Curriculum Vitae

Personal Information: Name: Mohammod Johirul IslamSex: MaleNationality: BangladeshiMarital Status: MarriedNo. of dependents: Three (wife and two sons)Permanent Address: Vatikasor (Boro Bari), Mymensingh Sadar, Mymensingh, Bangladesh Present Address: BMB, MBSTU, Santosh, Tangail.Date of Birth: 26-Oct-1976Mobile number: +88 01751795668E-mail: johir75@yahoo.comLanguage proficiency: Bangla is mother language but fluent both in writing and speaking in English

Academic Qualification:

Degree/ Exam MajorGraduatio

n YearUniversity/ Institution Result

PhDPathological

MedicineMar 2015

Dept. of Biochemistry, Hamamatsu University School of Medicine, Japan

PhD awarded

M. Sc. (Thesis) Biochemistry Jul 2000Dept. of Biochemistry & Molecular Biology, University of Dhaka, Bangladesh

First Class

B. Sc. (Honors)

Biochemistry May 1998Dept. of Biochemistry & Molecular Biology, University of Dhaka, Bangladesh

First Class

HSCScience

Sep 1993Ananda Mohan Govt. College, Mymensingh, Bangladesh

First Division

SSCScience

Sep 1991The Edward Institution, Mymensingh,Bangladesh

First Division

Career History:

Feb 2018-Pressent: Serving as a full-time Assistant Professor at the Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh.

Feb 2017-Feb 2018: Served as a full-time Lecturer at the Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh.Key Role: Assigned to teach the undergraduate students of the department of Biochemistry and Molecular Biology as well as to conduct research independently and in a team.

June 2016-Feb 2017: Served as a full-time Assistant Professor at the Department of Public Health Nutrition, Primeasia University, Banani, Dhaka, Bangladesh.Key Role: Assigned to teach the undergraduate students of Public Health Nutrition Department.

April 2015 – Feb 2016: Served as a full-time Assistant Professor at the Department of Biochemistry, Hamamatsu University School of Medicine (HUSM), Japan. HUSM (www.hama-med.ac.jp) is a research based public medical university in Japan. Reporting to: Head (Professor) of the Department of Biochemistry, HUSM, Japan.Key Role: Assigned to teach the undergraduate medical students, supervised the PhD students and conduct research independently and in a team under the supervision of department's head, generate data, report data to the head regularly, write the draft manuscripts and pass to the department’s head for publication. In this department, I was mainly assigned to conduct research on Hepatitis C virus (HCV) project. This project mainly focuses on making suitable mice models for HCV infection study.

Sep 2013-Feb 2014: Served as a part-time Research Assistant at the Department of Biochemistry, Hamamatsu University School of Medicine, Japan. Key Role: Assisted professor in his research.Sep 2012-Feb 2013: Served as a part-time Teaching Assistant at the Department of Biochemistry, Hamamatsu University School of Medicine, Japan. Key Role: Assisted professor in preparing his teaching materials.

Oct 2005-Apr 2011: Served as a full-time Senior Research Officer in Molecular and Serodiagnostic Laboratory at International Center for Diarrheal Disease Research, Bangladesh (ICDDR, B). ICDDR,B (www.icddrb.org) is an international health research organization. Reporting to: Head (Senior Scientist) of Clinical Laboratory, Laboratory Sciences Division, ICDDR, B.Key Role: Assigned to set up and standardize various serological, biochemical tests, different types of ELISA and PCR, analyze patients’ data, write draft manuscripts and pass to the head of the laboratory for publication.

Oct 2001-Sep 2005: Served as a full-time Research Officer in Molecular Genetics Lab at ICDDR, B.Reporting to: Head (Senior Scientist) of Molecular Genetics Lab, ICDDR, B.Key Role: Assigned to conduct research independently and in a team under the supervision of laboratory head, generate data and report data to the head of the laboratory regularly for publishing papers. This lab focused research on pathogenic bacteria and bacteriophages’ (especially diarrheagenic) project. In that project, I was mainly involved to conduct research on isolation, purification, serological, biochemical and molecular characterization of different pathogenic bacteria and viruses obtained from clinical and environmental water samples in Bangladesh.

