Minutes of the Graduate Faculty Council Meeting Tuesday, September 20, 2011 Members (12): Thomas Drummer (Math), Ashutosh Tiwari (Chem), Craig Friedrich (MEEM), Blair Orr (PCMI), Greg Waite (Geo), Eugene Levin (Sch Tech), Keat Ghee Ong (Biomed), Steve Seidel (CompSci), Barry Solomon (SocSci), Mi Hye Song (Bio), Dave Watkins (Civil), Carl Anderson (Eng) Guests (7): Heather Suokas (Grad Sch), Debra Charlesworth (Grad Sch), Jacque Smith (Grad School), Nancy Byers-Sprague (Grad Sch), Felicia Chong (GSG), Pushpa Murthy (Chem), Erik Nordberg (Libr) 1) Meeting called to order at 4:08 pm. 2) Review and approval of 09/06/11 meeting minutes. 3) Committee Reports:

a. Call for Volunteers to Form a Thesis/Dissertation Guideline Review Committee (Dean Huntoon): The new procedures that were approved last year have been put into place as of January 2011. After using them for two semesters Dean Huntoon has received feedback from students and faculty. In response to feedback, Dean Huntoon has drafted a new version of the guidelines. She would like a committee formed to help her revise and finalize the guidelines. What problems are the current guidelines creating? The guidelines are rigorous (specific fonts, formats, etc) and the Graduate School staff does not have the time to check all of those guideline details. Students find it very difficult to achieve all of the requirements named in the current guidelines. Blair Orr and Steve Seidel volunteered. Felicia (GSG) will also inform the GSG President requesting a volunteer from the Graduate Student Government.

4) Old Business: a. Biochemistry & Molecular Biology PhD Proposal- Non-departmental (P. Murthy): At the 09/06/11 GFC

meeting, members were asked to bring the proposal back to their departments to discuss any questions or concerns that they may have. Questions/Comments: Being that this is a PhD degree should the core courses actually be at the 6000 level rather than the 5000 level? P. Murthy agrees and will make the change. The second paragraph of 6.1 (Required Core Courses) states “The courses may be at the 3000-, 4000-, or 5000-level.” This referring to the additional courses needed for the degree. Should they actually be allowed to take 3000-level courses? Yes, because depending on the competence of the student some of them may need to take 3000-level courses to get up to speed. Do all the departments involved (Chemistry, Biology and Forestry) allow 3000-level courses for a PhD degree? The representatives for Chemistry, Biology and Forestry all agree that this is allowed. With the text change above from 5000-level to 6000-level, the sentence should now include 6000-level courses. Is this proposal emulating any other PhD program on campus? No. What is meant by core faculty? Anybody who would like to be considered core faculty is expected to actively participate by teaching and committing to the graduate program committee. Motion to approve this proposal with the two above text changes passed. This should be emailed to Helene Hiner in the Provost’s Office in order for her to forward to the Senate.

b. Biomedical Engineering MS Proposal (K. Ghee Ong): At the 09/06/11 GFC meeting, members were asked to bring the proposal back to their departments to discuss any questions or concerns that they may have. Questions/Comments: There are some concerns that this proposal does not include core courses. There are similar degree programs on campus that do not have core courses. Some degree programs have core courses and some do not. They are going to set some guidelines. Are your students primarily supported by external resources? Yes, most are externally supported. Section 6 (Program Requirements) states that “graduate students will be required to attend the Graduate Seminar.” How do you ensure that this happens? There are no consequences if this is not followed. Attendance is taken. The assumption is that the students follow the guidelines. The Library representative present at the meeting wanted to point out that some proposals state that there are no additional costs. New graduate program proposals should be attentive to potential costs associated with access to licensed journals and per-article downloads,

particularly in new discipline areas. More graduate students equal more resources being used at the Library. This may be something departments can look at in the future when developing a proposal. Motion to approve this proposal passed. This should be emailed to Helene Hiner in the Provost’s Office in order for her to forward to the Senate.

5) New Business: a. Category Revisions for Graduate Faculty (Dean Huntoon): Right now we have two classes of graduate

faculty: full members and adhoc members (there to serve on one student’s committee). In reality there are many kinds of people that are part of the graduate faculty. Some are members of the Michigan Tech faculty, some are off campus faculty, and some are research scientists. The new categories and definitions are as follows: 1) Full Members: Members of the academic faulty holding the rank of assistant professor, associate professor or professor, 2) Affiliated Members: Members holding the rank of lecturer, adjunct, and emeritus faculty and faculty holding a rank with a prefix of visiting, 3) Contributing Members: Members with special technical expertise that are employees of Michigan Tech and have been nominated for membership in the Graduate Faculty by an academic department or school and have been appointed to the Graduate Faculty by the dean of the Graduate School (Research Scientists, research engineers which are now called full membership, if they have a terminal degree in their field), 4) Temporary Members: Members with special technical expertise that are not employees of Michigan Tech. Temporary members must be nominated for membership in the Graduate Faculty by an academic department or school and must be appointed to the Graduate Faculty by the dean of the Graduate School. Questions/Comments: Nancy Byers Sprague sends out an email each year asking that chairs review the list and remove those who no longer should be listed as Graduate Faculty. Will all these categories have the same rights and privileges? Yes. The way it is proposed here eliminates a lot of the confusion that was caused in the past where the people within the categories all had different roles. Is the way it stands now with only two classes creating a big problem? No, it is not a big problem but based on faculty feedback there is a need to distinguish between regular grad faculty who do hold a regular tenure track appointment and the others. Is the distinction between affiliated members and contributing members so much that the two need to be separated? Affiliated include lecturers which are faculty and contributing members are people like research scientists/engineers which are staff. If nobody has a problem with the two being combined then Dean Huntoon will combine them. The members are asked to bring the proposal back to their department to discuss and get feedback including on whether to combine the two categories mentioned above.

b. Changes to GACS (Dean Huntoon): In the past the Graduate Assistant Cost Share (GACS) has been available to assist the professors at the proposal stage. When an assistant professor writes a proposal, they can receive tuition if the sponsor provides full stipend. This has worked really well for some faculty but not all faculty. The faculty in which this works for have taken advantage of it, written proposals, and received funding. The faculty in which it did not work for have a hard time getting graduate students (due to lack of funding) to help them get the initial data needed to write a winning proposal to receive external funding. The National Science Foundation has now said that they no longer require discloser of cost share. If we continue to commit GACS at the proposal stage the University would be responsible for tracking all the GACS. Currently when there is left over money from GACS when the project ends, the money needs to be given back to the Graduate School. Rather than committing GACS at the proposal stage there would be a return to the departments once per year based on how much external support for graduate students were expended in the previous year. The money can then be used for a variety of reasons including to support students or to help incoming faculty. The goal is to stimulate further growth in the number of students supported by sponsored projects. Questions/Comments: What about the new departments just starting? The new departments tend to get a boost in the GTA allocations to help with that. The hope with this new proposal is that everybody will get something. Who will control the money? The money will go to the department chair. Can this be used for stipend or just tuition? That has yet to be determined but it is leaning towards tuition only. What happens if the funding source does require cost share? The proposal writer would go to the department chair rather than the graduate school to ask for the money. This proposal has been approved by the dean’s council and is supported by the Provost, chairs in engineering, and the VPR’s. Will this proposal be put into place whether the GFC approves or not? Yes. When will this start? The earliest that it could possibly start is this coming January. Being that the money

goes to the chair to use as they see fit, there is risk that the money will not be used for incoming faculty. The GFC sees this as a problem. A strong recommendation could be made to consider the early career faculty. Why does it need to go to the chair; why not to the PI? That option was not popular with the dean’s and chairs. The members are asked to bring the proposal back to their department to discuss and get feedback.

6) Motion to adjourn at 5:10 pm.

September 20, 2011 (Last update: 09/07/11)

Handouts of the Graduate Faculty

Council

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Proposal for a non-departmental Ph.D. Program in Biochemistry and Molecular Biology (BMB) Submitted by the Biochemistry and Molecular Biology Doctoral Planning Group

Contacts: P. Murthy (Chemistry), R. Wusirika (Biological Sciences), C.P. Joshi (Forestry and

Environmental Sciences)

March 21, 2011

There is a growing world-wide demand for scientists and engineers with advanced training in biochemistry and molecular biology. In particular, there is a recognized need for society to understand and respond to problems associated with human health, medicine, forestry and agriculture at the biochemical and molecular levels. Powerful new research tools for understanding these complex processes, such as complete genomes (of humans, animals, crop plants and trees), multi-scale computer models, and applications of “omics” technologies including pharmacogenomics (designing specific therapies based on individual genomes) are being rapidly developed. To successfully participate in these advanced research and development endeavors students need graduate-level training in biochemistry and molecular biology. Furthermore, these research problems and the techniques used to address them are inherently interdisciplinary in nature, and therefore span traditional departmental boundaries.

Michigan Tech has a long and rich history of research in the exciting field of biochemistry and molecular biology. Recent conceptual and technological advancements have widened the scope of what is possible to study in these fields and correspondingly, many recent faculty hires in individual departments and through the Strategic Faculty Hiring Initiative have increased the ranks of those around campus (Biological Sciences, Chemistry, Forest resources and Environmental Sciences, Chemical Engineering, Biomedical Engineering, Mathematics) engaged in biomedical research, plant genomics and other health-related biochemistry and molecular biology studies. Our ability to carry out cutting edge research in these areas will strongly benefit from greater coherence and integrated graduate training. Here, we propose a new doctoral degree program in Biochemistry and Molecular Biology (BMB) which would consolidate our dispersed resources and expertise. This would provide a more appropriate degree program for some of our current and future graduate students as well as a stronger and more focused educational experience for all students involved in molecular level investigations of life processes. Items required by the University Senate for proposing new academic programs (Proposal 108.1.1) are detailed in this proposal.

This program would be categorized within the one or both of the following two CIP codes: • 26.0210 Biochemistry/Biophysics and Molecular Biology • 26.0299 Biochemistry, Biophysics and Molecular Biology, Other

1. General description and characteristics of the program

A growing number of faculty and graduate students at Michigan Tech are working in the area of biochemistry and molecular biology. These include members of the Departments of Chemistry, Biological Sciences, Chemical Engineering, Biomedical Engineering and the School of Forest Resources and Environmental Sciences. Active research programs, courses, and a growing number of graduate degrees based on work in this area already exist. The current initiative is to build on the established and emerging research programs by developing a new,

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coherent, non-departmental Ph.D. program whose primary focus is the graduate education of students in the interdisciplinary areas of biochemistry and molecular Biology (BMB). A core group of 14 graduate faculty members will be involved in the BMB Ph.D. program (Table 1). The BMB Core Faculty are those who likely would advise Ph.D. students in the program, teach relevant lecture and laboratory courses, serve on qualifying exam committees, be elected to serve on the steering committee and otherwise perform programmatic duties of graduate faculty. Current members are from the Departments of Biological Sciences, Chemistry, and the School of Forest Resources and Environmental Sciences. The BMB program is open to faculty and students with overlapping research and academic interests. Michigan Tech faculty with close research interests include Drs. S. Bagley (BL), M.H. Song (BL), D. Shonnard (CM), C.-A. Peng (CM), A. Minerick (CM), C. Heldt (CM),T. H. Donahue (MEEM), S.Donahue (BE), M. Frost (BE), R. Rajachar (BE) and others. We expect that some of these faculty members will be interested in participating in the BMB Ph.D. program by joining the BMB Core Faculty group and participating in associated teaching and service duties. Other faculty members advise graduate students who will benefit from the new course offerings and other educational activities resulting from this program as their research focus needs a detailed understanding of biochemistry and molecular biology. We anticipate that a coherent program in BMB will help to attract future faculty with diverse expertise in this area into the above departments as well as other department such as the Departments of Chemical Engineering and Biomedical Engineering. Table 1. BMB Core Faculty Department of Biological Sciences Rupali Datta, Ph.D. Associate Professor Plant Biochemistry, Environmental Remediation, Plant-Microbe Interactions Office: 530 Dow Environmental Sciences and Engineering Building Phone: (906) 487-1783; Email: rupadatta@mtu.edu K. Michael Gibson, Ph.D., FACMG Professor Inherited human genetic disorders Office: 740 Dow Environmental Sciences and Engineering Building Phone: (906) 487-2025; Email: kmgibson@mtu.edu Michael Gretz, Ph.D. Professor Carbohydrate biochemistry Office: 730 Dow Environmental Sciences and Engineering Building Phone: (906) 487-3175; Email: mrgretz@mtu.edu Wan Jin Jahng, Ph.D. Assistant Professor Vision mechanism, retinal degeneration, functional proteomics Office: 501 Dow Environmental Sciences and Engineering Building Phone: (906) 487-2192; Email: wjahng@mtu.edu

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Ramakrishna Wusirika, Ph.D. Associate Professor Plant Molecular Biology, Comparative Genomics, Bidirectional Promoters and Transposons Office 505 Dow Environmental Sciences and Engineering Building Phone: (906) 487-3068; Email: wusirika@mtu.edu Thomas Werner, Ph.D. Assistant Professor Evolution, Genetics, Toxicology, Developmental Biology, Insect Immunology, Virology Office 523, Dow Environmental Sciences and Engineering Building Phone: (906) 487-1209; Email: twerner@mtu.edu Department of Chemistry Tarun Dam, Ph.D. Assistant Professor Glycobiology; protein-glycan interactions in immune regulation and pathogen invasion Office: 701C Chemical Science and Engineering Building Phone: (906) 487-2940; Email: tkdam@mtu.edu Pushpalatha Murthy, Ph.D. Professor Phospholipid and Phosphoinositide metabolism and biochemistry Office: 505 Chemical Science and Engineering Building Phone: (906) 487-2094; Email: ppmurthy@mtu.edu Martin Thompson, Ph.D. Associate Professor Protein-protein interactions and design of small peptide-based inhibitors of protein-interactions Office: 510C Chemical Science and Engineering Building Phone: (906) 487-3522; Email: thompson@mtu.edu

Ashutosh Tiwari, Ph.D. Assistant Professor Protein misfolding diseases’ with special emphasis on neurodegenerative diseases. Office: 402B Chemical Science and Engineering Building Phone: (906) 487-1840; Email: tiwari@mtu.edu

School of Forest Resources and Environmental Sciences Victor Busov, Ph.D. Associate Professor Functional genomics of woody development Office: 185, Noblet Building, School of Forest Resources and Environmental Science Phone: 906-487-1728; Email: vbusov@mtu.edu

Oliver Gailing, Ph.D. Assistant Professor Ecological genetics and genomics Office: 167, Noblet Building, School of Forest Resources and Environmental Science Phone: (906-487-1615); Email: ogailing@mtu.edu

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Chandrashekhar Joshi, Ph.D. Professor Development of fast growing bioenergy trees for efficient cell wall deconstruction to biofuels Office: 168 Noblet Building, School of Forest Resources and Environmental Science Phone: 906-487-3480; Email: cpjoshi@mtu.edu Hairong Wei, Ph.D. Assistant Professor Plant systems biology and bioinformatics Office: 176, Noblet Building, School of Forest Resources and Environmental Science Phone: 906-487-1473; Email: hairong@mtu.edu Organizational Structure and Administration The Biochemistry Ph.D. program, as an interdisciplinary, cross-department program, will be administered through the Graduate School. Participating faculty will elect a three-member steering committee. The committee will elect a Graduate Program Director who will work closely with the Dean of the Graduate School and will be assisted by a staff member. Most biochemistry and molecular biology grants are affiliated with the Biotechnology Research Center (BRC) so the staff member of BRC will provide some assistance. The Graduate Program Director and the Steering Committee, with the help of BMB Core faculty, will review applications, make admission decisions, determine whether or not changes to the program need to be made (e.g., changing the “approved” curriculum or adding or removing faculty from participation). The home departments of the core courses are committed to offering them on a regular basis. Students enrolled in the program will be housed within the home department of their advisors. The home departments will provide office space, computational resources, and necessary supplies and infrastructure support, and will consider the students for departmental teaching assistantships when appropriate and available. All such students will be counted as members of their home departments for the purposes of internal university accounting.

