nathalie kapp, md, mph · 2016. 6. 27. · updates for second trimester procedures 4. the case for...
TRANSCRIPT
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Update on abortion care
Nathalie Kapp, MD, MPHDepartment of Reproductive Health and Research
World Health Organization
Training Course in Sexual and Reproductive Health Research
Geneva, February 2009
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Outline
1. Introduction
2. Updates for first trimester procedures
3. Updates for second trimester
procedures
4. The case for family planning
5. Future directions
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Worldwide 1 in 5 pregnancies
ends in induced abortion
20
49
16
15
19
50
16
15
World
Induced abortions
Spontaneous abortionsUnwanted or mistimed births
Less developed
countries
More developed
countries
Wanted births
28
44
13
14
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Safe Abortion: Technical and Policy Guidance for Health Systems
Methods of abortion
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Outline
1. Introduction
2. Updates for first trimester procedures
3. Updates for second trimester
procedures
4. The case for family planning
5. Future directions
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USA mortality rates (deaths per 100,000)
0
1
2
3
4
5
6
7
8
9
10 Surgical Ab ≤8weeks
Surgical Ab 9-10weeks
Surgical Ab 11-12weeks
1st trimesterspontaneous Ab
Surgical Ab 13-15weeks
Term delivery
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Surgical methods of first trimester abortion
Surgical methods– Aspiration; D&C not recommended
Manual vacuum aspiration (MVA)– Small, easy to transport, don't require electricity
– May be used throughout first trimester
– Compared to electric (EVA)Less blood loss and pain <50 days gestation, but prolonged procedure
Quieter procedure
No differences in complete
abortion rate (effectiveness)
or patient satisfaction (Wen, 2007)
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Cervical preparation
Recommendations differ:WHO: all <18 years, nulliparas >10 weeks gestation, all
> 12 weeks
RCOG: all < 18 years, all >10 weeks gestation
SFP: all 12-14 weeks, consider for all adolescents
Discomfort, cost and inconvenience to patients should be balanced with very low risks of injury– Perforation rare
– Cervical lacerations occur 1/1000 cases (Hakim-Elahi, 1990)
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Cervical dilation methods
Mechanical dilation usually with Pratt or
Denniston dilators
Pharmacologic preparation: misoprostol
– Optimal regimen: 400 mcg vaginally, 3-4 hours prior
to procedure
Oral administration associated with higher rates of side-
effects
– Preferable to women over osmotic dilators
No differences in complication rates
Prefer 1-day procedures (MacIsaac, 1999; Goldberg, 2005)
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Antibiotic prophylaxis
Periabortal antibiotic prophylaxis reduces risk of
infection
– Meta-analysis demonstrates 45% decrease in
infectious complications (Sawaya, 1996)
– Universal prophylaxis costs less and is as effective as
screen-and-treat
– Regimens vary:
ACOG: doxycycline, 300 mg
RCOG: metronidazole 1 gm rectally at time of abortion,
followed by 1-gm azithromycin or 7 days of doxycycline
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Medical abortion in the first trimester
Allows abortion without surgical procedure
Multiple safe, effective regimens available:– Mifepristone/ misoprostol: 93-99%
– Methotrexate/ misoprostol: 88-95%
– Misoprostol alone: 83-95%
Few contraindications to use
Extensive research into optimal, cost-effective regimens– Maximise access, acceptability
Varied use of medical methods– France, Sweden >50% of first trimester abortions
– UK only 18%
– USA varies from 0-32% depending on the state
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Medical abortion regimens
Classic regimen
– Mifepristone 600 mg followed 36- 48 hours later by misoprostol400 mcg orally (or gemeprost) for <49 day gestations
Evidence-based regimens:
– Mifepristone at lower doses
200mg is equivalent to 600 mg
– Misoprostol by other routes
Vaginal routes more effective, less side-effects and extend gestational age to 63 days
Buccal/ sublingual may be similar to vaginal, but less studied
