muscle histology

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MUSCLE HISTOLOGYDr Prennie VidieraFr. Muller Homoeopathic Medical CollegeMuscle is a collection of muscle fibres supported by connective tissue. Mesodermal in origin.

Special terms Plasma membrane Sarcolemma Cytoplasm sarcoplasm Smooth ER sarcoplasmic reticulum Mitochondria sarcosomes Muscle tissue is made up basically of cells called MYOCYTES

Myocytes are elongated in one directionMUSCLE FIBRES

TYPESSkeletal Muscle

Smooth Muscle

Cardiac Muscle

SKELETAL MUSCLEMade up of long, cylindrical fibresMultinucleated cells

General Architecture Supported by connective tissue framework

Carries blood vessels & nerves Transmits the force of contraction The framework of connective tissue provides support to muscle fibres in following manner:

EPIMYSIUM: dense connective sheath surrounding the entire muscle. PERIMYSIUM: connective tissue covering bundles of muscle fibres fascicles.ENDOMYSIUM: loose connective tissue composed of reticular fibres supporting individual muscle fibre.

Structure of skeletal muscle fibreElongated Has many flat nuclei located just beneath the sarcolemma Shows cross straitions Made up of compactly packed long cylindrical myofibrils in the sarcoplasm arranged parallel to the long axis

Types of skeletal muscle fibresRED MUSCLE FIBREHigh content of myoglobin & cytochrome Many mitochondria Rich blood supply Slow & continuous contraction Smaller in diameter E.g: postural muscles WHITE MUSCLE FIBRELow content of myoglobin & cytochrome Few mitochondria Poor blood supply Rapid contractions Larger in diameterE.g: extra ocular muscles


Smooth muscle fibres are elongated spindle shaped cells Non straited Single elongated nucleus central in positionInvoluntary Supplied by autonomic nervous system

L.S. Of Smooth Muscle

Found in the walls of hallow viscera G.I.T , blood vessels, ureters etc


Shows many structural & characteristics intermediate between those of skeletal & smooth muscle.

Cardiac muscle fibres are shorter than the skeletal muscle fibres & show branching pattern.

One or two nuclei placed in the centre

Presence of darkly staining transverse lines across the fibres intercalated discs

Specialised cell junctions between the ends of adjacent muscle fibres Cross section