2. Rationale

The new program responds to a national and international need for more researchers to address problems in the areas of human health, disease treatment and sustainable environment at a molecular level. Advanced education in biochemistry, molecular biology and related fields is essential for creative and productive approaches to these problems. This initiative is motivated by the following:

• This program provides a mechanism for recruiting more highly qualified graduate students by providing

a degree that encompasses the interdisciplinary nature of biochemical research better than existing programs within individual academic departments. Currently, students interested in BMB must apply to programs in Biological Sciences, Chemistry, or the School of Forest Resources and Environmental Studies, which have their own curriculum and culture. This new BMB program would attract additional Ph.D. students who wish to have a broader interdisciplinary academic experience focused on biochemistry and molecular biology.

• The new program builds on current strengths with a core group of 14 faculty in three different departments committed to the BMB program. The program could be offered as soon as it is approved. Several existing students are already interested in entering the program.

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• Many graduate-level biochemistry and molecular biology courses are currently offered at Michigan Tech

in separate departments and this program would streamline existing faculty effort by helping to identify and eliminate redundancies and increase enrollments in courses that are currently undersubscribed. New graduate courses will be added to address existing deficiencies and serve the needs of students in several disciplines. The new courses along with existing courses will be organized into a coherent program.

• The Ph.D. in BMB is attractive to students as they will have a degree in their area of interest. In addition, the area of expertise of students will be obvious to academic and private sector employers because it is not currently apparent to employers that Michigan Tech students educated in Chemistry, Biological Sciences, or Forest Resources and Environmental Studies have specialized Ph.D. – level training in biochemistry and molecular biology.

• The new program would enhance interdisciplinary research at Michigan Tech by bringing together graduate students and faculty housed in different departments who are conducting related research.

• The new BMB program will be housed in the Graduate School. It will be overseen by a Steering Committee made up of BMB Core Faculty.

• Research in biochemistry and molecular biology is well funded and the new program could help with

efforts to increase external funding.

3. Discussion of related programs within the institution and at other schools

There are currently three biochemistry Ph.D. programs (The University of Michigan, Ph.D. in Biological Chemistry; Michigan State University, Ph.D. in Biochemistry and Molecular Biology; Wayne State University, Ph.D. in Biochemistry and Molecular Biology) in the State of Michigan. The character of the biochemistry degree programs vary depending on the research emphasis of the faculty. The faculty involved in this program at Michigan Tech form a unique and broad mix involving biological chemistry, molecular and cellular biology, chemical biology, plant physiology, biomedical science and engineering, biochemical engineering, biomechanical engineering, forest molecular biology and genomic sciences. This combination of subject areas spans the major sub-disciplines of biochemistry and molecular biology. Job opportunities for Ph.D. graduates in BMB are excellent and are expected to remain so as a result of national and international priorities in medicine, health, agriculture, forestry and bioenergy fields. 4. Projected enrollment

We anticipate that 2-5 students will enter the program immediately and that within five years the program will have between 15-20 students. 5. Scheduling plans We are aiming for implementation by Fall Semester 2011. Participating departments have committed to offer core courses on a regular basis.

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6. Curriculum design Course requirements are designed to ensure that all students have a firm understanding of the fundamentals of biochemistry and molecular biology, including the principles underlying biochemical structure, biochemical dynamics, molecular biology, genomics and biotechnology. These principles will be covered in three core courses BMB5010, BMB5020 and BMB5030. The set of core courses will be offered annually. This ensures that students will be able to complete the core courses and be prepared to take the qualifying examinations during their second year. 6.1 Required Core Courses Three 5000-level courses (three credits each), a seminar course (BMB5040; one credit), and doctoral research (BMB 6990) will form the core of the curriculum for the BMB doctoral program. The courses are BMB 5010: Advanced Biochemistry, BMB 5020: Advanced Molecular Biology, and BMB5030: Modern BMB techniques, descriptions in Section 7 below). These courses cover the fundamentals of biochemistry and molecular biology. The three core courses will be developed and team taught by the BMB core faculty from the departments of Biological Sciences, Chemistry, and the School of Forest Resources and Environmental Sciences. These courses will provide the necessary background in the areas of biochemistry and molecular biology including genomics and biotechnology. The Departments of Chemistry and Biological Sciences and the School of Forest Resources and Environmental Sciences have agreed to support the creation of these new courses. In addition to the nine core course credits above, students, depending on their academic background, may be required to take additional courses to provide the breadth and depth necessary for graduate research. The necessary courses will be suggested by the student’s Advisor in consultation with the Advisory Committee. The courses may be at the 3000-, 4000- or 5000- level. A partial listing of 5000 level courses is included below (7.2). Courses used to satisfy the requirements for a degree will conform to Graduate School policies regarding required grades, overall GPA, and academic level. Students will be required to complete a seminar course (BMB5040, 1 credit). Instead of duplicating seminar courses offered by other departments, BMB5040 may include elements of graduate level seminar courses currently offered by other departments such as Biological Sciences (BL5503), Chemistry (CH5900) and the School of Forest Resources and Environmental Sciences (FW5800) and others. Students conducting research will enroll in (BMB6990). Students will need a total of 60 credits beyond a Bachelor degree or 30 credits beyond a Master degree, per Graduate School requirements. 6.2 Qualifying Examination Each student must pass a written qualifying exam followed by an oral exam no later than the end of the second year of graduate study (Spring semester of second year). This examination will cover topics covered in the core courses BMB 5010, BMB 5020 and BMB 5030. The purpose of the examination is to determine the student’s mastery of knowledge in biochemistry and molecular biology and the ability to apply this knowledge. Each examination will be written by a committee of four faculty members who have been involved in teaching BMB5010, BMB5020 and BMB5030. All students in the program will take the same qualifying exam. The committee will grade the qualifying exam and conduct the oral examination. On the basis of the student’s

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performance, the committee will decide whether or not each student passes; a student will pass if a majority of committee members vote in the affirmative. Students who do not pass the examination will be allowed a second attempt. Failure to pass the Qualifying examination in two attempts will result in dismissal from the Ph.D. program; both attempts must be completed by the end of the second year.

6.3 Proposal defense The student will present a proposal followed by an oral defense of the research plan to his/her Advisory Committee. The proposal should be submitted within one year of successfully completing the qualifying examinations above (6.2) and no later than the completion of the third year in the Ph.D. program. The student's advisory committee must unanimously agree that the research plan is acceptable. The oral proposal is open to the University community. 6.4 Doctoral dissertation and final oral examination The research conducted by the student will be presented to the Advisory Committee as a written dissertation. An oral presentation of that dissertation will be made following the completion of the written work. The committee will consist of at least four members of the graduate faculty. At least one of these will be from outside the student's administrative home department or school. The dissertation is acceptable if the advisor and at least two of the remaining three members of the Advisory Committee concur on its acceptance. The oral defense is open to the University community. 7. New course descriptions BMB5010 Advanced Biochemistry This course will focus on the relationships between structure and function of proteins, nucleic acids lipids and carbohydrates. Specific topics include enzyme catalysis, binding and allosterism, protein-protein interaction and protein-nucleic acid interaction, membrane function and signal transduction. Classic and current papers may accompany the lecture material. Foundations in basic biochemistry and molecular biology are required for this course. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: Fall. BMB5020 Advanced Molecular Biology This course will focus on the gene structure, gene duplication gene expression, gene regulation, DNA recombination, DNA repair and transposition. Comparison between prokaryotes and eukaryotes will be drawn. Genomics and modern biotechnology methods will be discussed. Classis and current papers may accompany the lecture material. Foundations in basic biochemistry and molecular biology are required for this course. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: Fall. BMB5030 Modern BMB Laboratory This is an intensive laboratory course that focuses on protein chemistry, nucleic acid chemistry, genomics and biotechnology. Students will rotate between research labs of four faculty where they will gain in-depth laboratory experience in modern biochemistry and molecular biology. Credits: 3.0. Lec-Rec-Lab: (0-0-3). Semesters Offered: Spring. BMB6990 Doctoral Research Original research that culminates in a PhD dissertation. Credits: Variable to 12.0.May be repeated; Graded Pass/fail only. Semesters offered: Fall/Spring. Restrictions: Permission of instructor required. Must be enrolled in one of the following level(s): Graduate

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7.1 Courses currently offered in Biochemistry and Molecular Biology at the 5000 level

• BL5030 - Molecular Biology Molecular biology of gene structure, expression and regulation. Molecular techniques and their application to biotechnology and genomes are covered. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: Fall; Restrictions: Must be enrolled in one of the following Level(s): Graduate.

• BL 5035 – Bioimaging Current concepts in light and electron microscopy and scanning probe techniques. Theory

and practice of fluorescence (including confocal and multi-photon), atomic force, scanning and transmission electron, and video microscopy as applied to biological specimens with an emphasis on sample preparation. Emphasis will be placed on application of advanced techniques. Half semester course. Credits: 2.0. Lec-Rec-Lab: (0-4-0). Semesters Offered: Fall - Offered alternate years beginning with the 2010-2011 academic year. Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

• BL 5042 - Scanning Electron Microscopy of Biological Specimens Hands-on training in operation of the scanning

electron microscope (SEM). Students prepare biological specimens of their choice for observation. Emphasis will be placed on application of advanced techniques. Successful completion of course is prerequisite to becoming a certified SEM operator in the ACMAL. Half semester course. Credits: 2.0 Lec-Rec-Lab: (0-2-6) Semesters Offered: Fall - Offered alternate years beginning with the 2010-2011 academic year Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior. Pre-Requisite(s): BL 5035

• BL 5052 - Fluorescence and Video Microscopy of Biological Sciences Hands-on training in fluorescence

microscopy and video microscopy. Students prepare biological specimens of their choice for observation. Emphasis will be placed on application of advanced techniques. Half semester course. Credits: 2.0 Lec-Rec-Lab: (0-2-6) Semesters Offered: Spring - Offered alternate years. Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior . Pre-Requisite(s): BL 5035

• BL 5062 - Transmission Electron Microscopy of Biological Specimens Hands-on training in operation of the

transmission electron microscope (TEM). Students prepare biological specimens of their choice for observation. Emphasis will be placed on application of advanced techniques. Successful completion of course is prerequisite to becoming a certified TEM operator in the ACMAL. Half semester course. Credits: 2.0 Lec-Rec-Lab: (0-2-6). Semesters Offered: Spring - Offered alternate years. Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior. Pre-Requisite(s): BL 5035

• BL 5145 - Plant-Microbe Interactions Interactions between plants and microorganisms in the environment. Topics

include microbial virulence, signaling, gene expression, beneficial interactions and disease resistance in plants. Laboratory will focus on plant biochemical and microbiological methods as they relate to environmental problems. Credits: 3.0 Lec-Rec-Lab: (2-0-2) Semesters Offered: Fall Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

• BL 5503 - Graduate Research Seminar Seminar is designed to facilitate critical discussions of student research

projects at various stages of their development. The presenter will provide a seminar on their project and research goals, which will establish the foundation for the discussion thereafter. Credits: 1.0; May be repeated. Lec-Rec-Lab: (0-1-0). Semesters Offered: Fall

• CH 5110 - Pharmaceutical Chemistry: Drug Action Focuses on structural and mechanistic approaches to

pharmaceuticals and drug action. General principles of absorption, distribution, action, metabolism, and toxicity of drugs will be presented followed by action of drug classes such as antibiotics, cardiovascular, and anti-inflammatory drugs. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: Spring. Restrictions: Must be enrolled in one of the following Level(s): Graduate

• CH 5120 - Pharmaceutical Chemistry: Drug Design Focuses on the important concepts in the design and synthesis

of drugs. Rational basis for drug design including synthetic, computational, and biochemical concepts will be

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discussed. Topics include structure-activity relationships, synthesis and reaction mechanism, and case studies of drugs. Credits: 3.0 Lec-Rec-Lab: (3-0-0) Semesters Offered: Fall Restrictions: Must be enrolled in one of the following Level(s): Graduate

• CH 5210 - Analytical Separations Covers theory and applications of modern gas chromatography, high

performance liquid chromatography, and ion chromatography as well as instrumentation for these techniques. Studies trace organic analysis and environmental problems. Credits: 3.0 Lec-Rec-Lab: (3-0-0) Semesters Offered: Spring. Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

• CH 5230 - Mass Spectrometry and Fluorescence Fundamentals and applications of gas chromatography-mass

spectrometry, liquid chromatography-mass spectrometry and fluorescence spectroscopy. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: On Demand Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

• CH 5570 - Advanced Biophysical Chemistry A discussion of experimental techniques and applications of physical

chemistry principles to the study of the structure, dynamics, and chemical reactions of proteins, nucleic acids, and other biopolymers. Credits: 3.0. Lec-Rec-Lab: (3-0-0). Semesters Offered: On Demand. Pre-Requisite(s): CH 3520

• FW 5070 - Developmental and Ecological Genetics Course will provide current knowledge on signal perception,

transduction and response pathways in higher eukaryotes with most examples primarily from but not limited to plants in a lecture and colloquium format. Topics will cover major developmental pathways, and molecular bases of adaptation to biotic and abiotic factors. Credits: 3.0 Lec-Rec-Lab: (1-2-0) Semesters Offered: Fall Pre-Requisite(s): BL 5030

• FW 5076 - Molecular Techniques in Ecology The course provides knowledge on molecular techniques used in

ecology, population biology, and evolutionary studies. Credits: 3.0; Graded Pass/Fail Only Lec-Rec-Lab: (3-0-0) Semesters Offered: Fall - Offered alternate years beginning with the 2010-2011 academic year

• FW 5082 – Gene Expression Data Analysis Students will learn statistical methods and skills for analyzing large-

scale gene expression data resulting from high-throughput technologies, become familiar with various bioinformatics tools and resources, and develop useful working knowledge of how to analyze genetic data. Credits: 3.0 Lec-Rec-Lab: (3-0-0) Semesters Offered: Spring - Offered alternate years beginning with the 2010-2011 academic year

