· mtec’s goals for 2020 10-11 funding overview 12 membership growth 13 research 14-18...
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The Medical Technology Enterprise Consortium (MTEC) is a 501(c)(3) nonprofit organization designed to accelerate the translation of medical technologies into solutions that prevent and treat injuries and restore the health of United States military personnel and veterans.
MTEC is a public-private collaboration between the U.S. federal government (primarily DoD organizations) and the academic institutions, private companies, and non-profit organizations that make up MTEC’s membership. This collaboration uses a simplified contracting vehicle (the Other Transaction Agreement (OTA)), which enables federal sponsors to quickly and openly partner with MTEC members in a more transparent manner. The OTA tears down the walls that traditionally restrict such
Through “technology pull” for specific clinical needs or “technology push” described in open concept white papers, the MTEC fosters a strong dialogue between the worldwide medical technology base and the military R&D community. Our flexible and tailorable solicitations use complexity, maturity, and cost factors to assist in channeling discussions and ultimate proposals that have higher acceptance rates by military evaluators. This value add service makes the MTEC a significant asset to both the military and industry clients.
open transactions, enabling rapid and repeated interaction between government, private technology developers, and funding partners.
The consortium membership includes academic research centers, large industry leaders, small companies, as well as major medical research centers from around the world. MTEC reaches this community through multiple channels to seek out technologies that can enhance the military’s performance on the battlefield. As single bidders or teamed proposers, our members have the opportunity to respond to government-funded requests for proposals within multiple research domains that are relevant to both military medicine and civilian medical needs.
MTEC at a Glance
We are dedicated to identifying emerging medical technologies and facilitating faster
transition from the laboratory to the patient on the battlefield, at the bedside, and -
ultimately - across the globe.
Table of Contents MTEC at a Glance 6
Table of Contents 7
President’s Letter 8
2019 Highlights 9
MTEC’s Goals for 2020 10-11
Funding Overview 12
Membership Growth 13
Research 14-18
Infectious Disease 14
Combat Casualty Care 15
Operational Medicine 16
Clinical & Rehabilitative Medicine 17
Medical Simulation & Information Services 18
Portfolio of Funding Sponsors 19
Research & Development Success Stories 20-21
Solicitation Process 22-23
Technology and Company Outreach 24
Feedback from Sponsors & Members 25
Board of Directors 26
Updates on the 2019 Strategic Plan 27
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A Special Thanks:MTEC would like to express our appreciation to the military sponsors who demonstrate their faith in our ability to provide access to emerging technologies and providers who make the real work happen. Thank you so very much for your combined trust and participation!
Joint Program Committees 1, 2, 5, 6, 8
What a year! MTEC has significantly expanded its DoD-outsourced prototyping activities, and an ever growing number of new technology providers have widened the spectrum of medical capabilities being explored. With a significant increase in available funding, MTEC’s membership has grown to offer innovative solutions to military medical needs. Work funded in our early awards is now reaching completion, and the first products are starting to transition to the clinic. It has been extremely satisfying to be a part of these efforts!
2019 - Making a Difference
Dr. Lester Martinez Lopez, MD, MPH, Major General (Retired), U.S. ArmyPresident & Chairman of the MTEC Board
n Monitored the first MTEC project to transition to the marketplace: BioBridge Global obtained U.S. Food and Drug Administration (FDA) approval for an adult human mesenchymal stem cell product useful for regenerative medicine therapies
n Developed strong alliances with BIO, Advamed, and MedTech Innovator to expand MTEC’s reach, resulting in an increase in membership and access to military-relevant technologies
n Implemented solutions to address lessons learned that will drive improvements in 2020:
n Implemented several mechanisms to help members team and understand military requirements
n Established collaborations with military project managers to drive milestone compliance
n Reduced research overhead costs to apply more funding to projects
2019 Highlights:n Expanded funding sponsors to include five Joint Program
Committees (JPC-1, 2, 5, 6, 8), U.S. Army Medical Materiel Development Activity (USAMMDA), several military laboratories (U.S. Army Institute of Surgical Research (USAISR), Walter Reed Army Institute of Research (WRAIR)), Defense Health Agency (DHA), Naval Medical Research Center (NMRC), Office of Naval Research (ONR), Joint Operational Medicine Information Systems (JOMIS), and Congressional Special Interest (CSI) funding
n Added $80M in new funding for a total program exceeding $177M in contract ceiling
n Grew membership in 2019 to 336 active organizations (22% increase from 2018)
n Launched the “Open Concepts” Request for Information, which led to several new funding opportunities with targeted research topics, and will result in at least 15 new awards
As MTEC looks forward to the new year, we anticipate further expansion into other military services and federal organizations and increased collaboration within the private sector.
