mr spectroscopy of the brain - ucsdspinwarp.ucsd.edu/neuroweb/ppt/mrs-45.pdf · mr spectroscopy of...
TRANSCRIPT
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MR Spectroscopy of the Brain
John R. Hesselink, M.D.
Department of Radiology University of California
San Diego
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Magnetic Resonance Spectroscopy
A measure of brain chemistry
1H (proton), 23Na, 31P Serially monitor biochemical changes:
tumors, stroke, epilepsy, metabolic disorders, inflammation/infection, neurodegenerative disease
Correlate with anatomic MRI for diagnosis Recognized by AMA, Medicare, Medicaid
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Electromagnetic Spectrum
Shortwave UHF/VHF/FM Radar Microwave AM Radio
102 104 106 108 1010 1012
Frequency (Hertz)
Radio waves Infrared Visible light Ultraviolet X-rays Gamma rays Cosmic rays
102 106 1010 1014 1016 1018 1020 1022
Frequency (Hertz)
NMR NMR
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NMR Spectrum
Frequency (MHz)
Frequency (MHz)
Nuclear Resonance Frequencies at 1.5T
0.3T 1.0T 1.5T 3.0T 4.0T 7.0T
10 50 100 200 300
Proton Resonance Frequencies at Different Field Strengths
K N O C Na Li P F H
1 25 50 75
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Proton MR Spectrum
Frequency (Hertz)
NAA Choline Water
64,000,000 64,000,064 64,000,128 64,000,192 64,000,256 64,000,320
Creatine
0 1.0 2.0 3.0 4.0 5.0 Parts per million (ppm)
1.5 Tesla
Fat
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Basic Principles of MRS
Imaging: Use all the signal from fat to water to make the image
Fat suppression: Put voxel inside brain Water suppression: CHESS or IR STEAM or PRESS pulse sequence acquisition Fourier transform to separate signal into individual
frequencies Chemical shift: Electron cloud affects the local
magnetic field experienced by the protons Convert hertz to ppm, assign NAA as the reference
at 2.0 ppm, & reverse the order
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Proton MR Spectrum Effect of Field Strength
Frequency (Hertz) 4.0 3.0 2.0 1.0
ppm
64,000,256 64,000,192 64,000,128 64,000,064
Hertz 4.0 3.0 2.0 1.0
ppm
32,000,160 32,000,096 32,000,032 1.5T
0.75T 32H
64Hz
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Normal MR Spectrum
Lying
Lazy
No
Good
Crooks
Cheat
My Insurance
Lipid
Lactate
NAA
Glutamates
Creatine
Choline
Myo-Inositol Brian Ross, Huntington Medical Research Institute
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Observable Proton Metabolites
0.9-1.4 Lipids Products of brain destruction 1.3 Lactate Product of anaerobic glycolysis 2.0 NAA Neuronal marker 2.0-2.4 Glutamine/Glx Neurotransmitters 3.0 Creatine Energy metabolism 3.2 Choline Cell membrane marker 3.5 myo-inositol Glial cell marker, osmolyte hormone receptor mechanisms 1.2 Ethanol Triplet 1.48 Alanine Present in meningiomas 3.4&3.8 Glucose Increased in diabetes 3.8 Mannitol Rx for increased ICP
ppm Metabolite Properties
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Basic Principles (MRS)
STEAM (STimulated Echo Acquisition Mode) - 90o refocusing pulse (like GRE) - shorter echo times - decreased signal-to-noise
PRESS (Point REsolved SpectroScopy) - 180o refocusing pulse (spin-echo)
CSI (Chemical Shift Imaging) - multi-voxel MRS
SI (Spectroscopic Imaging) - overlay of MR spectrum on MR image
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Similar to MRI in that different echo times change the information obtained
Short TE (30 msec): metabolites with short and long T2 relaxation times observed
Long TE (270 msec): only metabolites with long T2 relaxation times observed
lose peaks from lipid, Glx & mI
TE 144 msec: inverts lactate @ 1.3 ppm
MR Spectroscopy Effect of Echo Time
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Grade 2 Fibrillary Astrocytoma
TE 270 TE 30
Effect of Echo Time
Lipids, glutamates & myo-inositol have short T2 and drop out at longer echoes
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Single voxel, short TE Single large voxel For initial diagnosis
Multi-voxel, long TE
Multiple small voxels Assess extent of gliomas Followup of gliomas
MR Spectroscopy Imaging Techniques
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Observable Metabolites What’s missing?
DNA, RNA, most proteins, enzymes, phospholipids
Where are the Neurotransmitters?? Glutamate/GABA – Yes, but why not acetylcholine, dopamine, serotonin?
