mnews 3 - mis magazine

MC-MMAG3 Rev.1

BONDBONETM - A NEW GRAFTING MATERIAL PAGE 06

2nd Quarter, 2011

INTERNATIONAL MAGAZINE®

COMPLETE PROSTHETIC KIT PAGE 15

PAGE 22ARE YOU SURE?

Dear Friends,

We are proud to introduce the third issue of MNEWS international magazine. This edition of MNEWS contains information about new innovative products and services of MIS such as: bone regeneration materials, computer guided implantology and new tools for an easy and precise restoration. As in previous issues, we are sharing with you some of our recent clinical researches and an insight on our quality assurance and regulation affairs department. You will also find initial information about MIS’s first global conference which will take place in Cancun, Mexico on May 2011, looking forward to seeing you there.

Best regards,

Idan KleifeldCEO

2 MNEWS 2nd Quarter, 2011

Published by MIS, which reserves the right to ameliorate the products described in this manual as well as to revise this publication at any time and without informing any person of such revision or change. All rights reserved. No part of this publication may be reproduced, transcribed, stored in an electronic retrieval system translated to any language or computer language, or be transmitted in any form whatsoever without the written consent of the publisher.

CONTENTS.

08

16

22

34

Printed on 135gsm inside pages, 250gsm cover.

World Symposium in Cancun, Mexico

New MIS Kits

Fully Guided Implantology Using the Mguide System from MIS

Bone Grafts and Dental Implants

04The MIS biomaterials line features our unique collagen membrane and fully synthetic bone substitute.

BIOMATERIALS

Enables optimal procedures, fast and complete resorption

BONDBONE™ New Bone Graft Material

06

Complete Prosthetic Kit

CPK15

Research19

QA & RA Department Vice President Interview

Quality Control26

MIS Exhibitions31

Distributor Contact Information

36

© 2011 MIS Corporation. All rights reserved.

When you have finished with this, please recycle it


The MIS Bone augmentation materials include a line of fully synthetic Bone Grafts: 4BONE HA & ßTCP, bi-phasic calcium sulfateand a membrane made of collagen type I & II of porcine origin.

4BONE RCM – Resorbable Collagen Membrane

4BONE RCM is a resorbable porcine skin-sourced collagen membrane used for guided bone regeneration (GBR) and guided tissue

regeneration (GTR). It is indicated for use in oral surgery procedures, to help facilitate the healing process. The unique cross-linkage technology enables the membrane to maintain a functional barrier for four to six months. 4BONE RCM is derived from porcine collagen, which has been successfully used in a variety of medical

and dental applications for many years due to its high degree of biocompatibility. Porcine tissue is viewed as the material of choice in many medical xenograft procedures. In the literature, it has been demonstrated that the immunogenicity of porcine collagen is very low (lower than seen with bovine collagen). Porcine

BONE GRAFTS AND MEMBRANES

MIS presents the 4BONE RCM - a resorbable collagen membrane and the 4BONE - a synthetic bone graft.

4BONE

Focus on


For more information about MIS Bone augmentation materials, please see www.mis-implants.com/bb

collagen also avoids many of the issues related to bovine spongiform encephalopathy (BSE).

Purified collagen types I and III from skin are used for 4BONE RCM. Mechanical strength is assured as the fibrous structure is conserved. Cross-linkage is achieved by submersion in the cross-linking reagent. It creates chemical bonds between the molecules and enhances the resorption time.

Neutralization eliminates the residual cross-linker. Chemical analysis of residual reagent. The unique collagen cross-linkage technology provides excellent resorption control, allowing sufficient time for osseous defects to achieve optimum bone regeneration. We can directly control the level of collagen cross-links

to affect the longevity and degradation profile of the material.

4BONE RCM permits the diffusion through microporosity of fluids and nutrients related to soft tissue health. Cross-linkage technology differs from one membrane to the next, and these differences considerably influence the degradation of the membrane over time. 4BONE RCM degradation has been tested in animal models.

4BONE – Synthetic Bone Graft

4BONE is a fully synthetic bone graft with optimized

morphology, forming an ideal habitat for architectural vital new

bone to grow in. It is composed of HA (60%) and ßTCP (40%). A permeable interconnected micro and macro porosity promotes invasion of osteogenic cells by osteoconduction, which permits the diffusion of biological fluids, leading to fast formation of bone. The optimized morphology and resorption properties enable predictable treatment outcomes.

The d i s t r i b u t i o n o f t h e macroporosity and microporosity (70% macroporosity and 30% microporosi ty, which are interconnected) is of great importance for the colonization of the biological fluids. 4BONE has both microporosity and macroporosity, in contrast to

most other ceramics, which are only macroporous.The 4BONE’s global porosity is 70%, and

the combinated macroporous and microporous structure is compatible with the bone generating cell size. Permeability is obtained via interconnected microspores, which allow vascularization of the biological fluids into the granule. Once the biological fluids flow through the granule, the microporosity acts as a sieve that attracts the bone generating cells, allowing the formation of new bone from the inside of the granule (osteogenic).

By its nature, 4BONE publishes osteogenic properties. It helps regenerate bone cell tissue. 4BONE is integrated during the natural remodeling process of the human bone and is replaced by living natural bony crystals, similar to human bone. Chemically, the hydroxyapatite is a calcium phosphate that is as close as possible to the natural composition of the human bone mineral. The hydroxyapatite contained in 4BONE is wholly resorbable due to its small crystal size.

The macroporosity of 4BONE, of between 300 and 600 μm, is similar to bone type 2&3. This promotes a deep invasion of osteogenic cells through osteoconduction. Microporosity, with pores smaller than 10μm, is similar to bone type 1&3. The micropores are interconnected, allowing biological fluid diffusion distribution

Product manager of MIS bone augmentation materials.

Noam Sorek


When it comes to dental bone grafting, time is of the essence for dentists and patients alike. Rapid setting of the graft material followed by fast and complete resorption allow optimized procedures and improved outcomes. BONDBONE™ is a recently released synthetic osteoconductive, bioresorbable bone graft material developed to facilitate handling and reduce time in dental augmentation procedures. Composed of

biphasic calcium sulfate and delivered in a granulated powder form in 1cc and 0.5cc drivers, it is designed for filling, augmentation or reconstruction of bony defects in the oral and maxillofacial region. Thanks to a decade of technological advances, augmentation methods using materials in a granulated form from different sources, such as autographs, allografts, xenographs and alloplasts, are now

well-integrated in routine surgical dental care. With BONDBONE™, dentists have access to a new material that incorporates all the well-documented biocompatible, osteoconductive, and bioresorbable properties of calcium sulfate which offers several additional advantages.