• FW 5089 - Tools of Bioinformatics Computer applications in molecular biology. Hands-on experience with using

popular computer programs for DNA, RNA and protein sequence analysis, database management, data editing, assembly, and organization, multiple sequence comparisons, protein structural analysis, evolutionary relationships of genes, use of Internet for data retrieval, comparison and analysis. Credits: 4.0 Lec-Rec-Lab: (2-1-2) Semesters Offered: Fall - Offered alternate years beginning with the 2011-2012 academic year Restrictions: Must be enrolled in one of the following Level(s): Graduate

• FW 5413 - Sustainable Biomass Production and management systems involving biomass for bioenergy and biofuels applications in native forests and energy plantations. Emphasis on integration across systems and values in the context of environmental sustainability. Credits: 3.0 Lec-Rec-Lab: (2-1-0) Semesters Offered: Fall - Offered alternate years beginning with the 2010-2011 academic year Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

• FW 5413 - Sustainable Biomass Production and management systems involving biomass for bioenergy and biofuels

applications in native forests and energy plantations. Emphasis on integration across systems and values in the context of environmental sustainability. Credits: 3.0 Lec-Rec-Lab: (2-1-0) Semesters Offered: Fall - Offered alternate years beginning with the 2010-2011 academic year Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

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• FW 5800 - Master's Graduate Seminar Presentation by students of current forest resource- related problems and

research. Some instruction on presentation skills. Credits: 1.0 Lec-Rec-Lab: (0-1-0) Semesters Offered: Fall, Spring Restrictions: Must be enrolled in one of the following Level(s): Graduate

• FW 5850 - Effective Grantsmanship Workshop Ability to write successful grant application is an important part of

graduate education. Students will learn basic techniques of grant writing for federal, industrial, and international funding agencies and will submit a well-organized proposal for peer review in the class. Credits: 2.0 Lec-Rec-Lab: (1-1-0) Semesters Offered: Spring Restrictions: May not be enrolled in one of the following Class(es): Freshman, Sophomore, Junior

7.2 Potential additional courses New courses will be offered based on the needs of graduate students and the expertise and availability of affiliated faculty. Potential new courses include, Bioremediation; Cancer/tumor metabolism; and Metabolic impact of pollutants. 8. Library and other learning resources The program builds on existing resources, so it is not anticipated that new library or other learning resources will be required. 9. Computing Access Fee Initially each student will pay the Computing Access Fee appropriate to the advisor's home department. The program will revisit this issue as circumstances dictate. 10. Faculty resumes Attached below. 11. Description of available/needed equipment Faculty listed in Table 1 have fully functioning laboratories with the necessary equipment and computers. No new equipment is required to startup this program. 12. Program costs No new resources are requested, and costs associated with recruiting and other program administration will be handled through the Graduate School and the departments of Biological Sciences, Chemistry, and Forest resources and environmental sciences and the BRC. 13. Space No new space is required

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14. Policies, regulations and rules Described in Section 1 (faculty participation) and Section 6 (curriculum requirements) above. 15. Accreditation requirements Not applicable 16. Internal status of the proposal Approved by the Department Chairs and the Deans of the College of Sciences and Arts and the School of Forest Resources and Environmental Sciences (See attached signature sheet). Preliminary review by the Dean of the Graduate School completed. Reviews by the Provost, Dean’s Council, Graduate Faculty Council, and University Senate are pending. 17. Planned implementation date There are students currently attending Michigan Tech who are interested in the BMB PhD program so we are aiming for implementation by Fall Semester 2011.

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Biographical Sketch

Victor B. Busov

Associate Professor Michigan Technological University

School of Forest Resource Environmental Science 185 Horner Hall

Phone:906-487-1728 Fax:906-487-2915

Houghton, MI 49931 E-mail: vbusov@mtu.edu

Education Oregon State University Molecular biology Post-doc., 2004 North Carolina State University Genetics Ph.D.,2001 Southern Illinois University Forestry M.S., 1996 Bulgarian Higher Forestry Institute Forestry B.S., 1990 Appointments 05/08-present Associate Professor. Michigan Technological University. Functional genomics of adaptation and

development in trees. 03/04–05/08 Assistant Professor. Michigan Technological University. Functional genomics of adaptation and

development in trees. 12/01—01/04 Post-doctoral Research Associate, Oregon State University

Activation tagging for gene discovery in poplar. 08/96--12/01 Graduate Research Assistant. North Carolina State University.

Microarray analysis of auxin-regulated gene expression in loblolly pine. 08/94--01/96 Graduate Research Assistant, Southern Illinois University

Allozyme analysis of diversity and genetic structure of black walnut in central U.S. 01/96--06/96 Intern (during M.S. work), Westvaco Corporation (now MeadWestvaco)

Clonal propagation of loblolly pine and cottonwoods. 11/90--08/94 Research Associate. Bulgarian Academy of Sciences

Breeding, propagation and conservation of Fagus species in southeastern Europe. Selected Publications 1)Gou, J., Strauss, S.H., Tsai, C.J., Fang, K., Chen, Y., Jiang, X., and Busov, V.B. (2010) Gibberellins Regulate Lateral Root Formation in Populus through Interactions with Auxin and Other Hormones. Plant Cell 22:623-639. 2)Busov, VB, Yordanov, Y Gou, J, Meilan, R, Ma, C, Regan, S and Steven Strauss (2010) Activation tagging is an effective gene tagging system in Populus. Trees Genetics and Genomes. DOI: 10.1007/s11295-010-0317-7 3)Xiaoqi Cui, Tong Wang, Huann-Sheng Chen, Victor Busov and Hairong Wei (2010) TF-finder: A Software Package for Identification of Transcription Factors Involved in a Biological Process Using Microarray Data and Existing Knowledge. Bioinformatics. 11: 425 4)Katherine M. Han, Palitha Dharmawardhana, Renee´ S. Arias, Cathleen Ma, Victor Busov and Steven H. Strauss. (2010) Gibberellin-associated cisgenes modify growth, stature and wood properties in Populus. Plant Biotech J. p 1–17. 4)Busov VB, Brunner AM, Strauss SH. 2008. Genes for control of plant stature and form. New Phytologist 177: 589-607. 5)Tuskan GA, …Busov V et al.. 2006. The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science. 313, 1596-1604. 6)Busov VB, Brunner A, Meilan R, Filichkin, S, Ganio, L, Gandhi, S, Strauss, SH. 2005. Genetic transformation: A powerful tool for dissection of adaptive traits in trees. New Phytologist.167: 9-18. 7)Brunner, AM, Busov VB, and Strauss SH. 2004. The Poplar Genome Sequence: Functional Genomics in a Keystone Plant Species. Trends in Plant Science 9: 49-56

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8)Busov VB, Meilan R, Pearce DW, Ma C, Rood SB, Strauss SH. 2003. Activation tagging of a dominant gibberellin catabolism gene (GA 2-oxidase) from poplar that regulates tree stature. Plant Physiology. 132: 1283-1291. Synergistic Activities 1)Member of IUFRO Working Party S3. 02-03 2)Member of American Society of Plant Biologist 3)American Association for the Advancement of Science (AAAS) 4)Namkoong’s Family Fellowship for Academic and Teaching Excellence, 2000 5)North Carolina Biotechnology Consortium Travel Award, 2001. 6)Ad Hoc reviewer: NSF Multiple Directorates and Programs, USDA-NRI Competitive Grants Program. 7)Ad Hoc manuscript reviewer: Transgenic Research, Plant Science, Tree Physiology, Plant Molecular Biology, New Phytologist. 8)Invited participant in the Populus genome sequence annotation jamboree. Dec 6-10, 2004, Joint Genome Institute, Walnut Creek, CA Collaborators Allen, N., NCSU; Brunner, A.M., OR State U; Davis, J., DOE; DiFazio, S.P., DOE, ORNL; Garcia, C., NCSU; Goldfarb, B., NCSU; Johannes, E., NCSU; Kung, F., S. Illinois U.; LeBude, A., NCSU; Pearce, D., U. of Lethbridge, CAN; Pregitzer, K., MTU; Rink, G., U.S. Forest Service; Rood, S.B., U. of Lethbridge, CAN; Sambeek, J.V., U.S. Forest Service; Sederoff, R.R., NCSU; Spiker, S.L., NCSU; Strauss, S.H., Oregon State U.; Sun, Y., NCSU; Swain, S., CSIRD, Austrailia; Tsai, C.-J., MTU; Tschaplinski, T.J., ORNL Oakridge, TN; Tuskan, G.A., ORNL, Oakridge; Whetten, R.W., NCSU; Woeste, K.E., Purdue University Graduate and Post-Doctoral Advisors M.S. Advisor: Kung, F., Southern Illinois University Ph.D. Advisor: Goldfarb, B., NC State University; Spiker, S.L., NC State University Post-doctoral Advisor: Strauss, S.H., Oregon State University Advisor and Postgraduate-Scholar Sponsor Hao Wei (OSU); Rewati Potkar (MTU); Zhan Ye (MTU); Trisha Colling (MTU); Chamini Geethenjalee (MTU); Shiv Thammannagowda (MTU); Fuyu Xu (Ph.D., MTU); Christine Zawaski (MTU); Elizabeth Etherington (OSU); Rama Joshi (MTU) Mahita Kadmiel (MTU); Rajinikanth Mohan (MTU)

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Biographical Sketch

Tarun K. Dam Assistant Professor

Department of Chemistry Michigan Technological University

1400 Townsend Drive, Houghton, MI 49931 Phone: 906 487 2940

Email: tkdam@mtu.edu Education University of Calcutta, Calcutta, India Protein Biochemistry Ph. D. 1994 Indian Institute of Science, India Protein Biochemistry Trainee, 1993-1995 Albert Einstein College of Medicine, NY Protein Biophysics Postdoc, 1996-2000 Appointments 2010- Assistant Professor, Michigan Technological University, MI 2000-2010 Instructor (Full time Faculty), Albert Einstein College of Medicine, NY Selected publications 1) Dam, T. K. and Brewer, C. F., Maintenance of cell surface glycan density by lectin-glycan interactions: a homeostatic and innate immune regulatory mechanism. Glycobiology 20, 1061 1064 (2010). http://glycob.oxfordjournals.org/content/20/9/1061.full.pdf+html 2) Dam, T. K. and Brewer, C. F., Lectins as pattern recognition molecules: the effects of epitope density in innate immunity Glycobiology 20, 270-279 (2010). http://glycob.oxfordjournals.org/cgi/content/full/20/3/270?view=long&pmid=19939826 3) Dam, T. K., Gerken, T. A. and Brewer, C. F. Thermodynamics of multivalent carbohydrate-lectin cross-linking interactions: importance of entropy in the bind and jump mechanism. Biochemistry, 48, 3822-3827 (2009). http://www.ncbi.nlm.nih.gov/pubmed/19292456 4) Dam, T. K., Torres, M., Brewer, C. F. and Casadevall, A., Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand. J. Biol. Chem. 283, 31366-31370 (2008). http://www.jbc.org/content/283/46/31366.long 5) Dam, T. K., and Brewer, C. F., Effects of clustered epitopes in multivalent ligand-receptor interactions. Biochemistry, 47, 8470-8476 (2008). http://pubs.acs.org/doi/abs/10.1021/bi801208b 6) Dam, T. K., Gerken, T. A., Cavada, B. S., Nascimento, K. S., Moura, T. R., and Brewer, C. F., Binding studies of -GalNAc specific lectins to the -GalNAc (Tn-antigen) form of porcine submaxillary mucin and its smaller fragments. J. Biol. Chem. 282, 28256-28263 (2007). http://www.jbc.org/content/282/38/28256.long 7) Dam, T. K. and Brewer, C. F. Fundamentals of lectin-carbohydrate interactions, in Comprehensive Glycoscience, (Kamerling, J. P., ed.), Elsevier Ltd., Vol. 3, pp. 397-452 (2007). http://www.sciencedirect.com/science?_ob=RefWorkIndexURL&_idxType=TC&_cdi=48257&_refWorkId=3687&_explode=5584000008,5584000010&_alpha=&_acct=C000050221&_version=1&_userid=10&md5=48905b7cd1c795793063a99d0dce51b6&refID=5584000010#5584000010 8) Dam, T. K., Gabius, H.-J., André, S., Kaltner, H., Lensch, M., and Brewer, C. F. Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants. Biochemistry, 44, 12564-12571 (2005). http://pubs.acs.org/doi/abs/10.1021/bi051144z

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9) Dam, T. K., Oscarson, S., Roy, R., Das, S. K., Page, D., Macaluso, F. and Brewer, C. F. Thermodynamic, kinetic and electron microscopy studies of concanavalin A and Dioclea grandiflora lectin cross-linked with synthetic divalent carbohydrates. J. Biol. Chem. 280, 8640-8646 (2005). http://www.jbc.org/content/280/10/8640.long 10) Dam, T. K. and Brewer C. F. Carbohydrate-lectin cross-linking interactions: structural, thermodynamic, and biological studies. Methods in Enzymology (Recognition of Carbohydrates in Biological Systems; Y.C. Lee & R. T. Lee, ed.), 362, 455-486 (2003). http://www.ncbi.nlm.nih.gov/pubmed/12968382 11) Hegde, S. S., Dam, T. K., Brewer C. F. and Blanchard, J. S. (2002), Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6’)-Iy aminoglycoside N-acetyltransferase. Biochemistry 41, 7519-7527 (2002). http://www.ncbi.nlm.nih.gov/pubmed/12044186 12) Dam, T. K. and Brewer, C. F. Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry. Chemical Reviews 102, 387-429 (2002). http://pubs.acs.org/doi/abs/10.1021/cr000401x 13) Dam, T. K., Roy, R., Page, D. and Brewer, C. F. Negative cooperativity associated with binding of multivalent carbohydrates to lectins. Thermodynamic analysis of the “Multivalency Effect”. Biochemistry 41, 1351-1358 (2002). http://www.ncbi.nlm.nih.gov/pubmed/11802737 14) Dam, T. K., Roy, R., Das, S. K., Oscarson, S. and Brewer, C. F. Binding of multivalent carbohydrates to concanavalin A and Dioclea grandiflora lectin. Thermodynamic analysis of the “Multivalency Effect”. J. Biol. Chem. 275, 14223-14230 (2000). http://www.jbc.org/content/275/19/14223.long 15) Dam, T. K., Bachhawat, K., Rani, P. G. and Surolia, A. Garlic (Allium sativum) lectins bind to high mannose oligosaccharide chains. J. Biol. Chem. 273, 5528-5535 (1998). http://www.jbc.org/content/273/10/5528.long Synergistic Activities 1) Received Young Scientist Award for “outstanding accomplishments and contributions in the field of microcalorimetry” given at ‘Biocalorimetry 2001 Conference: Philadelphia, PA. 2) Developed educational materials, which have been published in several books, such as Animal Lectins: A Functional View, (Vasta and Ahmed ed., Taylor and Francis); Comprehensive Glycoscience, (Kamerling, J. P., ed., Elsevier Ltd) and Lectins: Analytical Technologies, (Nilsson, C., ed., Elsevier B.V. Elsevier B.V). 3) Reviewed manuscripts for scientific journals, namely, The Journal of Biological Chemistry, Biochemistry, Biophysical Journal, Proceedings of the National Academy of Sciences, Biochimica et Biophysica Acta, Glycobiology, Glycoconjugate Journal, Journal of the American Chemical Society, European Journal of Biochemistry, Phytochemistry, Analytical Biochemistry. 4) Published a book review in the journal Carbohydrate Research. 325, 233-234 (2000). 5) Received invitation to deliver oral presentation at national scientific meetings and universities. Collaborators Thomas Gerken (Case Western Reserve University, Ohio) Arturo Casadevall, John Blanchard (Albert Einstein College of Medicine, New York) Benildo Cavada (FederalUniversity of Ceará, Brazil) Marit Sletmoen (The Norwegian University of Science andTechnology, Norway) Hans-J Gabius (Ludwig-Maximilians-University, Germany) René Roy (Université du Quebec à Montréal, Canada) Stefan Oscarson (Stockholm University, Sweden) Membership Society for Glycobiology American Chemical Society American Society for Biochemistry and Molecular Biology

