myelitis.ppt
TRANSCRIPT
![Page 1: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/1.jpg)
Myelitis
Dr. Kiking Ritarwan, MKT, SpS
![Page 2: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/2.jpg)
Myelitis
Inflamation of the spinal cord I. Transverse Myelitis, II. Disseminata, III. Difussa Transverse myelitis (MYELOPATHY) is a syndrome
characterized by acute spinal cord dysfunction both halves the cord in transverse section.
![Page 3: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/3.jpg)
Myelitis transversalis– inflamasi akut atau sub akut – mengenai suatu area fokal di medula spinalis – karakteristik klinis disfungsi neurologis pada saraf
motorik, sensorik dan otonom dan traktus saraf di medula spinalis
![Page 4: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/4.jpg)
MYELITISGray matter…… Poliomyelitis.White matter …. Leukomyelitis.The whole crossectional are…Tranversemyelitis.Lesions are multiple and wide spreadOver a long vertical extent….. DiffuseOr Disseminated.Combined meninges and spinal cord…Meningomyelitis.Combined meninges and root--- meningpradiculitis.Inflammatory disease limited to the spinal dura…. Pachymeningitis.Infected material collects in the epidural or subdural space… Epidural spinal Or subdural spinal abcess or Granulomatous.
CLASSIFICATION OF INFLAMMATORY DISEASEOF THE SPINAL CORD … SEE TRANSPARANTS
![Page 5: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/5.jpg)
ACUTE TRANSVERSE MYELITIS
IS USUALLY BILATERAL AND TENDS TO CAUSE MORE SEVERE WEAKNESS THAN THE TYPICAL ATTACKS OF PARTIAL MYELITIS.
The condition may be peri infectious or postinfectious process and has been associated with many viral infection, including poliovirus, echovirus and coxsackieviruses.
![Page 6: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/6.jpg)
Etiologie Transverse myelitis
1. Congenital – vascular malformation 2. Infectious – viral infection 3. Autoimune- peri or post infection or vaccinial
myelitis. 4. Multiple sclerosis 5. Neoplastic 6. Toxic- secondary to heroin injection 7. Vascular 8. Degenerative- irradiation 9. Idiopathic.
![Page 7: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/7.jpg)
PATOLOGI
JHTMC (John Hopkins Transverse Myelitis Center) JHTMC (John Hopkins Transverse Myelitis Center) kondisi inflamasi yang berhubungan dengan kondisi inflamasi yang berhubungan dengan mekanisme mekanisme immune-mediatedimmune-mediated
Pasien myelitis transversalisPasien myelitis transversalis perubahan inflamasi perubahan inflamasi pada medula spinalisnyapada medula spinalisnya
Abnormalitas patologi ( bervariasi )Abnormalitas patologi ( bervariasi )– infiltrasi lokal oleh limfosit dan monosit dalam segmen infiltrasi lokal oleh limfosit dan monosit dalam segmen
medula spinalis dan daerah perivaskuler medula spinalis dan daerah perivaskuler – adanya aktifitas yang bervariasi dari mikroglia dan astrogliaadanya aktifitas yang bervariasi dari mikroglia dan astroglia
![Page 8: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/8.jpg)
Besar dan luasnya gambaran inflamasi Besar dan luasnya gambaran inflamasi faktor etiologi dan profile perubahan faktor etiologi dan profile perubahan myelopati :myelopati :– Myelitis post infeksius Myelitis post infeksius perubahan perubahan white matter white matter, ,
demielinasi, gangguan aksonaldemielinasi, gangguan aksonal– myelitis transversalis myelitis transversalis gambaran yang gambaran yang
melibatkan keduanya secara bersamaan baik melibatkan keduanya secara bersamaan baik whitewhite maupun maupun grey mattergrey matter
![Page 9: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/9.jpg)
Viral causes of acute myelitis
Herpesvirus: HSV2, Varicella Zoster, HSV1, Epstein barr, Cytomegalo, human herpes6.
Enterovirus: Poliovirus, Enterovirus 70, Echovirus, Coxsackievirus.
Arbovirus: west nile virus Other: Mumps, HIV, Dengue.
![Page 10: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/10.jpg)
Affinities virus in myelitis
Enterovirus anterior horn or nuclei of the brain stem
Herpes zoster dorsal root ganglion
![Page 11: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/11.jpg)
Clinical manifestation
Acute paraplegic or Quadriplegic. Urinary retention. Sensory disturbances
![Page 12: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/12.jpg)
Diagnostic prosedure
CSF examination: - mild to moderate lymphocytic pleocytosis (10-1000
cell/mm3), elevated protein (100-500 mg/dl), and normal or mildly depressed glucose level.
• PCR- virus spesific PCR and antibody titer should be performed.
• MRI-T2 weighted shows increased signal intensity involving gray matter and surronding white matter.
![Page 13: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/13.jpg)
PROSEDUR DIAGNOSTIKPROSEDUR DIAGNOSTIK
Dikutip dari : Transverse Myelitis Consortium Working Group. Proposed diagnostic criteria and nosology of acute transverse myelitis. Neurology 2002 ; 59 : 499 - 505
![Page 14: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/14.jpg)
DIAGNOSIS BANDING :DIAGNOSIS BANDING :
Multiple sclerosisMultiple sclerosis Penyakit sistemik (SLE, Sjorgen disease)Penyakit sistemik (SLE, Sjorgen disease) Venous infarctVenous infarct Malformasi vaskuler (fistula AV, AVM, angioma Malformasi vaskuler (fistula AV, AVM, angioma
kavernosa)kavernosa) Fibrocartilagenous embolismFibrocartilagenous embolism Myelopati radiasiMyelopati radiasi
![Page 15: Myelitis.ppt](https://reader035.vdocuments.us/reader035/viewer/2022070508/577cc0161a28aba7118ece04/html5/thumbnails/15.jpg)
Treatment Viral myelitis
Antiviral treatment: Glucocorticoid Spasticity: baclofen (lioresal) 10 mg q6h,
benzodiazepin and tizanidine.