mthfr & genetic basics - doctor doni...what is mthfr? gene and enzyme that turns folic acid into...
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By Dr. Doni Wilson
The Answers You Need to Take Control of Your Health
MTHFR & Genetic Basics
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Genetics + Stress = Health
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
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Footnote
© 2017 Dr. Doni Wilson
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What are Stresses? Major Life Stresses
Daily StressesFood Sensitivities
InfectionsMedications
Physical TraumaLack of Sleep
Elevated Blood SugarLack of Nutrients
Toxins
© 2017 Dr. Doni Wilson
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Genetics + Stress = Health
© 2017 Dr. Doni Wilson
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How to Read a Genetic Report?
Letters, numbers and colors.Genes code for enzymes.
Genes have 2 strands and 2 possible SNPs.Heterozygous = 1 SNP (yellow)
Homozygous = 2 SNPs (red)
We all have some SNPs!
© 2017 Dr. Doni Wilson
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What Are SNPs? Genetic variations.
Potential traffic jams.
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
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What are Cofactors?
Nutrient(s) required for enzyme to function.
© 2017 Dr. Doni Wilson
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What is MTHFR? Gene and enzyme that turns folic acid into folate.
“Folic acid” and “folate” are often used interchangeably, but they are different.
Folate is found in nature.Folic acid is synthetic.
MTHFR A1298CMTHFR C677T
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
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Health Risks Associated with MTHFR? Migraines
Anxiety and DepressionMiscarriages and Neural Tube Defects
InsomniaCervical Dysplasia (abnormal pap smears)
Heart DiseaseDiabetesCancer
Alzheimer’s
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
How much does it affect me?
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What is Methylation? “B Vitamin Cycle”
What our B vitamins are up to!
Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine).
Then SAM recycles back around to Homocysteine.
Negatively Affected by Stress.
© 2017 Dr. Doni Wilson
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What is SAM?
Used in the body to do all sorts of good!
Protects our DNAHelps make healthy new cells
Makes and breaks down neurotransmittersand helps get rid of histamine (think of allergies).
© 2017 Dr. Doni Wilson
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What is Homocysteine? Recycling SAM.
Connects up with Folate and B12.
Can also go down the glutathione pathway.Glutathione is a major anti-oxidant in our bodies -
a cell protector.
Can be measured in blood work.
© 2017 Dr. Doni Wilson
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What can block Methylation?
InflammationMetalsAlcohol
LPS from gut bacteriaNitric Oxide (uncoupled)
© 2017 Dr. Doni Wilson
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What can I do to address MTHFR?
• Avoid Folic Acid.• Eat foods high in folate.• Find out if you need Folate.• What is blocking methylation?• Do you have enough cofactors?• Address YOUR stress!
© 2017 Dr. Doni Wilson
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What can I do to address MTHFR?
© 2017 Dr. Doni Wilson
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What tests do I need to do? Genetic panelRun software
Blood test for Homocysteine
May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut
bacteria, nutrient levels, methylmalonic acid
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
Methylation Panel
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© 2017 Dr. Doni Wilson
Organic Acids Panel
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© 2017 Dr. Doni Wilson
Urine Sulfur Strips
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© 2017 Dr. Doni Wilson
Cortisol & Neurotransmitter Panel
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© 2017 Dr. Doni Wilson
Food Sensitivity & Stool Panels
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Footnote
© 2017 Dr. Doni Wilson
Additional Panels
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Will Supplements Help? Which?
Yes - Important to Individualize!
Vitamin B6, MagnesiumOther B vitamins
Minerals/Electrolytes
Methyl-Folate (5MTHF)Methyl-Cobalamin (B12)
© 2017 Dr. Doni Wilson
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Will Supplements Help? Which?
© 2017 Dr. Doni Wilson
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Dr. Doni’s 5-step Approach
© 2017 Dr. Doni Wilson
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Remove Blocks
By decreasing “stresses” in our bodies, we improve
methylation.
© 2017 Dr. Doni Wilson
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Stress
Inflammation
Decreased Methylation
Leaky Gut + Dysbiosis + Blood Sugar Issues
Oxidative Stress + Chronic Infection
© 2017 Dr. Doni Wilson
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Address Downstream Pathways
© 2017 Dr. Doni Wilson
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Sulfur & Glutathione
Nitric Oxideand
Histamine
Neurotransmitters© 2017 Dr. Doni Wilson
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Support Cofactors First!
© 2017 Dr. Doni Wilson
MagnesiumMinerals/Electrolytes
Vitamin B6 Other B vitaminsHydroxo B12 trial
Molybdenum (if needed)
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Assess Methylation
© 2017 Dr. Doni Wilson
Know your homocysteine level!
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Add Methylation Supportonly IF needed !!
© 2017 Dr. Doni Wilson
5MTHF +
Methyl B12 +
B6 (P5P)
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Genetics + Stress = Health
© 2017 Dr. Doni Wilson
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© 2017 Dr. Doni Wilson
Stress Remedy Program
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https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-
Solutions-Package.pdf
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© 2017 Dr. Doni Wilson
MTHFR 5 Step Approach Workshop
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Dr. Doni’s 5-Step Approach
© 2017 Dr. Doni Wilson
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Workshop Sessions
© 2017 Dr. Doni Wilson
1. Identify blocks and assess downstream pathways 2. Address blocks and cofactors 3. Assess progress 4. Implement methylation5. Assess progress6. Plan for continued success
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© 2017 Dr. Doni Wilson
MTHFR 5 Step Approach Workshop
Sign Up Here
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THANK YOU!
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© 2017 Dr. Doni Wilson