module 5 pharmaceutics. 1. ra 8203 was signed into law on: a.september 4, 1996 b.september 13, 1988...
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MODULE 5 Pharmaceutics
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1. RA 8203 was signed into law on:
A. September 4, 1996B. September 13, 1988C. October 4, 1996
D. September 13, 1986E. September 4, 1992
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2. A complete pharmacy internship program based on RA 5921 article III section 18c shall consist of at least: A. 480 hours
B. 960 hoursC. 160 hours
D. 980 hoursE. 940 hours
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3. This means a method of secret writing that substitutes other letters or characters for the letter intended, or transpose the letter after arranging them in blocks or squares.
A. CodeB. CipherC. Secret Keys
D. SubstitutionE. NOTA
CODE – system of words or other systems arbitrarily used to present wordsSECRET KEYS – characteristic styles or symbols kept from the knowledge of others or disclosed confidentially to only one or a few
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4. RA 3720 is also known as:
A. Pharmacy LawB. Consumer Act of the PhilippinesC. Food, Drugs, Cosmetics and Devices ActD. Senior Citizens ActE. Special Law on Counterfeit Drugs
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5. Amount of morphine subject to life imprisonment to death penalty and a fine of 500,000 pesos to 10M pesos:
A. 500gB. 50gC. 10g
D. 1gE. 20g
MARIJUANA – 500 g SHABU – 50 g
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6. Ratio of the weight of a substance to the weight of an equal volume of another substance taken as a standard.
A. DensityB. Specific gravity
C. Optical ActivityD. Refractive index
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7. Compute for the specific gravity of potassium dichromate (K2Cr2O7) if its weight t in air =5.76g and its weight in oil 3.08g. The sp.gr of the oil is 0.86.
A. 1.86B. 1.85
C. 1.87D. 1.88
Sp. Gr = [ wt. in air/ (wt. in air – wt. in oil)] x sp. Gr of oil
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8. Floatation method for the determination of specific gravity is based on whose scientist’s principle?
A. AristotleB. Newton
C. EinsteinD. Archimedes
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9. A type of hydrometer which is used to determine the alcohol strength of any liquid containing only alcohol and water.
A. Falle’s hydrometerB. Baume hydrometer
C. Thalles’ hydrometerD. Nicholson’s hydrometer
Baume hydrometer – used for liquid heavier or lighter than waterNicholson’s hydrometer – type of hydrometer with constant depth of immersion but variable weight. Other examples of such will be Fahrenheit hydrometer, Lovi’s bead
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10. A method of expressing concentration where in concentration is directly proportional to the moles of solute and inversely proportional to the volume of solution
A. %w/vB. %w/w
C. MD. m
M – symbol for MOLARITYm – symbol for MOLALITY
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11. The pH value is calculated mathematically as the:
A. Log of the hydroxyl ion (OH-) concentration.B. Negative log of the OH- concentration.C. Log of the hydrogen ion (H+) concentration.D. Negative log of the H+ concentration.E. Ratio of H+ /OH- concentration.
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12. Which property is classified as colligative?
A. Solubility of a soluteB. Osmotic pressureC. Hydrogen ion (H+) concentrationD. Dissociation of a soluteE. Miscibility of the liquids
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13. Which equation is used to predict the stability of a drug product at room temperature from experiments at accelerated temperatures?
A. Stokes equationB. Young equationC. Arrhenius equationD. Michaelis-Menten equationE. Hixson-Crowel l equation
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14. The pH of a buffer system can be calculated with the:
A. Noyes-Whitney equationB. Henderson-Hasselbalch equationC. Michaelis-Menten equationD. Young equationE. Stokes equation
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15. Based on the relation between the degree of ionization and the solubility of a weak acid, the drug aspirin (pKa 3.49) will be most soluble at
A. pH 1.0B. pH 2.0C. pH 3.0
D. pH 4.0E. pH 6.0
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16. Normally, how many % of water is contained in a hard gelatin capsule?
