module no:306, 3 rd floor, phase2, ticel bio park, taramani, chennai - 600 113| dr. cn ramchand...
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Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com
Dr. CN RamchandCEO,
Saksin lifesciences Pvt. Ltd
Chennai & San Francisco
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 2
My experien
ces
Funding and development of biotech start-
upsOverview-India
& in Kerala
General outline
Vice President & Head of New Drug Discovery
Director & World Wide executive member
Chief Scientific Officer
President and CEO
President & CEO Advisor Advisor
Education
Early days
Semi-
Entrepreneur
Entrepreneur
Scientific publications= > 150
Patents => 60Conferences organized => 8
Nanoparticles for biological applications
Curcumin based products The Fish oil story
Value added basic research
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 5
Major players in the country
Advantage IndiaSkilled manpower
Large consumer base
Government funding/Venture funding
Good IT support
English proficiency Raw materials aplenty
Ancient knowledge
Ecological /Cultural diversity Agricultural base strong
Indian biotech in global contextLeadership vacuum
Publications and Patents still less
Research in Industry not significant yet
No dialogue between academics and industries
Less number of startups
Academia not ready to take risk for a venture
Less number of R&D Institutes & Universities
Shortage on mentors, advisors
Lack of awareness about opportunities
One mentionable pointUniversity’s role in supporting Innovation & Entrepreneurship
Spun off from Oxford University in 1993
Spun off from Oxford University in 1959
Spun off from Cavendish Laboratory at
the University of Cambridge in 2000
Spun off from Carnegie Mellon
University in 1994
Country Period No. Spinouts
US 1980-2003
4543
Canada 1962-2003
1100
France 1984-2005
1230
Netherlands 1980-1990s
300
Australia 1984-1999
97
UK 1981-2003
1650
Columbia University- >100 spin offs
Roadmap to success
Learning by example
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 15
Reverse pharmacology
Conventional drug discovery
Associated issues
Strategy
Curcumin
Capsaicin
6-Gingerol
Lycopene
Resvertrol
Diallyl sulphide
Indole-3-carbinol
Source SourceActive Phytochemical Active PhytochemicalApplication Application
Caffeic acid phenethyl ester
Anti-inflammatory, antioxidant, antiamyloid,antiarthritic.
Long-term analgesic,
anti-inflammary, anti-psoriasis.
Antitumor,anti-carcenogenic,
antiarthritic.
Strong antioxidant, Anti-inflammatory,
anti-HIV.
Anti-ageing, antioxidant, antidiabetic.
Neuroprotective,Cardioprotective
antidiabetic, antiviral.
Inhibits H. pylori, anticarcinogenic.
Anticarcinogenic, antioxidant,
antiatherogenic.
Antimicrobial, antioxidant.
Anti-inflammatory, antimitogenic,
antifungal.
Sulphoraphane
Epicatechin gallate
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 19
Development of Novel biologics at Saksin Lifesciences
Wet AMD
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com
Age related AMD
Dry, or Atrophic or Non-neovascular macular degeneration
Wet or Exudative or Neovascular macular degeneration
Abnormal blood vessels begin to grow underneath the retina
Blood vessels may leak fluid or blood, blurring or distorting central vision.
Macula
Optic disc
Wet AMD Dry AMD
Fovea centralis
Disease causing factor
Receptor in eyesDisease causing factor Disease complex formed
AMD
Anti-VEGF Fab
Disease causing factor
No AMD
No complex formed
Mechanism of the novel drug
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com
DNA extraction using magnetic nanoparticles
Magnetic nanoparticles
DNA extractionMagnetic
nanoparticles
using
Applicable to various biological systems
Quick and robust
Can be performed without using sophisticated instruments
High yield and purity Easy to use for large number of samples
Patent application number5676/CHE/2014
UK patent application GB 2455780.
Patent application number1067/MUM/2006
GM crops, Micro-propagation, Bio-fertilizers & Bio-pesticides, Animal Improvement
r-DNA Products, Vaccines & Diagnostics, Monoclonal Antibodies, Stem Cells, Tissue Specific delivery methods
Enzymes , Fermentation based Products & Food, Biotech Instruments & Equipment, Bio-energy & Bio-fuel,
Bioinformatics, Bio-mining
Soil & Water remediation, Bio-safety & GMOs
Viable applications
Healthcare
Agriculture
Environment
Industry
Technology development funds Technology in-licensing funds
Market entry funds Funds for patent protection
Technology scale-up/validation/de-risking funds
Expansion funds
Funding
Government of
India/Kerala
Venture capitalist
For more information visit :http://
www.venturecenter.co.in/funding
Department of Scientific & Industrial Research (DSIR)
Ministry of Micro Small Medium Enterprises (MoMSME)
Department of Science and Technology (DST)
National Innovation Foundation (NIF)
Kerala Venture Capital Fund
National Research Development Corporation (NRDC)
Department of Bio-Technology (DBT)
World Bank & ICICI Bank collaboration
Bill and Melinda Gates Foundation
Amrita Vishwa Vidhyapeetham- TBI
Major funding sources
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 32
Biotechnology in India/Kerala-Thrust areas
Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 33
Advantage Kerala
Prebiotics & Probiotics Agri-foods
Pharmaco-genomics
and Nutri-
genomics
FCR enhancers
Regional Research Laboratory, Thiruvananthapuram
Kerala Forest Research Institute, Peechi
Kerala Agricultural University, Vellayani
Central Tuber Crops Research Institute,
Thiruvananthapuram
Central Institute of Fisheries Technology,
Ernakulam
Rubber Research Institute of India,
Kottayam
Central Coir Research Institute,
Kalavoor, Alappuzha
Central Marine Fisheries Research Institute, Ernakulam
National Research Center for Oil Palm (Regional Center), Palode,
Thiruvananthapuram
Indian Cardamom Research Institute,
Myladumpara, Idukki
Indian Institute of Spices Research, Kozhikode
Central Plantation Crops Research
Institute, Kasargod
Regional Cancer Center,
Thiruvananthapuram
Center for Water Resources Development and Management,
Kunnamangalam, Kozhikode
Major research institutes in
Kerala