16

Biographical Sketch

Rupali Datta

Assistant professor Department of Biological Sciences Michigan Technological University

1400 Townsend Drive, Houghton, MI-49931 Phone: (906) 487-1783

Email: rupdatta@mtu.edu

Education Osmania University, India Biology and Chemistry B.S., 1987 University of Hyderabad, India Life Sciences M.S. 1989 University of Hyderabad, India, Life Sciences Ph.D. 1997 Appointments 2008-present Associate Professor, Department of Biological Sciences, Michigan Technological University, Houghton,

Michigan 2004-2008 Assistant Professor, Department of Earth and Environmental Sciences, University of Texas at San Antonio,

San Antonio, Texas 2003-2004 Research Assistant Professor and Senior Lecturer, Earth and Environmental Science Department,

University of Texas at San Antonio, 2002-2003 Post-doctoral Fellow and Lecturer-I, Earth and Environmental Science Department, University of Texas at

San Antonio, San Antonio, Texas 1998-2001 Post-doctoral Associate, Plant Pathology Department, University of Florida, Gainesville, Florida 1997-1998 Visiting Research Fellow, Japanese Society for Promotion of Science Fellowship) Niigata University,

Niigata, Japan

Honors 1991-96 Junior and Senior Research Fellowships from the University Grants Commission, Govt. of India 1992 American Society for Plant Physiologists (ASPP) fellowship for Plant Biochemistry course at the University

of California, San Diego 1994 Young Scientist Fellowship by 16th International Union of Biochemistry and Plant Molecular Biology

Congress 1996-97 Senior Research Fellowship in project funded by Department of Science and Technology (Govt. of India) 1997-98 JSPS Research Fellowship by the Japanese Society for Promotion of Science 2004 Outstanding Young Scientist Award, 2004 Association of Agricultural Scientists of Indian Origin (AASIO) 2005 University of Texas at San Antonio Faculty Research Award. 2005 Early Career Award in Research. Southern Branch of the American Society of Agronomy Selected Research Support United States Environmental Protection Agency, 2002, $391,473/2y (Total): Biogeochemistry of arsenic in contaminated soils of Superfund sites National Institutes of Health

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1) 2007, $414,550 (Direct): Novel Remediation Methods to Lower Human Health Risk from Exposure to Arsenic-Enriched Soils 2) San Antonio Life Sciences Institute - REF, 2004-05, $199,990 (Direct): A multi disciplinary approach to reduce human bioavailability and carcinogenicity of soil arsenic 3) Department of Housing and Urban Development - Lead Technical Studies Program, 2004 - 2006, $372,767 (Total): A novel phytoremediation method using vetiver grass to cleanup lead-based paint-contaminated soils (Joint-PI) 4)Department of Defense – Small Business Innovative Research, Phase-I, 2006-2007, $100,000 (Total): A new method to clean up chromium and metal enriched stormwater in Naval shipyards (Principal) 5) Department of Defense – Small Business Innovative Research, Phase-II, 2008-2010, $750,000 (Total): A new method to clean up chromium and metal enriched stormwater in Naval shipyards (Principal) Selected Refereed Publications (out of >160 refereed publications): 1) Sarkar, D. and R. Datta (2003). A modified in-vitro method to assess bioavailable arsenic in pesticide-applied soils. Environ. Polln. 126: 263-266. 2) Sarkar, D. and R. Datta (2004) Health Risk from Soil Arsenic: Does one size fit all. Arch. Environ. Health, 59(7): 337-341. 3) Datta, R. and D. Sarkar (2005) Consideration of soil properties in assessment of human health risk from exposure to arsenical pesticide appl. soils. Integr. Env. Assess. Mgmt. 1 (1): 55-59. 4) Sarkar, D., R. Datta, and S. Sharma (2005) Fate and bioavailability of arsenic in organo-arsenical pesticide applied soils. Part-I. Incubation Study. Chemosphere, 60: 188-195. 5) Sarkar D., R. Datta, S. Sharma and K. Sand (2006) Arsenic biogeochemistry and human health risk assessment in organo-arsenical pesticide applied acidic and alkaline soils - Incubation study. Sci. Total Environ. 372 (1): 39-48. 6) Makris K.C., D. Sarkar and R. Datta (2006) Evaluating a waste by-product as a novel sorbent for arsenic. Chemosphere 64(5): 730 – 741. 7) Makris K.C., S. Quazi, R. Nagar, D. Sarkar, and R. Datta and V.L. Sylvia (2008) In-vitro model improves prediction of soil arsenic bioavailability: Worst-case scenario. Environ. Sci. Technol. 42: 6278-6284. 8) Nagar R., K. Makris, D. Sarkar, R. Datta and Sylvia V (2009) Bioavailability and Bioaccessibility of arsenic in a soil amended with drinking water treatment residuals. Arch. Environ. Contamin. Toxicol. 57(4): 755-766. 9) Andra S, Datta R, Sarkar D, Bach S, Mullen C (2010) Synthesis of phytochelatins in vetiver grass upon lead exposure in the presence of phosphorus. Plant and Soil 326: 171-185. 10) Das P, Datta R, Makris K, Sarkar D (2010). Vetiver grass is capable of removing TNT from soil in the presence of urea. Environmental Pollution 158: 980-983. 11) Makris K, Sarkar D, Salazar J, Punamiya P, and Datta R (2010) Alternative amendment for soluble phosphorus removal from poultry litter. Environ. Sci. Pollut. Res. 17(1):195-202. 12) Nagar R, Sarkar D, Makris K, and Datta R (2010) Effect of solution chemistry on As sorption by Fe- & Al-based drinking-water treatment residuals. Chemosphere. 78(8): 1028-1035. 13) Andra S, Datta R, Sarkar D, Bach S, Mullen C (2010). Synthesis of phytochelatins in vetiver grass upon lead exposure in the presence of phosphorus. Plant & Soil. 326(1-2): 171-185. 14) Das, P., Datta, R., Makris, K., and Sarkar, D. (2010). Vetiver grass is capable of removing TNT from soil in the presence of urea. Environ. Pollut. 158(5): 980-983). 15) Andra S, Sarkar D, Saminathan S, and Datta R. (2010) Predicting potentially plant-available lead in contaminated residential sites. Environ. Monitor. Assess. DOI 10.1007/s10661-010-1559-4 (E-publication ahead of print).

18

Biographical Sketch

Oliver Gailing Assistant Professor of Ecological Genomics

School of Forest Resources and Environmental Science Michigan Technological University, Houghton, MI 49931

Tel: 906-487-1615, email: ogailing@mtu.edu Web Page: http://forest.mtu.edu/faculty/gailing/

Professional preparation M. Sc. (Botany), University of Bochum, Germany, 1994 Ph.D. (Genetics), University of Halle, Germany, 2000 PostDoc (Genetics), Leibniz Institute IPK-Gatersleben, Germany, 2002-2002 Post lecturer qualification (Habilitation, Forest Genetics), University of Goettingen, Germany, 2009 Appointments 2009-present Assistant Professor, Michigan Tech University 2008-2009 Research Scientist, Goettingen University, Germany 2002-2008 Assistant Professor (“Wiss. Assistent”) , Goettingen University 2000-2002 Research Scientist (PostDoc), Leibniz Institute IPK-Gatersleben, Germany 1996-2000 Research Scientist (Ph.D), Leibniz Institute IPK-Gatersleben, Germany 1994-1996 Research Scientist, Bochum University, Germany Five recent publications most closely related to the proposed project: Gailing, O., Vornam, B., Leinemann, L.L & R. Finkeldey. 2009. Genetic and genomic approaches to assess adaptive genetic variation in plants: forest trees as a model. Physiologia Plantarum 137:509-519. doi: 10.1111/j.1399-3054.2009.01263.x. Curtu, A. L., Gailing, O. & R. Finkeldey. 2009. Patterns of contemporary hybridization inferred from paternity analysis in a four-oak-species forest. BMC Evolutionary Biology. 2009, 9: 284, doi:10.1186/1471-2148-9-284. Gailing, O., Langenfeld-Heyser, R. Polle, A. & R. Finkeldey. 2008. QTL loci affecting stomatal density and growth in a Quercus robur progeny: implications for the adaptation to changing environments. Global Change Biology 14:1934-1946. doi:10.1111/j.1365-2486.2008.01621.x Gailing, O. 2008. QTL analysis of leaf morphological characters in a Quercus robur full-sib family (Q. robur x Q. robur subsp. slavonica). Plant Biology 10: 624-634. Doi: 10.1111/j.1438-8677.2008.00063.x Curtu, A. L., Gailing, O. & R. Finkeldey. 2007. Evidence for natural hybridization within a species-rich oak (Quercus spp.) community. BMC Evolutionary Biology 7:218. Doi:10.1186/1471-21-48-7-218. Five additional significant publications: Durand , J., E., Bodenes , C., Chancerel, Frigerio, J.-M., Vendramin,G., Sebastiani, F., Buonamici, A., Gailing, O., Koelewijn, H.P., Villani F., Mattioni, C., Cherubini, M., Goicoechea, P.,Herran, A., Ikaran, Z., Cabane, C., Ueno, S., de Daruvar, A., Kremer, A. & C. Plomion. 2010. SSR mining in oak ESTs and bin mapping of 256 loci in a Quercus robur L. full-sib pedigree. BMC Genomics 11:570.

Gailing, O., Wachter, H., Heyder, J., Schmitt H.-P, & R. Finkeldey. 2007. Chloroplast DNA analysis in oak stands (Quercus robur L.) in North Rhine-Westphalia with presumably Slavonian origin: Is there an association between geographic origin and bud phenology? Journal of Applied Botany and Food Quality 81: 165-171. Curtu, A.L., Gailing, O., Leinemann, L. & R. Finkeldey. 2007. Genetic variation and differentiation within a natural community of five oak species (Quercus spp.). Plant Biology 9:116-126. Mottura, M.C, Finkeldey, R., Verga, R.A. & O. Gailing. 2005. Development and characterization of microsatellite markers for Prosopis chilensis and P. flexuosa and cross-species amplification. Mol. Ecol. Notes 5: 487-489. Gailing, O., Kremer, A., Steiner, W., Hattemer, H.H. & R. Finkeldey. 2005. Results on quantitative trait loci for flushing date in oaks can be transferred to different segregating progenies. Plant Biology 7: 516-525.

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Synergistic activities 1) Ad hoc reviewer for international Journals (e.g. BMC Plant Biology, BMC genomics, Conservation Genetics, Molecular Ecology, New Phytologist, Plant Biology, Physiologia Plantarum, Plant Cell and Environment, Plant Systematics and Evolution)

2) Ad hoc reviewer for Agence Nationale de la Recherche (France); ERANET, European Union's 6th Framework Program for Research

3) Session Chair in international conferences, (AOX symposium, 2009, Evora, Portugal, Fagaceae Genomic conference (Raleigh November 10 -13, North Carolina)

4) Ph.D. Committees: Klaus Richter (University Kassel, 2009), Jerome Durand (University of Bordeaux, December 2009) 5) Developed a new class in Ecological Genomics Honors and Awards 1/2009: Habilitation (Post Lecturer Qualification) for Forest Genetics and Forest Tree Breeding at the Georg-August University of Göttingen 7/2000 Luther certificate of the University Halle / Wittenberg for the PhD thesis Graduate and Postdoctoral advisors: Prof. Dr. Reiner Finkeldey, Prof. Dr. Konrad Bachmann, Prof. Dr. Thomas Stuetzel Thesis Advisees: PhD (co-supervisor): Indrioko Sapto (2005), Pandey Madhav (2005), Cao Cuiping (2006), Curtu Alexandru Lucian (2006), Mottura Martin (2006), Derero Abayneh (2007), Ayele Bekele Taye (2008), Akinnagbe Akindele (2008), Nuroniah Hani (2009), Nguyen Nga (2009), Richter Klaus (2009), Rachmayanti Yanti (2009) Master (co-supervisor): Duyen Ngo Thi (2004), Pandey Madhav (2004), Villarin Randy (2007), Gauli Archana (2007), Min Yazar (2007), Desta Demissew Sertse (2008)

Bachelor (co-supervisor): Nesemann Kai (2004), Hesse Katrin (2007), Maschek Daniela (2007), Gottwald Christoph (2008),Hinrichsen Julia (2008), Hess Bastian (2008)

20

Biographical Sketch

Gibson, K. Michael Professor and Chair

Department of Biological Sciences Michigan Technological University

1400 Townsend Drive, Houghton, MI-49931 Phone: (906) 487-2025

Email: kmgibson@mtu.edu

Education University of California, Riverside, CA Biochemistry B.S. 1977 University of Colorado, Boulder, CO Chemistry M.S. 1979 University of California, San Diego, CA Chemistry Ph.D. 1983 Appointments, Honors, Awards 1984 - 1986 Postdoctoral Fellow, Dept. Pediatrics, University of California, San Diego, La Jolla, CA 1985 - 1986 Bank of America-Giannini Foundation Fellow 1986 - 1988 Assistant Research Biochemist, Dept. Pediatrics, Univ. of California, San Diego, La Jolla, CA 1988 - 1998 Senior Research Scientist, Institute for Metabolic Disorders, Baylor University Medical Center

and Baylor Research Institute, Dallas, Texas 1991 - 1992 Alexander von Humboldt Foundation Research Fellow, Heidelberg, Germany 1989 - 1994 Assistant Professor of Biomedical Studies, Baylor University, Waco, Texas 1989 - 1995 Adjunct Assistant Professor of Biological Sciences, Southern Methodist University, Dallas, TX 1994 - 1998 Associate Professor of Biomedical Studies, Baylor University, Waco, TX 1995 - 1998 Adjunct Associate Professor of Biological Sciences, Southern Methodist University, Dallas, TX 1995 - 1998 Adjunct Associate Professor/Neurology, Univ. Texas Southwestern Medical School, Dallas, TX 1998 - 2001 Associate Professor, Depts. of Molecular and Medical Genetics and Pediatrics, Oregon Health

