miptec blsw hp 2016 - basel life · 2016. 9. 7. · the basel life science week is becoming a great...

Basel, Switzerlandwww.basellife.org

FinalProgramme

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Level Sponsors

A special thank you goes to the congress level sponsors:

Platinum

Gold

Silver

Bronze

Travel grants are sponsored by

And also a special thank you to:

- Industry symposia organisers - Item sponsors- Workshop organisers - Exhibitors- Forum sponsors - Media partners

List current per 22 August 2016

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Table of Content

Level Sponsors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Welcome Letter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Programme Overview

Monday, 19 September 2016. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

Tuesday, 20 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Wednesday, 21 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Thursday, 22 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Floor Plan Hall 4.0 (Session Rooms) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Detailed Scientifi c Programme

Monday, 19 September 2016. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13

Tuesday, 20 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Wednesday, 21 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

Thursday, 22 September 2016 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28

Poster Overview (Exhibition, Hall 4.1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37

Floor Plan Hall 4.1 (Exhibition) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38

Exhibitor List . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40

General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41

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Welcome to the Basel Life Science Week 2016!

Basel Life Science week is an international event with participants from over 45 countries. Our specifi c goal is to catalyse the innovation process amongst creative and passionate individuals. The steering and programme committees invite you to immerse yourself into the programme and help facilitate innovative exchange of ideas and make new networks.

The Basel Life Science Week is becoming a great magnet for life science innovati-on. The 2016 programme will see a convergence of many great offerings – which include: The DayOne programme on Precision Medicine from BaselArea.Swiss, the ILMAC Exhibition on Laboratory Equipment, and the Medical Devices and Diagnostics conference “Medtech&Pharma” - will all take place the same week. You can access all these programmes from links on the Basel Life Science Week homepage (www.basellife.org).

One of the new themes for the 2016 programme is developing open standards for the implementation of Precision Medicine with 3 Forums on “Best Practi-ces”. Digital technology is advancing the delivery of precision medicine and the “Basel Agenda” programme will look at the future of medicine. Drug discovery has always relied on innovative technologies – and Microfl uidics will be in the spotlight this year. Forums on human health (Aging and Infectious diseases); ad-vanced technologies for drug discovery (Stem Cells, Peptide Therapeutics, Protein Production), and focused sessions on Synthetic Biology, Medicinal Chemistry, and Synergy of combination therapies will once again take place.

The MipTec Exhibition on Drug Discovery brings together over 100 vendors to showcase cutting edge technologies that help advance R&D in the life sciences. In 2016, the Product Innovation Award has been expanded to recognize outstan-ding achievement in the development of these technologies. The Innovation-Avenue is a platform for showcase start-ups in life sciences – and this program-me has been extended to enable more start-ups to participate.

For the community, we offer many resources to explore career and personal development. The Jumpstarting Innovations is a day long programme for bud-ding entrepreneurs and Venture Capitalist to meet and exchange ideas. Career training workshops, by renowned Career Coaching professionals, will run before and during the main program of the conference.

The conference continues to evolve and we are in deep gratitude to the countless volunteers involved in the programme development. Our heartfelt thanks to the City of Basel, BaselArea.swiss / INet / Swiss Innovation Park, Messe Basel, and our many sponsors for their continuing support.

We look forward to meeting you at Basel Life Science Week 2016!

Best wishes,

Bhupinder Bhullar, Steering Committee Chair

Gregor Dernick, Programme Chair

Daniel Gygax, Programme Chair

Martin Fussenegger, Scientifi c Advisor

Haike Suering, Exhibitors‘ Representative

Roland Bucher, Exhibitors‘ Representative

Sabine Adam, Congrex Switzerland

Welcome Letter

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eMonday, 19 September 2016

Kairo 1 Kairo 2 Lima09.00

09.15 – 12.45

Career Workshopwith Peggy McKee

09.15 – 12.00

Workshop: Genome Editing

Merck

09.30

10.00

10.30

11.00

11.30

12.00

12.3012.30 – 13.30

Break13.00

13.30

13.45 – 16.00

Career WorkshopPeggy McKee

14.00

14.30

15.00

15.30

Courses & Workshops Industry Symposium Keynote Lecture Networking Events Oral Session Scientifi c Forums

Programme Overview

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Tuesday, 20 September 2016

Hall 4.1 Hall 4.1 Delhi Kairo 1 Kairo 2 Shanghai 1 Shanghai 2 Shanghai 3 Boston (1–3) Lima Darwin09.00

08.45 – 18.00Vendor

Exhibition

Coffee is available

during the opening hours

08.45 – 09.15 Welcome Coffee in the exhibition area (Hall 4.1)


09.3009.15 – 10.15

Peptide Thera peutics Forum 2016

09.15 – 10.15Stem Cells in Biomedicine

09.15 – 10.15Basel

Agenda09.15 – 10.15

Protein Production

09.15 – 10.15Medicinal

Chemistry and Drug Discovery

10.00

10.00 – 18.00Poster

Exhibition

Running activity throug-hout the

conference

10.3010.15 – 11.00

Coffee Break in the exhibition area (Hall 4.1)10.15 – 11.00

Coffee Break in the exhibition area (Hall 4.1)

11.0011.00 – 12.00



11.00 – 12.00Basel

Agenda 11.00 – 12.00

Protein Production



11.30

12.0012.00 – 13.30

Lunch Break in the exhibition area (Hall 4.1)12.00 – 13.30

Lunch Break in the exhibition area (Hall 4.1)

12.3012.15 – 13.15

Career Workshop

Peggy McKee

12.15 – 13.15Industry Symp

Essen Bioscience


Czech Republic

13.00

13.30 13.30 – 13.35Welcome WordsBhupinder Bhullar

14.00 13.35 – 14.20Keynote 1

Richard MasonJohnson & Johnson

14.3014.30 – 15.30

Peptide Therapeutics Forum 2016


14.30 – 15.30Basel

Agenda14.30 – 15.30

Protein Production

14.30 – 15.30Drug Discovery

Sciences15.00

15.30

15.30 – 16.15Coffee Break in the exhibition area (Hall 4.1)

15.30 – 16.15Coffee Break in the exhibition area (Hall 4.1)16.00

16.3016.15 – 17.15



16.15 – 17.15Basel

Agenda16.15 – 17.30

Protein Production


Sciences17.00

17.30 17.15 – 18.00 Welcome Reception

Hall 4.1

17.15 – 18.00 Welcome Reception

Hall 4.1

Programme Overview


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eTuesday, 20 September 2016


08.45 – 18.00Vendor

Exhibition

Coffee is available

during the opening hours



09.3009.15 – 10.15



09.15 – 10.15Basel

Agenda09.15 – 10.15

Protein Production



10.00

10.00 – 18.00Poster

Exhibition

Running activity throug-hout the

conference

10.3010.15 – 11.00



11.0011.00 – 12.00



11.00 – 12.00Basel

Agenda 11.00 – 12.00

Protein Production



11.30

12.0012.00 – 13.30



12.3012.15 – 13.15

Career Workshop

Peggy McKee


Essen Bioscience


Czech Republic

13.00

13.30 13.30 – 13.35Welcome WordsBhupinder Bhullar

14.00 13.35 – 14.20Keynote 1

Richard MasonJohnson & Johnson

14.3014.30 – 15.30



14.30 – 15.30Basel

Agenda14.30 – 15.30

Protein Production


Sciences15.00

15.30

15.30 – 16.15Coffee Break in the exhibition area (Hall 4.1)

15.30 – 16.15Coffee Break in the exhibition area (Hall 4.1)16.00

16.3016.15 – 17.15



16.15 – 17.15Basel

Agenda16.15 – 17.30

Protein Production


Sciences17.00

17.30 17.15 – 18.00 Welcome Reception

Hall 4.1

17.15 – 18.00 Welcome Reception

Hall 4.1

Programme Overview


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Wednesday, 21 September 2016

Hall 4.1 Hall 4.1 Delhi Kairo 1 Kairo 2 Shanghai 1 Shanghai 2 Shanghai 3 Boston (1–3) Lima09.00

08.45 – 17.00Vendor

Exhibition

Coffee is available during

the opening hours

08.45 – 17.00Poster

Exhibition

Running activity

throughout the conference

08.45 – 09.15Welcome Coffee in the exhibition area (Hall 4.1)