List of publications (21)Published in peer reviewed high impact journals:

1. Faruque SM, Chowdhury N, Khan R, Hasan MR,Nahar J, Islam MJ, Yamasaki S, Ghosh AN, Nair GB, Sack DA: Shigelladysenteriae Type 1-Specific Bacteriophage from Environmental Waters in Bangladesh. Appl Environ Microbiol69:7028-7031, 2003.

2. Faruque SM,Naser IB, Islam MJ, Faruque ASG, Ghosh AN, Nair GB, Sack DA,Mekalanos JJ: Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages. Proc. Natl. Acad. Sci. USA 102: 1702-1707, 2005.

3. Faruque SM, Islam MJ, Ahmad QS, Faruque ASG, Sack DA, Nair GB, Mekalanos JJ: Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage. Proc. Natl. Acad. Sci. USA 102: 6119-6124, 2005.

4. Faruque SM, Islam MJ, Ahmed QS, Biswas K,Faruque ASG, Nair GB, Sack RB, Sack DA, Mekalanos JJ: An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple antibiotic-resistant epidemic strain in Bangladesh. J Infect Dis 193: 1029-36, 2006.

5. Nessa K, Ahmed D, Islam MJ, Kabir FML, Hossain MA: Usefulness of a Multiplex PCR for Detection of DiarrheagenicEscherichia coli in a Diagnostic Microbiology Laboratory Setting. Bangladesh J Med Microbiol 01: 38-42, 2007

6. Kimura W, Sharkar MTK, Sultana N, Islam MJ, Uezato T, Miura N: Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. Transgenic Research 22: 659-666, 2013

7. Noritake H, Amin MB, Nakamura K, Islam MJ, Wu YX, Hashimoto S, Uddin MKM, Suda T, Kobayashi Y, Sugimura H, Miura N: TGFα, c-MYC, mutated CTNNB1 and their combinations act distinctly on the Hep3B tumors in nude mice. Med J Osaka Univ56:11-21, 2014

8. Islam MJ, Hikosaka K, Noritake H, Uddin MKM, Amin MB, Aoto K, Wu YX, Sato E, Kobayashi Y, Wakita T, Miura N: Pol I-transcribed hepatitis C virus genome RNA replicates, produces an infectious virus and leads to severe hepatic steatosis in transgenic mice. Biomed Res. 2015;36(3):159-67

9. Uddin MKM, Kimura W, Ishikura T, Koseki H, Yoshida N, Islam MJ, Amin MB, Nakamura K, Wu YX, Sato E, Aoto K, Miura N: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation. Biomed Res. 2015;36(4):235-45

10. Islam MJ*, Amin MB, Uddin MKM, Hikosaka K, Noritake H, Wu YX, Aoto K, Miura N: Mouse homologues of hepatitis C virus human entry factors inhibit the entry of HCVpp in human hepatoma cells. Biores Comm. 2(1), 128-133, 2016.

11. Amin MB, Miura N, Uddin MK, Islam MJ, Yoshida N, Iseki S, Kume T, Trainor P, Saitsu H, Aoto K: Foxc2 (CreERT2) knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenital Anomalies 2017; 57, 24–31

12. Mansur AZ, Akter A, Mazumdar HT, Rumana R, Asaduzzaman M, Fatema B, Juliana FM, Mannan A,

Islam MS and Islam MJ*: Assessment of Antenatal Care (ANC) and Demography Parameters on Pregnant Women in Bangladesh. IOSR-JNHS Vol. 6, Issue 3, Ver. VIII, pp 37-44, 2017.

13. Islam MJ*, Uddin MKM, Amin MB, Islam MS, Asaduzzaman M and Miura N: Hepatic steatosis becomes severe with age in the livers of full-length HCV genome transgenic mice. Biores Comm. 3(2), 430-434, 2017.

14. Asaduzzaman M, Bappy SR, Fatema B, Haque S, Islam MJ, Sikder MA, Aktar S, Khatun M, Juliana FM, Islam MS: Effect of HCV on hemoglobin, blood cells and random blood glucose levels among serologically positive HCV patients. IOSR-JNHS Vol. 6, Issue 5, Ver. I, pp 41-45, 2017.