Work funded in our early awards is now reaching completion, and
the first products are starting to transition to the clinic.
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MTEC’s Goals for 2020Increase the diversity of Government funding sponsors
Enhance MTEC’s relationship with the venture capital investor community
Concentrate outreach efforts on additional philanthropic funders
Initiate outreach to corporate development offices
Implement a solicitation management software to streamline the solicitation-to-award schedule
The U.S. Army Medical Research and Development Command (MRDC) has been MTEC’s leading funding sponsor. For 2020, research and prototyping efforts will focus on the future operational environment to project and sustain soldier lethality to include renewed emphasis on the following priorities.
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Funding OverviewMTEC experienced significant growth in funding, awards, and diversity in sponsorship in 2019. We expect this trend to continue in 2020, with approximately $60M already identified for execution.
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2019201820172016
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Cumula�ve Awarded Ceiling with Cost Share
29FUNDING
OPPORTUNITIES
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(REQUESTS FOR INFORMATION)
$177MILLION
GOVERNMENT FUNDING
$31MILLION
COST-SHARE
Cumulative Awarded Ceiling with Cost Share Distribution of Funding by Sponsor
Membership GrowthMTEC membership has continued to grow in 2019, increasing to 336 member organizations, 60% of which represent nontraditional defense contractors (NDCs). Academia and small businesses offer emerging innovations and new trends to the consortium. Large industry plays an important role in presenting opportunities for potential licensing agreements and acquisitions. Other members provide critical support services, such as regulatory consultants, contract research organizations (CROs), and contract development and manufacturing organizations (CDMOs). MTEC makes a conscientious effort to recruit members from all of these different organizations to create a well-rounded consortium.
Benefits of MTEC Membership:
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336 Member Organizations Membership Growth
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SMALL BUSINESSESinnovative emerging companies, mostly nontraditionalsACADEMIAdoing early prototype development and candidate testingLARGE INDUSTRYleaders serving as go-to-market transition partners
2016 2017 2018 2019
OTHERSincluding nonprofit companies and medical centers
n Facilitates the transition to long-term prototype agreements
n Provides access to other military contracting opportunities beyond MTEC
n Provides introductions to Fortune 500 companies, venture, and foundations as additional funding sources
n Provides a means for open and transparent communication between the government and technology providers to better understand the military needs
n Promotes teaming among offerors to provide the sponsor with more complete proposals that better meet technical requirements
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336
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Military Infectious DiseasesOBJECTIVE: Prevent infectious disease threats to eliminate their impacts on operational readiness.
Specific areas of interest include:
n Vaccines and drugs to prevent parasitic diseases (malaria)
n Vaccines to prevent diarrheal diseases
n Vaccines to prevent viral diseases (dengue, hanta)
n HIV countermeasures
n Therapies to prevent and treat combat wound infections
n Protection from disease-carrying arthropod vectors
n Countermeasures against emerging infectious diseases
2019 Awards
Project Title Prime Awardee(s) Federal Ceiling Value Cost Share Sponsor*
Dual Activities of Novel SRI International $999,939 $0 WRAIRLipoxygenase Inhibitors toCombat Gram-NegativePathogens and Sepsis
Development of Adaptive Phage $10,902,428 $990,559 NMRCPersonalized Bacteriophage TherapeuticsTherapeutic for the Treatmentof Bacterial Infections
Electroceutical Technology Indiana University $200,000 $100,000 USAMRDCagainst Bacterial Drug Resistance
2019 Solicitations Pending Award in 2020
Solicitation Title Expected Number Anticipated Federal Sponsor of Awards Ceiling Value
Military Infectious Diseases – 4 $10,000,000 USAMRDCPrototype InnovationProgram (MID-PIP)
Combat Casualty CareOBJECTIVE: Reduce the mortality and morbidity associated with major combat related to trauma across the spectrum of care - from battlefield to CONUS-based hospitals.