A. 8-10B. 12-16C. 20-25
D. 2-5E. 5-10
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17. The largest size of hard, empty gelatin capsule that can be swallowed is:
A. 00B. 000C. 1
D. 5E. 0
The smaller the number the bigger the capsule
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18. This chemical agent is used to render the capsule opaque
A. Titanium dioxideB. SorbitolC. Magnesium oxide
D. SilicaE. Lactose
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19. This is a method of preparing tablets in which the powder mixture is compacted in large pieces and subsequently broken down or sized into granules
A. Wet granulationB. Dry granulationC. Direct compression
In dry granulation, the powder mixture is slugged or compressed into large flat tablets or pellets of about 1 inch in diameter. The slugs are broken up by hand or by the mill and pass through a screen.
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20. The following statement/s is/are true for wet granulation method:
I. Liquid binder is added to the powder mixture to facilitate the adhesion of the powder particles
II. Over-wetting of the powder can result in granules that are too soft for proper tableting and under wetting can result in tablets that are too hard and tend to crumble
III. Granules may be dried in thermostatically controlled ovens which constantly record the time, temperature and humidity
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21. Amount of shabu subject to life imprisonment to death penalty and a fine of 500,000 pesos to 10M pesos:
A. 10gB. 20gC. 50g
D. 100gE. 5000g
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22. An ordinary prescription shall be preserved for a period of_______.
A. 5 yearsB. 1 year
C. 3 yearsD. 2 years
5 years – POISON1 year – DANGEROUS DRUGS
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23. When the generic name and brand name are NOT legible, this is a/an___________ prescription.
A. ViolativeB. Erroneous
C. ImpossibleD. NOTA
Impossible prescription:•Only the generic name is written but is NOT legible•Generic name does NOT correspond with the brand name•Both generic and brand name are NOT legible•Drug product prescribed is NOT registered with the BFAD
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24. Supplies or medicines to be given to senior citizen should not exceed
A. One day supplyB. One week supply
C. One month supplyD. One year supply
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25. Most biological are stored at this temperature:
A. 2 – 8°FB. 12 – 8°F
C. 2 – 8°CD. 12 – 8°C
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26. LAL stands for:
A. Limulus Antibiotic LysateB. Lyophilized Antibiotic LysateC. Limulus Amoebocyte LysateD. Lyophilized Amoebocyte Lysate
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27. The normal moisture content of hard gelatine capsules:
A. 2 -5%B. 12 – 16%
C. 20 – 24%D. 25 – 30%
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28. When the generic name is not written in a prescription, this is a case of:
A. Violative prescriptionB. Erroneous prescription
C. Impossible prescriptionD. NOTA
Violative prescription:
•Generic name is NOT written•Generic name is NOT legible and brand name is legible•Brand name is INDICATED and instructions added (e.g. “NO SUBSTITUTION”)
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29. “Rule of Thumb” is the principle applied for testing:
A. AmpulesB. Implantations
C. VialsD. Compressed Tablets
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30. It refers to the release or movement of the components of the plastic container into the contents:
A. SorptionB. Absorption
C. AdsorptionD. Leaching
Sorption and Absorption – refers to the binding of drug molecules to the polymer material of the plastic container
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31. It states that vapor pressure of component is equal to its mole fraction times vapor pressure in the pure state at that same temperature.
A. Raoult’s lawB. Henry’s law
C. Charles’ lawD. Fick’s law
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32. Which of the following is not a colligative property?
A. Boiling point elevationB. Freezing point depressionC. Vapor pressure elevationD. Osmotic pressure
- vapor pressure LOWERING
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33. Dissociation constant for substances that dissociates into 5 ions
A. 4.2B. 1.8
C. 3.4D. 2.6
B – 2 ionsC – 4 ionsD – 3 ions
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34. Compute for the E value of Papaverine sulfate HCl (MW 376) which is a 2 ion electrolyte dissociating 80% in a given concentration.
