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NanoDESK INTERNATIONAL WORKSHOP ON SAFE IMPLEMENTATION OF

NANOMATERIALS IN PLASTIC INDUSTRY

Carlos Fito López

ITENE – Technical Coordinator

[email protected]

International Iberian

Nanotechnology Laboratory (INL)

October 18th 2017

Outline

1. Concept and Objectives

2. Overall view of the workplan and deliverables

3. Progress so far and main results

4. Summary comclusions

NanoDESK INTERNATIONAL WORKSHOP

1. Concept and objectives

NanoDESK INTERNATIONAL WORKSHOP


4

Project Objectives (Following SUDOE indicators)

• Promotion of the nanotechnology as KET to support the

development of new added value plastic materials

based on the use of engineered nanomaterials (ENMs)

• Ensure the technical viability and safety of process

and products based on the use of ENMs

Technical Objectives :

The project focused on the development of a set of web based applications to promote

investment and safe use of nanofillers in the plastic industry, including:

• A decision support system to assist companies, an in particular SMEs, in the selection

of nanofillers to meet the performance criteria of added value composites;

• A new information searching tool to assist companies in the identification of market

trends and nanotechnology applications;

• An interactive observatory on the safety of nanostructured polymer based materials;

• A set of computational modelling approaches (QSAR models) to support the

characterization of the toxicological profile of target nanofillers;

• A set of novel exposure estimation models to support SMEs in the evaluation of the

risk posed by the use of nanofillers in workers, consumer and


5

Project Concept

Mercado

• Nanotechnology has the potential to contribute

significantly to the future of plastic, promoting the

development of a new generation of smart and innovative

products.

• However, the current uncertainty about the effects of ENMs

on the environment and human health, and the consequent

lack of regulation, are a difficult barriers to overcome by

the plastic sector


6

Project Concept

Mercado

• The main outcome of the project will be the NanoDESK platform, with a preliminary version

expected in April 2018.


7Mercado

7

Membership

• Instituto Tecnológico del Embalaje,

Transporte y Logística (ES)

• ProtoQSAR 2000 SL (ES)

• Universitat Rovira i Virgili (ES)

• International Iberian Nanotechnology

Laboratory (PT)

• Centre National de la Recherche

Scientifique. Délégation Midi-Pyrénées.

Centre d'Elaboration de Matériaux et

d'Etudes Structurales (FR)

• Instituto Valenciano Seguridad y Salud

Trabajo (ES)

• Universidade do Porto. Faculdade de

Ciências

• Start-date: 01/06/2016

• End-date: 31/05/2019

• Budget: 799.375,84 €

• Funding scheme: FEDER


8

Main Results

Obj. Products GT Due

Dev

elo

pm

ent

of

a w

eb p

latf

orm

to

pro

mo

te t

he

use

of

ENM

s in

th

e P

last

ic In

du

stry

P1.1. Specification sheets of ENMs and nanocomposites GT1 11.16

P1.2. Computerized multicriteria decision tree GT1 03.17

P2.1. Data mining algorithms GT2 02.17

P2.2. Advanced web searching engine GT2 06.17

P3.1. NanoQSAR models. GT3 03.18

P4.1. Worker Exposure Estimation model GT4 02.18

P4.2. Environmental Exposure Estimation model GT4 03.18

P4.3. Consumer Exposure Estimation model GT4 06.18

P5.1. Polymer based nanocomposites safety Observatory GT5 06.18

P5.2. Strategic plan of the plastic sector GT5 07.17

P6.1. NanoDESK web Platform (beta) GT6 03.18

P6.2. NanoDESK web Platform (Complete version) GT6 01.19

9

Dissemination / communication

• Project Website

http://sudoenanodesk.europeanprojects.net/


2. Overall view of the work plan and

timetable

NanoDESK 1st Stakeholder´s day

2. Overall view of the workplan and timetable

11

Project activities

• GT1. Definition of the specifications and uses of

nanomaterials in the plastic industry

• Objective: description of 10 ENMs

• Results: data inventory and multicriteria

decision tree

• P1.1. Data sheets of ENMs and nanocomposites (11.2016)

• P1.2. Computerized Multicriteria Decision Tree (02.2017)

• GT2. Development of advanced tools for data searching

• Objective: development of advanced tools to retrieve

specific data on the physicochemical and

(eco)toxicological of ENMs

• Results: advanced-parameter search algorithm

• P2.1. Advanced-parameter search algorithms (02.2017)

• P2.2. Advanced Web Searching Engine (06.2017)


12

Project activities

• GT3. Optimization and development of QSAR models

• Objective: optimization and development of QSAR

models to predict toxicological properties

• P3.1. QSAR models covering 4 properties (03.2018)