BONDBONE™ - A NewGrafting Material

New from MISBONDBONETM - a recently released synthetic osteoconductive, bioresorbable bone graft material, developed to facilitate handling and reduce time in dental augmentation procedures.

Optimizing procedures and enabling complete regeneration of newly formed bone


Robust performance in extreme environments

BONDBONE™ is considered to be a breakthrough in the field of dental bone

grafting. It offers high performance with optimal healing, yet it contains absolutely no components other than pure, safe calcium sulfate, unlike other calcium sulfate-based materials that may contain additives such as polymers, to improve their bone grafting capabilities. Dentists working with BONDBONE™ for the first

time will notice an important difference right from the start: BONDBONE™ is the

only calcium sulfate material that can set in the presence of blood and saliva. The setting

time of approximately three minutes allows for outstanding handling properties. Patients

may also notice a difference: the reaction temperature of BONDBONE™ is lower than 30º C (85º F) and it has a neutral PH, thus reducing the patient’s discomfort during surgery. Additionally, because it is a synthetic material, it can help overcome patient objections to having material derived from animal or humans placed inside their bodies.

Excellent binder

BONDBONE™ is a versatile material that can be used in a variety of techniques. In addition to being used alone in a bone

regenerative technique, it can be mixed as a binder with other suitable bone-filling agents to prevent particle migration in an osseous defect. This creates an outstanding composite graft and allows predictable outcomes. BONDBONE™ can also be used as a resorbable barrier over other bone graft materials. BONDBONE™ enables a significant reduction in procedure time. The initial pliable paste hardens in two to five minutes allowing excellent handling time.

Osteoconductive

The unique porous structure of BONDBONE™ allows infiltration of growth factors through its micropores and angiogenesis, as well as cell proliferation through its macropores. It completely resorbs, leaving behind natural bone, at a rate that corresponds to the established bone generation rate of 4-10 weeks.

Advantages

▪ Moldable▪ Fast and efficient setting under blood and

saliva (2-5 min)▪ Preserves the 3D space▪ High crystalline percentage▪ Resorbtion rate equivalent to bone growth

(4-10 weeks)▪ Average reaction temperatue of 30ºc▪ neutral PH

BONDBONE™ - A NewGrafting Material

MIS has already launched the BONDBONE™ in 22 countries and gave doctors the opportunity to experience the product first hand.

BONDBONE™ Launch

BONDBONE Symbol & Syringe

BONDBONE™ Driver


AN EVOLVING RELATIONSHIP

BONE GRAFTS AND DENTAL IMPLANTS


According to several market surveys, there is a common trend for continuous growth in the bone graft market over the next few years. Do you agree, and what are the major factors contributing to this process?The trend is clear. We are constantly pushing the envelope by placing implants in severely complicated sites. Therefore, the need for bone augmentation procedures is continuously growing. Good results are achieved by applying available techniques to augment resorbed alveolar ridges to prerequisite widths and heights for proper implant position.

Patients are aware of the possibility of replacing their missing teeth with implants while rejecting both removable dentures and fixed partial dentures. Therefore, the application of bone grafts and membranes

is constantly rising. According to recent publications, 30 – 40% of implant procedures require some kind of bone augmentation; as the number of implants inserted worldwide is constantly rising, so does, evidently, the application of bone grafts.

In a recent study, Benić et al. (2009) compared five-year results of implants that were inserted either simultaneously with guided bone regeneration or standard implantation without bone regeneration. They showed that, clinically, implants placed with concomitant bone regeneration performed similarly to implants placed into native bone concerning implant survival, marginal bone height and peri-implant soft tissue parameters.

Bone grafting accompanying dental implant procedures are becoming increasingly common. MNEWS discussed the reasons for this trend with Professor Carlos Nemcovsky, a leading researcher and clinician with extensive experience in the field of bone grafts, the suitability of various types of bone graft and the benefits of each type of graft for different bone augmentation procedures. He also reviews the special advantages of BONDBONE™, the new bonding graft material from MIS.

Prof. Nemcovsky provides insight on the actual status of autogenous bone as the gold standard in bone augmentation procedures.


Technological advances over the past decade are leading to a new era in bone regeneration. Are allografts, xenografts and synthetic grafts capable of replacing autogenous bone for bone augmentation?

This is a complex question, for which we don’t really have a definite answer. Recent studies have shown that results of alveolar bone augmentation procedures, achieved with several bone grafts, are comparable to autogenous bone. A systematic review of randomized controlled clinical trials by Esposito et al. (2006), which evaluated the efficacy of various bone augmentation procedures for dental implants, concluded that bone substitutes may replace an autogenous bone even in extremely atrophic ridges. Jensen and Terheyden (2009) reviewed the clinical results with different bone grafts and bone substitute materials for bone augmentation procedures in localized alveolar ridge defects. They found that survival rates of implants placed in an augmented bone are comparable to rates of implants placed in a pristine bone. On the other hand, the autogenous bone is still considered the gold standard by several authors. However, the potential for intraoperative complications, donor site morbidity, poor quality or quantity of available bone, limited shapes and sizes of available grafts and fast resorption rate largely limit its application.

The faith and vitality of autogenous bone grafts is not clear. A study by Zerbo et al. (2003) showed that the majority of the osteocytes in autogenous bone grafts do not survive grafting, and that non-vital bone is progressively remodeled into vital bone; this process is apparently completed seven months after grafting. A series of articles by Polimeni et al. (2004, 2005), evaluating the prognostic factors for alveolar regeneration with GBR that significantly influence bone regeneration, reported that the two most important principles in bone augmentation procedures seem to be cell occlusion and space provision. Our research group has recently completed a research evaluating the added effect of an autogenous bone to mineralized bone allograft (FDBA). Our findings show that large vertical and/or horizontal

ridge deficiencies may be treated with FDBA and collagen barrier membranes with a good clinical outcome. However, no added effect of the application of a layer of autogenous bone in these bone augmentation procedures could be demonstrated.

Various augmentation materials such as autografts, allografts, xenograf ts, and alloplasts are available. Are there any advantages of slowly degradable or non-resorbable bone grafts over the others? Is there a definite indication of what bone graft to use for each procedure? Do you think that an ideal bone graft should resorb at a similar rate to bone regeneration?

Most of the bone grafts applied nowadays are mainly osseoconductive, with minimal inductive effects. The osteogenic potential of a bone defect considerably varies, depending on its extent and morphology. The characteristics of a single grafting material will not be suitable for all indications. In addition, these characteristics may influence the time needed for completion of the bone regeneration process.