09.3009.15 – 10.15


09.15 – 10.15Jumpstarting Innovation I

09.15 – 10.15Infectious Diseases

09.15 – 10.15Protein

Production

09.15 – 10.15Aging &

Drug Discovery

09.15 – 10.15Best Practices in Clinical and

Research Genomics and Data

Warehousing

10.00

10.3010.15 – 11.00


Coffee Break in the exhibition area (Hall 4.1)11.00

11.00 – 12.00Peptide

Therapeutics Forum 2016



11.00 – 12.00Protein

Production

11.00 – 12.00Aging &

Drug Discovery



Warehousing

11.30

12.0012.00 – 13.30


Lunch Break in the exhibition area (Hall 4.1)12.30

12.15 – 13.15Workshop

Grass & Partners


PerkinElmer


Molecular Devices


Italian Embassy

13.00

13.30

13.30 – 14.15Keynote 2

Susan M. Gasser14.00

14.3014.30 – 15.30



14.30 – 15.30Best practices in genomics data

analysis for clinical and research applications

14.30 – 15.30Protein

Production

14.30 – 15.30Aging &

Drug Discovery

14.30 – 15.30Status and Future of Research Data

Warehouses

14.30 – 15.30Best practices in data storage integrity and

security

15.00

15.30

15.30 – 16.15 Coffee Break in the exhibition area (Hall 4.1)

15.30 – 16.15 Coffee Break in the exhibition area (Hall 4.1)16.00

16.3016.15 – 17.15





16.15 – 17.30Protein

Production

16.15 – 17.15Aging &

Drug Discovery


Warehouses


security

17.00

17.3017.15 – 18.00 Interactive Poster Session & Apéro

Poster Area Hall 4.117.15 – 18.00 Interactive Poster Session & Apéro

Poster Area Hall 4.118.00

18.00 – 20.00ILMAC exhibitors & get together event in the ILMAC exhibition halls / foyer



Programme Overview

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eWednesday, 21 September 2016

Hall 4.1 Hall 4.1 Delhi Kairo 1 Kairo 2 Shanghai 1 Shanghai 2 Shanghai 3 Boston (1–3) Lima09.00

08.45 – 17.00Vendor

Exhibition


the opening hours

08.45 – 17.00Poster

Exhibition

Running activity




09.3009.15 – 10.15




09.15 – 10.15Protein

Production

09.15 – 10.15Aging &

Drug Discovery



Warehousing

10.00

10.3010.15 – 11.00


Coffee Break in the exhibition area (Hall 4.1)11.00

11.00 – 12.00Peptide

Therapeutics Forum 2016



11.00 – 12.00Protein

Production

11.00 – 12.00Aging &

Drug Discovery



Warehousing

11.30

12.0012.00 – 13.30


Lunch Break in the exhibition area (Hall 4.1)12.30

12.15 – 13.15Workshop

Grass & Partners


PerkinElmer


Molecular Devices


Italian Embassy

13.00

13.30

13.30 – 14.15Keynote 2

Susan M. Gasser14.00

14.3014.30 – 15.30





14.30 – 15.30Protein

Production

14.30 – 15.30Aging &

Drug Discovery


Warehouses


security

15.00

15.30

15.30 – 16.15 Coffee Break in the exhibition area (Hall 4.1)

15.30 – 16.15 Coffee Break in the exhibition area (Hall 4.1)16.00

16.3016.15 – 17.15





16.15 – 17.30Protein

Production

16.15 – 17.15Aging &

Drug Discovery


Warehouses


security

17.00

17.3017.15 – 18.00 Interactive Poster Session & Apéro

Poster Area Hall 4.117.15 – 18.00 Interactive Poster Session & Apéro

Poster Area Hall 4.118.00




Programme Overview

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Thursday, 22 September 2016


08.45 – 16.30Vendor

Exhibition


the opening hours

09.00 – 16.00Poster

Exhibition

Running activity




09.30

09.15 – 10.15Basel

Microfl uidics Workshop

09.15 – 10.15Best practices in genomics

data analysis for clinical and research applications

09.15 – 10.15Molecluar Diagnostics

09.15 – 10.15Synthetic biology

09.15 – 10.15Aging &

Drug Discovery

09.15 – 10.15Status and Future of Research

Data Warehouses

09.15 – 10.15Synergy Forum

09.15 – 10.15Best

practices in data storage integrity and

security

10.00

10.3010.15 – 11.00



11.00

11.00 – 12.00Basel






11.00 – 12.00Aging &

Drug Discovery


Data Warehouses


11.00 – 12.00Best


security

11.30

12.0012.00 – 13.30



12.30

12.15 – 13.15Workshop

Grass & Partners

13.00

13.30

13.30 – 14.15Keynote 3

Dr. Shai Silberberg

14.00

14.30

14.30 – 15.30Basel


14.30 – 15.30Jumpstarting Innovation II

14.30 – 15.30 Synthetic biology

14.30 – 15.30Aging &

Drug Discovery

14.30 – 15.30Best Practices

in Clinical and Research

Genomics and Data

Warehousing

14.30 – 15.30Synergy Forum15.00

15.3015.30 – 16.15



16.00

16.15 – 17.15Basel




16.15 – 17.15Aging &

Drug Discovery



Genomics and Data

Warehousing

16.15 – 17.15Synergy Forum16.30

Programme Overview


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eThursday, 22 September 2016


08.45 – 16.30Vendor

Exhibition


the opening hours

09.00 – 16.00Poster

Exhibition

Running activity




09.30

09.15 – 10.15Basel






09.15 – 10.15Aging &

Drug Discovery


Data Warehouses


09.15 – 10.15Best


security

10.00

10.3010.15 – 11.00



11.00

11.00 – 12.00Basel






11.00 – 12.00Aging &

Drug Discovery


Data Warehouses


11.00 – 12.00Best


security

11.30

12.0012.00 – 13.30



12.30

12.15 – 13.15Workshop

Grass & Partners

13.00

13.30

13.30 – 14.15Keynote 3

Dr. Shai Silberberg

14.00

14.30

14.30 – 15.30Basel



14.30 – 15.30 Synthetic biology

14.30 – 15.30Aging &

Drug Discovery



Genomics and Data

Warehousing

14.30 – 15.30Synergy Forum15.00

15.3015.30 – 16.15



16.00

16.15 – 17.15Basel




16.15 – 17.15Aging &

Drug Discovery



Genomics and Data

Warehousing

16.15 – 17.15Synergy Forum16.30

Programme Overview


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Floor Plan Hall 4.0 (Session Rooms)

Shanghai 1

Boston 1–3

Darwin

Shanghai 2+3

Overview Hall 4.0 (Session Rooms)

Delhi

Main entrance Speakers’ Service Centre

Secretariat

Kairo 1+2

Lima

2016 Sept 19–23

Posters

KeyNotes

Workshops

ForumsCourses

Sept 19–22

Science Week Leading in Europe

The International Life Science

Exhibition

Sept 20–22

Competence in Process and Laboratory Technology

Sept 20–23 Sept 22–23

Innovative drug-device combinations & diagnostics

Conference ExhibitionPartnering

You are here

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Scientifi c Programme Monday, 19.09.2016

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Workshops and Courses

09.15 – 16.00 Career Workshops with Peggy McKee Kairo 1-2

09.15 LinkedIn – What you should know?P. McKee (Career Confi dential, Gunter, United States)

10.30 Resumes – 3 simple changes to get more interviewsP. McKee (Career Confi dential, Gunter, United States)

11.45 Job search solutions – where are the hidden jobs?P. McKee (Career Confi dential, Gunter, United States)

13.45 Job interviews – how to get more offers?P. McKee (Career Confi dential, Gunter, United States)

15.00 How to get a promotion?P. McKee (Career Confi dential, Gunter, United States)

09.15 – 12.00 Genome Editing: Strategies for Engineering Lima a Model Cell Line

Hosted by Merck

09.15 Genome Editing in Human Stem Cells – Creation of Novel and Relevant Models for Basic Research and Drug DiscoveryM. Gerber (Merck KGaA, Saint Louis, United States)

09.45 Targeted Integration: Nuclease and Donor Design ConsiderationsJ. Gustin (Merck KGaA, Saint Louis, United States)

10.15 Break

10.30 Screening Methods: Basic and AdvancedE. Patterson (Merck KGaA, Saint Louis, United States)

11.15 Special Considerations for iPS/Stem CellsJ. Gustin (Merck KGaA, Saint Louis, United States)

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Scientifi c Programme Tuesday, 20.09.2016

Keynote

13.30 – 14.20 Welcome Words Boston 1-3

B. Bhullar (BasePort, Basel, Switzerland)

Keynote Lecture 1

Introduction of the Keynote lectureC. Klöpper (BaselArea.swiss, Switzerland)

Making the connection: the role of collaboration in driving innovation forwardR. Mason (Johnson and Johnson Innovation, London, United Kingdom)

Scientifi c Forums

09.15 – 17.15 Peptide Therapeutics Forum 2016 Delhi

Chairs:E. Kitas (Roche Innovation Center, Basel, Switzerland)R. Stocklin (Atheris SA, Geneva, Switzerland) T. Vorherr (Novartis Pharma AG, Basel, Switzerland)

09.15 Opportunities for chemical protein mimics in vaccine designR. Liskamp (University of Glasgow, United Kingdom)

09.45 Targeting peptides versus proteins by vaccination: size mattersM. Bachmann (University of Berne, Switzerland)

10.15 Coffee break

11.00 A chemical space approach to discover novel antimicrobial peptidesJ.-L. Reymond (University of Berne, Switzerland)

11.30 Specifi c inhibition of beta-secretase processing of the Alzheimer’s disease amyloid precursor proteinL. Rajendran (University of Zurich, Switzerland)