– Home administration of misoprostol
– Earlier follow-up
High predictability of sonography at 1 week
– Interval between mifepristone and misoprostol
24 hour interval is as effective; with vaginal, may use 6-8 hours (or earlier) apart
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Evidence-based regimens
Mifepristone-
misoprostol
Methotrexate-
misoprostol
Misoprostol-
only
Gestational
age
63 days 49 days 63 days
Mifepristone
or MTX
dose
200 mg 50 mg/m2 IM
or 25-50 mg
oral
N/A
Misoprostol
dose
800 mcg
vaginal
800 mcg
vaginal
800 mcg
vaginal
Misoprostol
timing
24 hours
after
mifepristone
3-7 days after
MTX
Every 6, 8, 12
or 24 hours
for 3 doses
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Side-effects and complications after first
trimester medical abortion
Vaginal bleeding– Mean duration is 9 day with a range 1-45
– Average drop in Hgb 0.7%
Abdominal pain and cramping– Majority of women
– NSAIDs with or without narcotics generally offered to womenIn UK, 60% women used narcotics during medical abortion
Gastrointestinal distress– Many experience nausea, vomiting
Resolve in 2-6 hours after misoprostol
Diarrhoea rare with vaginal misoprostol
Infection– Endometritis is rare (0.1-0.9%)
– No data to suggest use of prophylactic antibiotics
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Outline
1. Introduction
2. Updates for first trimester procedures
3. Updates for second trimester
procedures
4. The case for family planning
5. Future directions
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Beyond the first trimester….
42 million abortions globally– 10-15% in the second trimester
– USA data: (CDC, 2005)
6.2% at 13-15 weeks, 3.8% at 16-20 weeks and 1.4% at >21 weeks
– At >16 weeks' gestation, medical abortions (n = 847) made up 2.2% of abortions in the US
More common with increasing gestational age: 7% of abortions greater than 21 weeks
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Medical versus surgical abortion in the
midtrimester
Which is superior?– Both have improved over last 30 years
D&E safer than intra-amniotic instillation methods
– Cochrane review included 2 RCTs (Lohr, 2008)D&E compared to prostaglandin F2a
D&E compared to mifepristone/ misoprostol
– Conclusion: D&E superior to prostaglandin F2a, further trials are needed to determine superiority for modern medical methods
Ethical stance– Principles of autonomy, beneficience, justice
Women should be offered a choice (Grimes, 2008)
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Surgical methods: D&E
D&E preferred surgical technique
– Hysterotomy, D&C, hysterectomy are less safe
Safety of D&E:
– Low rate of complications
In the range of 4% (includes haemorrhage, retained
products, etc)
– Safety depends on trained, experienced providers
– Can be performed on outpatient basis
Availability can be regional
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Medical versus surgical abortion in the
midtrimester
Medical abortions preferable for:– Complete anatomical evaluation of foetus
– Woman is a poor surgical candidate
– May be dictated by facility
– Absence of trained surgeons
Negatives aspect of medical procedures:– Time consuming
– More painful
– May be more costly
– Local practice has large effect on outcomes
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Medical regimens: combination
mifepristone and misoprostol
Mifepristone dose 200 mg followed 36-48 hours later by misoprostol– 24-hour interval prolongs abortion time, but may be more convenient
(Heikinheimo, 2007)
– Misoprostol dosing varies:RCOG/ WHO: 800 mcg vaginally, followed by 400 mcg orally every 3 hours up to 4 doses
Vaginal dosing superior, but similar efficacy for repeat sublingual after loading dose
Abortion times are within 6-11 hours (varies by gestational age and parity)
General principles:– Combination regimen decreases abortion time (from misoprostol-only)
by about 45%
– Total misoprostol dose is lower with mifepristone, thus side-effect rates are also lower
– Shortened time-to-abortion allows transient foetal survival more commonly and accentuates biologic differences
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Time to abortion: combination mifepristone
and misoprostol versus singular misoprostol
Kapp, 2007
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Accentuating biologic differences