Success of any bone augmentation procedure is largely dependent on four major corner


stones: presence of bone forming cells, primary wound closure, space creation, maintenance and angiogenesis. Therefore, the bone grafts and membrane should remain functional for a sufficient time, to allow new bone formation, especially in large non-self contained defects. If either one will resorb or disappear before new bone has been formed, the empty space will be replaced by soft tissue, leading to less than optimal results. It seems that small, enveloped, self contained defects may adequately heal with any kind of bone graft; the problem appears in cases where treatment of large horizontal or vertical alveolar ridge deficiencies is necessary.

Our research group published interesting comparative studies on the biomaterial resorption rate and healing site morphology of bovine bone mineral (BBM) and β-TCP in the dog model (Artzi et al. 2004). At 24 months, β-TCP was completely resorbed and BBM showed no significant resorption. However, it should be noted that new bone formation in β-TCP grafted defects did not accompany the resorption rate of the biomaterial. In esthetic areas, non-resorbable bone grafts such as xenografts, mostly from bovine origin, seem to be indicated. However, the biomechanical properties of this

Our research group has recently completed research evaluating the added effect of autogenous bone to mineralized bone allograft (FDBA).

Evaluating Research


newly regenerated bone have not been fully evaluated, therefore, certain concerns exist when this kind of graft is applied in largely atrophic stress-bearing areas. Porous Bi-phasic hydroxyapatite (HA) – tri-calcium-phosphate (TCP) compound bone grafts similar to 4-Bone® are resorbable synthetic bone grafts composed of two grafts with different characteristics, while the HA phase that composes 60% of the whole compound resorbs very slowly; the remaining TCP will resorb faster. The overall resorption rate of this material seems to accompany new bone tissue formation. Therefore, in indicated cases, improved results can be expected. In a recent study that evaluated sinus floor augmentation with hydroxyapatite/biphasic tricalcium phosphate graft materials in humans (Artzi et al. 2008), we concluded that biphasic HA/TCP presents excellent biocompatible

and osteoconductive properties.

Are grafts presenting adequate 3D stability for vertical alveolar ridge augmentations?

Several factors will influence the choice of a bone augmentation procedure, from which we can enumerate: defect characteristics; remaining bone volume; predictability; complexity and morbidity of the procedure; whether the bone graft can accomplish the three-dimensional support necessary for the case; complications rate; consequences and possibility for treatment in case they are present; total length of the treatment period until the final rehabilitation will be in the patient’s mouth; the surgeon’s experience and skill; and the cost.

Every surgical procedure presents advantages and disadvantages. Priority should be given to those procedures that are simpler and less invasive, involve less risk of complications, and reach their goals within the shortest time frame.

Bone blocks are mainly indicated for cases where 3D stability of the bone graft is required. However, application of these should be carefully evaluated and their extreme sensitivity to an adequate technique should be taken into consideration. Although originally, most blocks were autogenous and from different donor areas, a series of excellent studies recently published by Chaushu and Nissan

have shown the possibility of utilizing allogeneic bone blocks for alveolar ridge augmentation procedures with good clinical and histological results.

Evidently blocks have greater 3D stability and excellent results may be achieved, but their integration is slower than particulate grafts. However, complications in procedures with use of blocks may have more serious consequences than with a particulate graft.

Spontaneous exposure of bone blocks may lead to exfoliation of the whole block with an extremely negative outcome. In most cases, similar results can be achieved with particulate bone grafts, where 3D support is achieved by tenting screws and with a lower risk for complications with serious consequences. In our latest research, to be published in Clinical Oral Implants Research (Beitlitum, Artzi and Nemcovsky), only a particulate bone graft was used to treat large horizontal and/or vertical ridge deficiencies of over three millimeters in 50 patients.

A staged approach, where bone augmentation was performed prior to implant placement, was applied for extreme cases, where primary implant stability and predictable implant osseointegration could not be guaranteed.

For these cases, bone augmentation procedures were performed in the first stage, while implants were placed in a second procedure performed 5-7 months later. In certain cases with vertical ridge deficiency where a two-stage procedure was performed, supporting stainless steel screws were inserted in the treatment area, leaving part of their extension exposed and thus serving as supporting tenting posts.

Where needed, another bone augmentation procedure was performed together with implant placement. Results showed that large vertical and/or horizontal ridge deficiencies may be treated with mineralized bone allograft and cross-linked collagen barrier membranes with a good clinical outcome. The main parameter to negatively affect the degree of new calcified tissue formation was spontaneous membrane exposure, which happened in 24% of all the cases in this study.

The majority of alveolar bone defects require the application of bone graf ts. Are there defects where bone grafts are

mandatory and others where they are not?

Although this point has already been partially addressed, it should be clear that the two most important principles in bone augmentation procedures seem to be cell occlusion and space provision. We know that small, enveloped defects surrounded by bone walls will heal with no need for bone grafts or barrier membranes. However, in larger defects, those two principles must be achieved by the application of a bone graft that will support healing for the necessary period and avoiding in-growth of gingival tissues cells by the use of a barrier membrane.

Does physiological bone growth in young individuals have any effect on the resorption of a bone graft?

Data available from the effect of bone grafting in young individuals is mostly from cleft palate surgical treatment. Apparently, bone grafting in these patients is very successful. Bone healing in young individuals is faster; however, it is difficult to conclude that in these patients bone grafts will resorb faster with a negative effect on the overall process. We have no information as to which type of bone graft is the most convenient for these patients. Until we have definite scientific evidence, implant procedures in young patients should be delayed until most of the physiological development has occurred. Although bone grafting may be performed at an earlier age, final evaluation and implant placement should be performed later on.

Is the quality and quantity of new bone formation affected by bone type, bone quality, or remaining bone volume? How efficient is a bone graft as a space maintainer?

Quality and quantity of new bone formation are largely dependent on four major factors: presence of bone forming cells, primary wound closure, space creation and maintenance, and angiogenesis. Evidently, in cases where the remaining bone is sparse and/or composed of a large percentage of bone marrow, bone


forming cells may be sparse, thus leading to delayed new bone formation. Inductive materials are not yet clinically regularly applied, therefore, osteogenesis is based only on the presence of bone forming cells in the treatment area and the application of a conductive material that will allow their repopulation in the defect area. Largely atrophic ridges present a greater challenge, where all factors are extremely important. In these cases, an adequate bone graft and membrane that will allow for space provision and cell occlusion for a sufficient time are needed.

Use of calcium sulfate compounds for bone grafts has largely declined. Are there still any indications for the application of calcium sulfate in bone grafting procedures?

Calcium sulfate (known also as plaster of Paris) has been applied in oral surgeries for a long time. However, it is sparsely applied nowadays, apparently, due to the fast resorption rate and instability in blood and saliva. Calcium sulfate has a fast resorption rate and is apparently completely resorbed by the body in four to six weeks. In bone enveloped defects, this period could be enough to allow healing, however, those defects could also heal without grafting.