14.30 Brain-Shuttle - BACE1 peptide inhibitor conjugates lower brain Aβ levelsE. Kitas (Roche Innovation Center, Basel, Switzerland)

15.00 Recent advances in solid phase peptide synthesisP.D. White (Novabiochem, Merck, Beeston, United Kingdom)

15.30 Coffee break

16.15 Enabling methods for the rapid total chemical synthesis of proteinsO. Seitz (Humboldt University Berlin, Germany)

16.45 Function of human type sialyloligosaccharide for the bioactivity of glycoproteinsY. Kajihara (Chemistry, Osaka University, Toyonaka, Japan)

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09.15 – 17.15 Stem Cells in Biomedicine Kairo 1-2

Chairs: R. Heilker (Boehringer Ingelheim, Biberach, Germany)K. Christensen (Roche Innovation Center, Basel, Switzerland)C. Cusulin (Roche Innovation Center, Basel, Switzerland)

09.15 Metabolic regulation of neural stem cellsM. Knobloch (University of Zurich, Switzerland)

09.45 Development of iPSC-based assays for drug development in neuroscience: tauopathies as an entry pointA. Cabrera Socorro (Janssen Pharmaceutica (J&J), Beerse, Belgium)

10.15 Coffee break

11.00 Bioprinted tissue models for substance evaluationM. Rimann (Zurich University of Applied Sciences, Switzerland)

11.20 Application of stem cell glycomics for effi cient generation of de novo iPS cell lines using glycan biomarkersT. Satomaa (Glykos in Finland, Helsinki, Finland)

11.40 Genome editing in human stem cells - creation of novel and relevant models for basic research and drug discoveryM.A. Gerber (Merck KGaA, St Charles, United States)

14.30 Human induced pluripotent stem cell derived bronchial epithelium to model primary ciliary dyskinesiaJ. de Vos (University Hospital of Montpellier, France)

15.00 To be announced

15.30 Coffee break

16.15 Assessment of anti-cancer drug induced cardiotoxicity in human induced pluripotent stem cell (hiPSC) derived cardiomyocytes using a multiparametric approachM. Vlaming (Pluriomics B.V., Leiden, The Netherlands)

16.45 Human iPSC-derived cardiomyocytes: a comparison with primary cells and applications in standard and 3D cell culture modelsC. Zuppinger (University of Berne, Switzerland)

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09.15 – 17.15 Basel Agenda Shanghai 1

Chair: B. Hofrichter (ConCeplus GmbH, Weggis, Switzerland)

09.15 WelcomeB. Hofrichter (ConCeplus GmbH, Weggis, Switzerland)

09.20 Today Winner – A very brief outlookB. Hofrichter (ConCeplus GmbH, Weggis, Switzerland)

09.30 Infl uencing personal health & wellbeing via wearables & health promoting platformsM. Heuer (dacadoo ag, Zürich, Switzerland)

09.45 When consumer health and health care delivery is aligned!R. Schegg (Healthbank, Baar, Switzerland)

10.00 How booking platforms will infl uence patient journeysP. Kersten (Doctena, Brussles, Belgium)

10.15 Coffee break

11.00 New adherence potentials in joint B2C modelsP. Lichtenberg (Visionarity, Basel, Switzerland)

11.15 Panel Discussion

14.30 Setting the SceneA. Ruzicic (INSEAD Alumni Association Switzerland - Healthcare Club, Zurich, Switzerland)

14.45 Bringing greater value to European healthcare systems: Maximizing outcomes and optimizing costsH. Riband (Amgen, Zug, Switzerland)

15.00 How booking platforms will infl uence patient journeysZ. Khayat (MaRS EXCIT, Toronto, Canada)

15.15 Precision medicine & the regulatory challengeT. Senderovitz (Danish Medicines Agency, Copenhagen, Denmark)

15.30 Coffee break

16.15 How can we make type 2 diabetes 13 times cheaper and cure the patients in doing so?B. van Ommen (TNO, Zeist, Netherlands)

16.25 Panel Discussion

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09.15 – 17.30 Protein Production – Current challenges Shanghai 2-3 in protein science: from fundamental research to drug development

Chairs: R. Assenberg (Janssen Biologics B.V., Leiden, The Netherlands)T. Huber (Novartis Pharma AG, Basel, Switzerland)I. Hunt (Novartis Phamra AG, Basel, Switzerland)B. Shrestha (Novartis Pharma AG, Basel, Switzerland)

09.15 New approaches in the selection of candidate therapeutic binders with calcium dependent fragment assembly separation technology (CD-FAST)D.J. O’Connell (University College Dublin, Ireland)

09.45 Protein Production – Dealing with the UnpredictableD. McMillan (UCB Pharma, Slough, United Kingdom)

10.15 Coffee break

11.00 Beyond the prokaryotic ribosome: structural and functional insights into eukaryotic and mitochondrial ribosomesN. Ban (ETH Zurich, Switzerland)

11.30 Native mass spectrometry – new perspectives for drug discoveryJ.T.S. Hopper (University of Oxford, OMass Technologies Ltd, United Kingdom)

14.30 Engineering the way to selective inhibition of human Nav1.7: a target for painS. Ahuja (Genentech, Inc. Portland, United States)

15.00 Human integral membrane protein production for structural and functional studies at the SGCA. Quigley (Structural Genomics Consortium, Oxford, United Kingdom)

15.30 Coffee break

16.15 Directed evolution of G protein-coupled receptors: enabling structure-guided drug discoveryM. Schütz (University of Zurich, Switzerland)

16.45 Building a complete picture: kinetics, thermodynamics and structural determination of stabilised G protein-coupled receptorsE. Segala (Heptares, Welwyn Garden City, United Kingdom)

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09.15 – 12.00 Medicinal Chemistry and Drug Discovery Lima

Chairs: G. Grundler (FNHW, Muttenz, Switzerland)D. Gygax (FNHW, Muttenz, Switzerland)

09.15 Beyond affi nity: what enthalpy, entropy, kon and koff can disclose about ligand optimization in drug discoveryG. Klebe (Philipps University Marburg, Germany)

09.45 Discovery of LTX-315 – a potential fi rst-in-class oncolytic peptideB.E. Haug (University of Bergen, Norway)

10.15 Coffee break

11.00 Drug Discovery with Small-Molecule CMRT™ Macrocycles – Design and ExperienceH. Thomas (Cyclenium Pharma Inc., Sherbrooke, Canada)

11.30 Macrocycles addressing challenging therapeutic targets with unmet medical needsD. Obrecht (Polyphor Ltd, Allschwil, Switzerland)


12.15 – 13.15 Career Workshops with Peggy McKee Shanghai 1

Networking for Career SuccessP. McKee (Career Confi dential, Gunter, United States)

Oral Session

14.30 – 17.15 Drug Discovery Sciences Lima

Chair: G. Dernick (Hoffmann-La Roche, Basel, Switzerland)

14.30 S.M.A.R.T. Steroids – NMDA Receptors Modulators Acting As CNS TherapeuticsE. Kudova1, L. Vyklicky2, M. Smidkova1, M. Nekardova1, E. Zbornikova1, M. Balastik2, K. Vales2, P. Mares2, J. Palecek2

1Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, v.v.i., 2Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic

14.45 DIANA assay for ultrasensitive enzyme quantifi cation and inhibitor screeningV. Navratil, J. Schimer, P. Majer, J. Konvalinka, P. SachaInstitute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic

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15.00 Long fl uorescence lifetime or label-free? A comparative study of high throughput screening methodologies to minimise assay interferencesP. CraggsScreening, Profi ling and Mechanistic Biology, GSK, Stevenage, United Kingdom

15.15 Maldi mass spectrometry: a label-free solution for ultra-high-throughput screeningM. Hamester, J. Fuchser, F.J. Mayer, V. SauerlandMass Spectrometry, Bruker Daltonics, Bremen, Germany

15.30 Coffee Break

16.15 High-throughput microfl uidic platform for culture of 3D kidney tissue modelsH. Lanz, M. Vormann, A. van den Heuvel, K. Wilschut, C. Ng, R. van Vught, S. Trietsch, J. Joore, P. Vulto, S. QuaderMimetas, Leiden, The Netherlands

16.30 „Structured Confocal”, a new twist for superior 3D live cell imaging in a (smart, compact) boxC. Seebacher1, A. Deeg1, T. Moore2, R. Uhl1

1TILL I.D. GmbH, Martinsried, 2Analytik Jena AG, Jena, Germany

16.45 Quantitative high-content screening methods reveal a regulation of cell-to-cell variability of the energy metabolism of brain cellsG. Azarias1, H. de Castro2, J.-Y. Chatton2, B. Weber1