15. Hossain N, Das B, Alam MD, Juliana FM, Islam MJ, Hossain MN, Fatema B, Day BR, Asma R, Asaduzzaman M: Susceptibility pattern of nitrofurantoin against uropathogens in selected areas of Dhaka city, Bangladesh. IOSR-JNHS Vol. 6, Issue 5, Ver. VIII, pp 60-65, 2017.

16. Alam MD, Mousumi SJ, Rana R, Islam MS, Akter MS, Juliana FM, Islam MJ, Hossain MN, Fatema B, Asma R, Asaduzzaman M: Ceftriaxone resistance patterns of uropathogens isolated from urinary tract infection patients in selected areas of Dhaka city, Bangladesh. IOSR-JNHS Vol. 6, Issue 5, Ver. IX, pp 28-34, 2017.

17. Islam R, Faysal SD, Amin MR, Juliana FM, Islam MJ, Alam MJ, Hossain MN, Asaduzzaman M: Assessment of PH and total dissolved substances (TDS) in the commercially available bottled drinking water. IOSR-JNHS Vol. 6, Issue 5, Ver. IX, pp 35-40, 2017.

18. Bari FS, Juliana FM, Fatema B, Islam MJ, Mannan MA, Asaduzzaman M: Impact of lymphatic filariasis (LF) on hemoglobin content and anemia: A cross-sectional based study. Journal of Health, Medicine and Nursing, Vol. 44, 2017.

19. Bari FS, Juliana FM, Islam MJ, Fatema B, Mannan MA, Asaduzzaman M: Lymphatic Filariasis (LF); Treatment receiving types in Bangladesh. Int J Health Sci Res. 2017; 7(12): 1-5.

20. Sikder MA, Abedin MZ, Zubair MA, Islam MJ, Lee CJ, lee HJ: Flavonoids regulate airway MUC5AC Mucin expression through modulation of multiple signaling pathways. A Journal of Pharmacology. 2017; 7(3): pp21-33.

21. Asaduzzaman M, Basak R, Islam MS, Juliana FM, Ferdous T, Islam MJ, Mamun AA, Sabrina S, Uddin MM, Islam MK: Vitamin D deficiency and insufficiency in healthy pregnant women living in Dhaka, Bangladesh. IOSR-JDMS Vol. 17, Issue 4, Ver. 9, pp 66-73, 2018

*= Corresponding author

Attended at the international conferences for Oral Presentation:

1. Islam MJ, Hikosaka K, Noritake H, Uddin MKM, Amin MB, Aoto K, Wu YX, Sato E, Kobayashi Y, Wakita T, Miura N: Pol I-transcribed hepatitis C virus genome RNA replicates, produces an infectious virus and leads to severe hepatic steatosis in transgenic mice. The15th Kyungpook- Hamamatsu Joint Medical Symposium held on 5-7 Oct, 2015 in Daegu, South Korea.

2. Islam MJ, Hikosaka K, Noritake H, Amin MB, Uddin MKM, Sato E, Wakita T, Miura N: The HCV genome transgenic mice produce an infectious virus particle and lead to severe steatosis in liver. The 37th Annual Meeting of the Molecular Biology Society of Japan held on 25-27 Nov, 2014 in Yokohama, Japan.

Attended at the international and national conferences for Poster Presentation:

1. Uddin MKM, Kimura W, Nakamura K, Islam MJ, Amin MB, Miura N: Loss of Foxc2 in the branchial mesenchyme links the interrupted aortic arch in conditional Foxc2 knockout mouse. The 14 th Kyungpook-Hamamatsu Joint Medical Symposium held on 25 Sep, 2014 in Hamamatsu, Japan.

2. Uddin MKM, Kimura W, Nakamura K, Amin MB, Nakamura K, Islam MJ, Yamagishi H, Miura N: The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse. The 7th TAKAO International Symposium on Etiology and Morphogenesis of Congenital Heart Disease held on 13-15 July, 2013 in Tokyo, Japan.

3. Islam MJ, Hikosaka K, Noritake H, Miura N: Molecular mechanism of HCV entry into hepatocytes. The 65 th

Annual Meeting Japan Society for Cell Biology held on 19-21 June, 2013 in Nagoya, Japan.

4. Hossain MA, Islam MJ, Habib MA, Alam MA, Jamiruddin R, Ahmed D: Prevalence and pattern of hepatitis C virus genotypes in Bangladesh. 2012 Workshops Abstracts-NRL, Australia.