A recent study (Slater et al. 2008) showed that calcium sulfate

resorption in the human maxillary sinus is accompanied by calcium

phosphate precipitation, which may contribute to its biocompatibility and

rapid replacement by bone.

Calcium sulfate hardens after mixing it with water. However, excess of blood or saliva in the working area may impede proper crystallization and cause early dissolution. Use of calcium sulfate as the sole graft in bone augmentation procedures seems, therefore, extremely limited. Certain clinicians recommend it as a bone graft binder to achieve better stability, however, results have not always been supportive of this application, apparently due to the characteristics of the commercially available calcium sulfate products as previously mentioned.

Recently, MIS launched a novel biphasic calcium sulfate (BONDBONE™), composed of both hemihydrate and dihydrate phases. What are the most distinctive advantages of BONDBONE™ in implant surgery in regards to handling and the possibility of using it as a composite graft?

This calcium sulfate compound is relatively new in the market, therefore, no long-term scientific evaluation has yet been published. I am aware that several studies are being performed and that soon scientific evidence for its application will be available. This innovative material is composed of a two-phase calcium sulfate composite dispersed within each other in a unique and controlled particle size distribution. The hemihydrate phase has the advantage of being plastic and moldable immediately after being mixed with fluids, and may act as a cement used to bind other graft particles. However, it does not harden in contact with excess of fluids (such as blood or saliva), and therefore, it remains soft in the interface. It has a very low shearing and tensile strength and presents a fast resorption rate. On the other hand, the second phase, composed of dihydrate, presents high strength and a resorption rate similar to bone growth and it is stable in the presence of blood and saliva. However, it is not plastic and cannot be shaped to the desired form or used as particle binder. The idea behind this interesting product is that the dihydrate acts as a seed for particles, enhancing the hardening speed of the whole compound. BONDBONE™ is a novel, self-reinforced bone augmentation material, made from highly pure biphasic medical grade calcium sulfate. BONDBONE™ presents a fast and efficient setting under blood and saliva in two to five minutes, with a neutral PH. It can, therefore, be used as a particle binder and molded to the desired form in the treatment area. It does not release heat during hardening, and its hardened state has a high crystalline percentage and 46% porosity. Finally, the resorption rate is between four to ten weeks, which is similar to bone growth. Handling is extremely “user-friendly ” and once placed, it can be shaped to the desired form in the treatment area and immediately hardened by simple pressure with a dry gauze pad. Therefore, we may have, apparently, the advantage of 3D stability as we have with bone blocks, but with an easier application technique and faster integration.

A leading researcher and clinician with extensive experience in the field of bone grafts.

Professor Carlos Nemcovsky


PRECISE, SIMPLE AND EASY

®

M a k e i t S i m p l e

IT’S ABOUT TIME...MIS is proud to present BONDBONE™, a unique synthetic bonding-graft material, developed to facilitate handling and reduce implantation time in dental augmentation procedures.

You don't need to change your current graft material! Just add BONDBONETM in order to enhance the healing process. To learn more about BONDBONETM and MIS visit our website: mis-implants.com

© MIS Corporation. All rights reserved.

INNOVATION

TM

®

PRECISE, SIMPLE AND EASY

The Complete Prosthetic Kit is designed to implement the necessary professional cooperation between technicians and dentists. It contains all the necessary components for the dentist to take an impression after implementation, as well as all the elements used by the technician for fabricating custom-made crowns and bridges. Using the CPK ensures an accurate fit for the impression

procedure and the restorative process. It also enables a simple restorative process by offering three primary vertical height crowns (4-6-8 mm). Each of the height crowns has four additional Gingiva heights (1-2-3-4mm). This allows a wide variety of restorative options for standard and wide platform.

MIS recognizes the need for full collaboration between the dentist and the technician. The Complete Prosthetic Kit (CPK) introduced by MIS, is a comprehensive set designed for the full restoration of parallel inserted implants and restoration of a single implant case. The CPK features readymade components for an easy and simple impression and transfer. It provides a wide variety of esthetic options for the restorative process, due to the wide range of sizes that are offered.

A comprehensive set designed for full restoration on implants.

The CPK

CPK COMPLETE PROSTHETIC KIT


Prosthetic Planing Kit

Prosthetic Tool Kit

For a dental professional, minimizing chair and lab time and achieving better restoration results are of paramount importance. With this in mind, MIS has designed two new kits that enable doctors and lab technicians to provide patients with a better restoration in a shorter time frame.

NEW KITS FROM MIS MAKING RESTORATION SIMPLE


The MIS Prosthetic Planning Kit consists of replicas of the entire MIS superstructure range. The kit allows the doctor or the technician to test the superstructures in order to select the ideal size, diameter and shape of the superstructure on a case-by-case basis. The superstructure replicas are designed for quick, efficient and easy handling. They are made of titanium with color coding. Red signifies a standard platform, green signifies a wide platform, in accordance with MIS color coding. These replicas can be easily placed in either the analogs in the plaster model or the implant in the patient’s mouth, using a special snap-on screw technique.

The MIS Prosthetic Tools Kit, which was developed especially for doctors preforming implant restoration. Instead of modifying the regular surgical kit by including all necessary tools and removing those tools that aren’t required, the MIS Prosthetic Tool Kit consists of all the tools that are needed for a successful restoration. The kit consists of a torque wrench, a locator placing tool, and abutment holders that offer improved handling when prepping the abutment. MIS hex drivers and abutment indicators are also a part of the kit. The kit also includes additional tools to help ensure an easy restoration procedure.

MIS Prosthetic Planning Kit – Superstructure replicas

MIS Prosthetic Tools Kit – For successful restorations


ADThe MIS SEVEN implant is the only implant system in the world that comes with a specially designed and sterilized final drill, allowing a short and safe drilling procedure.

INNOVATION


The Innovative MIS Angulated Abutment

®

MULTI UNIT


The MIS R&D department performs ongoing research projects in cooperation with world-class scientists and engineers. These individuals are committed to the continuous development of advanced solutions and technologies for the global dental implant market. The department maintains a continuous cooperation with universities, research institutes and dental clinics all over the world. Laboratory and field studies are also conducted in the areas of tissue culture and tissue engineering, in collaboration with prestigious scientific laboratories and top university dental schools. MIS is proud to announce that towards the end of 2010 several prominent research and case studies have been published. These clinical publications are the outcome of several years of extensive clinical work. MIS places significant importance on research and continues to invested a great deal of resources in research and development. We would like to take this opportunity to present the worldwide spread of recent MIS scientific works that have significantly improved the quality and success of our products.