• Results: set of 4 QSAR models to predict

bioaccumulation, genotoxicity, dermal and oral toxicity

• GT4. Development of exposure estimation models

• Objective: development and validation of models

to support the estimation of the exposure levels

and quantification of environmental release

• Results: set of 3 models to support risk assessment

• P4.1.Worker Exposure model implemented in web (03.2018)

• P4.2.Environmental exposure estimation model (02.2018)

• P4.3.Consumer Exposure estimation model (03.2018)


13

Project activities

• GT5. Development of the PNC Observatory

• Objective: development and implementation of

the NanoDESK PNC Observatory

• P5.1. Observatory web site (06.2018)

• P5.2. Strategic plan of the plastic sector (07.2017)

• P5.3. Consumer Exposure estimation model (03.2018)

• Results: Observatory on the safety of

nanostructured plastic material

• GT6. Development of the NanoDESK platform

• Objective: design and development of the NanoDESK

web platform, integration of tools and validation by

stakeholders.

• Results: Delivery of the NanoDESK platform (June 18)

• P6.1. Web platform NanoDESK – Beta (03.2018)

• P6.2. Web platform NanoDESK – Final (01.2019)


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Scheduled events

Events Date Location

Join Workshop 15/11/2016 Sevilla (Spain)

1st NanoDESK Stakeholder´s day 28/03/2017 Valencia (Spain)

First NanoDESK International workshopOctober

2017Braga (Portugal)

Join Workshop on regulatory challenges

and risk assessment of ENMs

December

2017Madrid (Spain)

2nd NanoDESK Stakeholder´s dayMarch

2018Toulouse (France)

Join Workshop on nanotechnology

challenges

June

2018Valencia (Spain)

3rd NanoDESK Stakeholder´s daySeptember

2018Oporto (Portugal)

NanoDESK successful experiencesNovember

2018Barcelona (Spain)

Workshop on modelling approaches for

regulatory risk assessment

February

2019Tarragona (Spain)

Second NanoDESK international workshop April 2019 Toulouse (France)

Final NanoDESK dissemination event April 2019 Valencia (Spain)

International Networking workshop with

plastic manufacturersMay 2019 Braga (Portugal)

Channel Id Description

Social

networks

Twitter

Facebook

Lindkedin

@nanodesk

https://es-es.facebook.com/Invassat.gva

www.linkedin.com/groups/8596648

MultimediaProject

videos2

Other E-learning Webinars


GT1. Specifications and uses of nanomaterials in the plastic industry

• Ag• Al2O3• CaCO3• Nanoclay• Sb2O5• SiO2• ZnO• CNT• Nanocellulose• TiO2• Graphene

NANOMATERIALS FORMULATION SUPPLIERS SPECIFIC PRODUCT

Silver nanoparticles (Ag NPs)

10nm

ON-Q* Catheters Halyard, formerly

AcryMed

SilvaGard®

Silver nanoparticles (Ag NPs)

15nm

powder, polymer-coated nanoparticles (25%

silver, 75% polymer)

SSNano Sky

Spring

Nanomaterials Inc

GACOMP (Polymer

dispersions)

Titanium dioxide nanoparticles

(TiO2 NPs)

Dry powder TiO2 min 97% (wt.), Al2O3 max

1.7% (wt.), C 0.2% (wt.)

Chemours Ti-Pure™ R-101

Aluminium oxide nanoparticles

(Al2O3 NP) 40nm

Dispersion in hexanediol diacrylate (HDDA),

30% NP content

BIK Nanobyk-3602

CaCO3-80nm CaCO3, +98% Pure, APS: 80 nm mKnano MKN-CaCO3-P080

Multiwall carbon nanotubes-

95nm diameter and 1.5um

lenght

Dry powder, 100 % NANOCYL NANOCYL® NC7000™

Montmorillonite

10 nm (thickness) / 42 nm

(interlayer distance)

Layered aluminosilicate (montmorillonite)

modified with an organic salt

(hexadecyltrimethylammonium bromide)

BYK additives Clay 1 – Cloisite

Sb2O5/SnO2 (85:15)

15nm

NanoArc® Antimony Tin Oxide nanopowder,

100% crystalline, non-porous, non-

agglomerated particles.