Specific areas of interest include:n Hemorrhage control and resuscitation
n Traumatic brain injury caren Blood and blood products far forwardn Burn injury and organ supportn Tactical combat casualty care interventionsn Extremity and maxillofacial trauma treatmentn Prolonged field care
2019 AwardsProject Title Prime Awardee(s) Federal Ceiling Value Cost Share Sponsor
Oxygen Carrier for Use in Virtech Bio $6,948,432 $913,487 USAMRDCHemorrhagic Shock Resuscitation
The Effects of Complete and Partial REBOA University of Michigan $1,607,524 $248,922 USAMRDCwith Pharmacologic Treatment inSwine Models of Hemorrhagic Shock
BurRapid Epidural Drainage Critical Innovations, LLC $998,799 $225,302 USAMRDCAttachment for Traumatic Brain Injury
Rugged Real-Time Wearable Sensor for Aptitude Medical Systems, Inc. $2,499,759 $0 USAMRDCAssessment of Coagulopathy at Point of Injury
Circulating cfDNA Fragments for Detection Children’s Hospital $2,191,389 $369,350 USAMRDCand Diagnosis of Traumatic Brain Injury of Philadelphia
In-Field Detection of Acute Subdural Kitware, Inc. $1,517,474 $0 USAMRDCHematomas Requiring Urgent, Life-SavingTreatment in Severe TBI Patients
2019 Solicitations Pending Award in 2020Solicitation Title Expected No. of Awards Anticipated Federal Ceiling Value Sponsor
Multi-Domain Life Saving Trauma Innovations (MuLTI) 3 $5,700,000 USAMRDC
Hemorrhage Detection Technology Minimum of 1 $2,000,000 USAMMDA
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Military Operational MedicineOBJECTIVE: Develop countermeasures that address military-relevant stressors and prevent physical and psychological injuries during training and operations in order to maximize health, readiness, and performance.
Specific areas of interest include:
n Musculoskeletal injury
n Blunt, blast, and accelerative injury
n Behavioral health, wellness and resilience
n Psychiatry and clinical psychology disorders
n Health, readiness, and performance in austere environments
n Fatigue, cognitive health and performance
n Human operator health and performance in complex systems
n Environmental toxicant exposure
n Performance nutrition and weight balance
n Directed energy health hazards
n Biomedical aspects of human performance optimization and enhancement
2019 Awards and Solicitations
Project Title Prime Awardee(s) Federal Ceiling Value Cost Share Sponsor
Validation of Wearable Institute for Behavior Resources $244,949 $0 USAMRDC Sleep and Fitness Monitor with the Sleep Tank Model
Mobile Stress and Design Interactive, Inc. $1,924,129 $0 USAMRDC Anger Management Tool (MSAT) Expansion and Evaluation
LifeLens Physiologic Monitoring LifeLens Technologies, LLC $2,996,970 $0 USAMMDA Platform – Ascent
Optimizing the Scalability of Rehat LLC $1,222,973 $0 USAMRDC Evidence-Based Behavioral Sleep Medicine Practices with iREST
Integrated Tele‐Sleep Mobile Platform University of Maryland, Baltimore $2,000,000 $0 USAMRDC Tele‐Sleep Decision Assist Tool
Clinical and Rehabilitative MedicineOBJECTIVE: Develop restorative treatments to maximize function of wounded Service members in terms of duty, performance, and quality of life.