What’s New in the MIS Research Labs


Stella Chaushu DMD, MSc, and Gavriel Chaushu, DMD, MSc.

ABSTRACT

The surgical-orthodontic approach is the most commonly used modality in patients with impacted teeth. It is also the most challenging. The prognosis of treatment is uncertain, treatment takes much longer and is more painful, and the enhanced biomechanical efforts required to bring the tooth to its ideal position frequently cause deleterious side effects to the remainder of the dentition. Skeletal anchorage is a useful aid in these cases. It can be judiciously exploited to assess the prognosis of canine movement, open adequate space for the canine and build-up a reliable anchorage unit that will allow the application of controlled directional forces with fewer side effects on the anchorage teeth. Treatment is facilitated and shortened because the resolution of the impaction may be performed separately before or even simultaneously with treatment of the remainder of the dentition, as two distinct force systems. The present article reviews some of the main indications for implant anchorage in treatment of impacted teeth.

Skeletal Implant Anchorage in the Treatment of Impacted Teeth: A Review of the State of the Art

Published in Seminars of Orthodontics. 2010; 16(3)

Eran Gabay, DMD, PhD, Omer Cohen, DMD, PhD, Eli E. Machtei, DMD

ABSTRACT

Purpose. Preparation of a one-piece dental implant abutment is often needed to achieve a proper emergence profile for a definitive restoration. However, this procedure may compromise osseointegration through the production of heat. The aim of this study was to measure heat production during implant abutment preparation with different volumes of water irrigation using a one-piece implant system. Materials and Methods. Forty-five one-piece dental implants were used in this study. The implants were divided into three groups according to the water flow rate used during abutment preparation: 30 mL/min (G30), 15 mL/min (G15), and without water irrigation (G0). Thermocouples were positioned at the most coronal and most apical threads. The abutments were prepared using a high-speed dental handpiece. Preparation continued for 120 seconds or until the implant temperature reached 47°C. Results. The time needed to reach 47°C in the most coronal thread of group G0 was 5.73 ± 1.16 seconds. After the preparation was stopped at 47°C, the temperature continued to increase until reaching a maximum temperature. None of the implants in the water irrigation groups reached 47°C. The time needed to reach maximum temperature was significantly shorter for group G0 than the groups with water irrigation. A strong positive correlation was found between coronal and apical recordings. Conclusion. Prosthetic preparation of onepiece dental implants without irrigation induced a rapid increase in temperature. Water irrigation reduced heat production during abutment preparation in a dose-dependent manner. INT JORAL MAXILLOFAC IMPLANTS 2010;25:1131–1136

Heat Production During Prosthetic Preparation of a One-Piece Dental Implant

Published in The International Journal of Oral & Maxillofacial Implants (JOMI). 2010; 25(6)


Charles Marin, Rodrigo Granato, Marcelo Suzuki, Malvin N. Janal, Jose N. Gil, Carlos Nemcovsky, Estevam A. Bonfante, Paulo G. Coelho

ABSTRACT

This study characterized the interplay between topography/chemistry and early bone response of etched and non-etched resorbable blasted media (RBM) processed surfaces. Screw root form Ti.6Al.4V implants treated with alumina blasting / acid etching(AB/AE), RBM alone (RBM), and RBM + acid etching (RBMa) were evaluated. The surface was characterized by scanning electron microscopy, atomic force microscopy, and X -ray photoelectron spectroscopy. Implants placed in the tibia of dogs remained three and five weeks in vivo. Following euthanasia, half of the specimens were torqued to interface failure and the remaining subjected to bone-to-implant contact (BIC) and bone area fraction occupied (BAFO) between threads evaluation. The AB/AE surface was rougher than the RBM and RBMa. Higher levels of calcium and phosphorous were observed for the RBM surface compared to the RBMa. No significant differences were observed in torque, BIC, and BAFO between surfaces. Woven bone formation at three weeks and its initial replacement by lamellar bone at five weeks were observed around all implant’s surfaces.

Biomechanical and Histomorphometric Analysis of Etched and Non-etched Resorbable Blasting Media Processed Implant Surfaces - An Experimental Study in Dogs

Published in Journal of Mechanical Behavior of Biomedical Materials. 2010; 3(5)


Traditionally, surgical dental procedures were characterized by maximal

exposure of the alveolar bone. The basic thought was: “a good

surgeon makes a big opening and exposes the bone completely”.

This outlook didn t́ change for decades, until now. Minimally invasive

surgery is now entering the realm of dental surgery. Because of

new x-ray possibilities like DVT and 3D simulation, diagnosis is

more precise. Ahead of the surgery, the alveolar bone form and

structure are already known, so maximal exposure is not necessary

anymore. This interview explores a conservative implantologist’s view

of minimally invasive, fully guided implantology using the Mguide

system from MIS.

Dr. Martin NemecDr. Martin Nemec is a certified specialist in implantology and periodontology, digital volume tomography and aesthetic dentistry. He is the author of two books and several articles on various aspects of these fields.

How has the Mguide system affected surgery time?

Mguide changed my timetable. Due to trustworthy planning and a safe template, I don´t have to open up the entire surgical area as I previously had to do. Almost 96% of our surgeries are performed using tissue punch or with cuts of less

than 5mm. This saves time, and the workflow is faster than before. The average time for a single implant is about 12 to 16 minutes. For example, in my timetable, we take 35 minutes for four implants in the upper jaw or lower jaw. Patients appreciate the speedy surgical procedure and the lack of stitching, which saves additional visits to the clinic.


“Never Change A Method That Works!”

ARE YOU SURE?23 MNEWS 2nd Quarter, 2011

Who performs the planning?

In most cases, I am the one who performs the planning, but there are additional possibilities. In the planning software shell, you are given the option to share the case with other implantologists or colleagues, and you choose the remote function in the service center that allows the administrator or a colleague to plan the case under your control. On my screen, I see the planning steps in real time. It´s a big step in

global know-how sharing.

Are there any special tools for the Mguide system?

What is special with the Mguide system is that almost every surgical and drilling tool fits through the sleeve in the template, which allows you to make, for example, a bone compression or an internal sinus lift through the sleeve with 100% control in any direction. And there’s more. You see, the Mguide system is a complete system: there are a lot of tools, starting with the planning software, going through the surgical part and ending with the prosthodontic part. Everything is standardized with high precision.

Must the software be purchased?

It´s not necessary to buy the software, as it’s available for free. The MGuide system is a pay per use system. The big advantage is that there

are no upfront costs.

Time for the process?