Rose, 2006
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Medical regimens: misoprostol alone
Alternative to mifepristone combination
– Less effective, prolonged duration, higher rate of side-
effects
Range of effective doses
– Loading dose is useful
– Vaginal dosing superior to other routes
Includes sublingual/ buccal administration
– Side- effects misoprostol route and dose related
– Recent recommendations (WHO endorsed): 400 mcg
vaginal every 3 hours up to 5 doses
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Adjunctive procedures: osmotic dilators
Osmotic dilators decreased time to abortion with older induction methods– 14-24 hours prior to induction with prostaglandins E2 or F2a
2 RCTs of placement with misoprostol-induced abortions (Borgatta, Jain)– Did not shorten abortion interval or decrease complication rates
– Increased analgesic need
Compared to mifepristone– 12 and 24 hours prior to induction, mifepristone is superior (Prairie, Ho)
– No benefit when placed 6 hours prior to gemeprost (Thong, 1992)
No benefit to dilator placement at initiation of inductive agent for combination mifepristone/ misoprostol– Whether advance placement (12-24 hours) is of benefit has not been
studied
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Complications: retained placenta
Older medical regimens – Increase in complications after 30 minutes to 2 hours
after foetal expulsion warranted routine surgical intervention
Expectant management for misoprostol alone or in combination with mifepristone– No increase in complication rates including
transfusion
– Intervention rates after abortion using combination method range from 2.5-10% in multiple studies
Interventions should be only for excessive bleeding or fever
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Outline
1. Introduction
2. Updates for first trimester procedures
3. Updates for second trimester
procedures
4. The case for family planning
5. Future directions
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Preventing unwanted pregnancies
"It is estimated that 100,000 maternal deaths
each year could be prevented if women
who didn't want children used effective
contraception."
Marston and Cleland, 2003 World Health Report
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In Hungary, abortion rates declined as
contraceptive use increased
0
10
20
30
40
50
60
70
80
1958 1960 1962 1964 1966 1968 1970 1972 1974 1976 1978 1980 1982 1984 1986
Years
Ab
ort
ion
s p
er
1,0
00
wo
me
n
0
10
20
30
40
50
60
70
% m
od
ern
co
ntr
ac
ep
tiv
e u
se
Abortions per 1,000 women % modern contraceptive use
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In Europe, abortion rates have
declined most in Eastern Europe
90
2418
11
44
18 17 120
20
40
60
80
100
Eastern Southern Northern Western
1995 2003
Abortions per 1,000 women aged 15-44
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Effect of family planning on abortion
rates
Source: Marston & Cleland, Relationships between contraception and abortion: a review of the evidence. 2003
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Modern versus traditional methods
Source: Marston & Cleland, Relationships between contraception and abortion: a review of the evidence. 2003
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Modern versus traditional contraceptive
methods
In Armenia
– Withdrawal most common contraceptive
method
– 25-33% of traditional method users
experienced method failure in 1 year
88% pregnancies were terminated
– Traditional method use accounts for 51% of
abortions in Armenia
Source: Ali & Shah. The impact of inducted abortion on uptake and continuation of contraceptive use in Armenia.
2004
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Contraception post-abortion
Critical element of comprehensive post-
abortion care
Provision in combination with family
planning counselling results in an
increased contraceptive uptake
– Reduces repeat pregnancy and abortion
Source: Kero, et al. Increased contraceptive use on year post-abortion. 2005
Masch, et al.The effect of consolidation of abortion services on patient outcomes. 2008
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The richer a woman is, the more likely her contraceptive
need is met ...