& Science University, Portland, Oregon 1998 - 2005 Director, Biochemical Genetics Laboratory, Oregon Health & Science University, Portland, OR 1999 - 2009 Board Certified Clinical Biochemical Geneticist, American College of Medical Genetics 2001 - 2005 Professor, Dept. Molecular and Medical Genetics, Oregon Health & Science University 2004- Komrower Memorial Lecturer, Annual Meeting, Society for Study of Inborn Errors of

Metabolism, Amsterdam, August 31 - September 4, 2004 2005- 2009 Director, Biochemical Genetics Laboratory, Children’s Hospital of Pittsburgh of UPMC 2005 - 2009 Professor, Pediatrics, Pathology, Human Genetics, University of Pittsburgh School of Medicine 2009- Pres Professor and Chair, Biological Sciences, Michigan Technological University 2008 NIH Site Visit, PDEGEN (Program in Developmental Endocrinology/Genetics), March 26-28. Selected Publications (from 258) 1) Harding CO, Gibson KM (2010) Therapeutic liver repopulation for phenylketonuria. J Inherit Metab Dis May 22. [Epub ahead of print] PMID: 20495959 2) Skvorak KJ, Hager EJ, Arning E, Bottiglieri T, Paul HS, Strom SC, Homanics GE, Sun Q, Jansen EE, Jakobs C, Zinnanti WJ, Gibson KM (2009) Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochim Biophys Acta 1792:1004-10. PMID: 19699299 3) Skvorak KJ, Paul HS, Dorko K, Marongiu F, Ellis E, Chace D, Ferguson C, Gibson KM, Homanics GE, Strom SC (2009) Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Mol Ther 17:1266-73. PMID: 19436271 4) Vardya I, Drasbek KR, Gibson KM, Jensen K (2010) Plasticity of postsynaptic, but not presynaptic, GABA(B) receptors inSSADH deficient mice. Exp Neurol June 4 [Epub ahead of print] PMID: 20570675

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5) Dósa Z, Nieto-Gonzalez JL, Korshoej AR, Gibson KM, Jensen K (2010) Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria). Epilepsy Res 90:39-46. PMID: 20363598 6) Acosta MT, Munasinghe J, Pearl PL, Gupta M, Finegersh A, Gibson KM, Theodore WH (2010) Cerebellar atrophy in human and murine succinic semialdehyde dehydrogenase deficiency. J Child Neurol May 5 [Epub ahead of print] PMID: 20445195 7) Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H (2009) Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. J Biol Chem 284:33521-34. PMID: 19759021 8) Pearl PL, Gibson KM, Cortez MA, Wu Y, Carter Snead O 3rd, Knerr I, Forester K, Pettiford JM, Jakobs C, Theodore WH (2009) Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men. J Inherit Metab Dis 32:343-52. PMID: 19172412 9) Pearl PL, Gibson KM, Quezado Z, Dustin I, Taylor J, Trzcinski S, Schreiber J, Forester K, Reeves-Tyer P, Liew C, Shamim S, Herscovitch P, Carson R, Butman J, Jakobs C, Theodore W (2009) Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency. Neurology 73:423-9. PMID: 19667317 10) Nylen K, Velazquez JL, Sayed V, Gibson KM, Burnham WM, Snead OC 3rd (2009) The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1(-/-) mice. Biochim Biophys Acta 1790:208-12. PMID: 19168117 11) Jansen EE, Struys E, Jakobs C, Hager E, Snead OC, Gibson KM (2008) Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development. BMC Dev Biol 8:112. PMID: 19040727 12) Drasbek KR, Vardya I, Delenclos M, Gibson KM, Jensen K (2008) SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex. J Inherit Metab Dis 31:662-8. PMID: 18696252 13) Stewart LS, Nylen KJ, Persinger MA, Cortez MA, Gibson KM, Snead OC 3rd (2008) Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism. Epilepsy Behav 13:290-4. PMID: 18514581 Nylen K, Velazquez JL, Likhodii SS, Cortez MA, Shen L, Leshchenko Y, Adeli K, Gibson KM, Burnham WM, Snead OC 3rd (2008) 14) A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype. Exp Neurol 210:449-57. PMID: 18199435 15) Hager EJ, Tse HM, Piganelli JD, Gupta M, Baetscher M, Tse TE, Pappu AS, Steiner RD, Hoffmann GF, Gibson KM (2007) Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis 30: 888-95. PMID: 18008182

22

Biographical Sketch

Michael R. Gretz Biotechnology Research Center

Department of Biological Sciences Michigan Technological University

Houghton, MI 49931-1295 Telephone: (906)487-3175, Email: mrgretz@mtu.edu www.desmids.mtu.edu

A. Professional Preparation: Ph.D. 1981, Arizona State University; Botany (Plant Biochemistry) B.Sc., 1977, Central Michigan University; Chemistry & Biology B. Appointments: 2010-present: Director, Biotechnology Research Center, Michigan Technological University 2007-2008: Visiting Scholar, Scripps Institution of Oceanography, UCSD 1999-present: Professor of Biological Sciences, Michigan Technological University 1993-1999: Associate Professor of Biological Sciences, MTU 1992-1993: Associate Professor of Biology (Tenured), George Mason University 1989-1992: Director, Shared Research Instrumentation Facility, GMU 1988-1989: Co-Director, Center for Basic and Applied Research, GMU 1986-1991: Assistant Professor of Biology, GMU 1984-1986: Postdoctoral Research Assoc., Univ. of Texas, Austin with R. Malcolm Brown 1981-1984: Postdoctoral Research Fellow, McMaster University with E. L. McCandless C. Publications: FIVE SELECTED PUBLICATIONS RELATED TO PROPOSED PROJECT: Bellinger, B.J., Gretz, M.R., Domozych, D, Kiemle, S and Hagerthy, S. 2010. The composition of extracellular polymeric substances from periphyton assemblages in the Florida Everglades. Journal of Phycology 46:674-678. Bellinger, B.J., Underwood, G.J.C., Ziegler, S.E. and Gretz, M.R. 2009. The significance of diatom-derived polymers in carbon flow dynamics within estuarine biofilms determined through isotopic enrichment. Aquatic Microbial Ecology 55:169-187. Domozych, D.S., Elliot, L, Kiemle, S.N. and Gretz, M.R. 2007. Pleurotaenium trabecula, a desmid of wetland biofilms: The extracellular matrix and adhesion mechanisms. Journal of Phycology 43:1022-1038. Hanlon, A.R.M., Bellinger, B.J., Xiao, G., Haynes, K, Ball, A.S., Osborn, M, Gretz, M.R., and Underwood, G.J.C. 2006. Dynamics of EPS production and loss in an estuarine, diatom-dominated microalgal biofilm over a tidal emersion-immersion period. Limnology & Oceanography 51:79-93. Bellinger, B.J., Abdullahi, A.S., Gretz, M.R. and Underwood, G.J.C. 2005. Biofilm Polymers: Relationship between carbohydrate biopolymers from estuarine mudflats and unialgal cultures of benthic diatoms. Aquatic Microbial Ecology. 38:169-180. OTHER PUBLICATIONS (last five years): Domozych, D.S.,. Lambiasse, L., Kiemle, S.N.. and Gretz, M.R. 2009. Structure and biochemistry of charophycean cell walls. II. Cell wall development and bipolar growth in the desmid Penium margaritaceum. Asymmetry in a symmetric world. Journal of Phycology 45:894-897. Domozych, D.S., Serfis, A., Kiemle, S. and Gretz, M.R. 2007. The structure and biochemistry of charophycean cell walls. I. Pectins of Penium margaritaceum. Protoplasma 230:99-115. Kiemle, S.N., Domozych, D.S. and Gretz, M.R. 2007. The exopolymers of desmids: Chemistry, structural analysis and implications in wetland biofilms. Phycologia 46:617-627. Apoya, M.D., Yin, L., Underwood, G.J.C. and Gretz, M.R. 2006. Movement modalities and responses to environmental changes of the mudflat diatom Cylindrotheca closterium. Journal of Phycology 42:379-390.

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Abdullahi, A.S., Underwood, G.J.C., and Gretz, M.R. 2006. Extracellular matrix assembly in diatoms (Bacillariophyceae). V. Environmental effects on polysaccharide synthesis in the model diatom Phaeodactylum tricornutum. Journal of Phycology 42:363-378. D. Synergistic Activities: Elected Treasurer, Phycological Society of America 2004-2006 AAAS Section G Committee representative 2006-2008 Organized NSF funded “Modern Methods” workshop at International Botanical Society meeting 2002 Patents: Magnetic alteration of cellulose during it's biosynthesis (with R. M. Brown, Jr. and D. B. Folsom). United States Patent No. 4,891,317, January 1990. Foreign counterparts E. Collaborators (last 48 mo.): Ziegler, Sue. Memorial University of Newfoundland, Canada Liepman, Aaron. Eastern Michigan University Hildebrand, Mark. Scripps Institution of Oceanography Roberts, Alison, University of Rhode Island Delwiche, Chuck, University of Maryland Domozych, David. Skidmore College Willats, William, University of Copenhagen Hagerthey, Scot. South Florida Water Management District Hotchkiss, Arland. USDA ERRC Wyndmoor Pauly, Markus, Michigan State University. – DOE Lab Spaulding, Sarah. EPA, Colorado Underwood, Graham. University of Essex, UK Handler, Robert. Michigan Technological University Graduate and Post-doctoral Advisors of M. Gretz: Aronson, Jerome. Arizona State University Sommerfeld, Milton. Arizona State University Brown, R. Malcolm, Jr. University of Texas, Austin McCandless, Esther. McMaster University, Ontario, Canada Graduate Students: Erin McKenney, M.S. expected 2012. Sarah Kiemle, Ph.D. 2010. Melba Apoya, Ph.D. 2006. Brent Bellinger, Ph.D. 2006. Abass Abdullahi, Ph.D. 2006. Yan Wang, Ph.D. 2000 Jingjie Lu, Ph.D. 1999 Brandon Wustman, Ph.D. 1998 Yalin Wu, Ph.D. 1993 Carla Kinslow, M.S. 1999 Postdoctoral Fellows Hosted: Sarah Kiemle, 2010-11, MTU Utpal Adhikari, 2009-10, University of Burdwan, India Ash Haeger, 2008-10, University of Leeds, UK Eric Koh, 1998-99, University of Otago, NZ Jean-Claude Mollet, 1993-95, UC Riverside

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Biographical Sketch

Wan Jin Jahng Assistant Professor

Department of Biological Sciences Michigan Technological University

1400 Townsend Drive, Houghton, MI-49931 Phone: (906) 487-2192

Email: wjahng@mtu.edu

Education Korea University, Seoul, Korea Agricultural Chemistry B.S. 1986-1990 Korea University, Seoul, Korea Organic Chemistry M.S. 1990-1992 University of Nebraska, Lincoln, NE Organic Chemistry Ph.D. 1995-2000 Harvard Medical School, Boston, MA Biochemistry, Proteomics Postdoc 2001-2003 Harvard Medical School, Boston, MA Biochemistry, Proteomics Research Associate 2004-2005 Appointments Professional Experience 2009-present Assistant Professor, Department of Biological Sciences, Michigan Technological University 2006-2009 Assistant Professor, Department of Ophthalmology, Adjunct Assistant Professor, Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina 2001-2005 Research Fellow, Research Associate, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School 1995-2000 Research and teaching assistant, Department of Chemistry, University of Nebraska-Lincoln 1994 Instructor, Department of Chemistry, Korea University 1990-1992 Research and teaching assistant, Department of Chemistry, Korea University 2010- Institutional Animal Care and Use Committee, Michigan Technological Unversity 2009- Graduate Committee, Biology Department, Michigan Technological University 2007-9 Proteomics Committee, University of South Carolina 2007- Scientific Advisory Board, Center for Molecular Dynamics-Nepal (Nonprofit NGO) 2006- Principal Organizer, Nepal Trauma Center Project 2003 Symposium Organization: Principal Organizer, U.S.-Korea Bioscience-Biotechnology Conference 2003 President, New England Bioscience Society (NEBS) 2003- Member, Association for Research in Vision and Ophthalmology (ARVO) 2001 Editor-in-Chief, New England Bioscience Society (NEBS) 1998 Nebraska Chapter President, Korean-American Scientists and Engineers Association (KSEA) 1996- Member, American Chemical Society (ACS) 1992-4 Republic of Korea Navy 1992- Life member, Korean Chemical Society (KCS) Honors 2010 Research Excellent Fund, Michigan Technological University, MI 2007 New Investigator Award, International Foundation, Korea 2003 Appreciation Award for the service of the 20th President, New England Bioscience Society, Boston, MA 2001 Appreciation Award for Annual Conference Editor-in-Chief. New England Bioscience Society, Boston, MA 2000 Outstanding Research Award. Department of Chemistry, University of Nebraska-Lincoln 1999 Outstanding Teaching Award. Department of Chemistry, University of Nebraska-Lincoln 1997 Distinguished Teaching Award. College of Arts and Sciences, University of Nebraska-Lincoln 1992 Seok Lim Korea University Alumni Faculty Scholarship, Graduate School, Korea University Publications