The turnaround time for the planning procedure is about 20 minutes. The planning software is very user-friendly. I work in my office and I didn t́ have to take a computer course to use the planning software. In my opinion, the software should be very easy to handle and if I need support, I want to have it immediately.

What sorts of dentists and patients is the software suitable for?

I believe that any dentist can use the Mguide system. All one needs is a computer and a little surgical experience. Likewise, I believe it is useful with all kinds of patient cases. I treat almost every patient this way.

What about safety?

We implantologists love to be safe while planning, in both surgery and during the prosthodontic treatment. I can t́ afford to do just testing. Because of the precision, I can be certain that I can achieve what I planned. I checked it out very carefully. I´m sure that the drilling is safe and the prosthetic treatment will be compatible. Since I´ve begun using the fully-guided procedures, the number of implant settings I perform has increased. I´m certain that this will significantly improve the implantology workflow.


© MIS Corporation. All rights Reserved.

MIS SEVEN Narrow implant is especially designed for narrow ridges and tight spaces and is accompanied by a variety of prosthetic options specifically designed for the Narrow platform. To learn more about MIS visit our website: www.mis-implants.com

SEVEN NARROW ø3.30mm

®

NEW!

®

QUALITY CONTROL! INTERVIEW

MIS is expanding its marketing goals while investing enormous efforts and resources in implementing global regulatory requirements and complying with international quality standards for its products and processes.

implementing global regulatory requirements

In several countries the sector of medical

devices has witnessed an annual growth rate

of 10%. With few exceptions, these countries

import more than 80% of their medical devices.

This situation is of increasing concern to the

ministries of health, which have recognized

the importance of regulating medical devices

and of international harmonizing regulatory

requirements. Within the context of health sector

reform, this is part of the strengthening of the

steering role of the ministries and of their function

as regulatory authorities to guarantee the safety,

efficacy and quality of medical devices used

by the population and health services.


XYZ ProbeXYZ computerize measuring machine.

Measuring Pins SetHighly accurate gauges.


What is a medical device?

Medical devices:▪ Are used on humans▪ Have therapeutic benefits▪ Generally have a physical or mechanical effect on the body or are used to measure or monitor functions of the body. Medical devices range from a bandage that you would put on a scratch to high-risk products such as pacemakers that are implanted in your body.

What is CE Marking (CE Mark)?

The letters “CE” are the abbreviation of French phrase “Conformité Européene”, which literaly means “European Conformity”. The term initially used was “CE Mark” and it was officially replaced by “CE Marking” in the Directive 93/68/EEC in 1993. “CE Marking” is now used in all EU official documents. “CE Mark” is also in use, but it is not the official term.

▪ CE Marking on a product is a manufacturer’s declaration that the product complies with the essential requirements of the relevant European health, safety and environmental protection legislations, in practice by many of the so-called Product Directives.

▪ CE Marking on a product indicates to governmental officials that the product may be legally placed on the market in their country.

▪ CE Marking on a product ensures the free movement of the product within the EFTA & European Union (EU) single market (total 30 countries). CE Marking on a product also permits the withdrawal of the non-conforming products by customs and enforcement/vigilance authorities.

On 21 March 2010 the last version of MDD 93/42/EEC released by the European Commission came into effect. Some of the major changes concerning MIS’s products are that all devices now require clinical data, including Class I devices. Also, this imposes more stringent requirements as to what constitutes “clinical evidence” and mandates stronger enforcement by authorities. A provision regarding E-Labeling has been made that opens the door for Instructions for Use to be delivered through electronic media instead of the “leaflet” format currently noted. This would be especially useful for MIS products that sell in many EU countries because it could potentially allow us to pass along the IFU on a CD or via other electronic means, eliminating the many different paper versions.

On February 2010 MIS successfully passed the “Ready for March 2010” quality audit.

510(k) Submissions for Obtaining FDA Clearance

In general, manufacturers introducing Class 2 medical devices (e.g. dental implant and abutments) to the US must submit an FDA 510(k). A 510(k) is also required for manufacturers that are changing the intended use of their medical device or changing the technology of a cleared device in such a way that it may significantly affects its safety or effectiveness.

Health Canada Medical Device License (MDL)

The Canadian Medical Device License (MDL) is required for companies that sell Class II, III, and IV medical devices in Canada. The MDL is a product approval and should not be confused with the MDEL, which is a permit for the company/distributor itself. Canada’s Medical Device License (MDL) is comparable to the US FDA 510(k) process. When applying for a Canadian Medical Device License, you will also need to prove that you have a certified ISO 13485:2003 quality system that also meets the specific requirements of the Canadian Medical Device Regulations (CMDR).

Israel Regulatory System

The Ministry of Health (MOH) in Israel is the government agency charged with meeting Israel’s health care needs and regulations. The MOH recognizes Food and Drug Administration (FDA) certification and the European Union CE Mark and approves products carrying such certifications without further requirements. Furthermore, the MOH implements FDA recommended indications fo r the dev ice . MOH approval stipulates marketing authorization in the USA and therefore accepts 510K and export certificates such as the Certificate to Foreign Government.

Microscope: stereo magnifier improves inspector’s working efficiency.

Mantis


What is Quality Assurance?

Quality assurance, or QA in short, refers to a systematic method for monitoring and evaluation of the various aspects of a project, service, or facility to ensure that standards of quality are being met. Two key principles characterize QA: “fit for purpose” (the product should be suitable for the intended purpose) and “right first time” (mistakes should be eliminated). QA includes regulation of the quality of raw materials, assemblies, products and components, services related to production and management, production and inspection processes. It is important to realize also that quality is determined by the intended users, clients or customers

and not by a society in general: it is not the same as ‘expensive’ or ‘high quality’. Even goods with low prices can be considered quality items if they meet a market need. QA is more than just testing the quality aspects of a product, service or facility; it analyzes the quality to make sure it conforms to specific requirements and complies with established plans. The QA&RA Department at MIS keeps the pace with current quality and regulatory requirements, thus maintaining MIS quality certification and product registrations status in the countries where MIS markets its products, which implies: ▪ implementing or modifying the quality requirements defined in ISO quality standards, specific quality requirements, special requirements for packaging, labeling, material

specifications, etc. ▪ determining the classification of the products according to different regulations ▪ ensuring the conformity of the products to the provisions of the Medical Device Directive. ▪ compiling technical files for products to be submitted and maintaining and amending the technical files. ▪ notifying the relevant regulatory bodies of any significant change in the system or product. MIS’s management is committed to continual improvement of all of its products, processes and services. MIS sees the processes and product quality as the main influence factor of the company’s activities and guides all of its employees accordingly. Performance of these activities will place quality as the core value of MIS.

