Histophysiology of muscle tissues

The structural unit of muscle tissue is muscle fibre

Muscle as organ

Skeletal muscles

Myofibril

Myofibril

Sarcomere

Myofilamentes

Mechanism of contractionhttp://www.youtube.com/watch?v=ELyoJZom5N0

Myofilaments sliding theory

Targets of calcium

Look inside

T- and L-systems

Look inside

Filaments arrangement

http://www.mechanobio.info/Home/essential-info/What-are-Motor-Proteins/myosin-role-in-contraction

Dystrophin Dystrophin stabilizes the sarcolemma and protects muscle fibres from long-term contraction-induced damage and necrosis. Dystrophin serves to link the intracellular microfilament network of actin to a complex series of linking proteins in the cell membrane, and hence to the extracellular matrix

How to get energy during contraction

Fitness

Physical training and ANS

Physical training

Physical training and resistence to stress

Will be discussed during circulatory system lecture

Smooth muscle tissue

Significance of smooth myocytes

Gastro-Intestinal smooth myocytes:

- Contractile type - Tone of gut, gut motility- pacemaker (Interstitial cells of Cajal) – tone control, generation of electrical slow waves

Significance of smooth myocytes

Vascular smooth myocytes:

-Tcontractile type - tone of vessel – resistence – blood pressure- secretory rype – matrix production

Types of smooth myocytes

News about smooth musclesmiRNA-mediated SMC remodelling

Contraction of of smooth myocyte

Filamentes arrangement in smooth myocyte

Molecular organisation of filaments in smooth myocyte

Caveolae of smooth myocyte

Caveolae nature

Caveolae significance

Regulation of smooth myocytes

Neural

Humoral

Paracrine

Diagnostics