A. 0.1554B. 0.1555
C. 0.1556D. 0.1557
E= (MW NaCl/i NaCl) x (i substance/ MW substance)E= (58.5/1.8) x (1.8/376)E= 0.15558 /0.1556
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35. A simplication of the White-Vincent method where the weight of the drug is fixed in 0.3g for one fluidounce of a 1% solution.
A. Modified White-Vincent methodB. Scowle’s methodC. Sprowl’s methodD. Cryoscopic method
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36. Dosage form made by compression or molding
A. TabletsB. Capsule
C. SyrupD. Suspension
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37. A characteristic of material for compression which describes the way the material flow thru the hopper
A. FluidityB. Compressibility
C. DrynessD. Particle size
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38. Spray drug lactose when used in direct compression can hold how many % of active ingredient?
A. 18%B. 15%
C. 20%D. 30%
It can hold 20-25% of the active ingredient
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39. Which of the following is not a glidant?
A. CAB-O-SILB. DL-Leucine
C. SyloidD. Talc
- It is solely used as an anti-adherent. (A), (C), & (D) are used as both glidant and anti-adherent. Glidants - improve flow property. Anti-adherent - prevents sticking & picking.
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40. Clays are limitedly used for what type of tablets due to its tendency to cause unwanted appearance?
A. White tabletsB. Colored tablets
C. BothD. NOTA
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41. Which solution is used as an astringent?
A. Strong iodine solution USPB. Aluminum acetate topical solution USPC. Acetic acid NFD. Aromatic ammonia spirit USPE. Benzalkonium chloride solution NF
Aluminum acetate - used as antiperspirants and wet dressings for contact dermatitisStrong iodine and Benzalkonium chloride – topical antibacterial solutionsAcetic acid - acidifierAromatic ammonia spirit – respiratory stimulant
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42. The particle size of the dispersed solid in a suspension is usually greater than
A. 0.5 μmB. 0.4 μmC. 0.3 μm
D. 0.2 μmE. 0.1 μm
A suspension is a two-phase system that consists of a finely powdered solid dispersed in a liquid vehicle
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43. In the extemporaneous preparation of a suspension, levigation is used to:
A. reduce the zeta potentialB. avoid bacterial growthC. reduce particle sizeD. enhance viscosityE. reduce viscosity
Levigation is the process of blending and grinding a substance to separate the particles, reduce their size, and form a paste.
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44. Which compound is a natural emulsifying agent?
A. acaciaB. lactoseC. polysorbate 20
D. polysorbate 80E. sorbitan
monopalmitate
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45. Rectal suppositories intended for adult use usually weigh approximately
A. 1 gB. 2 gC. 3 g
D. 4 gE. 5 g
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46. In the fusion method of making cocoa butter suppositories, which substance is most likely to be used to lubricate the mold?
A. Mineral oilB. Propylene glycolC. Cetyl alcohol
D. Stearic acidE. Magnesium silicate
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47. A very fine powdered chemical is defined as one that
A. completely passes through a #80 sieve.B. completely passes through a #120 sieve.C. completely passes through a #20 sieve.D. passes through a #60 sieve and not more than
40% through a #100 sieve.E. passes through a #40 sieve and not more than
60% through a #60 sieve.
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48. Which technique is typically used to mill camphor?
A. triturationB. levigationC. pulverization by
intervention
D. geometric dilutionE. attrition
Pulverization by intervention is the milling technique that is used for drug substances that are gummy and tend to re-agglomerate or resist grinding (e.g. camphor , iodine)
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49. The dispensing pharmacist usually blends potent powders with a large amount of diluent by
A. spatulationB. siftingC. trituration
D. geometric dilutionE. levigation
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50. Which type of paper best protects a divided hygroscopic powder?
A. waxed paperB. glassineC. white bond
D. blue bondE. vegetable parchment
Hygroscopic and volatile drugs are best protected by waxed paper , which is waterproof.