“SOME OF THE MAJOR CHANGES CONCERNING

MIS PRODUCTS ARE THAT ALL DEVICES NOW

REQUIRE CLINICAL DATA, INCLUDING CLASS I

DEVICES.”

Profile projector with multilayer coated projection lenses to provide high transmission with optimum contrast, ensuring high accuracy in dimensional measurements and surface inspection.

Comparator


SUCCES

MIS is expanding its marketing goals while investing enormous efforts and resources in implementing global regulatory requirements and complying with international quality standards for its products and processes.To learn more about MIS Quality Assurance visit our website: www.mis-implants.com.

© MIS Corporation. All Rights Reserved.

MIS Quality isYour Success...

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®

As a global company, MIS participates in major dental exhibitions and congresses worldwide, showcasing MIS’s top-of-the-line, innovative products. MIS also conducts case presentations and workshops with international opinion leaders. MIS welcomes you to visit our booth and participate in our scientific lectures at upcoming exhibitions and congresses.

MISEXHIBITIONS


MIS will be participating in the IDS (International Dental Show), which is the world’s leading trade show in dentistry. MIS will be a diamond sponsor in the upcoming 34th IDS which will be held in Cologne, Germany. The show will be held on March 22-26, 2011. You are invited to visit MIS’s stand and see all the new innovative products in the field of dental implants, bone grafts, computer guided implantology and much more.

VISIT MIS AT:

COLOGNE, 22-26.3.2011


EXHIBITION



IDS, Cologne.

It is with great pleasure that we invite you to join us at the 34th International Trade Show, which will be held in Cologne, Germany on March 22-26 2011.

The 1st MIS Global Conference – the first such conference hosted by MIS for dental professionals – is set to be the most exceptional event in the field of dental implantology in 2011. Merging cutting-edge science and clinical expertise, the conference will run over two exciting days, during which an impressive array of world-renowned experts will present the most contemporary and exceptional techniques in implant dentistry. The conference will be held at the luxurious Hilton Hotel & Conference Center in Cancun, Mexico . Together with the main stage presentations, the 1st MIS Global Conference will offer the unique opportunity to participate in a variety of workshops and hands-on live sessions, designed by MIS’s world-renowned education centers. The new Mguide computer guided implant surgery system

and the revolutionary new Bone grafting products are just a few of the topics that will be demonstrated during the event. These products are certain to improve quality of patient treatment, as well as to enhacing

the clinician’s experience. We invite you to join us at the 1st MIS Global Conference in Cancun, where you are sure to have a rejuvenating professional and personal experience in an amazing Caribbean atmosphere. You will also have the opportunity to share experiences with friends and colleagues during our various leisure activities. For more information about the MIS Global Conference, please visit : mis-implants.com/cancun

GLOBAL CONFERENCE IN CANCUN, MEXICO

MIS TO HOLD FIRST-EVER

The location in which the 1st MIS Global Conference will be held.

Hilton Cancun


CYPRUSMIS Cyprus26 Inomenon Ethnon st, Flat. 202, 6042 Larnaca, Cyprus

Tel. +357 24 633666Fax. +357 24 633666

CHINA Bioden-Tech Co. Ltd.No 28, Menzhuiwan Street (2-1-407) Chengdu, Sichuan Province

Tel. 18980871130

FRANCEMIS France43 Avenue Aristide Briand 92300 Levallois Perret

Tel. 08 10 89 50 30Fax. 00 33 134 160 737

ECUADORMIS Implants EcuadorCalle Reina Victoria N24-151 y Calama , Oficina 5A - Quito Tel. +593 997 05047

DOMINICIAN REPUBLIC MIS Implants DominicanaC/ Leonico Ramos 35 A, Cp10114 Mirador Del Norte, Santo Domingo

Tel. +180 9530 4595Fax. +180 9530 4595

CANADA MIS Implants Canada Inc640 Lakeshore Rd, Suite 103, Dorval, Qc H9S-2B6

Tel. 1(877) 633 0076Fax. 1(866) 533 4616

EL SALVADORServicios Odontologicos SotraEdif. Plaza del Sol. C.del Mediterraneo Col. La Sultana

Tel. +(503) 2243 2954/5005 Fax. +(503) 2243 2653

COSTA RICAOdontoWeb Profesional S.A.Rohrmoser, Del parque de la amistad 400 mts oeste y 50 norte, casa celeste a mano derecha

Tel. 506 22314000

COLOMBIA MIS Technologies S.A.Avenida 9 # 103 a 36 oficina 301, Bogota, Colombia

Tel. 00 (571) 6203800

GREECE Negrin Dental Ltd. Quality MaterialFokidos 51 - Athens

Tel. +30 210 7711605Fax. +30 210 7754065

HUNGARYMerfol Trading Ltd.Becsi ut 250, 1037 Budapest, Hungary

Tel. +36 14391300Fax. +36 1 3879523

HONDURASCIC DentalAve.Circunvalacion 2da calle S.O Edif. Rivoli plaza n17

Tel. +5045576589Fax. +5045576571

GUATAMALAImportadora y Exportadora Gil SA12 Calle 24 zona 1 Ciudad Guatemala

Tel. +50223828900Fax. +50222323055

HONG KONGMIS Hong Kong Limited3/5 Floor 80 Woo Sung Street, Jordan Kowloon, Hong Kong.

Tel. 852 3151 7202Fax. 852 3151 7203

GERMANYMIS Implants Technologies GMBHPaulinestr. 12A, 32427 Minden, Germany Tel. + 49 (571) 9727690Fax. + 49 (571) 9727691

ISRAEL Divident Ltd.Havradim 11A, Gane-Yehuda

Tel. +972 (3) 635 3539Fax. +972 (3) 635 3577

GEORGIAMIS GeorgiaBakhtrioni Str. 11a, Tbillsi

Tel. +995 32 366778Fax. +995 32 361875

INDIAConfident sales India (P) Ltd.No 47, 2nd Flr, Pete Channappa Indl Estate -Kamakshipalya, Magadi Rd Bangalore

Tel. +91 80 23482153Fax. +91 80 23482156

BELGIUM MIS Belgium5 Place Gustave Falmagne 5000 Namur ,Belgium

Tel. +32 81 74 6636Fax. +32 81 73 0836

AZERBAIJANCaspidentR. Behbudov Str. 48/1, Baku, AZ1014

Tel. +99412 4801449Fax. +99412 4407595

ARMENIAS&D Implant LLCPapazyan 16-31, 0012 Yerevan

Tel. +37410 21 01 58

BULGARIALab Technology Ltd.Lyulin bl.729, en.A, fl.7, ap.24, Sofia 1324

Tel. +359 2 983 2209Fax. +359 2 829 5045

ARGENTINAGrimberg Dentales S.A.Lerma 426, C.P C1414A, CABA Buenos Aires

Tel. +54 1148214114 Fax. +54 1148213229

BOLIVIA MIS BoliviaCalle Colombia no. 1532 - Cochabamba

Tel. +591 45 33 654

AUSTRALIAMore Group Pty Ltd.4 Giencoe St. Caulfield North Victoria 3161

Tel. +613 953 00777Fax. +613 952 83761

BELARUS KramadentBehtereva Sstr.10 office 1118, Minsk 220021

Tel. + 375172963184Fax. +375172951071

BALTICBALTIC Implant MIS SIAA. Caka Str. 33a, Riga, LV-1011

Tel. +371 (6) 7282006

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KOREAMIS Korea Co.Office No 301, Hyundae B/D, 709-6, Daelim2-Dong, Yeongdeungpo-Gu, Seoul, 150-908, Korea.