1Institute of Pharmacology and Toxicology, University of Zurich, Zurich, 2Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland

17.00 DNA encoded library derived molecule properties and library productivityO. Eidam, A.L. SatzRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

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Industry Symposia

12.15 – 13.15 Embassy of the Czech Republic Darwin Czech Centres of Excellence

Chair: M. Partl (CzechInvest, Düsseldorf, Germany)

12.15 Welcome speechR. Opatril (Embassy Berne, Switzerland)

12.20 Keynote speechH.E.K. Boruvka (Embassy Berne, Switzerland)

12.25 IOCB Drug discovery pipelineJ. Zahrádka (IOCB, Prague, Czech Republic)

12.35 20 years of pharmaceutical researchM. Kořínek (Apigenex, Prague, Czech Republic)

12.45 Functional Genomics ProgrammeR. Sedláček (Czech Centre for Phenogenomics, Prague, Czech Republic)

12.55 Life Sciences in the Czech RepublicH. Chlebna (CzechInvest, Prague, Czech Republic)

12.15 – 13.15 Essen BioScience Lima Learn How to Improve Translation of Phenotypic Assays

Using IncuCyte ZOOM Live-Cell Analysis System

Chair: T. Dale (Essen BioScience, Welwyn Garden City, United Kingdom)

12.15 Introduction to IncuCyte ZOOM® and the concept of long term live cell imagingT. Dale (Essen BioScience, Welwyn Garden City, United Kingdom)

12.20 IncuCyte ZOOM® Applications in Mechanistic SafetyK. Dernick (Roche, Basel, Switzerland)

12.45 Improving the translation of phenotypic assays with IncuCyte ZOOM® live-cell analysisT. Dale (Essen BioScience, Welwyn Garden City, United Kingdom)

13.05 Q&A and networkingT. Dale (Essen BioScience, Welwyn Garden City, United Kingdom)K. Dernick (Roche, Basel, Switzerland)

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Scientifi c Programme Wednesday, 21.09.2016

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Keynote


G. Dernick (Hoffmann-La Roche, Basel, Switzerland)

Keynote Lecture 2

Life Sciences today and tomorrowS. Gasser (FMI, Basel, Switzerland)

Scientifi c Forums

09.15 – 17.15 Peptide Therapeutics Forum 2016 Delhi

Chairs: E. Kitas (Roche Innovation Center, Basel, Switzerland)R. Stocklin (Atheris SA, Geneva, Switzerland)T. Vorherr (Novartis Pharma AG, Basel, Switzerland)

09.15 Making connections in peptide chemistryP.E. Dawson (The Scripps Research Institute (TSRI), La Jolla, United States)

09.45 Chemical biology of peptide natural products – structures, syntheses and bioactivitiesR.D. Süssmuth (Technische Universität Berlin, Germany)

10.15 Coffee break

11.00 Oxytocin MimeticsP. Alewood (The University of Queensland, Brisbane, Australia)

11.30 Therapeutic potential of Conus Venom peptidesB.M. Olivera (University of Utah, Salt Lake City, United States)

14.30 Knottins and beyond: mono- and oligovalent constrained peptide inhibitors for biomedical applicationsH. Kolmar (Biochemie TU, Darmstadt, Germany)

15.00 The challenges of targeting RXFP1, the receptor for the heart failure drug candidate serelaxin, with peptide mimetics and small moleculesR.A. Bathgate (Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia)

15.30 Coffee break

16.15 The infl uence of stabilization of peptide therapeutics on their immunogenic potentialT. Schwandt (Roche Innovation Center, Basel, Switzerland)

16.45 XTEN™ protein polymer for half-life extension and tumor drug deliveryV. Schellenberger (Amunix, Mountain View, United States)

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09.15 – 17.15 Jumpstarting Innovation – Early stage Kairo 1-2 investing, start-up-incubation and how to enable the future generation of biotech innovators

Chairs:S. Emmerth (BaselArea.swiss, Basel, Switzerland)B. Bhullar (BasePort, Basel, Switzerland)O. Gusyatiner (IF Lausanne, Switzerland)M. Fankhauser (IF Lausanne, Switzerland)

09.15 New Models in Life Science Investing: Integrating All StakeholdersA. Royston (VenBio, San Francisco, United States)


10.15 Coffee break

11.00 Immusoft CorporationM. Scholz (Immusoft Corporation, Seattle, United States)

11.30 What does it take to be innovative in pharma?O. Krylova (Scouting and Innovative Medicines Initiative External R&D Innovation, United Kingdom)

14.30 The asset-centric business model: the established trend in venture capital investingM. De Boer (Medicxi Ventures, London, United Kingdom)

15.00 Translating Innovative Science from the Laboratory to the PatientS. Minick (Arch Venture Partners, San Francisco, United States)

15.30 Coffee break

16.15 Novel ways for innovators to work collaboratively with the health innovation ecosystem. The MaRS / Canada storyZ. Khayat (MaRS EXCIT, Toronto, Canada)

16.45 Elthera: a novel approach for targeted cancer therapyA. Schmidt (Elthera AG, Zug, Switzerland)

09.15 – 12.00 Infectious Diseases Shanghai 1

Chairs: U. Jenal (University of Basel, Switzerland)D. Ritz (Actelion Pharmaceuticals Ltd., Allschwil, Switzerland)

09.15 Opening Remarks

09.20 Common themes in the evolution of drug resistanceS. Bonhoefer (ETH Zurich, Switzerland)

09.45 Discovery and development of novel macrocycle antibioticsG. Dale (Polyphor Ltd, Allschwil, Switzerland)

10.15 Coffee break

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11.00 Phage-Based TherapiesG. Resch (Université de Lausanne, Switzerland)

11.30 Salmonella single-cell dynamics in complex tissuesD. Bumann (Universtiy of Basel, Switzerland)

09.15 – 17.30 Protein Production – Current challenges Shanghai 2 in protein science: from fundamental research to drug development

Chairs:R. Assenberg (Janssen Biologics B.V., Leiden, The Netherlands)T. Huber (Novartis Pharma AG, Basel, Switzerland)I. Hunt (Novartis Phamra AG, Basel, Switzerland)B. Shrestha (Novartis Pharma AG ,Basel, Switzerland)

09.15 The Confo®body technology, a new platform to enable fragment screening on GPCRsC. Menet (VIB, Brussels, Belgium)

09.45 Harnessing the Flexibility of the ExpiCHO Transient Expression System: New Uses, New Protocols and Tips for Optimizing Protein ExpressionH. Chiou (Life Technologies, Themo, Carlsbad, United States)

10.15 Coffee break

11.00 Engineering antibodies for cancer immunotherapyC. Klein (Roche Innovation Center Zurich, Switzerland)

11.30 Therapeutic antibody potentiation by antigen- and Fc-dependent IgG hexamer formation

R.N. de Jong (Genmab, Utrecht, The Netherlands)

14.30 Targeting CD47 in cancer with bispecifi c antibodiesK. Masternak (Novimmune SA, Geneva, Switzerland)

15.00 CAP-Go: novel cell lines for the production of tailor-made glycoproteinsS. Wissing (Cevec, Cologne, Germany)

15.30 Coffee break

16.15 Bispecifi c FynomAbs: Novel modes of action through tailored architectureM. Silacci (Johnson & Johnson, Zurich, Switzerland)

16.45 Enabling the Generation of Multi-Functional Drugs for Ophthalmology and Oncology with DARPins H.K. Binz (Molecular partners, Zurich, Switzerland)

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09.15 – 17.15 Aging & Drug Discovery Shanghai 3

Chairs: A. Zhavoronkov (Insilico Medicine, Baltimore, United States)B. Bhullar (BasePort, Basel, Switzerland)B. Kennedy (Buck Institute for Research on Aging, Novato, United States)

09.15 KeynoteM. West (BioTime Inc., San Francisco, United States)

09.45 KeynoteR. Hariri (Celgene, Human Longevity Inc., New York, United States)

10.15 Coffee break

11.00 Strategies to get aging interventions into humansB. Kennedy (Buck Institute for Research on Aging, Novato, United States)

11.30 Maximising healthy lifespan – a national level priorityR. Barker (Precision Medicine Catapult, Innovate UK, Swindon, United Kingdom)

14.30 The role of INDY in fl y health, metabolism and longevity: a new approach for drug discovery.B. Rogina (University of Connecticut Health/School of Medicine, Farmington, United States)

15.00 Artifi cial intelligence for aging biomarker discovery in Asian populationM.-Y. Wong (Asia Genomics, Ltd, Singapore, Singapore)

15.30 Coffee Break

16.15 Applying actuarial methods to drug sales data to discover insights into longevity interventionsE. Debonneuil (ActuRx and Blue Antidote, Paris, France)A. Terlinden (Blue Antidote, Paris, France)

16.45 Prediction of mortality in older people, and individualized healthspan-promoting interventionsG. Fuellen (University of Rostock, Germany)

