musab bin shuayl, md case presentation. history : a 37-year-old woman with non-hodgkin’s lymphoma...
TRANSCRIPT
![Page 1: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/1.jpg)
Musab bin shuayl, MD
CASE PRESENTATION
![Page 2: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/2.jpg)
HISTORY: A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma)
presented to the emergency room (ER) complaining of
fever, nausea, vomiting, and diarrhea(non bloody) for 2 days . She reported having chemotherapy 5 days ago.
Past medical history :
The patient’s large cell lymphoma was initially diagnosed in 2010 after she developed a mass in the left side of her neck. Lymph node biopsy was positive for large cell lymphoma CD20+. Bone marrow biopsy was negative. She was treated with cyclophosphamide doxorubicin/vincristine/prednisolone (CHOP) for 6 cycles.
![Page 3: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/3.jpg)
HISTORY: FAMILY HISTORY
Her father died of colon cancer at age 83. Her mother had a cardiovascular accident at age
68 ,but is alive and otherwise healthy. She has 2 sisters, aged 33 and 26 years, who are healthy and alive
SOCIAL HISTORY
She is teacher and has no children. She has a 10-year smoking history but quit 3 months ago .
ALLERGY HISTORY : -VE
SYSTMIC REVIEW : unremarkable
![Page 4: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/4.jpg)
PHYSICAL EXAMINATION:the patient appeared fatigued and weak. She was experiencing chills, overall, looked ill
temperature of 101.8°F (38,8)
respiratory rate of 20 breaths/minute
heart rate of 122
blood pressure of 80/50 mm Hg.
![Page 5: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/5.jpg)
LAB ASSESSMENTS
CBC with differential
BUN, SCr
Electrolytes
LFTs
Urinalysis
Blood & urine cultures was taken
WBC=2.2, Neutrophil = 0.42 (2-7.5), Hgb=99 Plt=345
BUN=3, SCr=87
Na=139, K=3.6, Cl=104, HCO3=28
Tbili=16, ALT=117, AST=76, Alp=84
Normal
![Page 6: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/6.jpg)
HOSPITAL COURSE: The patient’s immediately started on Iv fluid(NS) and antibiotics (piperacillin and torbramycin).
Because of her unstable blood pressure and other signs of sepsis, she was quickly transferred to the intensive care unit (ICU) .
In the ICU she continued on IV fluid antibiotics and pressors were started to maintain the blood pressure. She was subsequently intubated as a result of volume overload from fluid
resuscitation. She was tapered off pressors 24 hours later and extubated 48 hours later .
cultures had no growth during her hospital stay. She was transferred to the oncology ward, finished her antibiotics and 12 days later was sent home.
![Page 7: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/7.jpg)
Neutropenic Fever
![Page 8: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/8.jpg)
NEUTROPENIC FEVER
Neutropenia is defined as an abnormally low level of neutrophils in the blood .
1 .Absolute Neutrophil Count (ANC) calculation :
ANC = (WBC count) x (neutrophil % + band %)
ANC<500 cells/microliter
ANC<1000 cells/microliter, falling, predicted nadir <500
Fever
>38.0°C (100.4°F) for more than 1 hour
-Neutropenic fever is a potentially fatal complication of anti-cancer treatment (Mortality
rates ranging between 15 and 20%. )
-Without timely treatment, studies showed a mortality rate of nearly 70%!!
![Page 9: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/9.jpg)
PATIENTS AT RISK
Neutropenia is a common side effect of many types of chemotherapy.Anyone on antineoplastic medication needs to be closely followed for the development of neutropenia.
Patients undergoing treatment for hematologic malignancies are at higher risk for developing neutropenia.
Acute lymphoblastic leukemia: 93%
CHOP (Non-Hodgkin): 22%
Cisplatin/etoposide (SCLC): 38%
Fluorouracil (colon): 22%
Ozer H et al. JCO 2000; 18: 20 3558-3585.
![Page 10: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/10.jpg)
PATHOGENESIS
Impaired skin barrier Directly from IV access, or from chemo side effects
Impaired immune system
Abnormal anatomy/occluded excretory mechanismsBiliary, bronchial, urinary from either tumor or post-surgical alterations in anatomy
![Page 11: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/11.jpg)
COMMON PATHOGENS TO CONSIDER IN A NEUTROPENIC PATIENT
Gram positive organismsS. Aureus
S. Epidermidis
Streptococcus spp.Enterococcus
Corynebacterium
Gram negative organismsPseudomonas
Klebsiella
E. Coli
Keep these in mind when initiating treatment
![Page 12: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/12.jpg)
IT COULD BE ANYTHING!
![Page 13: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/13.jpg)
CONCLUSION
A. Patients who are neutropenic and febrile should be considered unstable and seen promptly .
B. Antibiotics should be administered immediately upon the patient's arrival
Offer beta lactam monotherapy cefepime or ceftazosin with piperacillin-tazobactam as initial empiric antibiotic therapy for suspected neutropenic fever
C- Prior to any antibiotic administration, cultures must be obtained .
![Page 14: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/14.jpg)
CONCLUSION
D- COMPLETE PHYSICAL EXAM must be performed .
Carefully examine the skin, mouth, buccal mucosa, IV sites, external genitalia, and perirectal area
E. LABORATORY EXAM should include:
1 .Complete blood count with differential and platelets
2 .Aerobic and anaerobic cultures
3 .Electrolytes, BUN, Cr, Ca, Phos, Mg
4 .Liver function tests (AST, ALT, Bili)
5 .Urinalysis with microscopic exam (if symptomatic)
6 .Cultures of other sites if symptomatic
![Page 15: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/15.jpg)
CONCLUSION
If the patient is:
a. Afebrile for at least 24 hours
b. The blood cultures are negative 36-48 hours after being obtained
c. There is no identification of a localized infection
d. ANC≥1000 .
If any of the above 4 criteria are NOT present, the patient should remain hospitalized and on antibiotics. Consider fungal or viral causes
![Page 16: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/16.jpg)
•Neutropenic sepsis is a potentially fatal complication of anti-cancer treatment
•Aggressive use of inpatient intravenous antibiotic therapy has reduced morbidity and mortality 5
![Page 17: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/17.jpg)
THANKS!
![Page 18: Musab bin shuayl, MD CASE PRESENTATION. HISTORY : A 37-year-old woman with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma) presented to the emergency](https://reader036.vdocuments.us/reader036/viewer/2022081418/56649e7a5503460f94b7ad4b/html5/thumbnails/18.jpg)
NEUTROPENIC