2019 Awards and SolicitationsProject Title Prime Awardee(s) Federal Ceiling Value Cost Share Sponsor
Cardiosphere‐Derived Cells for the Cedars‐Sinai Medical Center $1,930,033 $0 USAMMDA Regeneration of Skeletal Muscle Following Traumatic Volumetric Muscle Loss
Enhanced Biologic Scaffold University of Pittsburgh $1,839,921 $140,786 USAMMDA for Volumetric Muscle Loss
Anti-Scar Treatment for Tesa Labtec GmbH $2,351,240 $0 USAISR Deep Partial Thickness Burns
A Novel Perfusion-Based, Scalable, and Southwest Research Institute $2,948,354 $0 USAMRDC Single-Use Cell Expansion Bioreactor Advanced Development and Demonstration in a Clinical Cell Manufacturing Environment
Development of a Universal Bioreactor RegenMed $3,000,000 $3,125,000 USAMRDC Platform for Development Organization Regenerative Medicine Clinical Manufacturing
Large-Scale Manufacturing of Extracellular University of Pittsburgh $1,995,843 $213,144 USAMRDC Matrix (ECM) Hydrogels for Regenerative Medicine Applications
Specific areas of interest include:
n Treatment of Neuromusculoskeletal (NMS) injury
n Battlefield pain management
n Biomanufacturing of regenerative medicine therapies
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Clinical & Rehabilitative Medicine Research Program (CRMRP)
Combat Casualty Care Research Program (CCCRP)
Clinical & Rehabilitative Medicine Research Program (CRMRP)
Medical Simulation & Information Sciences Research Program (MSISRP)
Military Operational Medicine Research Program (MOMRP)
U.S. Army Medical Materiel Development Activity (USAMMDA)
Clinical & Rehabilitative Medicine Research Program (CRMRP)
Medical Simulation & Information Sciences Research Program (MSISRP)
Office of Naval Research (ONR)
U.S. Army Medical Materiel Development Activity (USAMMDA)
Combat Casualty Care Research Program (CCCRP)
Clinical & Rehabilitative Medicine Research Program (CRMRP)
U.S. Army Institute of Surgical Research (USAISR)
Military Operational Medicine Research Program (MOMRP)
Naval Medical Research Center (NMRC)
U.S. Army Medical Materiel Development Activity (USAMMDA)
Walter Reed Army Institute of Research (WRAIR)
Diversified Portfolio of Funding SponsorsAlthough the U.S. Army Medical and Research Development Command’s Joint Program Committees are MTEC’s biggest funding sponsor, the portfolio of sponsors was well diversified in 2019.
Medical Simulation and Information Sciences
2019 AwardsProject Title Prime Awardee(s) Federal Ceiling Value Cost Share Sponsor
Assessment of Psychological and Design Interactive, Inc. $1,249,999 $0 USAMRDC Physiological Effects of Augmented Reality (APPEAR): Development of the Dual-Adaptation Protocol for Augmented Reality
APPEAR: Augmented Reality Psychological Design Interactive, Inc. $1,249,999 $0 USAMRDC Suitability Measures and Models
APPEAR: Psychological Chenega Healthcare Services, LLC $1,224,864 $0 USAMRDC
A Realistic, Portable and Deployable Chenega Healthcare Services, LLC $749,653 $0 USAMRDC Medical Patient Simulator Using Augmented Reality Technology for Mass Casualty Medical Response Training
I-Predict Thorax Model Prototype Phase II Southwest Research Institute $1,574,969 $0 ONR
Burn Patient Transfer System (BPTS) Chenega Healthcare Services, LLC $1,827,607 $0 USAMRDC
OBJECTIVE: Improve patient safety and quality of care by transitioning more capable healthcare information and medical simulation technologies and systems, addressing stakeholder priorities to bridge existing and future capability gaps in the military health system, and proactively integrating and implementing emerging technologies into military healthcare relevant applications.
Specific areas of interest include:
n Medical simulation (Joint Evacuation and Transport
Simulation (JETS), Point of Injury and Trauma Simulation (POINTS), Warfighter Performance, Resilience, Effectiveness, and Protection (WarPREP), Theater Hospital Operations Replication (THOR), Simulated Hospital Operations and Treatment System (SHOTS))
n Health information technology and informatics
n Medical capabilities to support dispersed operations
n Autonomous care and artificial intelligence at POI
2016 2017 2018 2019
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Research and Development Success Stories
Commercial Scale Up of Bone Marrow-Derived Mesenchymal Stem Cells (MSCs) for Regenerative MedicineProject Team: BioBridge Global; Rooster Bio, Inc.; StemBioSys; US Army Institute of Surgical Research
Beyond enabling the development of new regenerative medicine, MTEC funding has been instrumental in providing this project team a springboard for new business in the United States, such as:
n Expanded service offerings geographically
n Routine support provided to academic researchers and small companies working through clinical trial preparations
n Development of new capabilities and support for cell manufacturing
Human Tissue Engineered Blood Vessels for Vascular Reconstruction in the Injured WarfighterProject Team: Humacyte, Inc.