17.00 Artifi cial Intelligence for Aging Research and Drug DiscoveryA. Zhavoronkov (Insilico Medicine, Baltimore, United States)

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09.15 – 12.00 Best Practices in Clinical and Research Boston 1-3 Genomics and Data Warehousing

Chairs: C. Mason (Cornell University, New York, United States)J. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States )D. Brown (Genome England, London, United Kingdom)D. Burgwinkel (Comptence Center Records Management, Zollikon, Switzerland)D. Domine (WEGA, Geneva, Switzerland)S. Wagers (BioSci Consulting, Maasmechelen, Belgium)

09.15 Introduction to Best PracticesB. Bhullar (BasePort, Basel, Switzerland)

09.45 The role of genomics in the future of precision medicine – the UK experienceR. Barker (Precision Medicine Catapult, Innovate UK, Swindon, United Kingdom)

10.15 Coffee break

11.00 A next-generation platform for clinical data integration and real-time monitoring of clinical trials: why data and user centricity mattersD. Agrafi otis (Covance, Princeton, United States)

11.30 Protecting Genomic DataJ.-P. Hubaux (EPFL, Lausanne, Switzerland)

14.30 – 17.15 Best practices in genomics data analysis Shanghai 1 for clinical and research applications

Chairs: J. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States)C. Mason (Cornell University, New York, United States)

14.30 Cell Free, Cell-Bound, and Cross-Kingdom DNA BenchmarkingC. Mason (Cornell University, New York, United States)

15.00 The genetics clinics of the future: towards implementation of whole genome sequencing in diagnostic practiceI.J. Nijman (University Medical Center Utrecht, The Netherlands)

15.30 Coffee break

16.15 Biomarkers discovery and sample stratifi cation: a case studyN. Goffard (Illumina, Champagne-Ardenne, France)

16.45 Comprehensive molecular profi ling and mining of the bibliome for personalized treatment suggestions in cancerD. Stekhoven (ETH Zurich, Switzerland)

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14.30 – 17.15 Status and Future of (Standardized) Research Boston 1-3 Data Warehouses

Chair:D. Domine (WEGA, Geneva, Switzerland)

Co-Chair:S. Wagers (eTricks, Antwerp, Belgium)

14.30 To be announcedG. Landrum (Novartis, Basel, Switzerland)

14.50 Big data variety & veracity: the roche preclinical warehouseO. Roche (F. Hoffmann-La Roche Ltd, Basel, Switzerland)

15.10 Principles of research data managementM. de Francesco (UCB, Slough, United Kingdom)

15.30 Coffee break

16.15 Technical and legal requirements for data management in collaborative research projects: an example based on the IMI OncoTrack consortiumD. Henderson (Bayer Pharma AG, Berlin, Germany)

16.35 Mining a large-scale integrated data resource for target and lead discoveryJ.P. Overington (Stratifi ed Medical Ltd., London, United Kingdom)

16.55 Antimalarial drug discovery: the not-for-profi t PerspectiveP. Willis (Medecines for Malaria Venture (MMV), Geneva, Switzerland)

14.30 – 17.15 Best practices in data storage integrity Lima and security

Chairs: D. Burgwinkel (Comptence Center Records Management, Basel, Switzerland)D. Brown (Genome England, London, United Kingdom)

14.30 Blockchains as proof of data integrity in LifeScience and eHealthD. Burgwinkel (Information Governance Basel, Switzerland)

15.00 e-Estonia: confi dentiality, availability and integrity in a dynamic digital societyA. Piperal (Government of Estonia, Tallin, Estonia)

15.30 Coffee break

16.15 Ensuring Healthcare System Integrity with BlockchainI. Lohmus (Guardtime, Tallin, Estonia)

16.45 Unlocking the value of blockchain in healthcareA. Laeven (Amsterdam, Netherlands)


12.15 – 13.15 Workshop: Strategic recalibration: Shanghai 1 What’s next for me?

Hosted by Grass & Partner AG

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Industry Symposia

12.15 – 13.15 Perkin Elmer Shanghai 2

Improved Assays for Cell Toxicity

Combining whole well and high content analysis with 2D and 3D cell culture

12.15 – 13.15 Molecular Devices Shanghai 3

Implement high-throughput 3D analysis and live-cell imaging applications for samples from subcellular structures to spheroids

Chair: G. Chandy (Molecular Devices, Sunnyvale, United States)

12.15 Revolutionary tools for acquiring and analyzing 3D data from high-throughput assaysG. Chandy (Molecular Devices, Sunnyvale, United States)

12.45 3D live-cell imaging applications: from subcellular structures to spheroidsC. Holz (Molecular Devices (Germany) GmbH, Biberach an der Riss, Germany)

12.15 – 13.15 Embassy of Italy in Bern - Cluster ALISEI Lima

What is happening behind the Alps: ALISEI and the Italian life science ecosystem

Chair: F. Conicella (Bioindustry Park Silvano Fumero/bioPmed cluster/ALISEI, Colleretto Giacosa (TO), Italy)

12.15 Welcome Italian Embassy

12.20 What is happening behind ALPES: ALISEI and the italian life science ecosystemF. Conicella (Bioindustry Park Silvano Fumero/bioPmed cluster/ALISEI, Colleretto Giacosa (TO), Italy

12.30 Creabilis: from an Italian idea to a European biotech companyS. Traversa (Creabilis, Colleretto Giacosa (TO), Italy)

12.40 Dompé drug Discovery: an innovative technology platform targeting membrane proteinsA. Aramini (Dompè, Milano, Italy)

12.50 It is possible to see: imaging technology applied to drug discovery and developmentV. Lorusso (Ephoran MIS, Colleretto Giacosa (TO), Italy)

13.00 Digital Health: Opportunities and Challenges Ahead for Research-intensive CompaniesM. Santoro (CAMELOT Biomedical Systems, Genova, Italy)

13.10 Q&A

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Scientifi c Programme Thursday, 22.09.2016

Keynote


D. Gygax (FHNW, Muttenz, Switzerland)

Keynote Lecture 3

Increasing the predictive value of preclinical researchS. Silberberg (National Institute of Neurological Disorders and Stroke, NIH, Bethesda, United States)

Scientifi c Forum

09.15 – 17.15 Basel Microfl uidics Workshop 2016 Opening/ Delhi Key Note session

Chairs: F. Käser (BaselArea.swiss, Basel, Switzerland)H. Knapp (CSEM, Alpnach, Switzerland)

09.15 Welcome & Introduction

09.30 Elevator-Pitches given from the organising Partners

09.50 “Lab on chip” – microfl uidics, history, “organ on chip” and biomimetic channel networksA. Manz (KIST Europe, Universität des Saarlandes, Saarbrücken, Germany)

10.15 Coffee break

11.00 Insights, opportunities and risks in the production of microfl uidic devicesC. Denier (Weidmann Medical Technology, Rapperswil, Switzerland)

11.15 Spark assisted chemical engraving (SACE), an innovative technology for glass micromachiningC. Goyer (Posalux SA, Biel/Bienne, Switzerland)

11.30 Microfl uidic platform technologies for chemistry and life science applicationsM. Brivio (Micronit Microfl uidics, Enschede, The Netherlands)

11.45 Moderated Panel Discussion with the PresentersModerator: H. Knapp (CSEM, Alpnach, Switzerland)

14.30 Applying System Engineering and Microfl uidics in Next Generation SequencingK. Lutze (Qiagen, Hombrechtikon, Switzerland)

14.45 Nanofl uidic-based biosensors allow quantifi cation of circulating IgE from a drop of whole blood in 5 minutesI. Märki (Abionic SA, Lausanne, Switzerland)

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15.00 The automated use of MagSiMUS technology in drug discovery screening processesP. van Driessche (MagnaMedics Diagnostics BV, Geleen, The Netherlands)

15.15 Moderated Panel Discussion with the PresentersModerator: M. Collasius (Qiagen, Hombrechtikon, Switzerland)

15.30 Coffee break

16.15 Microfl uidic synthesis of targeted drugsW. van Hoeve (Tide Microfl uidics B.V., Enschede, The Netherlands)

16.30 Development and manufacturing of sustained release microspheres with INFINITY Microfl uidicR. de Bruin (Emultech, Einhoven, Netherlands)

16.45 Organs-on-chip technology for preclinical testingO.T. Guenat (AlveoliX AG, Berne, Switzerland)

17.00 Moderated Panel Discussion with the PresentersModerator: J. Lötters (Bronkhorst High-Tech, Ruurlo, Netherlands)

09.15 – 12.00 Molecular Diagnostics brought Shanghai 1 by NTN Swiss Biotech

Chairs: E. Kübler (FHNW, Muttenz, Switzerland)F. Baumberger (BFH, Berne, Switzerland)D. Gygax (FHNW, Muttenz, Switzerland)

09.15 The future of Personalized Healthcare: the importance of diagnostics and molecular information from an industry perspectiveM. Venturi (Hoffmann La Roche, Basel, Switzerland)