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51. This process is a form of pelletization, which refers to the formation of spherical particles from wet granulation
A. SpheronizationB. SluggingC. Spray chilling
D. Moist heatingE. Dry heating
•Slugging - a process in which the powder mixture is compressed into large flat tablet or pellet.
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52. Which excipient/s is/are used in the preparation of sugar-free chewable tablets?
I. Lactose II. Dextrose III. Xylitol
A. I onlyB. III onlyC. I and IID. II and IIIE. I, II, III
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53. This problem corresponds to the filling-in of the score line or indented logo on the tablet by the film.
A. PeelingB. PickingC. Orange peel effect
D. Mottling E. Bridging
•Peeling - appearance of large amounts of film fragments flaking from the tablet.
Picking – appearance of small amounts of film fragments flaking from the tablet.
Orange Peel Effect- pertains to the roughness of the tablet surface due to failure of spray droplets to coalesce.
Mottling- uneven distribution of color on the tablet surfaceBridging- Filling in of the score line or indented logo on the tablet by the
film.
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54. This type of dosage form allows a reduction in dosing frequency to that presented by a conventional dosage form
A. Extended releaseB. Delayed releaseC. Repeat Action
D. Modified ReleaseE. Targeted Release
Delayed release- designed to release the drug from the dosage form at a time other than promptly after administration.Repeat Action- Usually contains 2 doses of medication one for immediate and the second for delayed release.Targeted release - describes drug release directed towards isolating or concentrating a drug in a body region, tissue or site for absorption or for drug action.
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55. Yellow ointment is an example of
A. Hydrocarbon baseB. Oleaginous baseC. Absorption base
D. Water removable base
E. A & B
Hydrocarbon base is Oleaginous base
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56. The following ointment base/s is/are classified as hydrocarbon base/s
I. PetrolatumII. White ointmentIII. Polyethylene Glycol Ointment
A. I onlyB. I & IIC. I & IIID. III onlyE. I, II, III
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57. Polyethylene glycol Ointment, NF is:
A. Hydrocarbon baseB. Water Soluble baseC. Absorption base
D. Water Removable baseE. Oleaginous base
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58. These ointment base resembles cream in appearance
A. Hydrocarbon baseB. Water Soluble baseC. Absorption base
D. Water Removable base
E. Oleaginous base
Water removable bases are oil-in-water emulsion resembling creams in appearance. They are easily washed from skin and often called “water washable” base.
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59. These are semi-solid adhesive masses spread upon a backing material paper, fabric, moleskin or plastic
A. CreamB. PlasterC. Paste
D. OintmentE. Lotion
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60. The factor/s which play/s a part in percutaneous absorption is/are:
I. Molecular WeightII. Partitioning coefficientIII. Solubility
A. I onlyB. II onlyC. I & IID. II & IIIE. I, II, III
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61. In sugar coating of tablets, the greatest increase in the size of the tablet occurs at what stage of the process?