Either concentration too low, or molecules immobile & invisible to MRS
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1
WM
Normal MR Spectrum
1 2
2
GM
Hunter’s angle
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Metabolite Ratios Normal Abnormal
NAA/Cr 2.0 < 1.5
NAA/Cho 1.6 < 1.2
Cho/Cr 1.2 > 1.5
TE 144 msec
NAA/Cho 1.5 < 1.0
TE 30 msec
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MRS & Perfusion of Brain Tumors
Tumor histology
Degree of malignancy
Delineate tumor beyond T2 and enhancing margins
Guide biopsy
Follow response to therapy
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MRS of Brain Tumors
NAA decreased in tumors that displace or destroy neurons
Cr relatively constant, but decreased in malignant lesions
Cho increased in tumors (hypercellularity) Lipids seen in necrotic tumors - indicative of
high malignancy Lactate noted in highly cellular malignant
tumors that outgrow blood supply Myo-inositol elevated in low-grade gliomas
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History: 27 y/o male with a single seizure
708
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Dx: Low-grade fibrillary astrocytoma
{Page 2}
TE 35 msec
TE 144 msec
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History: 68 y/o man with episodes of severe parietal headaches
655 –
TE 35 msec
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Dx: Grade 2 fibrillary astrocytoma
{Page 2} 3 years later
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History: 39 y/o woman with fluctuating visual deficits
for several weeks
475
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{Page 2}
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{Page 3}
TE 30 msec TE 144 msec
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Dx: Highly anaplastic astrocytoma
{Page 4}
TE 35 msec
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MR Spectra Changes with Tumor Grade
As malignancy increases: NAA decreases Cr decreases Cho increases Lactate increases Lipids may increase
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History: 34 y/o man with headache and mental status changes
502
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{Page 2}
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Dx: GBM
{Page 3} 1 3
2
3
2 1
TE 35 msec
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History: 25 y/o woman with a well-controlled seizure disorder & 3-week
history of nausea & headaches
646
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{Page 2}
TE 30 ms
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Dx: Gliomatosis cerebri
{Page 3} 5 months later
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Effects of Radiation Therapy MR Spectroscopy
Low NAA Low Cr Low Cho High lipids High lactate
(Taylor JS, Langston JW, Reddick WE, et al. Int J Radiat Oncol Biol Phys 36:1251, 1996)
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High-grade Astrocytoma
Pre-treatment
6 Years s/p Radiation
Neuroimaging Clinics, November, 1998
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History: 53 y/o man 9 weeks s/p XRT & chemo for a GBM
520
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{Page 2}
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{Page 3}
TE 35 msec
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{Page 4} 4 months later
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Dx: Recurrent GBM
{Page 5}
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Other Brain Tumors
Metastases ↑ choline, ↓ NAA, ↑ lipids
Lymphoma ↑↑ choline, ↓ NAA, ↑ lipids
Meningioma ↑ choline, no NAA, ↓↓ creatine ↑ alanine (1.48 ppm) ↑ glutamates ( and at 2.0-2.4 ppm;
at 3.8 ppm) PNET
Very high choline
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History: 31 y/o woman with nausea, vomiting, and altered mental status
685
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Dx: Metastatic Adeno CA Lung
{Page 2}
TE 30 ms
TE 144 ms
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History: 41 y/o man with a right hemiparesis & speech difficulty
621
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{Page 2}
TE 35 msec
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Dx: Primary CNS Lymphoma
{Page 3}
CBV
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Three volumes 3100 pages
4700 images
www.clinicalmri.com
+
Chapter 43 - Perfusion and MRS for Brain Tumor Diagnosis by Meng Law, NYU
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History: 56 y/o man with new onset of seizures
491
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{Page 2}
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Dx: Meningioma
{Page 4}
Glx
& Glx
Alanine
Lactate TE 35 msec
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History: 42 y/o man with diabetes & a brain mass
495
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{Page 2}
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Dx: Tumefactive MS
{Page 3}
1 2
1
2 TE 35 msec
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History: 53 y/o woman with 4 days of headache, fatigue,
ataxia and poor memory
674
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{Page 2}
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{Page 3}
1
2
1
2
TE 35 msec
TE 35 msec
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Dx: Metastasis – Adeno CA Lung & chronic MS
{Page 4}
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Pathophysiology O2 oxidative phosphorylation ATP
PCr anaerobic glycolysis lactate Ischemia - disrupt cell electrical activity Infarction - compromise cell integrity Cell death depends on vascular supply (collateral