Nanophase

Nanoengineered

Products

NanoArc® Antimony Tin

Oxide nanopowder

Silica nanoparticles (SiO2 NPs)

20nm

25% by weight dispersion of surface-treated

particles in

Methoxypropylacetate/methoxypropanol

(MPA/MP)

BIK Nanobyk-3650

ZnO nanocrystals

45+/-5 nm

Colloidal suspension of ZnO nanoparticles in

diethylene glycol

ZnO concentration (%w): 1.0+/-0.2

Linari nanotech ZnO-DEG

Nanocellulose CNC / CNF Maine University CNF

Graphene - AVANVARE -



GENERAL PRODUCT DESCRIPTION

Producer Nanocyl / Nanocyl SA rue de l'Essor, 4 5060 Sambreville Belgium

Product commercial

name

NANOCYL® NC7000™ (Registered in ECHA)

Webpage http://www.nanocyl.com/product/nc7000/

Core material Multiwall carbon nanotubes. Catalytic Chemical Vapor Deposition (CCVD)

process.

Commercial

formulation

Dry powder, 100 %

Polymers that typically

incorporate the NP

Thermoplastic polyurethane (TPU) / PA66 (PolyAmide 66) / PA12

(PolyAmide 12) / HDPE (High Density Poly Ethylene) / PP (PolyPropylene) /

LDPE (Low Density Poly Ethylene) / EVA (Ethylene Vinyl Acetate) / ABS

(Acrylonitrile Butadiene Styrene) / PC (Poly Carbonate)

Applications Products requiring low electrical percolation threshold such as high-

performance electrostatic dissipative plastics or coatings

Sectors Industrial - ESD parts / Electronic Packaging /Automotive / Aerospace /

Construction / Wind Power / Sporting Goods

MATERIAL DESCRIPTION

Identification CAS

number

- EC number 936-414-1

Material Type Multiwall carbon nanotubes

Molecular Formula C / Allotropic form of carbon

Chemical Composition Carbon purity 90 % / Other components < 10 %

PHYSICAL-CHEMICAL CHARACTERISTICS

Physical appearance Solid black

powder

Tubular shape Fine powder

Average NP size

In dry state (TEM) In suspension (hydrodynamic

diameter)

9.5 nm diameter / 1.5 µm in length Not available

Size dispersity Not available

Surface area 250 – 300 m2/g

Surface tension 59.6 mN/m

Zeta potential Not available

Solubility < 2 mg/L

Density At 20°C was obtained: D 20/4 = 1.988

Crystallinity -

NP shape Tubular shape

pH -

(ECO)TOXICOLOGICAL INFORMATION

DNEL (Derived No Effect Level) – long term exposure: 0.05 mg/m3

Acute toxicity Dermal Inhalation Ingestion Genotoxicity

LD50 rat >

2,000 mg/kg

LD50 rat > 5,000

mg/kg

Not mutagenic

(Ames test).

Sub-Chronic

toxicity

Dermal Inhalation Ingestion Intravenous

5 days, rat, LOAEC: 2

mg/m³

repeated dose, 90 days,

rat, LOAEC: 0.1 mg/m³

lung (multifocal

granulomatous

inflammation)

Oral, repeated

dose, 28 days, rat,

NOAEL: 0.5 mg/kg

No carcinogenic

response.

(2-year bioassay in

the peritoneal cavity

of the rat)

Acute ecotoxicity

in animal models

Aquatic

invertebrates

Aquatic vertebrates

(fish)

Soil invertebrates Algae

Daphnia

magna,

freshwater,

48h, EC50 >

100 mg/l

Danio rerio, 14 days,

EC50 > 100 mg/l

Desmodesmus

subspicatus,

freshwater, 72h,

EC50: 134 mg/l

Long term

ecotoxixity in

animal models

Daphnia

magna, semi

static, NOEC >

25 mg/l

Danio rerio, semi static,

EC10: 100 mg/l

In silico models


Mercadohttp://dsstool.sudoenanodesk.europeanprojects.net/



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• GT2. Development of advanced tools for data searching


20

• GT5. Development of the PNC Observatory

21

Proposed structure



22

• GT.T3. Communication activities

• Be informed by clicking on

http://sudoenanodesk.europeanprojects.net

4. Summary conclusions


4. Summary conclusions

24

To conclude….

• According with the information described previously, NanoDESK will have a

direct impact on the plastic Industry, workers and consumers, providing the

industry with solutions to support the use of nanotechnologies in the near

term.

A close collaboration with the industrial partners is key to

ensure the application of the project results in a large

number of companies.

Selecting proper ENMs formulations

Designing of easy-to-use user interfaces of advanced

tool for risk assessment purposes

Delivery of the nanosafety observatory

A better understanding of the workplace, consumer and

environmental exposure will provide the stakeholders with

scientific and consensuated data to conduct regulatory

actions

Carlos Fito López

ITENE - Project Coordinator

[email protected]

Thank you for your

attention ¡

NanoDESK INTERNATIONAL WORKSHOP ON SAFE IMPLEMENTATION OF

NANOMATERIALS IN PLASTIC INDUSTRY

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