A. SealingB. SmoothingC. Color coating
D. Sub coatingE. Polishing
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62. Uneven distribution of color on the surface of tablets is:
A. PeelingB. MottlingC. Capping
D. LaminationE. Picking
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63. Strength of a product is expressed in terms of:
A. PotencyB. ActivityC. Toxicity
D. Therapeutic doseE. Lethal dose
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64. An example of a tetragonal crystal system is:
A. UreaB. Iodoform
C. IodineD. Sodium chloride
Iodoform – hexagonalIodine – rhombic
Sodium chloride - cubic
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65. These are properties which are dependent on the arrangement and to a lesser extent on the number and kind of atoms within a molecule:
A. IntensiveB. Colligative
C. ConstitutiveD. Extensive
Extensive – DEPENDENT on the quantity of matter in a systemIntensive – INDEPENDENT of the quantity of substance in the system (e.g. temperature, density, pressure, surface tension, viscosity)Colligative - e.g. Osmotic pressure elevation, vapor pressure lowering, Freezing point depression, and boiling point elevation
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66. These are solvents which are capable of acting both as proton acceptor and proton donor:
A. ProtophilicB. Protogenic
C. AmphiproticD. Aprotic
•Protophilic – solvents which are capable of accepting protons from the solute•Protogenic – solvent characterized to be proton-donating compound•Aprotic – solvents that neither accepts nor donate proton
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67. If a substance dissolves in a hundred to a thousand parts of solvent such substance is characterized to be:
A. SolubleB. Sparingly soluble
C. Slightly solubleD. Very slightly soluble
SOLUBILITY
Soluble 10 – 30 parts
Sparingly soluble 30 - 100 parts
Slightly soluble 100 – 1000 parts
Very slightly soluble 1000 – 10000 parts
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68. This is also known as the “shear thinning systems”
A. PseudoplasticB. Dilatant
C. ThixotrophicD. Rheopectic
Dilatant – “shear thickening system”Thixotrophic – gels and magmas when standing form semisolids and on shaking become fluid
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69. A phenomenon where in a gel takes up liquid without an observable increase in volume:
A. SweatingB. Syneresis
C. SwellingD. Imbibition
Syneresis – phenomenon in which the liquid portion of a gel is pressed outSwelling – process which involves the taking up of liquid by a gel with an observable increase in its volume
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70. This type of solution has a solute concentration equivalent to its limit of solubility
A. UnsaturatedB. Saturated
C. SupersaturatedD. NOTA
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71. Breaking down of materials by rubbing action between 2 surfaces.
A. AttritionB. Rolling
C. ImpactD. Scratching
Rolling - uses heavy rolling to crush materials. Impact - employs hammer/bars at high speed to break material.
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72. All are type of plastic containers, EXCEPT;
A. PVCB. PET
C. PPD. PD
PVC - polyvinyl chloridePET – polyethylenePP - polypropylene
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73. At what percent is is benzalkonium chloride used?
A. 0.2%B. 0.1%
C. 0.001%D. 0.002%
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74. A cool place would be
A. <8CB. 2-8C C. 8-15C
D. -20 - -15C
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75. Composition of the council of pharmaceutical education, EXCEPT;
A. Secretary of EducationB. Dean of UP College of PharmacyC. BFADD. DOST Secretary
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76. Qualification for Board examination, except;
A. Citizen of the PhilippinesB. Moral characterC. Completed internshipD. BS Pharmacy graduateE. NOTA
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77. Revocation of LTO may be due to the following except;
A. Selling of drug with “not for sale” markB. Failure to properly record dangerous drugsC. Absence of pharmacistD. AOTAE. NOTA
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78. RA 7432
A. Senior Citizen’s ActB. Pharmacy Law
C. Generic’s ActD. Dangerous Drugs Act
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79. RA 6425
A. Senior Citizen’s ActB. Pharmacy Law
C. Generic’s ActD. Dangerous Drugs Act
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80. RA 6675
A. Senior Citizen’s ActB. Pharmacy Law
C. Generic’s ActD. Dangerous Drugs Act
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81. A certain drug is considered counterfeit if it contains less than how many percent of the active ingredient it purports to posses?
A. 80B. 75C. 60
D. 85E. 90
Counterfeit drug/medicine refers to a drug which contains no amount of, or different active ingredients or less than eighty percent of the active ingredient it purports to possess (RA 8203, Section3)
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82. For how many years shall the Chairman and members of the Board of Pharmacy hold office after appointment?
A. 3B. 4C. 5
D. 6E. 2
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83. Any person who shall be employed as detailman by any pharmaceutical establishment shall be required to register with the:
A. PRCB. BFADC. Board of PharmacyD. DOHE. Council of Pharmaceutical Education
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84. Every prescription for external use filled in the drugstore shall bear what label?