Tel. +82 (0)2 842 2864Fax. +82 (0)2 842 2863

PHILIPPINESEIS Dental Medical SuppliesRm. 615, Don Santiago Building 1344 Taft Avenue, Ermita, Manila 1000, Philippines

Tel. +6325257813

SWITZERLANDMIS Switzerland AGWolleraustrasse 41b, 8807 Freienbach, Switzerland

Tel. +41 43 2052850Fax. +41 43 2052252

PARAGUAYGrupo Esthetic Center S.R.LAmerica 192 Casi Mcal. Lopez Asuncion

Tel. +(595) 21 229582Fax. +(595) 21 229582

SPAINMedical3 Importacion Service IbeAvda. Republica Argentina, 281 Local, 08023, Barcelona Tel. +349 321 14984 Fax. +34 93 2114984

VENEZUELA Top Dental CACalle Chacaito Edificio 1 Piso 1 -Oficina 11M - Bello monte Caracas6

Tel. +582129523352

ITALY Revello S.P.AVIA Enrico. Fermi 20, I-37136 - Verona.

Tel. + 39 (045) 8238611Fax. + 39 (458) 238612

UK MIS Implants UK Ltd2121-129 Old Road, Clacton on Sea, Essex CO15 3AW

Tel. +01255 424624Fax. +01255 221 524

NETHERLANDSMIS Netherland BVErfstede 4-b NL-3431 Kh Nieuwegein, Netherlands

Tel. +31(30) 600 0450Fax. +31 (30) 600 0458

RUSSIALiment Dmitrovskoe Shosse 9, Moscow 127434

Tel. +7(495)9763593 Fax. +7(495) 9777009

MEXICOMIS Implants Mexico, S.A. de C.VPatricio Petrarca #223-606, 11560 -D.F. Mexico

Tel. +52 55 55316753Fax. +52 55 552503431

PORTUGALSDS-Same Day Solutions LdaRua Central Park, 6, 1ºB, 2795-242 Linda-a-Velha

Tel. 00351 21 417 5017Fax. 00351 21 417 0331

THAILANDDental Innovation Co.Ltd.52/1 Sukhum vit-23, Wattana 10110 Bangkok, Thailand

Tel. + 66 2 320 1234Fax. + 66 2 322 7124

MACEDONIAEndomakMladinska Str. 277, 2400 Strumica Tel. +38922454543

TAIWANJong Shinn Dental Enterprise Co.1F, No 11, Yongnian St., Sanmin District - Kaohsiung

Tel. +886 738 60519Fax. +886 673 805838

POLANDGarmed Sp. Z.o.oPiaskowa 4, lok. U3 01-067 Warsaw

Tel. +(48) (22) 338 70 00Fax. + 48 (22) 3387001

TURKEY Misdent Ic Dis Tic. San. Ltd. StiMesrutiyet Cad. No:29/21 Kizilay – Ankara, Turkey

Tel. +90 312 419 01 91Fax. +90 312 419 01 93

ROMANIAMIS RomaniaSt. Grigore Alexandrescu 8 Sector 1, Bucharest

Tel. +40 (213) 175 337Fax. +40 (213) 175 332

MOROCCOMIS France MResidence Fellah RDC, Casablanca, Maroc

Tel. 212 224 758 61

PERUMisimplant-Peru Sac.Av. Larco 383, Piso 7, Miraflores 18 - Lima

Tel. +5117687472Fax. +5114476249

VIETNAMDawn Dental Distrubute Co. Ltd.006-008 Blk E, Hung Vuong Apt. Tan Da St., Dis 5 -Ho Chi Minh

Tel. +(84) 8 54051273Fax. +(84) 8 38593247

KAZAKHSTAN Daris - TTETulebaev Str. 8 ,050016 Almaty

Tel. +772 727 35165

SWEDENMIS SwedenWallingatan 11 SE-111 60 Stockholm Tel. +46 (0) 8 4100 94 99

SOUTH AFRICA Iss - Implants Support ServicesHazel Close Office Park 1D, 141 Witch Hazel Avenue, Highveld Techno Park, Centurion 0157

Tel. 27 12 665 1024 Fax. 012 665 0631

PANAMAMIS Technology PanamaCalle 4 con Avda. Mexico Edificio Conardo Planta Baja

Tel. +507 2271664Fax. +507 2275257

USAMIS Implants Technologies Inc.18-00 Fair Lawn Ave., Fair Lawn, NJ, 07410

Tel. 201-7979144 Fax. 201-7979145

SINGAPOREAce-Vita Pte Ltd151 Stevens Road #07-05 The Equatorial Singapore 257872

Tel. +(65) 9766 8188 Fax. +(65) 6227 2619

UKRAINE Dentek Ltd.Dimitrova Str. 16, of.8 Kiev 03150

Tel. +38(044) 2335558 +38(063) 2335558

Fax. +38(044)4982851

NICARAGUA ProdenicsaSede Central Los Pipitos, 1 1/2 C. al Noroeste - Clínica Centro de Diseño Dental

Tel. +505-22548222Fax. +505-22548222


All rights reserved. No part of this publication may be reproduced, transcribed, stored in an electronic retrieval system, translated into any language or computer language, or be transmitted in any form whatsoever, without the prior written consent of the publisher.


®

© MIS Corporation. All rights Reserved.

Three days of 360° Implantology. Round-out your professional expertise with new skills. Broaden your business to the horizon – and beyond. Explore 360° Implantology: a complete world of dental resources from MIS. Enjoy the full spectrum of luxurious Cancun fun.

MIS offers a wide range of implants, innovative kits and accessories that provide creative and simple solutions for the varied challenges of implant dentistry.

For more information and registation: Visit www.mis-implants.com/cancunmail: [email protected]: +972 (4) 9016706 +972 (54) 3304693

mnews 3 - mis magazine

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