Jaymee B. QuindaraCollege of Medicine

Mariano Marcos State University

Multiple

Multiple Sclerosis

Autoimmune

Demyelination Myelin Sheath Oligodendrocytes

Node of Ranvier

Conduction problems

Normal Anatomy of the CNS

Acute Attack

Chronic Lesions

Abnormal Impulse Conduction

• Slowed Conduction• Dispersion of Conduction• Increased Sensitivity of

Conduction• Blocked Conduction

Musculoskeletal

• Fatigue• Limb weakness• Dragging of foot and foot drop• Spasticity• Intention tremors• Muscular atrophy• Ataxic movements(shaky, irregular, uncoordinated)• Dysarthria with slurred speech

References:Blumenfeld, Hal. Neuroanatomy through Clinical Cases, 2nd ed. Sinauer Associates. 2010.Burke et, al. Medical Surgical Nursing, 5th ed. Pearson. 2011Fauci et, al. Harrison’s Principles of Internal Medicine, 19th ed. McGraw Hill. 2015Klein et, al. Adam’s and Victor’s Principles of Clinical Neurology, 10th ed. McGraw Hill. 2014Snell, Richard. Clinical Neuroanatomy, 7th ed. Lippincott Williams Wilkins. 2010