a previouslecture of inine entitled "Unfittingthe Unborn."

Wl!.at we are interested in at thistime is how this can take place, justwhat is the mechanism involved, from

. a biochemical viewpoint. To get aproper perspective of the magnitudeof this concept, it is important thatwe realize that the hypothesis weneed will· not only include the mech·anism of heredity, but also the mech.anism of growth control and the mech·anism of the control of morphology.To find such a mechanism, you willrealize at once that we must go tothe cell nucleus and start investigateing the chromosome and the gene.

Some years ago Dr. Fenton B.Turck of New York reported thirtyyears of research on this line, at leaston a line that became the openingdoor to an explanation of our ques­tion, in his book "The Action of theLiving Cell." He pointed out thatevery living cell is at all times secret­ing into its surroundings a specificsubstance of a specific antigenicnature that regulated the rate ofgrowth or repair of the cell. Whathe was investigating was really thecell blueprints, the seed of the cell,

as it were, that catalyzed the synthesisof new protein on the external cellwall. The nucleus is no doubt alsocarrying on a similar synthesis on itsrespective separating wall, in fact, theblueprint proteins themselves are sus­pected to be made in this way, whileon the outer cell wall the more simpleproteins of the cell are made frommaterials available in the culturemedium in which the cell lives. Whenwe talk about genes we are speakingof aggregates of various kinds of theseblueprint molecules. In fact, yourealize that the plans for such astructure as the human body mustbe quite a volume of blueprints. Weknow that chromosomes and genesare composed of monomolecular lay­ers of cholesterol on which lipopro.teins are adsorbed in similar mono­molecular layers, just like a stack ofblueprints. Also, it is suspected thatthese layers are duplicated by a tem­plate process that is just like offsetprinting, that the master copy seemsto he made in reverse out of stereoi·somerically opposite amino acids thanthe common ones found in the rest ofthe cell structures. The cell activi t.ybefore mitosis is a procC88 of makinga set of duplicated hlueprints for thenew cell.

Blood cannot coagulate without asupply of blueprints to determine then;lture of the protein to be formedfrom the precursors in the blood. Thecirculating platelet seems to be thesource for these blueprints.

. .- ~

. . ~ ..

The germ cells made by the sexglands must get a supply of theseblueprint factors to build the stackof blueprints in tbe master germ cell,must get them from the blood stream,possibly from the platelet again, andyou will appreciate the circumstancethat if the original source of suchblueprints for any specific tissue ismissing, say the islets of Langerhansin the pancreas, there will be no wayfor these blueprints to get into themaster plan. Suppose both parentshad diabetes, no islets of Langerhans,the offspring of such parents would,be bound to be born with diabetes.Such is actually true.

Turck found that these cell de·terminants could survive, at leasttheir antigenic characteristics couldsurvive, a temperature up to about700 degrees Centigrade. The ash ofspecific tissues will cause anaphy.lactic reactions if injected into sensi.tized animals with almost the samepotency as the fresh protein. Weknow that colloidal silica does notlose its colloidal form until heated tothis temperature (see reference I).

It is known that silica has a spe.cific adsorption power for choles.terol, and that cholesterol has aspecific adsorption power for pro·tcins, so here we may have a physico.chemical mechanism that is responsi.ble. for the primary function of theliving cell. Dr. George Crile was ableto make "synthetic" cells by usingbrain ash 'added to amino acid mix­tures which actually proceeded tosubdivide (reference 2).

Brain carries the most active groupof growth promoting factors of anytissue, no doubt because it has tocreate protein more speedily than anyother tissue ... the association fibel'sthat are memory pathways must bebuilt up as fast as we think. That is

why the best source of thromboplastinfor the stimulation of blood clottingis a brain extract. Thromboplastinis the common name for the connec·tive tissue ,blueprint substance, butalways in very crude and unrefinedforms.

The silica matrix seems to carrythe physical details that make theblueprints specific, in all probabilityserves the same purpose as a stereo·type metal in book printing. Dr.Carleton Bastian found years ago inhis experiments to promote spontane·ous generation of life that the silicacontent of the culture media was ofprime importance (reference 3). Hiswork was ridiculed at the time, butit is interesting to find Dr. Crile creat­ing living cells with brain ash out ofsterile and synthetic chemicals, thevery thing that was supposed to beimpossible at the time Dr. Bastianreported it, and his results werelaughed off with the comment thathis sterilizing methods were faulty.

No protein is ever found withouta mineral ash, but this fact is not wellknown. (Unless it be a non-specificblood protein with no antigenicpower.) In fact, it is very probablethat the mineral ash is the most im·pQrtant part of the protein, the thingthat determines its specificity and thecarrier of the hereditary factors inall living things.

It is well known that trace min.erals needed by plant life, if defici­ent, result in morphological deformi­ties in plant structures before the de·ficiency has reached the degree thatstops growth. This is indicative ofthe need for such trace minerals asblueprint materials, faulty ,blueprintsbeing produced before all growth isstopped. In the animal we must lookfor a mechanism that regulates thedegree of growth, as well as regulat­ing form. The immune bodies foundin the blood stream function as such.Antibodies are constantly beingformed against all natural tissues, aswell as against invading proteins.These are beginning to become a partof immunology under the subject ofNatural Tissue Anti,bodies (reference4). To illustrate how they work,note the reaction of the remainingkidney after one has been removed.It grows bigger, to twice normal size,to carry the load alone. The life ex­pectancy of the patient is not affect­ed. If you connect the circulation oftwo animals, cut out half the liver ofone, the liver in the OTHER animalbegins to grow. Over.activity, over·load, of the half-liver creates an ab7normal release of blueprint proteininto the bloodstream, which com·bines with aud reduces the temp~rary levels of liver antibody, therebyallowing ANY liver receiving the

blood so changed to start renewedcell division. By this system, anyorgan that is not used to its capacityregresses in size, if used beyond itscapacity, increases in size. It may heof interest to mention that concen­trated preparations of the blueprintsof many organs are commerciallyavailable, which are being success­fully used to stimulate repair of theheart, lungs, pancreas, etc., .afteryears of disease has caused the crea·tion of excess antibody. The speedof action sometimes is phenomenal,heart tissne often responding withinminutes to the removal of the inhibi·tory effect of excess circulating anti·body to heart tissue, the effect beingmeasurable cardiographically, the ac·tion being much like digitalis (ref­erence 5).