09.45 Biomolecular computing circuits for diagnostics and therapyY. Benenson (ETH Zurich, Basel, Switzerland)

10.15 Coffee break

11.00 Biomarker Discovery and Effi cient Profi ling Using Whole Transcriptome or Targeted TempO-Seq Gene Expression AssaysH. Van Steenhouse (BioSpyder Technologies, San Diego, United States)

11.30 Innovations in the molecular diagnosis of TB and drug resistance – current and future perspectives C. Gilpin (WHO, Geneva, Switzerland)

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09.15 – 17.15 Synthetic Biology Shanghai 2

Chairs:M. Fussenegger (ETH Zurich, Basel, Switzerland)S. Reddy (ETH Zurich, Basel, Switzerland)

09.15 Artifi cial metalloenzymes for synthetic biology purposesT.R. Ward (University of Basel, Switzerland)

09.45 Reimagine SequenceSpaceTMR. Kettleborough (Twist Bioscience, St Neots, United Kingdom)

10.00 Coffee break

11.00 Remote-controlled Mammalian Cells for Biomedical ResearchW. Weber (University Freiburg, Germany)

11.30 Make connections for life: superglue from fl esh-eating bacteria to create teams for control of cancer cell and immune signallingM. Howarth (University of Oxford, United Kingdom)

14.30 Harnessing the power of natural immune equilibrium to develop solutions for antigen-specifi c toleranceS. Kontos (Anokion, Lausanne, Switzerland)

15.00 How to improve your CRISPR/ Genome Editing experiments M. Cannieux (Integrated DNA Technologies, Leuven, Belgium)

15.30 Coffee break

16.15 Towards the expansion of the natural structural repertoire for the design of functional proteinsB. Correia (Anokion, Lausanne, Switzerland)

16.45 Panel discussion on synthetic biology impact on medicine

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09.15 – 17.15 Aging & Drug Discovery Shanghai 3

Chairs: A. Zhavoronkov (Insilico Medicine, Baltimore, United States)B. Bhullar (BasePort, Basel, Switzerland)B. Kennedy (Buck Institute for Research on Aging, Novato, United States)

09.15 Genomic approaches for discovery of lifespan interventionsV.N. Gladyshev (Brigham and Women‘s Hospital, Harvard, Boston, United States)

09.45 Integrated Biomarkers of AgingA. Moskalev (Russian Academy of Sciences, Syktyvkar, Russian Federation)

10.15 Coffee break

11.00 Targeting the stem cell niche to restore muscle regeneration in agingJ. Feige (Nestle Institute of Health Sciences, Lausanne, Switzerland)

11.30 The global healthspan extension initiative: selective approaches to validated technologies and integrated biomarkers Z.S. Zhumadilov (Nazarbayev University, Astana, Kazakhstan)

11.45 The main features of Healthcare System Development dedicated for longevity in KazakhstanV. Benberin (Research Institute on Gerontology and Anti-aging Medicine of the Republic of Kazakhstan, Astana, Kazakhstan)

14.30 The regulatory landscape of APP processingL.M. Camargo (UCB, Cambridge, United States)


15.30 Coffee break

16.15 Intervention in accelerated agingM. Scheibye-Knudsen (University of Copenhagen, Copenhagen, Denmark)

16.45 Panel Discussion: Current Issues in Aging & LongevityChair: M. Blagosklonny (Aging-US, Buffalo, United States)

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09.15 – 17.15 Synergy Forum Lima

Chairs: G. Ulrich-Merzenich (University Clinic Bonn, Germany)H. Schweim (University of Bonn, Germany)

09.15 Methods to assess SynergyG. Ulrich-Merzenich (University Clinic Bonn, Germany)

09.45 In vitro therapeutic synergy and iterative search for promising drug combinationsM. Gustafsson (Uppsala University, Sweden)

10.15 Coffee break

11.00 Mass-action law algorithms for quantitative simulation of interactions of multiple drug combinationsT.-C. Chou (Memorial Sloan Kettering Cancer Centre, New York, United States)

11.30 Discussion

14.30 Synergistic blockade of ErbB receptors and downstream signaling overcomes adaptive response in ErbB2-addicted tumorsR. Tamaskovic (University of Zurich, Switzerland)

15.00 A 3D image-based phenotypic screen of bi-specifi c antibodies targeting stem cells in a panel of patient derived colon carcinoma organoidsL. Price (OcellO BV, Leiden, The Netherlands)

15.30 Coffee break

16.15 Large-scale network analysis of an immune responseE. Miho (ETH Zurich, Switzerland)

16.30 Drug regulatory aspects for combination treatments: regulatory perspectiveH. Schweim (University of Bonn, Germany)

16.45 Massive parallel GPU accelerated DeepLearning in the cloud- the next generation of machine learning algorithms is preparing to take over the AI ecosystemR. Kienzler (IBM Watson, Zurich, Switzerland)

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09.15 – 12.00 Best practices in genomics data analysis for Kairo 1-2 clinical and research applications

Chairs: J. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States)C. Mason (Cornell University, New York, United States)

09.15 Integrative NGS for Drug Discovery and Precision MedicineJ. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States)


10.15 Coffee break

11.00 NGS in routine molecular diagnostic: status quo and prospectiveL. Quagliata (Universitätsspital Basel, Switzerland)

11.30 Open Forum

09.15 – 12.10 Status and Future of (Standardized) Research Boston 1-3 Data Warehouses

Chair: D. Domine (WEGA, Geneva, Switzerland)Co-Chair:S. Wagers (eTricks, Antwerp, Belgium)

09.15 The open PHACTS foundation – open semantic data services for drug discoveryB. Williams-Jones (Open PHACTS Foundation, Cambridge, United Kingdom)

09.35 eTRIKS: Reducing the effort needed to preserve and explore translational research dataS. Wagers (eTricks, Antwerp, Belgium)

09.55 Break Down The Firewall Between Data And Discovery with PerkinElmer SignalsC. Gänzler (PerkinElmer, Stuttgart, Germany)

10.15 Coffee break

11.00 BioStudies database – fi lling in the gaps between publications and structured datasetsU. Sarkans (EMBL-EBI, Cambridge, United Kingdom)

11.20 Optimise end-to-end bioprocess projects: from cell line development through to formulations and stability testingP.D. Gouldson (IDBS, Guildford, United Kingdom)

11.50 The roadmap and future of the tranSMART knowledge management / data warehousing platform K. Nangle (Transmart Foundation, Mannheim, Germany)

34


09.15 – 12.00 Best practices in data storage integrity Darwin and security

Chairs: D. Burgwinkel (Comptence Center Records Management, Basel, Switzerland)D. Brown (Genome England, London, United Kingdom)

09.15 Optimal secure storage model for genomic dataB. Bhullar (BasePort, Basel, Switzerland)

09.45 Storage for InforgsH. Mangalam (University of California Irvine, United States)

10.15 Coffee break

11.00 Management and Integration of data from multiple sourcesA. Ahonen-Bishopp (BC Platforms, Basel, Switzeland)

11.30 Data storage for 100,000 Genome ProjectD. Brown (Genome England, London, United Kingdom)

14.30 – 17.15 Best Practices in Clinical and Research Boston 1-3 Genomics and Data Warehousing

Chairs: C. Mason (Cornell University, New York, United States)J. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States )D. Brown (Genome England, London, United Kingdom)D. Burgwinkel (Comptence Center Records Management, Zollikon, Switzerland)D. Domine (WEGA, Geneva, Switzerland)S. Wagers (BioSci Consulting, Maasmechelen, Belgium)

14.30 Genome Data Analysis SummaryC. Mason (Cornell University, New York, United States)J. Dudley (Icahn School of Medicine at Mount Sinai, New York, United States)

15.00 Data Warehousing SummaryD. Domine (WEGA, Geneva, Switzerland)S. Wagers (eTricks, Antwerp, Belgium)

15.30 Coffee break

16.15 Data storage integrity and security summaryD. Burgwinkel (Competence Center Records Management, Zollikon, Switzerland)D. Brown (Genome England, London, United Kingdom)

16.45 The barriers to the delivery of Precision MedicineZ. Khayat (MaRS EXCIT, Toronto, Canada)

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14.30 – 17.15 Jumpstarting Innovation – Early stage Kairo 1-2 investing, start-up-incubation and how to enable the future generation of biotech innovators

Chairs: O. Gusyatiner (IF Lausanne, Switzerland)M. Fankhauser (IF Lausanne, Switzerland)S. Emmerth (BaselArea.swiss, Basel, Switzerland)

14.30 Opening remarks: Innovation Forum LausanneO. Gusyatiner (IF Lausanne, Switzerland)M. Fankhauser (IF Lausanne, Switzerland)C. Ciller (IF Lausanne, Switzerland)M. Broggi (IF Lausanne, Switzerland)

