Mrs. Anna Ward

James Martin MS

March 29, 2012

1. How many males are present?2. How many females are present?3. How many generations?4. How many children does the first generation

(I) couple have?5. How many marriages are represented?6. How many males have the disease?7. How many females have the disease?

DO NOW!!!In the Pedigree to the Right, tell me….

Don’t forget Pass Expectations

Schedule for today:9:15 - 10:15  Cougar Time10:20 - 11:20 2nd Period11:25 - 12:55: 3rd Period

12:20 - 12:50 Lunch1:00 - 1:55 4th Period2:00 - 3:00 5th Period3:05 - 4:15 CELEBRATION! (Johnson &

Rodriguez's Room)

Announcements

Huntington’s Disease

Sickle Cell Anemia

Hemophilia

Create your own PEDIGREE

Agenda

Huntington's disease is a genetic disorder passed down through families in which nerve cells in certain parts of the brain waste away, or degenerate.

Huntington’s Disease

If one of your parents has it, you have a 50% chance of getting it.

Onset of the symptoms usually starts around age 40.

One of the common traits marked in pedigrees

First Genetic Disease Mapped to a Chromosome (#4)

Huntington’s Disease

http://www.youtube.com/watch?v=65xf1olEpQM

Huntington’s Disease

Why do you think it would be important to use a Pedigree to track Huntington’s Disease???

What do you notice about this Pedigree?

Huntington’s Disease

Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shape. (Red blood cells are normally shaped like a disc.)

http://www.youtube.com/watch?v=iKQmQHh4E2w&feature=related

http://www.youtube.com/watch?v=qe59ar-GZmg

SICKLE CELL DISEASE

Sickle Cell Pedigree:HOW IS THIS DIFFERENT FROM THE

PEDIGREE FOR HUNTINGTONS?

SICKLE CELL DISEASE

Hemophilia refers to a group of bleeding disorders in which it takes a long time for the blood to clot.

Known as the “ROYAL DISEASE” from the infamous Russian Royal Family

HEMOPHILIA

http://player.discoveryeducation.com/index.cfm?guidAssetId=A6AC1338-DEC9-4AA1-AEED-18BCAE0239DB&blnFromSearch=1&productcode=US

HEMOPHILIA

Royal Family Pedigree

Think of a trait that some (but not all) of your family members carry.

Some examples may be:Left-HandednessCurly HairTongue RollingWidow’s PeakAttached EarlobesFrecklesAllegiesCleft Chin…….

CREATE YOUR OWN PEDIGREE

Begin By Drawing your family members, using a

CIRCLE—Women/girlsSQUARE—Men/BoysDO NOT SHADE ANYTHING AT THIS POINT

Here is a diagram to help you remember how to draw one:

SECOND STEP…

If anyone is deceased, Make a diagonal slash mark through their circle or square.

Then use a Marker to Color in any family member with the trait.

If you do not know the trait for sure, you can take it home and complete it over the weekend.

THIRD STEP

Label your pedigree with your name, your family name

Place a “key” at the bottom or side indicating what each shape means.

FOURTH STEP