A. Red labelB. White labelC. Red label showing in blank ink the components
and the word “External Use Only”D. White label showing red ink the Word “External
Use Only”E. NOTA
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85. The pharmacist examination shall consist of the theoretical examination on the subjects in:
A. ChemistryB. Biological ScienceC. Pharmacy
D. A and C OnlyE. AOTA
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86. The book kept for the purpose of recording the sale of poisons shall be open at all timed for inspection and shall be preserved for a period of at least __________ years after the last entry.
A. 1B. 2C. 3
D. 5E. 7
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87. The following substances are included in the list of violent poisons stated in RA 5921:
A. AtropineB. NitrobenzeneC. Strychnine
D. B and C onlyE. AOTA
Also include in the list are arsenical preparations, phosphorus, corrosive sublimate, hydrocyanic acid or prussic acid and such other poisonous substances which may be classified as violent by BFAD (RA 5921, Article IV, Section 34)
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88. This means a system of words or other systems arbitrary used to present words.
A. CodeB. CipherC. Secret Keys
D. SubstitutionE. NOTA
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89. The term Secretary, in RA 3720, means:
A. Secretary of DOHB. Secretary of Dept of Commerce and IndustryC. Secretary of EducationD. Secretary of Department of Agricultural
ResourcesE. AOTA
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90. Under RA 3720, if a food bears or contains any poisonous or deleterious substances which may render it injurious to health, it is deemed to be:
A. PoisonB. AdulteratedC. Misbranded
D. CounterfeitE. Hazardous
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91. If the seized drug was found to be counterfeit, the business establishment must be directed for preventive closure for a period of:
A. 15 daysB. 10 daysC. 30 days
D. 20 daysE. 60 days
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92. If the counterfeit drug is the proximate cause of death of the victim who unknowingly purchased and took the counterfeit drug, the penalty to be imposed shall be:
A. Life imprisonmentB. Fine of 500,000 to 5M PesosC. Fine of 100,000 to 10M PesosD. A & B OnlyE. A & C only
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93. The council of Pharmaceutical Education was created for the implementation of RA 5921. This council is composed of:
A. Secretary of Education B. BFAD administrator C. Chairman of the Board of PharmacyD. A & CE. AOTA
Other members are Undersecretary of Health Service, Dean of UP College of Pharmacy, Deans of the Colleges of Pharmacy representing duly, accredited private schools of pharmacy and a representative of a bona fide national pharmaceutical organization of the Philippines.
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94. If found guilty of neglect of duty, incompetence, malpractice or unprofessional or dishonorable conduct, after having been given the opportunity to defend himself in an administrative investigation, the Chairman or members of the Board may be removed by:
A. President of the PhilippinesB. Chairman of the Council of Pharmaceutical
EducationC. BFAD administratorD. PRC ComissionerE. Civil Service Commissioner
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95. Any person who shall be employed as detailman by any pharmaceutical establishment shall be required to register with the
A. PRCB. BFADC. Board of PharmacyD. DOHE. Council of Pharmaceutical Education
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96. Every prescription for external use filled in the drugstore shall bear what label
A. Red labelB. White labelC. Red label showing in black ink the component
and the words “For external use only”D. White label showing in red ink the word “For
external use only”E. NOTA
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97. The book kept for the purpose of recording the sale of poisons shall be open at all times for the inspection and shall be preserved for a period of at least ____ years after the last entry
A. 1B. 2C. 3
D. 5E. 7
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98. RA 3720 was signed into law on:
A. June 22, 1963B. June 22, 1969C. June 23, 1969
D. July 22, 1969E. July 22, 1963
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99. Prescription of Dangerous Drugs are written in:
A. DuplicateB. Triplicate C. One copy
D. Four copiesE. NOTA
one original, 2 duplicates ( Original- pharmacist, 1 copy- patient, 1 copy- practitioner)
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100. Head of the PDEA
A. Secretary of HealthB. Director GeneralC. NBI Chief
D. PNP ChiefE. BFAD Director