14.40 Cell to Cellestia Biotech AG: Transition from basic research to a Biotech companyR. Lehal (Cellestia Biotech, Lausanne, Switzerland)

14.55 Organoids for high-throughput screeningsS. Höhnel (SunBioscience, Lausanne, Switzerland)N. Brandenberg (SunBioscience, Lausanne, Switzerland)

15.10 JLINX: Accelerating early-stage transformative innovation – a partnership between J&J Innovation, Janssen & BioQube VenturesK. Hertogs (Johnson & Johnson Innovation, London, United Kingdom)N. Vandervelpen (BiQube Ventures, Zurich, Switzerland)

15.30 Coffee break

16.15 Biotech Beyond the Third DimensionK. Schmidt (CellSpring, Zurich, Switzerland)

16.30 Anokion: Launching a Platform TechnologyS. Kontos (Anokion, Lausanne, Switzerland)

16.50 Institutionalized generation of disruptive biotech venturesJ. Mata-Fink (Flagship Ventures, Boston, United States)

17.10 Closing remarks: Innovation Forum LausanneO. Gusyatiner (IF Lausanne, Switzerland)M. Fankhauser (IF Lausanne, Switzerland)C. Ciller (IF Lausanne, Switzerland)M. Broggi (IF Lausanne, Switzerland)

36



12.15 – 13.15 Workshop: Be on brand – in your resume, Shanghai 1 during an interview, in daily life

Hosted by Grass & Partner AG

Poster Award

The award ceremony will take place on Thursday, 22 September 2016 before the keynote speaker Dr. Shai Silberberg in room Boston 1-3.

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Poster Overview (Exhibition, Hall 4.1)

Post

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Bodendosen u. Medienanschlüsse mit Anschlussmöglichkeiten für:

Elektro

Sanität

Torschaltkasten UK ca. 1.30m

Steuerkasten UK ca. 1.30m

Halleninfosäule

Plakatwand

Recycling-Container

Internes Hallentelefon

Notausgang

Telefonkabine

Handtaster Brandmelde Anlage

Feuerlöschposten

Handfeuerlöscher Wasser-, Elektro- und Telefonanschlüsse

Elektro- und Telefonanschlüsse

Detail

Holzrückwand von 3.00 m Höhe.

Elekroverteilkasten

Stände entlang den Hallenwände

Warenlift

Medienpunktraster

Stützenraster

Bodenbelastung

Nutzhöhe der Halle / Max. Bauhöhe

Hallenfläche

Grundriss, Geschoss

Sicherheitsanlagen

Nutzlast 6'000 KgLxBxH: 6.50x2.45x3.20 m

1 Medienpunkt pro 15m2

600 Kg/m2 (Ausnahmen im Plan eingezeichnet)

ca. 80 x 80 m, 3 Geschosse

müssen zugänglich sein.

haben eine

(z.B. Feuerlöschposten) und

4'100 m2

11.4x11.4 m

Aufhängungen sind teilweise mittels in derBetondecke eingelassenen M10 Hülsen möglich.

3.50 m (Randstände 3.00 m)Ausnahmen im Plan eingezeichnet

Articles can be suspended at some points fromM10 sockets in the concrete ceiling

11,40

3,80 3,80 3,80

11,40

3,80 3,80 3,80

Floor sockets and media connections for connecting up:

Electricity

Medical service

Gate-operating box,

Hall information pillar

Poster wall

Recycling container

Internal hall telephone

Emergency exit

Telephone booth

Pushbutton for fire alarm system

Fire point

Hand-held fire extinguisher Water, electricity and telephone connections

Electricity and telephone connections

rear wooden wall 3.00m high

electrical distribution boxes

Stands along the hall walls

Goods lift

Media point grid

Pillar grid

Floor loading

Effective height of Hall / max. construction height

Hall surface area

Floor plan, storey

Safety facilities

Maximum permitted load: 6000 kgLxWxH: 6.50x2.45x3.20 m

1 media point per 15m2

600 Kg/m2 (Exceptions drawn in on plan)

3.50 m (Edge stands 3.00 m)

ca. 80 x 80 m, 3 Storeys

must be accessible

have a

(e.g. fire points) and

11.4x11.4 m

4100 m2

bottom edge approx. 1.30 m

Exceptions drawn in on plan

85

42.5 42.5

45 202095

Covering on hall pillar 3.00 m high

55

47.5 47.5

Nr.

Nr.

Pillar detail

4585

42.5 42.5

45 202095

55

47.5 47.5

45

StützendetailHallenstützenverkleidung 3.00m hoch

Detail

3m 5m 7m

4m 6m 8m

1m

2m

Aisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

BAisle

CAisle

D

Aisle

AAisle

B

@-Corner

Coffee 1

From MainEntrance

To MainEntrance

Coffee 2

3x2

4x33x2 3x2

3x3

4x6

3x4

3x4 - 1m23x4

3x4

4x6

4x23x4

3x3

3x3

3x3

3x4.5

3x4

2x4

4x5

3x2

3x3

3x33x2

3x3

3x3

2x3

2x3

3x2

3x3

4x6

5x4

4x3

3x3

3x3

3x3

4x7 - 4m2

2x3

2x3

2x3

3x2 3x2 4x2

3x2

2x3

3x2

3x3

3x3 6x3+3x1

3x4

3x4

To / FromLecture Halls

2x4

3x5

3x23x2

Coffee 3

2x44x2

3x2

3x2

2x3

3x4

3x4

3x4

3x3

4x2

4x2

3x7

3x4

P001P012

P013 P024

P025P046

P047 P058

P059P081P082 P093

P094

P117P106P105

P120 P118

3x2

2x2

2x2

2x3

2x3

3x2

3x2

3x3

3x3

7x6

4x4

4x3

StageInnovation

Village

3x2 3x2

2x3

2x2

3x2 3x2

P121 P129

P138 P130

P150

P151

P139

Bodendosen u. Medienanschlüsse mit Anschlussmöglichkeiten für:

Elektro

Sanität

Torschaltkasten UK ca. 1.30m

Steuerkasten UK ca. 1.30m

Halleninfosäule

Plakatwand

Recycling-Container

Internes Hallentelefon

Notausgang

Telefonkabine

Handtaster Brandmelde Anlage

Feuerlöschposten

Handfeuerlöscher Wasser-, Elektro- und Telefonanschlüsse

Elektro- und Telefonanschlüsse

Detail

Holzrückwand von 3.00 m Höhe.

Elekroverteilkasten

Stände entlang den Hallenwände

Warenlift

Medienpunktraster

Stützenraster

Bodenbelastung

Nutzhöhe der Halle / Max. Bauhöhe

Hallenfläche

Grundriss, Geschoss

Sicherheitsanlagen

Nutzlast 6'000 KgLxBxH: 6.50x2.45x3.20 m

1 Medienpunkt pro 15m2

600 Kg/m2 (Ausnahmen im Plan eingezeichnet)

ca. 80 x 80 m, 3 Geschosse

müssen zugänglich sein.

haben eine

(z.B. Feuerlöschposten) und

4'100 m2

11.4x11.4 m

Aufhängungen sind teilweise mittels in derBetondecke eingelassenen M10 Hülsen möglich.

3.50 m (Randstände 3.00 m)Ausnahmen im Plan eingezeichnet

Articles can be suspended at some points fromM10 sockets in the concrete ceiling

11,40

3,80 3,80 3,80

11,40

3,80 3,80 3,80

Floor sockets and media connections for connecting up:

Electricity

Medical service

Gate-operating box,

Hall information pillar

Poster wall

Recycling container

Internal hall telephone

Emergency exit

Telephone booth

Pushbutton for fire alarm system

Fire point

Hand-held fire extinguisher Water, electricity and telephone connections

Electricity and telephone connections

rear wooden wall 3.00m high

electrical distribution boxes

Stands along the hall walls

Goods lift

Media point grid

Pillar grid

Floor loading

Effective height of Hall / max. construction height

Hall surface area

Floor plan, storey

Safety facilities

Maximum permitted load: 6000 kgLxWxH: 6.50x2.45x3.20 m

1 media point per 15m2

600 Kg/m2 (Exceptions drawn in on plan)

3.50 m (Edge stands 3.00 m)

ca. 80 x 80 m, 3 Storeys

must be accessible

have a

(e.g. fire points) and

11.4x11.4 m

4100 m2

bottom edge approx. 1.30 m

Exceptions drawn in on plan

85

42.5 42.5

45 202095

Covering on hall pillar 3.00 m high

55

47.5 47.5

Nr.

Nr.