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Five related 1) Lee, H., Chung, H, Hunt, R.C., Lamoke, F., Arnouk, H., Wood, P.A., Hrushesky, W. J. M. and Jahng, W. J. (2010) Cleavage of the retinal pigment epithelium-specific protein RPE65 under oxidative stress, International Journal of Biological Macromolecules, in press. 2) Zhang, Z., Hrushesky, W. J. M., Wood, P.A., Hunt, R. C., and Jahng, W. J. (2010) Melatonin reprogrammes proteomic profile in light-exposed retina in vivo, International Journal of Biological Macromolecules, in press. 3) Chung, H., Lee, H., Lamoke, F., Hrushesky, W. J. M. Wood, P. A., and Jahng, W. J. (2009) Neuroprotective Role of Erythropoietin by Anti-apoptosis in the Retina, Journal of Neuroscience Research, 87, 2365-2374. 4)Xue, L., Jahng, W. J., Gollapalli, D., Rando, R. R. (2006) The Palmitoyl Transferase Activity of Lecithin Retinol Acyltransferase, Biochemistry 45, 10716-10718. 5) Xue, L., Gollapalli, D., Maiti, P., Jahng, W. J., and Rando, R. R. (2004) A Palmitoylation Switch Mechanism in the Regulation of the Visual Cycle, Cell 117, 761-771. Five others: 6) Hamirally, S., Kamil, J. P., Ndassa-Colday, Y. M., Lin, A. J., Jahng, W. J., Baek, M. C., Noton, S., Simpson-Holley, M., Knipe, D. M., Golan, D. E., Marto, J. A., and Coen, D. M. (2009) Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina During Human Cytomegalovirus Nuclear Egress, PLoS Pathogene, 2009 Jan; 5(1): e1000275 Epub 2009 Jan23. 7) Karukurichi, K. R., de la Salud-Bea, R., Jahng, W. J., Berkowitz, D. B. (2007) Examination of the New -(2’ Z-Fluoro)vinyl Trigger with Lysine Decarboxylase : The Absolute Stereochemistry Dictates the Reaction Course, Journal of the American Chemical Society 129, 258-259. 8) Kim, J., Jahng, W. J., Vizio, D. D., Lee, J., Rubin, M. A., Shisheva, A., and Freeman, M. R. (2007) The Phosphoinositide Kinase PIKfyve Mediates EGF Receptor Trafficking to the Nucleus, Cancer Research 67, 9229-9237. 9)Berkowitz, D. B., de la Salud-Bea, R., Jahng, W. J. (2004) Synthesis of Quaternary Amino Acids Bearing a (2’Z)-Fluorovinyl alpha-Branch: Potential PLP Enzyme Inactivators. Organic Letters 6, 1821-1824. 10) Furukawa, N., Ongusaha, P., Jahng, W. J., Choi, C. –S., Kim, H.-J., Araki, K., Lee, Y. H. Kaibuchi, K., Kahn, B. B., Masuzaki, H., Kim, J. K., Lee, S. W., Kim, Y.-B. (2005) Role of Rho-kinase in Regulation of Insulin Action and Glucose Homeostasis, Cell Metabolism, 2, 119-129. Synergistic Activities 1) 2007 Development of new teaching course: Systems biology, functional proteomics (2008 Spring semester), USC 2) 2007-9 Proteomics Center Committee member, Development of Differential 2D Electrophoresis, USC 3) 2006- Principal Organizer, Nepal Trauma Center Project 4) 2006 Director, Science Summer Camp for middle and high school students in South Carolina 5) 2003 Principal Organizer, U.S.-Korea Bioscience-Biotechnology Conference, Harvard Medical School Selected Collaborators & Other Affiliations Dr. Heywon Chung, Department of Ophthalmology, Asan Medical Center, Seoul, Korea. Project: Retina Degeneration-Apoptosis Prof. Donald M. Coen, Department of Biological Chemistry and Molecular Pharmacology, rvard Medical School, Boston, MA 02115. Project: Human Cytomegalovirus Phosphorylation Signal Transduction Graduate Advisors and Postdoctoral Mentor M.S.: Prof. Bong Rae Cho, Department of Chemistry, Korea University, Seoul, Korea Ph.D.: Prof. David B. Berkowitz, Department of Chemistry, University of Nebraska, Lincoln, NE Postdoc.: Prof. Robert R. Rando, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

26

Biographical Sketch

Chandrashekhar P. Joshi Professor of Plant Molecular Genetics

Biotechnology Research Center School of Forest Resources and Environmental Science

Michigan Technological University, Houghton, MI 49931 Tel: 906-487-3480 Fax: 906-487-2915

email: cpjoshi@mtu.edu Web page: http://forest.mtu.edu/faculty/joshi/

Current Research Interests: Biotechnological improvement of lignocellulosic materials in poplars for better bioenergy production Education Ph.D. University of Poona, India Biochemistry 1982 M.Sc. University of Poona, India Botany 1977 B.Sc. University of Poona, India Botany 1975 Appointments: 2010-present WCU Visiting Professor, Chonnam National University, Gwangju, S. Korea 2008-present Professor, Michigan Tech University, Houghton, MI 2007-2009 Director, Biotechnology Research Center, Michigan Tech University 2004-2009 Director, SFRES graduate programs, Michigan Tech University 2004-2008 Associate Professor, Michigan Tech University, Houghton 1999-2004 Assistant Professor, Michigan Tech University, Houghton 1996-1999 Research Assistant Professor, Michigan Tech University, Houghton 1990-1996 Research Scientist, Texas Tech University, Lubbock 1988-1990 Research Associate, Ohio State University, Columbus 1985-1988 Scientist, National Chemical Laboratory, Pune, India 1983-1985 Visiting Scientist, Max Planck Institute, Cologne, Germany 1980-1983 Scientist, National Chemical Laboratory, Pune, India 1979-1980 Research Student, National Chemical Laboratory, Pune, India 1977-1979 Lecturer in Botany, S.P. College, Pune, India Some selected recent and significant publications: 1) Zhu X, Pattathil S, Mazumdar K, Brehm A, Hahn MG, Dinesh-Kumar, SP and Joshi CP.: VIGS offers a functional genomics platform for studying plant cell wall formation. Molecular Plant 3: 818-833, 2010. 2) M. Kumar, S. Thammannagowda, V. Bulone, V. Chiang, K-H Han, C P. Joshi, S. D. Mansfield, E. Mellerowicz, B. Sundberg, T. Teeri, and B. E. Ellis: An update on the nomenclature for the cellulose synthases genes from Populus. Trends in Plant Science 14: 248-254, 2009. 3) C. P. Joshi, Brunner A, Busov V, Meilan R, Thammanagowda S, and Tsai C.: Poplars. In: The Transgenics: Compendium of transgenic crop plants: Transgenic forest tree species. C. Kole and T. Hall (eds). Blackwell Publishing, Oxford, UK. PP. 1-34, 2008 4)C.P. Joshi and S.D. Mansfield: The cellulose paradox: simple molecule, complex biosynthesis. Current Opinion in Plant Biology 10: 220-226, 2007. 5) C. P. Joshi: Genomics of Wood development. In Aluízio Borém (Ed) Forest Biotechnology. Universidade Vicosa, Brazil, PP 273-295. 2007 6) Tuskan GA, … Joshi C, et al The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science 313: 1596 –1604, 2006. 7) Suchita Bhandari, Takeshi Fujino, Shiv Thammanagowda, Dongyan Zhang, Fuyu Xu, and C P. Joshi: Coordinate expression of tension stress-responsive and secondary cell wall-associated KORRIGAN endoglucanase and three cellulose synthase genes in aspen trees. Planta 224: 828-837, 2006.

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8) Chandrashekhar P. Joshi, S. Bhandari, P. Ranjan, U. C. Kalluri, X. Liang, T. Fujino, and A. Samuga: Genomics of cellulose biosynthesis in poplars. New Phytologist 164: 53-61, 2004 9) L. Wu, C.P. Joshi, and V.L. Chiang: A xylem-specific cellulose synthase gene from aspen (Populus tremuloides) is responsive to mechanical stress. Plant Journal 22(6): 495-502, 2000 10) K. Osakabe, C-C. Tsao, L. Li, J. L. Popko, T. Umezawa, D. T. Carraway, R. H. Smeltzer, C. P. Joshi, V. L. Chiang: Coniferyl aldehyde 5-hydroxylation and methylation direct syringyl lignin biosynthesis in angiosperms. Proceedings of National Academy of Sciences, USA, 96 (16): 8955-8960, 1999. Synergistic activities 1) Spearheaded establishment of M. S. and PhD degrees in Forest Molecular Genetics at Michigan Tech 2) Currently editing two books on poplar genomics and bioenergy; author of three approved US patents 3) Director of Biotechnology Research Center 2007-2009, MTU 4) Current member of Research Advisory Council and Chair of the Institutional Biosafety Committee, MTU 5) Graduate Program Director, 2004-2009, SFRES, MTU 6) Faculty judge: Western Upper Peninsula Science Fair (Grades 4-9) and Graduate Poster competitions 7) Ad hoc reviewer for numerous International journals and NSF, USDA and DOE proposals; 8) Panel service: NSF (2005, 2006 & 2007); DOE (2006), USDA-NRI (2008) 9) Distinguished Teaching Award Finalist, Assistant Professor Category, MTU, 2004; fellow of SFI, 2010 10) PI on a successful US Department of Education grant for establishing transatlantic dual degree program in Forest Resources and Biotechnology 11) PI or Co-PI on over $6 million grants from national and international agencies at Michigan Tech Collaborators Coauthors and Collaborators (Last 48 months)(Our Science 2006 paper has over 100 coauthors) Arioli Tony, Bhandari Suchita, Chiang Vincent, Crasta Oswald, Davis Mark, Festucci-Buselli R, Fei Z, Fujino Takeshi, Haigler Candace, Harding Scott, Jiang Y, Kalluri Udaya, Li Laigeng, Liang Xiaoe, Liu, Yunxia, Lu, S, Mansfield Shawn, Otoni W, Podila Gopi, Ranjan Priya, Samuga Anita, Tsai Chung-Jui, Thammanagowda Shiv, Turner Simon, Williamson R, Xu Fuyu, Yi, X, Zhang Dongyan Graduate and Postdoctoral Advisors Dr. P.K. Ranjekar, Late Prof. Otto Schieder, Prof. Desh Pal Verma, Prof. Henry Nguyen Thesis and Postdoc Advisees PhD: Chen-Chung Tsao (1998), Udaya Kalluri (2003), Anita Samuga (2003), Priya Ranjan (2005), Shivegowda Thammanngowda (2007), Fuyu Xu (2009) MS: Zihao Wang (2003), Siau Voo (2006), Asha Lakkavaram (2006), Rajesh Chavli (2000), John Saida (2008), Jake Ladd (2010), Aparupa Sengupta (2009) Postdocs and other staff: Xiaoe Liang, Shanfa Lu, Yihua Zhou, Takeshi Fujino, Suchita Bhadari, Dongyan Zhang, Yunxia Liu, Ramesh Thakur, Xiaohong Zhu Undergraduate Research Advisors Marie Wilkening, Hwee Chi Tay, James Wee, Katherine Kieckhafer, Laura Kluskens, Katie Kruger, Ellen Brenna, Ashley Sharp, Megan McQuillan, Jill Recla, Kristina Flesher, Eric Koronka, Ayushi Kawatra, Ian Bonner, Sandra Orlowski, Nathan Fettinger, Eric Hollender, Justeen Beaune, and Josh Papacek

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Biographical Sketch

Pushpalatha P. N. Murthy Professor

Department of Chemistry Michigan Technological University

Houghton, MI-49931 Tel: 906-487-2094; Fax:906-487-2061

E-mail: ppmurthy@mtu.edu Education Miranda House, Delhi University, Delhi, India Chemistry B.Sc. (Hons) 1972 Indian Institute of Technology, Kanpur, India Chemistry M.Sc. 1974 Brown University, Providence, RI Bioorganic Chemistry Ph.D. 1979 The Univ. of Mich., Ann Arbor, MI Bioorganic Chemistry 1979-1980 The Univ of Michigan, Ann Arbor, MI Neuroscience 1980-1982 Appointments Sept.99 - present: Professor, Dept. of Chemistry, Michigan Technological University, Houghton, MI Feb. 06 - May 06: Sabbatical leave at CSIRO Canberra, and CAMBIA, Canberra, Australia Aug. 01 - July 04: Chair, Dept. of Chemistry, Michigan Technological University, Houghton Aug. 00 - Aug.01: Interim Chair, Dept. of Chemistry, Michigan Tech. University, Houghton, MI Sep. 91 - Aug. 99: Associate Professor, Dept.of Chemistry, Michigan Tech. Univ., Houghton, MI Mar. 93 - May 93: Visiting Assoc. Prof (on sabbatical leave), Biotechnology Dept., Cornell University, Ithaca, NY Sep. 92 - Dec. 92: Visiting Assoc. Prof (on sabbatical leave), Michigan State University, East Lansing, MI Sept. 86 - Aug. 91 Assistant Professor, Department of Chemistry, Michigan Technological University, Houghton, MI Sept. 85 - Aug. 86 Visiting Asst. Professor, Department of Chemistry and Chemical Engineering, Michigan Technological University, Houghton, MI Aug. 82 - Jan. 85: Research Chemist, Stauffer Chemical Company, Dobbs Ferry, NY. Selected Publications 1) S.C. Johnson, M.Yang, P.P.N. Murthy (2010) Heterologous expression and functional characterization of a plant alkaline phytase in Pichia pastoris. Protein Express. Purif. 74, 196-203. 2) C. Xue, S. Velayudhan, S. C. Johnson, R. Saha, A. Smith#, W. Brewer, P.P.N. Murthy, ST. Bagley, Haiying Liu (2009) Highly water –soluble, fluorescent, conjugated fluorine-based glycopolymers with poly(ethylene glycol)-tethereed spacers for sensitive detection of Escherichia coli. Chem. Eur. J. 15, 2289-2295. 3) Pushpalatha P.N. Murthy (2007) Identification of inositol phosphates by NMR spectroscopy: unraveling structural diversity. In Proceedings of the Bouyoucos conference on Biogeochemical interaction of inositol phosphates in the environment, B.L. Turner, A.E. Richardson, and E.J. Mullaney (Editors), CB international, Cambridge, MA, pp 7-22 4) Ping Yang, Bernard Spiess, Pushpalatha P.N. Murthy, Richard E. Brown (2007) Influence of metal cations on the intramolecular hydrogen-bonding network in phosphorylated compounds. J. Phys. Chem. 111, 3602-3612 5) Cuihua Xue, Sonali P. Jog, Pushpalatha P. N. Murthy, and Haiying Liu (2006) Synthesis of highly water-soluble fluorescent conjugated glycopoly(p-phenylene)s for lectin and Escherichia coli. Biomacromolecules, 7, 2470-2474 6) Bakul Dhagat Mehta, Sonali P. Jog, Steven C. Johnson and Pushpalatha P.N. Murthy (2006) Lily pollen alkaline phytase is a histidine phosphatase similar to mammalian multiple inositol polyphopsphate phosphatase (MINPP), Phytochemistry, 67, 1874-1886. 7) B.G. Garchow, S.P. Jog, B. D. Mehta, J.M. Monosso (posthumous), P.P.N. Murthy (2006) Alkaline phytase from Lilium longiflorum: purification and structural characterization. Protein Express. Purif. 46, 221-232.