Humacyte has developed technology to bioengineer human acellular vessels (HAVs) that can be used to repair or replace damaged vasculature in warfighters and civilians. Humacyte’s HAVs are now being clinically evaluated in patients experiencing blood vessel damage caused by blunt trauma, penetrating injuries, or other catastrophic events. MTEC funding has provided Humacyte an opportunity to partner with the military to navigate the uncharted regulatory pathway of innovative products to treat vascular injuries.
Manufacturing of a Negative Pressure Wound Therapy Dressing for Hand Wounds: ReHeal GloveProject Team: University of Texas at Arlington, ReHeal LLC
The team at University of Texas, Arlington used MTEC funding provided through the prototype acceleration award to establish the manufacturing, assembly, sterilization, and packaging process for the ReHeal Glove. The award has successfully advanced the development of the ReHeal Glove to its next milestone, which enabled the team to successfully receive funding (2019) via the Congressionally Directed Medical Research Program (CDMRP) for early feasibility pilot trials in human subjects.
Fast Onset Abdominal Management (F.O.A.M.)™ Preclinical StudiesProject Team: Critical Innovations LLC
F.O.A.M.™ is designed to control severe intra-abdominal bleeding in critically ill trauma patients, when surgical intervention is not immediately available. MTEC funding has been instrumental in assisting Critical Innovations in propelling the device through key development milestones and closer to regulatory submission, where the program has achieved Breakthrough Device Designation from the Food and Drug Administration and has delivered very encouraging porcine study survival data. The device is now transitioning to large-scale manufacture.
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Solicitation and Award MethodologiesMTEC has developed tailored but formalized solicitation methods aligned to both funding sponsor desires as well as the complexity and maturity of the technologies being advertised for bid.
OPTION 1
OPTION 2(~4-6 months)
OPTION 3(~7-8 months)
OPTION 4(~10 months)
Request for Project Information (RPI)
White Paper to Full Proposal
Direct to Full Proposal
Solution Brief
Offeror submits RPI (Market research,
information only used to inform future RPIs)
Offeror Submits Full Technical and
Cost Proposal
STEP 1 STEP 2 STEP 3
STEP 1 STEP 2
Offeror submits White Paper
Offeror invited to submit Full Technical and
Cost Proposal
Offeror invited to an in-person or virtual Solution Brief Pitch
Offeror invited to submit
Full Cost Proposal
Offeror submits Solution Brief
The use of an “electronic basket” provides a means to maintain technically acceptable and reasonably priced proposals at a ready to award status for two years.
Any funding sponsor can access these proposals as funding becomes available without re-solicitation, thereby allowing the speedy and efficient use of future FY funding, expiring funds, or withheld appropriations.
n The use of the basket saves time and is responsive to military needs and funding availability.
n The OTA often reaches award quicker than the standard FAR based process, thereby reducing the risk of fund expiration.
n The “cost share in excess of requirement” evaluation factor can bring additional funding beyond the sponsor’s base funding.
n Frequent, open communications between Government and industry helps map industry capabilities and trends to Government needs, leading to more responsive proposals.
n Post evaluation teaming is facilitated to bring segregated capabilities together in one proposal and project execution.
MTEC’s Basket Provision
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MTEC OTA Benefits
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“Joining MTEC has been the best decision we have made in our first two years of our medical device launch. The MTEC staff has opened doors to connections and expertise that has truly been an enormous boost to our business that has helped define our path into 2020.”
Tim Koehler, CEO. RAIN Scientific Inc.
Technology and Company OutreachAn important facet of the MTEC mission is our ability to provide technology solutions that are responsive to the military’s medical needs. In support of this goal, MTEC conducts outreach at several venues to recruit businesses and universities with military-relevant technologies. The outreach goals for 2020 include:
n Attend large medical conferences, such as BIO and ADVAMED Med Tech
n Present and/or exhibit at small and large conferences
n Participate in medical investment/venture conferences to foster collaborative opportunities with the investor community
n Conduct annual military “pitch days” through MedTech Innovator
n Attend military symposia (MHSRS), geography-centric events (SoCalBio), and research topic-specific meetings (annual vision research funders)
n Visit university campuses to explain the workings and benefits of military funding
n Interact with other funders (venture and foundations) to determine collaborative opportunities that overlap with military needs
MTEC’s membership integrates diverse organizations into cohesive teams that provide
innovative medical solutions to both the military and the global community.
