MULTIPLE MYELOMA The Second Most Common Hematologic Malignancy1

Bone pain that is persistent or recurrent, and fractures6

Recurrent unexplained infections, such as pneumonia6

Nervous system disorders6

Shortness of breath or evidence of heart or kidney failure6

GLOBAL BURDEN: MULTIPLE MYELOMA BY THE NUMBERS

SIGNS AND SYMPTOMS

References:1. International Myeloma Foundation. What is Multiple Myeloma? https://www.myeloma.org/what-is-multiple-myeloma. Accessed January 2019. 2. Kazandjian. Multiple myeloma epidemiology and survival: A unique malignancy. Semin Oncol. 2016;43(6):676-681dol:10.1053/j/seminoncol.2016.11.004 3. International Myeloma Foundation. Myeloma Action Month. http://mam.myeloma.org/educate/. Accessed January 2019. 2/6. 4. National Cancer Institute. Cancer Stat Facts. Myeloma. https://seer.cancer.gov/statfacts/html/mulmy.html. Accessed January 2019 5. Rifkin RM, et al. Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics. Clin Lymphoma Myeloma Leuk. 2015 Jun;15(6):368-76. 6. American Cancer Society. Signs and Symptoms of Multiple Myeloma. https://www.cancer.org/cancer/multiple-myeloma/ detection-diagnosis-staging/signs-symptoms.html. Accessed January 2019.

Multiple myeloma is the second most common hematologic malignancy in the world2

Persistent tiredness due to anemia or kidney failure6

Multiple myeloma is a cancer of plasma cells, which are types of white blood cells found in the bone marrow. In multiple myeloma, cancerous plasma cells grow uncontrollably and crowd out the normal plasma cells in the bone marrow.1

Most patients are treated in the community setting5

Each year there are more than 138,000 new diagnoses of multiple myeloma worldwide3

This disease is most frequently diagnosed in 65 –75 years old4