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8) P. P. N. Murthy (2006) Structure and nomenclature of inositol phosphates, phosphoinositides, and glycosylphosphatidylinositols. Subcellular Biochemistry series: Volume 39, Biology of Inositols and Phosphoinositides (Eds. A. N. Lahiri and B.B. Biswas), Plenum Publishing Co. Ltd., London, pp 1-20. 9) P. Yang, P.P.N. Murthy, R.E. Brown (2005) Synergy of intramolecular hydrogen bonding network in myo-inositol-2-phosphate: theoretical investigation s into the electronic structure, proton transfer and pKa. J. Amer. Chem. Soc. 127, 15848-15861. 10) S.P. Jog, B. G. Garchow, B. D. Mehta, P.P.N. Murthy (2005) Alkaline phytase from lily pollen: Investigation of biochemical properties. Archives of Biochemistry and Biophysics 440, 133-140 11) G. Pliska-Matyshak, B. Narasimhan, R. Kinnard, S. Carstensen, M.Ritter #, L. von Weymarn #, and P.P.N. Murthy (1997) Novel phosphoinositides in barley aleurone cells, additional evidence for the presence of phosphatidyl-scyllo-inositol. Plant Physiol. 113, 1385-1393. # Undergrad student Synergistic Activities 1) Developing a new inquire-based lab course “Research methods in Biomolecular Chemistry”. This project is funded by the NSF-CCLI program. 2) Developed a new course for chemistry majors interested in teaching high school chemistry: Design and Operation of a High School Chemistry Laboratory. I worked with local high schools to develop this course. The aim of the course is to address topics necessary for the design and introduction of a chemistry laboratory in high schools including ordering, storage, tracking, and disposal of chemicals, safety issues, developing new lab experiments and demonstrations, preparation of reagents on large scale, and internships in local high schools. The need for such a course was identified by a workshop organized by the American Chemical Society on Secondary Chemical Education curriculum and our own alumni. This course is now offered every other year. 3) Worked on a curriculum for two new degree programs now offered in the Department – BS in Biochemistry and Molecular Biology and BS in Pharmaceutical Chemistry 4) Developed a new course for the BS in Pharmaceutical Chemistry program - Pharmaceutical Chemistry I – Mechanism of Drug Action. This course is now offered every year. 5) Finalist for Outstanding Teacher of the Year award for 1989-90 in Assistant Professor category. Collaborators and Other Affiliations Dr. Richard Brown, Dept. of Chemistry, Michigan Technological University Dr. Haiying Liu, Dept of Chemistry, Michigan Technological University Dr. Victor Raboy, USDA, Aberdeen, Idaho Graduate Advisors and Postdoctoral Sponsors Ph.D. Advisor: Prof. David Cane, Brown University Postdoctoral sponsor: Prof. Masato Koreeda, Univ of Michigan, Ann Arbor, MI Postdoctoral sponsor: Prof. Bernard Agranoff, Univ of Michigan, Ann Arbor, MI Thesis Advisor (Ph.D.) Dr. Laura Barrientos, Center for Disease Control, Atlanta; Dr. Bhuvaraha Murthy, Ohio State University, Columbus, Ohio; Dr. Barry Garchow, Univ of Pennsylvania; Dr. Sonali Jog, Univ of Southern California; Dr. Bakul Dhagat Mehta, Univ of Missouri, Columbia; Dr. Gay Pliska-Matyshak, Henry Ford Hospital, Detroit, Dr. Steven Johnson, Univ of Illinois, Urbana-Champaign

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Biographical Sketch

Ashutosh Tiwari Assistant Professor

Department of Chemistry, Michigan Technological University,

1400 Townsend Drive, Houghton, MI 49931 Phone: (906) 487-1840(Work)

Fax:(906) 487-2061 Email:tiwari@mtu.edu

Web page: http://www.chemistry.mtu.edu/pages/faculty/faculty.php?fac=tiwari Current research interests ‘Protein misfolding diseases’ with special focus on neurodegenerative diseases. Education Jawaharlal Nehru University (JNU), New Delhi, India Biotechnology Ph.D. 1999 Jamia Millia Islamia, New Delhi, India Biosciences M.Sc. 1993 All-India Institute of Medical Sciences (AIIMS),New Delhi India Human Biology, specialization in biophysics 1991 B.Sc.(Hons) Appointments 2009 – Assistant Professor, Department of Chemistry, Michigan Technological University, Houghton, MI. 2009 – Adjunct Research Assistant Professor, Department of Neurology, University of Massachusetts Medical School (UMMS), Worcester, MA. 2005 – 2009 Research Assistant Professor, Department of Neurology, UMMS, MA. 2003 – 2005 Instructor, Department of Neurology, UMMS, MA. 2000 – 2003 Post-Doctoral Fellow, Department of Neurology, UMMS, MA. 1999 – 2000 Post-Doctoral Fellow, Department of Neurology, Massachusetts General Hospital, Boston, MA. 1995 – 1999 Senior Research Fellow, Center for Biotechnology, JNU, New Delhi, INDIA. 1993 – 1995 Junior Research Fellow, Center for Biotechnology, JNU, New Delhi, INDIA. Five recent publications 1) Molnar KS, Karabacak NM, Johnson JL, Wang Q, Tiwari A, Hayward LJ, Coales SJ, Hamuro Y, and Agar JN. A common property of amyotrophic lateral sclerosis-associated variants: Destabilization of the Cu/Zn superoxide dismutase electrostatic loop. J Biol Chem. (2009) 284(45): 30965-30973. 2) Tiwari A, Liba A, Sohn SH, Seetharaman SV, Bilsel O, Matthews CR, Hart PJ, Valentine JS, and Hayward LJ. Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis. J Biol Chem. (2009) 284(40): 27746–27758. 3) Karabacak NM, Li L, Tiwari A, Hayward LJ, Hong P, Easterling ML, and Agar JN. Sensitive and specific identification of wild-type and variant proteins from 8 to 669 kDa using top-down mass spectrometry. Mol Cell Proteomics. (2009) 8(4): 846-56. 4) Cao X, Antonyuk S, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, and Hart PJ. Structures of the G85R variant of SOD1 in familial ALS. J Biol Chem. (2008) 283(23): 16169-77. 5) Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, and Whitelegge JP. Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxides dismutase-1. J Biol Chem. (2008) 283(13): 8340-8350. D) Five additional significant publications: 1) Tiwari A and Bhat R. Stabilization of yeast hexokinase A by polyol osmolytes: Correlation with physicochemical properties of aqueous solutions. Biophys Chem. (2006) 124(2): 90-99. 2) Tiwari A, Xu Z, and Hayward LJ. Aberrantly increased hydrophobicity shared by mutants of Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. J Biol Chem. (2005) 280(33): 29771-29779.

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(Featured in August 19, 2005 issue of the Journal of Biological Chemistry as ‘Paper of the Week’ (J Biol Chem. (2005) 280: e99939)). 3) Rodriguez JA, Shaw BF, Durazo A, Sohn SH, Doucette PA, Nerissian AM, Faull KF, Eggers DK, Tiwari A, Hayward LJ, and Valentine JS. Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis. 4) Proc Natl Acad Sci USA. (2005) 102(30): 10516-10521. Chacko B, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, deCaestecker M, and Lin K. Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling. Mol Cell. (2004) 15(5): 813-23. 5) Tiwari A and Hayward LJ. Familial ALS Mutants of Cu/Zn Superoxide Dismutase are Susceptible to Disulfide Reduction. J Biol Chem. (2003) 278(8): 5984-5992. Synergistic activities 1) Ad-hoc reviewer for Biophysical Journal, Journal of Neuroscience Research, and Cellular and Molecular Life Sciences. 2) Member of ‘Graduate Admissions and Recruiting Committee’ for Chemistry department at MTU. 3) Member of ‘Biochemistry Curriculum Committee’ for Chemistry department at MTU. 4) Member of ‘University Animal Care Committee’ and ‘Institutional Biosafety Committee’ at MTU. Collaborators Robert Brown (UMMS), Lawrence Hayward (UMMS), Zuoshang Xu (UMMS), Hoi Pang Low (UMMS), Robert Matthews (UMMS), Jeffrey Agar (Brandeis University); John Hart (UTHSCA), Joan Valentine (UCLA), Patricia Heiden (MTU), Haiying Liu (MTU), Rudy Luck (MTU). Supervising and advising of students and trainees At UMMS: Brian Mitchell Haas (summer student, Harvard University, MA); Benoy M. Chacko (graduate student, UMMS); Charusheila Ramkumar (graduate rotation student, UMMS) and Laura Baldassari (summer student, Worcester Polytechnic Institute, MA). At MTU: Kyrie Pappas (project CH471, Spring 2010); Claire Drom (CH4995, Fall 2010). Research technicians supervised: At UMMS: Hongru Zhou (UMMS); Kumudini Misra (UMMS).

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Biographical Sketch

Martin Thompson Associate Professor

Department of Chemistry Tel: (906) 487-3522 Michigan Technological University Fax: (906) 487-2061

1400 Townsend Drive Email: thompson@mtu.edu Houghton, MI 49931

Education Arizona State University, Tempe, AZ. Ph.D. Chemistry Ph.D. 2000 Dissertation “Synthesis and Characterization of the Photophysical and Photochemical Properties of Sequence Specific DNA-Binding Probes,” Advisor: Neal Woodbury Arizona State University, Tempe, AZ. Chemistry, with a Concentration in Biochemistry B.S. 1995, Appointments 2009-present Associate Professor, Department of Chemistry, Michigan Technological University Assistant Professor, Department of Chemistry, Michigan Technological University (2003-2009) 2004 Visiting Scientist, Department of Biological Chemistry, University of Michigan Medical Center 2002-2003 Postdoctoral Fellow, Department of Biological Chemistry, University of Michigan 2000-2002 Postdoctoral Assistant, Howard Hughes Medical Institute, University of Michigan Other Activities 2010-present Councilor, Upper Peninsula Section of the American Chemical Society 2007 Panel Member, National Institutes of Health, Center for Scientific Review, Study Section ZRG1 GGG-F(90) 2006-2009 Chair, Upper Peninsula Section of the American Chemical Society Reviewer for: FEBS Letters, Protein Expression and Purification, Journal of Medical & Biological Sciences Professional Affiliations American Chemical Society, Biophysical Society, Council on Undergraduate Research Research Interests Fluorescence-based bioanalytical methods and biosensors; quantification of modification-dependent protein-protein interactions associated with transcription; development of assays for drug discovery; molecular recognition; cell-specific targeting using peptidomimetics; Five Significant Publications 1) Thompson, M. (2010) Thermodynamic and Kinetic Analysis of Bromodomain–Histone Interactions. Vol 466, Biothermodynamics, Part B. Methods in Enzymology, pp.383-407 2) Thompson, M. (2009) Polybromo-1: The chromatin targeting subunit of the PBAF complex. Biochimie 91, 309-319. 3) Thompson, M., and Chandrasekaran, R. (2008) Thermodynamic analysis of the acetylation dependence of bromodomain-histone interactions. Anal. Biochem. 374, 304-312. 4) Kupitz, C., Chandrasekaran, R., and Thompson, M. (2008) Kinetic analysis of acetylation-dependent Pb1 bromodomain-histone interactions. Biophys. Chem. 136, 7-12. 5) Chandrasekaran, R., and Thompson, M. (2007) Polybromo-1 bromodomains bind histone H3 at specific acetyl-lysine positions. Biochem. Biophys. Res. Comm. 355, 661-666. Additional Significant Publications 1) Thompson, M. (2007) Spectral properties and DNA targeting features of thiazole orange-peptide bioconjugates. Biomacromolecules 8, 3628-3633. 2) Thompson, M. (2006) Synthesis, photophysical effects, and DNA targeting properties of oxazole yellowpeptide bioconjugates, Bioconjugate Chemistry 17, 507-513.

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3) Chandrasekaran, R., and Thompson, M. (2006) Expression, purification and characterization of individual bromodomains from human Polybromo-1, Prot. Expr. Purif. 50, 111-117. 4) Babendure, J., Liddell, P. A., Bash, R., LoVullo, D., Schiefer, T. K., Williams, M., Daniel, D. C., Thompson, M., Taguchi, A. K. W., Lohr, D., and Woodbury, N. W. (2003) Development of a fluorescent probe for the study of nucleosome assembly and dynamics, Anal. Biochem. 317-327, 1-11. 5) Thompson, M., and Woodbury, N. (2001) Thermodynamics of Specific and Non-specific DNA-binding by Cyanine Dye Labeled DNA-binding Domains, Biophysical J. 81, 1793-1804. Recent Collaborators Sarah Green (MTU), Haiying Liu (MTU), Lanrong Bi (MTU), Shiyue Fang (MTU), Kedmon Hungwe (MTU), Pushpalatha Murthy (MTU), Justin Carlson (Chemotrope) Graduate and Postgraduate Advisees Current graduate students: Katrina Bugielski Past graduate students: Renu Chandrasekaran, Jon Maxwell, Renee Kerr, Mark Parmley, Wendy VanAken, Joshua Bailey Undergraduate students: Talisha Sutton, Sam Stam, Christopher Kupitz, Andrew Spaeth, Kelli Whelan, Kirk Koebke, Jesus Fransisco Glaus Garzon, Marie Wilkening, Joshua Bailey Postdoctoral Advisees: Alexis Black, Momoko Tajiri

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Biographical Sketch

Hairong Wei Assistant Professor of Systems Biology & Molecular Biology

School of Forest Resources and Environmental Science Michigan Technological University

1400 Townsend Drive, Houghton, MI 49931 Email: hairong@mtu.edu Phone: (906) 487-1473 Fax: (906) 487-2915

http://forest.mtu.edu/faculty/wei/index.htm

Current Research Interests Systems Biology: Gene network constructions & gene function prediction Bioinformatics and Genomics on tree growth & wood development Biological database design and development Impact of CO2 and abiotic stress on gene network New algorithm/software/pipeline development Education Beijing Forestry University, P.R. China Agricultural Sci. BS & 4 years Beijing Forestry University, P.R. China Plant Genetics MS & 3 years University of Hawaii at Manoa Plant Mol. Biol Ph.D. & 5 years University of Chicago Computer Sci. MS & 1.5 years University of Minnesota Bioinformatics Post-doc & 1.5 years University of Alabama at Birmingham Biostatistics Post-doc & 1 year Appointments 2008~Present Assistant Professor, Michigan Technological University, Houghton, MI 2006~2008 Bioinformatics Developer, Wicell Research Institute, Inc., Madison, WI 2005~2006 Bioinformatics Scientist, Operon Biotechnologies, Inc., Huntsville, AL 2004~2005 Postdoc, Biostatistics, University of Alabama, Birmingham, AL 2003~2004 Postdoc, Bioinformatics, University of Minnesota, Minneapolis, MN 1996~2001 Res. Assistant, Plant Mol. Biology, University of Hawaii, Honolulu, HI 1995~1996 Res. Assistant, Plant Genetics, University of Hawaii, Honolulu, HI 1989~1995 Assistant Professor, and Lecturer, Forestry Genetics, Beijing Forestry University Some selected publications 1) Cui, X, T. Wang, H.S. Chen, V. Busov and H. Wei. 2010 TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base. BMC Bioinformatics, 11:425 2) Ming, R., S. Hou,…, H. Wei, …, M. Alam. 2008. The draft genome sequence of transgenic papaya, Carica papaya. Nature, Vol. 452, No. 7190:991-996. 3) Wei, H., P. F. Kuan, S. Tian, C. Yang, J. Nie, S. Sengupta, V. Ruotti, G. Jonsdottir, S. Keles, J. Thomson and R. Stewart. 2008. A study of the relationships between oligonucleotide properties and hybridization intensity in NimbleGen platform. Nucleic Acids Research, Vol. 36, No. 9:2926-2938. 4) Pan, G., S. Tian, J. Nie, C. Yang, V. Ruotti, H. Wei, G. Jonsdottir, R. Stewart, and J. Thomson. 2007. Whole genome analysis of Histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell, Vol. 1, No 3:299~312. 5) Wei, H, S. Persson, T. Mehta, V. Srinivasasainagendra, L. Chen, G. Page, C. Somerville, A. Loraine. 2006. Transcriptional coordination of the metabolic network in Arabidopsis thaliana. Plant Physiology. 142(2):76274.