Feedback from Sponsors and Members
“The transparency, efficiency, and adaptability offered by MTEC and its outstanding team accelerate every step of the award process, from development to reporting.”
Anne Germain, Ph.D., Co-Founder and CEO, Noctem, LLC
“The MTEC OTA empowers member organizations of all sizes and academic institutions to work together with the Government to deliver advanced technologies and vital re-search to those who have sacrificed so much for our country.”
Sara Langdon, Program Manager, USAMRMC
“MTEC has rapidly improved our ability to bring in innovative solutions and, where necessary, accelerate partnerships with the DoD. The OTA significantly enhances our ability to address critical Service member needs from medical R&D.”
CDR Christopher Steele, Director & Joint Program Committee-5 Chair, Military Operational Medicine Research Program, USAMRDC, Funding Sponsor
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Dr. Andrew Omidvar, MBADr. Andrew Omidvar joined Philips as Vice President of Enterprise and Government R&D for Healthcare. He is responsible for shaping the long-term business strategy for Philips in the Federal Government Research & Development sector. Dr. Omidvar’s experience and network will be beneficial to MTEC as he can help guide and align strategies to the stakeholder’s mission and vision. He can also advance and guide innovations required for our service members to commercialization and bring industrial scale to military medical solutions. He has been instrumental in bridging gaps between requirements and R&D innovations to further support who needs them the most. Dr. Omidvar is a new addition to MTEC’s Board of Directors because he has a clear vision and path from what could be to what can be.
Board of DirectorsMTEC’s Board of Directors have decades of experience in both the military and medical domains who provide strategic oversight to the consortium. The Board includes several representatives from member organizations across MTEC’s various segments, such as small business, large business, and academia. In addition, the Board includes three members with expertise in the areas of fundraising and financial management, legal technology transfer and acquisition, and military research. For profiles, visit: mtec-sc.org/board-members.
According to the MTEC Bylaws, the Board of Directors operates on a cycle where term limits are predetermined. We would like to thank Les Sherman, who represented the at-large member segment, for his service. Les has decades of experience producing medical devices for military use, and he provided MTEC with an invaluable “real world” perspective. He will be sorely missed! We wish him well on the ski slopes of Colorado, where he counts every day on the mountain a good day.
But as we say goodbye to one, we are excited to welcome our newest member – Dr. Andrew Omidvar.
Updates on the 2019 Strategic PlanGoal 1: Improve Outcomes for Our Sponsors
n Proposal acceptance rate > 40%
n Diversity of funding sponsors increased
n User’s manual published and military “OTA Workshop” conducted. BIDs (BAA Information Delivery System) delayed, but MTEC will pilot the program in Q1 2020
Goal 2: Provide Research and Business Opportunities for Our Members
n Strong relationship building between the military and our members
n Venture capital addendum in operation to enhance reviews by investor groups
n Educational webinars offered
Goal 3: Develop and Encourage Collaborationsn Over 70% of awards were made to teams
n MTEC’s teaming software (collaboration database tool) and teaming newsletter are active
Goal 4: Serve as a Conduit for External Fundingn Partnering with foundations and investors will be
a priority in 2020
n Launched Lives Restored philanthropic campaign
n Actively revising our philanthropic approach, since initial efforts did not meet expectations
Goal 5: Generate and Maintain Resources to Fulfill MTEC Mission
n Growth in the number of awards has increased the resources available for MTEC operations
n Prudent budgets have maintained low operational costs (1.7%)
n Surplus generated additional research funding to be awarded in 2020
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mtec-sc.org
Membership BenefitThe MTEC provides direct access to government sponsors, networking opportunities with leading technology partners, and funded solicitations for leading research that aligns with military, governmental, and often civilian needs.
Kathy Zolman MTEC Director of Program Operations [email protected]
Funding Sponsor BenefitThe government sponsor gains ready access to a consortium of diverse, capable technology providers. Effective, streamlined solicitation processes lead to better proposals and better potential of success in R&D efforts.
Lauren Palestrini MTEC Director of Research [email protected]
Philanthropic BenefitIndividuals and corporations can partner with MTEC to fund much needed medical research and development that may benefit our nation’s warfighters, but also both Americans and global civilian populations.
Susan Raymond, Ph.D. MTEC Director of Strategic Funding [email protected]