flow) & cell type (neurons > glia)
Cerebral Ischemia/Infarction MR Spectroscopy
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Cellular Energy Production
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History: 4 day old boy with low Apgars
726
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Dx: HIE
{Page 2} TE 35 msec
TE 144 msec
TE 144 msec
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498
Newborn with low APGAR scores
T1W
T2W
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{Page 2}
T2W
1
2
1
2
TE 35 msec
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Dx: Severe HIE
{Page 3}
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The Developing Brain A Changing Spectrum
Less NAA
Increased choline and myo-inositol
Progression to adult pattern follows myelination
Danielsen & Ross, MRS Diagnosis of Neurological Diseases, Marcel Dekker, Inc. 1999
Newborn
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History: Newborn with high pitched
cry after difficult delivery
488
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Dx: Normal newborn
1
2
{Page 2}
1
2
TE 35 msec
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Dx: Normal fetal MRS – mega cisterna magna
History: 24 week fetus with intracranial fluid
on ultrasound
695
TE 35 msec
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MRS of Trauma
Diffuse axonal shear
injury
Outcome correlates with NAA/Cr ratio
Any lactate or lipid = worse prognosis
5 days
4 months
Danielsen & Ross, MRS Diagnosis of Neurological Diseases, Marcel Dekker, Inc. 1999
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History: 68 y/o woman with chronic MS
479
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{Page 2} 1
2 2
1
TE 35 msec
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Dx: Gliosis - brain scar
{Page 3}
TE 35 msec
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Inflammatory/Infectious Brain Disorders (MRS)
Pyogenic abscess/cysticercosis/hydatid cyst Resonances from lactate, amino acids(0.9ppm),
alanine(1.5ppm), acetate(1.92ppm) & succinate(2.4ppm) No NAA peak
Tuberculoma: resonance from lipid due to caseous material
(Poptani H, Gupta RK, Jain VK, et al. Magn Reson Imag 13:1019, 1995)
(Gupta RK, Poptani H, Kohli A, et al. In J Med Res 101:19, 1995)
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Pyogenic Brain Abscess
AJNR 16:1593, 1995
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Pyogenic Brain Abscess
Courtesy of ED Gotsis, PhD, Euromedica, Athens, Greece
Acetate
Alanine
Lactate
Amino Acids
TE 35 msec
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History: 87 y/o woman on treatment for abdominal lymphoma
780 - 14316798
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Dx: Abscess (Nocardia & Gram + rods)
{Page 2}
Acetate Alanine Lactate
Succinate
TE 35 msec
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History: 38 y/o HIV+ male
with headache & weakness
505
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{Page 2}
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Dx: Toxoplasmosis
{Page 4}
1 2
2
1
TE 35 msec
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History: 67 y/o woman with progressively altered mental
status over several days
725
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Dx: Probable ADEM
{Page 2} Bronchitis 3 weeks earlier
TE 35 msec
TE 144 msec
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Pediatric Metabolic Brain Disorders (MRS)
Canavan’s disease Markedly increased NAA
Leigh’s, MERRF, MELAS Mitochondrial disorders Markedly increased lactate Ketones at 2.2
Peroxisomal disorders Increased sI @ 3.35 (syllo-inositol)
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Canavan’s Disease
TE = 30 TE = 270
Danielsen & Ross, MRS Diagnosis of Neurological Diseases, Marcel Dekker, Inc. 1999
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History: 7 month old boy with marked developmental delay
418
T2-weighted FLAIR
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{Page 2}
T1-weighted images
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Dx: Leigh's disease with metabolic acidosis
{Page 3}
Ketones
Ketones
Lactate
Lactate
TE 35 msec
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History: 41 y/o diabetic with headache, lethargy & inappropriate behavior
606
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{Page 2}
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Dx: Streptococcal abscess & diabetic ketoacidosis (venous pH = 7.28)
{Page 3}
2
1 3
1
3
2
Ketones (2.2 ppm)
Ketones
TE 35 msec
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Hepatic Encephalopathy
Missing myo-inositol
Reduced choline
Increased glutamine
Danielsen & Ross, MRS Diagnosis of Neurological Diseases, Marcel Dekker, Inc. 1999
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History: 62 y/o woman with hepatitis C, chronic alcoholism and increasing dementia
following liver transplantation
677
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Dx: Marchiafava Bignami disease
{Page 2}
TE 35 msec
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Human Dementia (MRS)
Alzheimer's disease: reduced NAA, elevated myo-Inositol
Disease theories:
1. β-Amyloid theory 2. Cholinergic hypothesis 3. Apolipoprotein E theory 4. Inositol hypothesis
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MRS in Dementia
Normal patient
Alzheimer disease
Danielsen & Ross, MRS Diagnosis of Neurological Diseases, Marcel Dekker, Inc. 1999
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