Poorest Second Middle Fourth Richest AverageWealth quintile
Regional average
Africa Latin America &
Caribbean
Central Asia North Africa &
West Africa
Asia Global average
100
80
60
90
70
50
40
30
20
10
0
Pe
r c
en
t o
f n
ee
d m
et
(Source: UN Millennium Project, 2006)
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Most abortions occur
in less developed countries
No. of
abortions
(millions)
Abortions per
1,000 women
15-49
More developed countries Less developed countries
% of total abortion rate
7
26
35
29
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Most abortions in developed countries are legal
and safe, compared to less than half in less
developed countries
52%
92%
45%
48%
8%
55%
0% 20% 40% 60% 80% 100%
World
More
developed
Less
developed
Legal Illegal
% of all abortions
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Safe vs. unsafe abortion
97% of unsafe abortions occur in developing
countries
Faster population growth in developing world
– Proportion of abortions that are unsafe vs. safe is
increasing
44% in 1995 to 48% in 2003
Cost of unsafe abortion is high
– Maternal mortality
– Financial costs
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(Source: Alan Guttmacher Institute, 1991)
Nigeria
South-East
Asia
Latin
America10
73
15
53
19
66
11
22
11
20
14
20
79
5
74
27
67
14
10 20 30 40 50 60 70 80 90 1000
Untrained lay practitioner/woman herself Trained midwife/nurse Physician
Poor rural
Poor rural
Poor rural
Higher income urban
Higher income urban
Higher income urban
Per cent of all abortions
In circumstances where abortion is illegal, the rich are more
likely than the poor to have access to a safe procedure
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Stating the obvious
Prevention works
– Abortion rates are lowest in those countries where
contraception and safe legal abortion are universally
available.
Prohibition does not
– Major abortion declines have occurred in countries
with legal abortion, but NOT in countries where
abortion is restricted.
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Global trend toward liberalization
Liberalized Restricted– Albania (1996) El Salvador (1998)
– Benin (2003) Nicaragua (2006)
– Bhutan (2004) Poland (1997)
– Burkina Faso (1996)
– Cambodia (1997)
– Chad (2002)
– Colombia (2006)
– Ethiopia (2004)
– Guinea (2000)
– Mali (2002)
– Nepal (2002)
– Portugal (2007)
– Saint Lucia (2004)
– South Africa (1996)
– Swaziland (2005)
– Switzerland (2002)
– Togo (2007)Source: Center for Reproductive Rights, 2007.
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Key findings from recent global
abortion statistics
The availability of abortion on broad grounds or on
request, as in developed regions, does not lead to high
abortion rates
When modern contraceptives are widely available and
prevalence is high, induced abortion rates are low
(Western Europe) or decline (Eastern Europe)
– Contraceptive provision is a critical element of post-abortion care
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Outline
1. Introduction
2. Updates for first trimester procedures
3. Updates for second trimester
procedures
4. The case for family planning
5. Future directions
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Future directions
Research is likely to focus on:
– Minimizing side-effects and pain
– Assessing medical regimens in special
populations
– Expanding levels of providers and services
– Social science research: understanding
barriers to safe abortion; linking safe abortion
reproductive health services; integration with
maternal health
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WHO guidance on safe abortion
Available for downloading at
http://www.who.int/reproductive-health/publications/safe_abortion/index.html
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Useful websites
www.guttmacher.org
www.gynuity.org
www.ipas.org
www.ippf.org
www.mariestopes.org.uk
www.medicalabortionconsortium.org
www.prochoice.org
www.who.int/reproductive-health
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Thank you Thank you
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Future work in prevention of unsafe abortion
Reduce the cost of medical abortion
De-medicalise provision of safe abortion (mid-level providers)
Better integrate abortion into maternal health and emergency services
Better understand socio-cultural, political, economic and legal barriers to safe abortion
Link safe abortion to other sexual and reproductive health services
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Abortion numbers have declined least
in less developed countries
46
36
10
42
35
70
10
20
30
40
50
World Less developed
countries
More developed
countries
1995 2003
Millions of abortions
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Abortion is legal in most of the North, and
increasing in the South
Legal on demand
██ Legal for health, mental health, socio-economic factors,
██ Legal for health, mental health
██ Legal for health, mental health
██ legal on requestLegal on request
██ legal for health, mental health, socioeconomic factorsLtal th, soors
██ legal for health, mental healthLegal for health, mental health
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Progress (or lack of it) in maternal mortality reduction
Note: Developed countries and developing countries with baseline MMR<50 and decrease in MMR between 1990-2005 are excluded from this categorization.