Pillar detail

4585

42.5 42.5

45 202095

55

47.5 47.5

45

StützendetailHallenstützenverkleidung 3.00m hoch

Detail

3m 5m 7m

4m 6m 8m

1m

2m

Aisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

BAisle

CAisle

D

Aisle

AAisle

B

@-Corner

Coffee 1

From MainEntrance

To MainEntrance

Coffee 2

3x2

4x33x2 3x2

3x3

4x6

3x4

3x4 - 1m23x4

3x4

4x6

4x23x4

3x3

3x3

3x3

3x4.5

3x4

2x4

4x5

3x2

3x3

3x33x2

3x3

3x3

2x3

2x3

3x2

3x3

4x6

5x4

4x3

3x3

3x3

3x3

4x7 - 4m2

2x3

2x3

2x3

3x2 3x2 4x2

3x2

2x3

3x2

3x3

3x3 6x3+3x1

3x4

3x4


2x4

3x5

3x23x2

Coffee 3

2x44x2

3x2

3x2

2x3

3x4

3x4

3x4

3x3

4x2

4x2

3x7

3x4

P001P012

P013 P024

P025P046

P047 P058

P059P081P082 P093

P094

P117P106P105

P120 P118

3x2

2x2

2x2

2x3

2x3

3x2

3x2

3x3

3x3

7x6

4x4

4x3

StageInnovation

Village

3x2 3x2

2x3

2x2

3x2 3x2

P121 P129

P138 P130

P150

P151

P139

Poster Plan – Regular Posters

Poster Plan – Late Breaker Posters

Overview Poster Area

Aisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

BAisle

CAisle

D

Aisle

AAisle

B

@-Corner

Coffee 1

From MainEntrance

To MainEntrance

Coffee 2


Coffee 3

StageInnovation

Village

Regular Posters

Late Breaker Posters

FromLecture Halls

ToLecture Halls

38

Floor Plan Hall 4.1 (Exhibition)

Aisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

BAisle

CAisle

D

Aisle

AAisle

B

@-Corner

Coffee 1

From MainEntrance

To MainEntrance

Coffee 2


Coffee 3

StageInnovation

Village

Regular Posters

Late BreakerPosters

FromLecture Halls

ToLecture Halls

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.1

Floor Plan Hall 4.1 (Exhibition)

Aisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

AAisle

BAisle

CAisle

D

Aisle

BAisle

CAisle

D

Aisle

AAisle

B

@-Corner

Coffee 1

From MainEntrance

To MainEntrance

Coffee 2


Coffee 3

StageInnovation

Village

Regular Posters

Late BreakerPosters

FromLecture Halls

ToLecture Halls

40

Exhibitor List

Name of Exhibitor Booth4titude B16ACEA Biosciences Inc. C34Active Motif A23Agilent C52Agilent Technologies C34(Seahorse XF products)Analytic Jena B54Andreas Hettich GmbH B46Andrew Alliance SA A48Aptuit (Switzerland) AG D 15Artel C54BD Life Science C64Beckman Coulter D43BioLamina B66BioNex Solutions C34Biotage AB A42Bio-Techne A46BioTek Instruments GmbH D36BioVariance GmbH D61Basel Life Science Week 2017 A35BlueCatBio B43BMG Labtech A24Bruker-Physik GmbH B47Bucher Biotec C34Cellular Dynamics B45Chemspeed D26Cisbio B55Cognex D45Corning C45Covaris Ltd. C62Credimex AG A45CSEM A43DeNovix Inc C34Dispendix GmbH D46Ectica Technologies D70Embassy of Italy in Bern – A37Cluster ALISEICzech Republic A31EQUIcon Software C46Essen Bioscience B64Euresearch D50Eurogentec D51Fluxion Biosciences C34Formulatrix B52Fritz Gyger AG A53/ C34GC biotech B.V. C41GORYO Chemical Inc. D53Hamamatsu A40Hamilton C53

Name of Exhibitor BoothHuawei D65iba life sciences D13InSCREENeX GMBH D58Integra B40Integrated DNA Technologies D22BVBAIntelliCyt Corporation C34Kommission für Technologie D50und Innovation KTIKoNECT C60Lab Services D41Labcyte A49Labcyte A51LC Patents D56LiCONiC AG D57Life & Brain GmbH C44Lifeonics C34Logos Biosystems C34Luminex A39MaxWell Biosystems AG D52MDPI AG, Multidisciplinary D60Digital Publishing InstitutemilliDrop D54Miltenyi Biotec C50Mimetas B.V. C56Molecular Devices A26Molecular Sensing GmbH A52MyCartis B14Nano Temper D11OcellO B.V. D62OMass Technologies Ltd D44Perkin Elmer C61Pivot Park Screening Centre C58Quantifoil B50ReproCELL B44SAL Scientifi c Limited D67Sartorius Stedim Biotech C43Seyonic A47SILA A45Sphere Fluidics C34SUN bioscience D42Susos AG A25Switzerland Innovation Park D50Basel AreaThermo Fisher Scientifi c C40Titian Software Ltd. B24Twist Bioscience B42Unchained Labs B26Xavo B62Zinsser Analytic B41

As per 22 August 2016

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General Information

AbstractsAll accepted abstracts are visible in the detailed interactive programme on the congress website (www.basellife.org) and on the Science Publication Network (SPN, www.sci-pub.net).

ATMAn ATM is located outside the Congress Center Basel on the left hand of the main entrance. VISA and MasterCard are accepted.

BadgesFor admission to all scientifi c forums your personal badge is required. You may attend any forum even if you did not register for it online (except Career Work-shops on Monday). Please wear your badge at all times. CHF 30 will be charged for replacement of a lost badge.

CloakroomA cloakroom is available on the ground fl oor during the secretariat opening hours and can be used free of charge. Please note that the cloakroom is unguarded.

Exhibition opening hoursTuesday, 20 September 2016 08.45 – 18.00Wednesday, 21 September 2016 08.45 – 17.00Thursday, 22 September 2016 08.45 – 16.30

InsuranceThe meeting organiser cannot accept liability for personal injuries sustained, or for loss or damage of property, either during, or as a result of the meeting. Please check the validity of your insurance.

Internet cornerSeveral internet terminals are located in the exhibition area and are available to all congress participants during the opening hours of the exhibition. An attendee list (names and provenance) can be viewed at the internet corner.

Coffee & lunchA light lunch (e.g. salad and soup) is served between 12.00 and 13.30 in the exhibition Hall 4.1 free of charge (on a fi rst-come, fi rst-served basis). Coffee is available throughout the day in the exhibition hall 4.1 between 08.45 and 17.00.

Networking Events

Welcome ReceptionTuesday, 20 September 2016 17.15–18.00 (Hall 4.1)

Poster Session and ApéroWednesday, 21 September 2016 17.15–18.00 (Hall 4.1)

42

General Information

PostersThe poster exhibition is located in Hall 4.1.

Poster session Poster mounting Poster removalWednesday,

21 September 201617.00 – 18.00

Tuesday,20 September 2016

09.00 – 10.00

Thursday,22 September 2016

16.00 – 17.00

Authors are kindly asked to be present at their posters during the poster session and the times shown above. All authors are required to mount and remove their posters at the above mentioned times.

Poster AwardThe Steering Committee is proud to grant the Poster Award at Basel Life Science Week 2016! This annual programme serves to highlight and reward high level presentations. Eligible candidates are all poster presenters at the Basel Life Sci-ence Week 2016. Award comprises CHF 300 for the winner, CHF 200 for the 2nd and CHF 100 for the 3rd place.

Judging and selection will take place at BLSW 2016 and is handled by the BLSW poster award selection committee.

The award ceremony will take place on Thursday, 22 September 2016 before the keynote speaker Dr. Shai Silberberg in room Boston 1–3.

Registration / Secretariat Opening HoursMonday, 19 September 2016 08.45 – 16.00Tuesday, 20 September 2016 08.15 – 17.30Wednesday, 21 September 2016 08.30 – 17.30Thursday, 22 September 2016 08.30 – 17.15

ResponsibilityThe participants acknowledges that he/she has no right to lodge damage claims against the organisers should the holding of the conference be hindered or pre-vented by political events (such as acts of terrorism, danger of hostility, war etc.) or by unexpected political or economical events or generally “force majeure”, or should the non-appearance of speakers or other reasons necessitate programme changes. With registration, the participant accepts this proviso.

Speakers’ Service Centre (SSC)The SSC is located close to all lecture halls. All speakers are kindly asked to hand in their PowerPoint presentation at the SSC at least 1 hour before the start of the session.

VenueThe conference takes place at the Congress Center Basel. Messeplatz 21CH-4058 BaselPhone: +41 58 206 28 20 (onsite)www.congress.ch

WLANFree wireless-LAN is available throughout the whole Congress Center Basel.

Save the date

BLSW 2017 11 – 15 September 2017

MipTec exhibition12 – 14 September 2017

Basel Life Science Week 2016 Day One – The Future of Health:

19 September 2016

Basel Life Science Week: 19 – 22 September 2016

MipTec Exhibition: 20 – 22 September 2016

ILMAC: 20 – 23 September 2016

Medtech & Pharma Platform: 22 – 23 September 2016

2017 Sept 1 1–15Science Week Leading in Europe

The International Life Science

Exhibition

Sept 12–14

Visit us a

t our

Booth C

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us at our

Booth C

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