nanosensors - github pages€¦ · 29 sers + machine learning is catching fire surface-enhanced...
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Nano-biosensors for medical research and services
Chatdanai Lumdee (Tua)
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Nanosensors
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Nanosensors
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Multiple rod-shaped bacteria shown between the larger white blood cells at urinary microscopy
White blood cells ~10-15 um
Most bacterial cells range in size from 0.2 to 10 microns
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Metabolites: small molecules < 900 Da
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Nanosensors
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Mechanical
Optical
Electrochemical
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Mechanical sensors
Body weight scale
A medical/clinical thermometer
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Mechanical sensors
http://www.microchem.com/Appl-MEMs-Cantilevers.htm Analyst (2010), 135, 827
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ACS Nano (2011), 5, 3670
Mechanical sensors
Cantilever Array Sensors Detect Specific Carbohydrate-Protein Interactions with Picomolar Sensitivity
Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc
ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV)
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Electrochemical sensors
NIOX VERO Medical device for measurement of exhaled
nitric oxide
Blood glucose monitoring device
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Electrochemical sensors
Microsystems & Nanoengineering (2017), 3, 17022
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Optical sensors
Optical microscope X-ray scan
Examples absorption, scattering, fluorescence
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ACS Nano 7, 11064 (2013)
Simplest form nanosphere
How nanostructures can help?
Optical nanosensors
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Plasmon resonance
Einc
k
Single NP in free space
50 nm diameter Au NP nm diameter in water
Frequency domain finite-element simulation
Active optical volume almost in the same order as a metabolite
Optical nanosensors
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50 nm diameter Au NP dimer (5 nm gap) in water
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Frequency domain finite-element simulation
Einc
k
Gap-plasmon
NP dimer in free space
Active optical volume in the same order as a metabolite
Optical nanosensors
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ACS Nano (2014), 8, 7639
(Review) Analyst (2016), 141, 756
Optical nanosensors
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Nano Lett. (2016), 16, 7857
Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels
Optical nanosensors
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Is labeling necessary?
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http://www.horiba.com/us/en/scientific/products/raman-spectroscopy/raman-academy/raman-faqs/what-information-does-raman-spectroscopy-give/
http://www.hamamatsu.com/eu/en/technology/lifephotonics/environment/SuperiorDetectionOfDiverseChemicals/index.html
Toward non-labeled detection: Raman scattering
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25Comparison of Raman spectrum of a BPE solution on a plain surface (bottom, blue line) and on a commercial SERS substrate (top, red line) measured at the same conditions
Technical Note: 51874, Thermo Fisher Scientific Inc.
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Biofluids/bodily fluids contain several metabolites
The 785 nm excited (b) SERS spectrum of fresh whole blood compared to (a) normal Raman spectrum of dried whole blood and (c) SERS spectrum of fresh plasma. The peak positions of the bands in the SERS spectrum of fresh whole blood are given in (b).
https://da-dk.mostphotos.com/365650/mess-of-cables
J. Phys. Chem. B (2012), 116, 9376
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Machine learning (i.e. statistics)
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28Analytical and Bioanalytical Chemistry (2015), 407, 7503
SERS + Machine learning breast cancer detection
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SERS + Machine learning is catching fire
Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study
Anal Bioanal Chem (2015), 407, 3271
Optical diagnosis of malaria infection in human plasma using Raman spectroscopy
Journal of Biomedical Optics (2015), 20, 017002
Conductive silver paste smeared glass substrates for label-free Raman spectroscopic detection of HIV-1 and HIV-1 p24 antigen in blood plasma
Anal Bioanal Chem (2017) 409:3253–3259
Optical diagnosis of dengue virus infection in human blood serum using Raman spectroscopy
Laser Phys. Lett. (2013), 10, 035602
Label-free blood serum detection by using surface-enhanced Raman spectroscopy and support vector machine for the preoperative diagnosis of parotid gland tumors
BMC Cancer (2015), 15, 650
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30A new method for early cancer detection -- https://www.youtube.com/watch?v=5GFoH5cwFGQ
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Continuous Glucose Monitoring
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Summary
Plasmon resonance
Raman and surface enhanced Raman spectroscopy
Nanoscale phenomena
Big data and machine learning