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Abortion rates have declined in all
major world regions
33 33
48
37
22
29 29 2831
21
0
10
20
30
40
50
Africa Asia Europe Latin
America
Northern
America
1995 2003
Abortions per 1,000 women aged 15-44
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Q: Why do unwanted pregnancies occur?
A: Usually because contraception failed or was not
used in the cycle of conception
(some 26 million of the estimated 76 million
unplanned pregnancies each year are thought
to be due to contraceptive failure)
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Reasons women give for not using contraceptives
even when at risk for unintended pregnancy
(Source: Measure DHS StatCompiler, 2006)
Health concerns
33%
Knowledge and
access problems
17%
Woman opposed
to use
22%
Religious
opposition
13%
Spousal
opposition
10%
Other
5%
(data from sub-Saharan Africa)
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Abortion-related mortality in the USA
Death rate for women obtaining legally induced
abortion (1988-1997)
– 0.7 per 100,000 legal induced abortions
Increased risk of death for each additional week of
gestational age
– 38%
Relative risk of abortion-related mortality (compared
to abortions ≤8 weeks gestation)
– 14.7 at 13-15 weeks gestational age
– 29.5 at 16-20 weeks gestational age
– 76.6 at or after 21 weeks gestational age(Source: Bartlett et al., 2004)
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The "Great Divide" in abortion legislation
(Source: United Nations, 2001)
Save
woman's
life
Preserve
physical
health
Preserve
mental
health
Rape
or
incest
Fetal
impairment
Economic
or social
reasons
On
request
Pe
r ce
nt o
f co
un
trie
s p
erm
ittin
g
0
20
40
60
80
100 96 99
88
55
85
54
81
30
81
26
75
19
65
14
Developed countries (N=48) Developing countries (N=145)
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Legality and safety
are not always synonymous
Legal Safe
UnsafeIllegal
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Abortion rates are similar regardless of the law
Africa 29
29
Europe
Region
North America
Asia
28
21
Rate
World 29
(Source: Sedgh G, et al. 2007)
Latin America 31
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Abortion rates are similar, but…
Africa 29
29
Europe
Region
North America
Asia
28
21
Rate
World 29
(Source: Sedgh G, et al. 2007)
Latin America 31
Safe Unsafe
<0.5 29
18 11
25 3
1 29
21 <0.5
15 14
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Abortion rates in Europe
Europe 28
44
Northern
Region
Western
Eastern
17
12
Rate
(Source: Sedgh G, et al. 2007)
Southern 18
Safe Unsafe
25 3
39 5
17 <0.5
15 3
12 <0.5
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Unsafe abortion costs health systems
In some countries as much as 50% of hospital Ob/gyn budgets are spent treating complications of unsafe abortion
A South Africa study (1997) estimated the national cost of treating complications of unsafe abortion at $1.274 million
A Nigeria study (2005) estimated the national cost of treating abortion complications at $19 million
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Conclusions
1. Unsafe abortion continues to be an important public health concern:
each year, nearly half of all abortions are carried out using unsafe
procedures.
2. Some 66,500 women die each year due to complications of unsafe
abortions, and many more suffer important morbidity and injury,
including long-term sequelae (chronic pelvic pain, PID, fistula,
infertility).
3. At global scale, death due to complications of unsafe abortion is highly
correlated with the degree of restrictiveness of abortion legislation.
4. Unmet need for contraception to enable couples to fulfil their family-
size aspirations remains high in many regions of the world, and affects
particularly the young and the poor.