5. Islam MJ, Habib MA, Jamiruddin R, Ahmed F, Hossain MA: Prevalence of hepatitis C virus genotypes in Bangladesh. The 13th International Annual Scientific Conference held on 14-17 March, 2011 in Dhaka, Bangladesh.

6. Jamiruddin R, Habib MA, Islam MJ, Ahmed F, Hossain MA: Performance measurement for Molecular and Serodiagnostic Laboratory, Clinical Laboratory Services, ICDDR,B. The 13 th International Annual Scientific Conference held on 14-17 March, 2011 in Dhaka, Bangladesh.

Research Experience: Animal models: Making transgenic mice, handling mice (Bio safety level 3 lab’s mice) and analysing

mice (blood collection, drug treatment and tissue analysis etc.). Cell biology: Maintenance of various mammalian cell cultures, plasmid transfection into cells, making

transient and permanent cell lines expressing various genes, primary hepatocyte isolation. Primer design, making desired plasmid constructs, adding epitopes such as FLAG, HA etc. at the N-or C-

terminal ends of the desired proteins. Histology: Tissue (paraffin-and cryo-) sections, section immunohistochemistry, immunocytochemistry,

X-gal staining, H&E staining, immunofluorescence staining, Sudan IV, Oil Red O staining etc. Isolation, purification and molecular characterization of different pathogenic bacteria such as Vibrio sps,

Shigella sps, E.coli and bacteriophages obtained from Environmental Water Samples and Clinical Samples.

Identification of different diarrhoeagenic E. coli by hybridization with radiolabelled probes & enzyme chemical labelled probes.

Genetic analysis of hepatitis C virus (HCV).

Teaching Experience: Having about 4 years teaching experience to teach and assist the undergraduate students and PhD students in molecular biological research in home and abroad.

Laboratory skill:Strongly familiar with various laboratory techniques such as serological tests, qualitative and quantitative ELISAs, TLC, Gel Electrophoresis, SDS-PAGE, Luciferase Assay, DNA/ RNA probe preparation, Labelling probes with radio-isotope or ECL protocol, DNA, RNA, Plasmid and Protein isolation from cell culture and tissue specimens, Dot blots, Southern, Northern and Western Blots, Restriction fragment length polymorphism (RFLP) analysis, Immunoprecipitation (IP) Assay, Conventional PCR, RT-PCR, Real-Time PCR, In vitro transcription of RNA, Preparing standards for Real-Time PCR, Transcriptome analysis (Microarray), Gene cloning, Transformation and Sequencing etc. Also familiar with handling the different types of Fluorescence microscope, confocal microscope and FACS analyser.

Computer Literacy: Conversant with all operating systems, MS-Word, MS-Excel and PowerPoint.

Achievements: Discovery of six Vibrio cholerae-specific bacteriophages (JSF1, JSF2, JSF3, JSF4, JSF5 and JSF6) from environmental water samples in Bangladesh that were named after by my name and my supervisor’s name, and the manuscript of this unique finding was published in the Proceeding of National Academy of Sciences, USA (Proc. Natl. Acad. Sci. USA 102: 1702-1707, 2005) and brought much fame worldwide.

Research Grants Achieved: Apr 2015-Mar 2016: Achieved HUSM (Hamamatsu University School of Medicine, Japan) Grant-in-Aid

for Young Researcher Projects.

Apr 2014-Mar 2015: Achieved HUSM Grant-in-Aid for Graduate Student Projects.Fellowships Awarded:

Apr 2013-Mar 2015: Rotary Yoneyama Memorial Foundation Scholarship, Japan. Apr 2011-Mar 2013: Uehara Memorial Foundation Fellowship, Japan.

Membership: Member of Molecular Biology Society of Japan (MBSJ) Member of Rotary Yoneyama Scholar Alumni Association, Japan

References:Tetsuro Suzuki, PhDProfessor, Department of Infectious Diseases,Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192,JapanTel: +81-53-435-2336Fax: +81-53-435-2338Email: tesuzuki@hama-med.ac.jp

Dr. Shah M. FaruqueSenior Scientist & Director,Center for Food & Water Borne Diseases,ICDDR, B, Mohakhali, Dhaka-1212Email: faruque@icddrb.org