It has been known for 40 yearsthat such antibodies existed, but likeDr. Bastian's and Dr. Crile's work,the ideas were not consistent withorthodox scientific superstition, andnobody dared to be found investigat.ing such crack.pot conclusions. AsDr. A. P. Kelley recently said in hisboo k "Mycotrophy in Plants"(Chronica Botanica, 1950) on pageIS, referring to the non-integral,exogenous nature of plant root hairs,"Moreover, there is little prospectthat research will be done on suchstructures, for the ruling motive inbotanical science today appears to besubservience to the authority of tra·dition." (Dr. Kelley is trying to tellus that the root·hairs on plants inthe main are fungoid, bear the samerelation to the plant as barnacles doto the ship. Certainly, if we had onlyreceived our knowledge of ships byexamining those ailoat, we would behard to convince that the barnaclewas not an integral part of the engi­neering plans, and particularly so ifwe found the occupants of the shipmaking use of the barnacles in theirfood pattern.)

This discovery of the way growthand form are controlled by chemicaldeterminants has opened up an entirenew territory in physiology andtherapeutics. The endocrine regula­tors are now much more intelligiblein their mode of action. Thyroid, forinstance, does its work in the mainby releasing determinant factorsfrom adsorbed stores in connectivetissue, the basal metabolism responsebeing characteristic of the cell ac·tivity stimulated by the presence ofsuch determinants in stimulatinggrowth, repair or metabolism, incombination or alone, as the case maybe, depending on the part of the lifecycle involved.

The sex hormones operate, in themain, by steering these determinants

to the gonad, where the response isthe physiological one of increasedactivity. Any surplus of determinantin its original nondiffusible form isexcreted by the bile route (by theway, the bile being the normal outletfor any nondiffusihle waste products,colloidal carhon if injected into theblood being eliminated thereby) .Since the sex hormone moleculeseems to accompany the determinantto the gonad or liver, it also is ex­creted along with any determinantthat is thrown out with the bile. Theliver in most animals is known toeliminate sex hormones, but the rea­son or relation has been undecipher­able.

There will be a question as to therelation of cancer susceptibility tothe determinant status. It seems atthis early date that cancer is onlypossible when there is too little ofavailable natural blueprint material,so that the cells are easily led astrayinto new forms. That fits in with thestatement that cancer is biologicalanarchy. Only after the normal gov­erning powers have become incom­petent can cancer occur. Very en­couraging results are being shown by

feeding cancel' victims with concen·trates of the determinant from thetype of tissue that is being attackedby the cancer. It is undoubtedly oneof the many factors in the cancel'situation, but it is likely that en­docrine support, as well, is of pri­mary importance. JUllt how to man­age this restoration to normal endoc.rine balances is the most pressingproblem, in my mind, at this moment.X-Ray, like thyroid, acts to releasedeterminant factors from the cellchromosome. That is why X-Ray canhelp cancer, and is also why repeatedexposure to X-Ray can cause cancer.In the latter case, the released determ­minant causes the eventual develop­ment of natural tissue antibody tothe cells or tissue concerned, andrenders it susceptible to cancer bythe reduction locally of the deter­minant. The irritation theory of can­cer can act the same way, the pipe­smoker's constantly irritated lip trig.gers off too much antibody to thetissues involved, and the cancer canstart at the uritated point, the ,irri.tated cells losing so much determinantthat they ,become most susceptible tothe antibody.

N. F .A. Reprint 2-12-9

Page 3

there has probably been "10 dis­covery in biological science that hasshown such prompt practical rewardsas the Ulle of these determinants intherapeutics. It is highly suggestiveof the ultimate role of this newweapon, a thoroughly natural weapon,as distinguished from the array ofunwarranted experiments in toxic­ology that has characterized the re­cent history of pharmacology, evendown to the strange craze for the mas~

medication of water fluoridation. Wemust be careful to retain our horizonsof sanity to avoid being unduly in­fluenced by the specious logic ofthose responsible for the peculiarphilosophies of a modern medicaleducation, so well defined by thatHarvard professor as "the warpin:gof an unsuspecting immature mindinto a meticulous system of com­mercial superstitution."

REFERENCES:(1) "The CoUoid Chemistry of Silica and the

Silicates," Her, Cornell Univ. Press, 1955.(2) "The Phenomona of Life," a Radio-Elec·

tric Interpretation, W. W. Norton Co.,1936, Chapter 7.

(3) Carleston Bastian "The Origin of Life,"Lippincott, 1872.

(4) J. G. Kidd, M. D., W. F. Friedewald,M. D., Jo1. Exper. Med. 76:543, 76:557,1942.

(5) Vitamin News (Vitamin Products Com·pany-Milwaukee, Wisconsin) p. 195(954), "Applied Protomorphology" ­Vitamin Products Company-Milwaukee,Wisconsin.