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6) Persson, S., H. Wei, J. Milne, G. Page, C. Somerville. 2005. Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets. Proc Natl Acad Sci USA, 102: 8633-8638. (Faculty 1000 evaluation). 7) Wei, H., Y. Kaznessis. 2005. Inferring gene regulatory relationships by combining target-target pattern recognition and regulator-specific motif examination. Biotechnology and Bioengineering. Vol. 89, No1: 53-77. 8) K.M., S. Bhawan, T. Majima, H. Wei, V. Kumar. 2003. Cutting Edge: The NK cell receptor 2B4 augments Ag-specific CTL activity through CD48 ligation on neighboring T cells. Journal of Immunology. Vol.170, No 10: 4881 9) Albert, H and H. Wei. Sugarcane Ubi9 gene promoter and methods of use thereof. 2004, U.S. Patent No. 6706948 | Promoter of the sugarcane Ubi9 gene. 2004. U.S. Patent No. 6686513 B1 | Promoter of the sugarcane Ubi4 Gene. 2003. U.S. Patent No. 6638766 (http://www.uspto.gov). Teaching FW4099 Programming Skills for Bioinformatics Fall 2009, 2011 FW5082 Gene Expression Data Analysis Fall 2010, 2012 CS2321 Data Structure in Java Spring 2011 FW4500 Experimental Design and Data Analysis for Natural Science Spring 2012 Recent Synergistic Activities 1) Grant Proposal Reviews: NSF Organism and Environment Interaction. 2010 2) Grant Proposal Reviews: NSF of China Forestry Biotechnology, 2010. 3) Invited speaker: International Conference on Sustainable Management of Multi-purpose Poplar Plantations, IUFRO, China, 2010 4) Invited speaker: Plant and Animal Genome XIX Conference, Jan 2011, San Diego, California. Collaborators & Collaborators & Other Affiliations (within last 48 months) Co-authors and Collaborators: Xiaoqi Cui, Huann-sheng Chen, Victor, Busov, Pei-Fen Kuan, Guangjin Pan, Ron Stewart, James Thomson, Shulan Tian, Chuhu Yang, Jeff Nie, Srikumar Sengupta, Victor Ruotti, Gudrun Jonsdottir, Sunduz Keles. Vinodh Srinivasasainagendra, Chuhu Yang, and Ray Ming, Shaobin Hou, Yun Feng et al 82 co-authors of the article in Nature, Vol. 452, No. 7190:991-996, 2008 Advisor Fang Ruan, Ph.D. student in Systems Biology, Spring, 2010 to Present Yang Li, Master student in Genomics. Fall, 2009 to Present Hang Zhang, Master student in Computer Science, Spring, 2010 to Present

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Biographical Sketch

Thomas Werner

Assistant Professor Department of Biological Sciences DOW 523, 1400 Townsend Drive

Michigan Technological University Houghton, MI 49931

Phone: (906) 487-1209 FAX: (906) 487-3167

E-mail: twerner@mtu.edu Education 2005 Ph.D., Cell and Molecular Biology, Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, Sweden. 1997 M.Sc., Biology, Jena University, Jena, Germany. Appointments 2010 - present Assistant Professor, Department of Biological Sciences, Michigan Technological University, Houghton, MI. 2005 - 2010 Post-Doctoral Research Associate, Department of Molecular Biology, University of Wisconsin-Madison, Madison, WI. Honors and Awards 2005 - 2008 Postdoctoral Long-term fellowship, Human Frontier Science Program 2005 - 2007 Postdoctoral Long-term fellowship, European Molecular Biology Organization (declined in favor of the HFSP fellowship) 1998 – 2000 Graduate fellowship Umeå University 1990 Special Award at the National Youth Science and Technology Competition “Jugend Forscht” (“Youth researches”) , Mainz, Germany. Peer Reviewed Publications 1) Werner T., Koshikawa S., Williams T.M., Carroll S.B. (2010) Generation of a novel wing color pattern by the Wingless morphogen. Nature, Vol. 464, pp. 1143-1148. (Cover article) 2) Rebeiz M., Ramos-Womack M., Jeong S., Andolfatto P., Werner T., True J., Stern D.L., Carroll S.B. (2009) Evolution of the tan Locus Contributed to Pigment Loss in Drosophila santomea: A Response to Matute et al. Cell, Vol. 139, pp. 1189-1196. 3) Williams T.M. , Selegue J.E., Werner T., Gompel N., Kopp A., and Carroll S. B. (2008) The Regulation and Evolution of a Genetic Switch Controlling Sexually Dimorphic Traits in Drosophila. Cell, Vol. 134, pp. 610–623. 4) Jeong S., Rebeiz M., Andolfatto P., Werner T., True J., Carroll S.B. (2008) The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species. Cell, Vol. 132, pp. 783-93. 5) Werner T., Borge-Renberg K., Mellroth P., Steiner H. and Hultmark D. (2003) Functional diversity of the Drosophila PGRP-LC gene cluster in the response to LPS and peptidoglycan. J Biol Chem, Vol. 278, Issue 29, pp. 26319-22. 6) Choe K.M., Werner T., Stoven S., Hultmark D, Anderson K.V. (2002). Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila. Science, Vol. 296, Issue 5566, pp. 359-62. 7) Werner, T., Liu, G., Kang, D., Ekengren, S., Steiner, H. and Hultmark, D. (2000). A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci USA, Vol. 97, Issue 25, pp. 13772-7.

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Memberships Michigan Tech Biotechnology Research Center (BRC) Current Collaborations Sean B. Carroll and Shigeyuki Koshikawa, University of Wisconsin-Madison, WI. Advisors M.Sc. Advisor: Dr. Andreas Henke, Jena University, Jena, Germany Ph.D. Advisor: Dr. Dan Hultmark, Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, Sweden. Postdoctoral Advisor: Dr. Sean B. Carroll, University of Wisconsin-Madison, WI. Present Undergraduate Students Bryant Kollie, Roger Yeager

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Biographical Sketch

Ramakrishna Wusirika Associate PRofessor

Department of Biological Sciences DOW 505, 1400 Townsend Drive

Michigan Technological University Houghton, MI 49931

Phone: (906) 487-3068 FAX: (906) 487-3167

E-mail: wusirika@mtu.edu Web site: www.bio.mtu.edu/faculty/rwusirika.htm

Education National Chemical Laboratory, and University of Pune, Pune, India Biochemistry Ph.D., 1995 University of Hyderabad, Hyderabad, India Biochemistry M.Phil., 1990 University of Hyderabad, Hyderabad, India Biochemistry M.Sc., 1988 Osmania University, Hyderabad, India Biology B.Sc., 1986 Appointments 2009 – present Associate Professor Department of Biological Sciences, Michigan Technological University, Houghton, MI. 2003 - 2009 Assistant Professor Department of Biological Sciences, Michigan Technological University, Houghton, MI. 1999 - 2003 Post-Doctoral Research Fellow Department of Biological Sciences, Purdue University, West Lafayette, IN. 1997 - 1999 Post-Doctoral Research Fellow Department of Horticulture, Purdue University, West Lafayette, IN. 1995 - 1997 Post-Doctoral Research Fellow Division of Biochemical Sciences, National Chemical Laboratory, Pune, India. Recent Publications 1) Wusirika R, Li K, Bennetzen JL, Phillips RL (2010) Zea. In: Kole C (ed) Wild Crop Relatives: Genomic and Breeding Resources. Vol 1: Wild Relatives of Cereals. Springer, Heidelberg, Berlin, New York (in press) 2) Krom, N., and Ramakrishna, W. (2010) Conservation, rearrangement, and deletion of gene pairs during the evolution of four grass genomes. DNA Res doi: 10.1093/dnares/dsq022 3) Dhadi, S.R., Krom, N., and Ramakrishna, W. (2009) Genome-wide comparative analysis of putative bidirectional promoters from rice, Arabidopsis and Populus. Gene 429: 65-73. 4) Krom, N., and Ramakrishna, W. (2008) Comparative analysis of divergent and convergent gene pairs and their expression patterns in rice, Arabidopsis, and Populus. Plant Physiol. 147: 1763-1773. 5) Krom, N., Recla, J., and Ramakrishna, W. (2008) Analysis of genes associated with retrotransposons in the rice genome. Genetica 134: 297-310. 6) Xu, Z., and Ramakrishna, W. (2008) Retrotransposon insertion polymorphisms in six rice genes and their evolutionary history. Gene 412: 50-58. 7) Oakley, R.V., Wang, Y-S., Ramakrishna, W., Harding, S.A., and Tsai, C-J. (2007) Differential expansion and expression of α- and β-tubulin gene families in Populus. Plant Physiol. 145: 961-973. 8)Nagy, E., Lee, T-C., Ramakrishna, W., Xu, Z., Klein, P., SanMiguel, P., Cheng, C-P., Li, J., Devos, K., Schertz, K., Dunkle, L., and Bennetzen, J. (2007) Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. Theor. Appl. Genet. 114: 961-970. 9) Yan, L., Loukoianov, A., Blechl, A., Tranquilli, G., Ramakrishna, W., SanMiguel, P., Bennetzen, J.L., Echenique, V., and Dubcovsky, J. (2004) The wheat VRN2 gene is a flowering repressor down-regulated by vernalization. Science 303: 1640-1644. 20) Bennetzen, J.L., Coleman, C., Liu, R., Ma, J., and Ramakrishna, W. (2004) Consistent over-estimation of gene number in complex plant genomes. Curr. Opin. Plant Biol. 7: 732-736.

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11) Lai, J., Ma, J., Swigonova, Z., Ramakrishna, W., Linton, E., Llaca, V., Tanyolac, B., Park, Y.J., Jeong, O.Y., Bennetzen, J.L., and Messing, J. (2004) Gene loss and movement in the maize genome. Genome Res. 14: 1924-1931. 12) Swigonova Z, Lai J, Ma J, Ramakrishna W, Llaca V, Bennetzen JL, and Messing J. (2004) Close split of sorghum and maize genome progenitors. Genome Res. 14: 1916-1923. 13) Ramakrishna W, Deng Z, Ding CK, Handa AK, Ozminkowski RH Jr. A novel small heat shock protein gene, vis1, contributes to pectin depolymerization and juice viscosity in tomato fruit. (2003) Plant Physiol. 131: 725-735. Synergistic Activities 1) Member, American Society of Plant Biologists 2) Coordinator, Bioinformatics Program, Michigan Tech University 3) Ad hoc reviewer for several international journals and funding agencies (NSF, US-Israel BARD and U.S. Civilian Research and Development Fund) 4) Chief editor for a special issue of International Journal of Plant Genomics Collaborators Jeffrey Bennetzen (U. Georgia, GA), Phillip SanMiguel (Purdue Univ, IN), Jianxin Ma (Purdue Univ, IN), Ramanjulu Sunkar (Oklahoma State Univ, OK), Chung-Jui Tsai (U. Georgia, GA), Erich Grotewold (Ohio State Univ, OH), Sastry Jayanty (Colorado State Univ, CO), Rupali Datta (MTU), Wan Jin Jahng (MTU), Charles Kerfoot (MTU) Graduate and Postdoctoral Advisors PhD Advisor: Prabhakar Ranjekar, National Chemical Laboratory, Pune, India Postdoctoral Advisor: Jeffrey Bennetzen, University of Georgia, Athens, GA, Avtar Handa, Purdue University, West Lafayette, IN, Prabhakar Ranjekar, National Chemical Laboratory, Pune, India Thesis Advisor Current Ph.D. Surendar Reddy Dhadi, Kefeng Li and Sheikh Rafi Past Ph.D./M.S. Nicholas Krom, Zijun Xu, Deepak Kumar and Patience Tenney Curren Visiting Scientist Zhiying Dou Past Visiting Scientist Bashir Yusuf (Ahmadu Bello University, Nigeria) Undergraduate Students Advised Nari Kang, Matt Ogg, Sulagna Gupta, Katie Kruger, Megan McQuillan, Jill Recla, Benjamin Baer and Holly Grunst

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Response to Senate Proposal 51-04: Financial information for the proposed PhD in BMB program

I.a. There is a growing world-wide demand for scientists and engineers with advanced training in biochemistry and molecular biology. Michigan Tech has a long and rich history of research in the exciting field of biochemistry and molecular biology. Recent conceptual and technological advancements have widened the scope of what is possible to study in these fields and correspondingly, many recent faculty hires in individual departments and through the Strategic Faculty Hiring Initiative have increased the ranks of those around campus (Biological Sciences, Chemistry, Forest resources and Environmental Sciences, Chemical Engineering, Biomedical Engineering, Mathematics) engaged in biomedical research, plant genomics and other health-related biochemistry and molecular biology studies. Our ability to carry out cutting edge research in these areas will strongly benefit from greater coherence and integrated graduate training. I.b. Because no additional resources are requested, we expect this proposal to be consistent with the university’s resource allocation criteria. II.a. We anticipate that 2-5 students will enter the program immediately because they are the current students of faculty performing work relevant to the PhD program proposed here. In five years the program will have an estimated population of between 10-15 graduate students.

II.b. Initially, students will be drawn from existing programs. Specifically, these will be graduate students who would prefer a PhD in BMB rather than the one they are currently enrolled in and whose advisors comprise the core group of 14 faculty. For example, a participating faculty member in the Department of Chemistry has three graduate students. One is working on a project in protein expression, the other in enzyme mechanisms and the other in synthetic organic chemistry. For these students, this new program is more desirable than current offerings because it more closely aligns with their research interests. The University will be able to provide better service to these students by making this new program available. These students are currently under the auspices of the Dept of Chemistry, in this example, and the Dept of Chemistry will remain their administrative home unit even after the PhD in BMB comes on line. Similarly, students advised by faculty in other departments or schools will continue to have their current home department or school serve as their administrative home unit. The decision to enter the program is between the graduate student and the advisor. All costs for the student are incurred by respective administrative home unit – as is the case now. In the future, new students are expected to enter this program who would otherwise not have come to MTU. These students would have joined other universities with BMB PhD programs, as a BMB PhD program best reflects their areas of interest in research and education.

II.c. If the Biochemistry and Molecular Biology (BMB) B.S. degree offered as dual tracks in the Departments of Chemistry and Biological Sciences is an indicator of population changes, an increase is expected. The numbers for the Department of Chemistry revealed an increase of about 44 students in the four-year B.S. (Biochemistry and molecular biology and Phramaceutical chemistry) degrees, with no impact on the number of B.S. Chemistry majors. The Department of Biological Sciences has 31 students in the BMB B.S. degree program. In summary, we expect to

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see new growth, based on the undergraduate degree, where an increase in new students was seen as opposed to those entering the department and simply selecting a different major within the department.

II.d. Graduate students currently enrolled: Chemistry has 41; Forestry has 82; Biological Sciences has 38 graduate students

III.a. No effect.

III.b. The program introduces one course which is laboratory-based. This course will be team taught and the exercises will occur in the laboratories of member faculty. A lab fee will be charged to provide for expendable supplies.

The students’ administrative home departments will provide office space, computational resources, and necessary supplies and infrastructure support, and will consider the students for departmental teaching assistantships when appropriate and available. All such students will be counted as members of their home departments for the purposes of internal university accounting.

III.c. Students enrolled in the program will be housed within the home department of their advisors. The faculty members who have students in this program are the advisors.

III.d. The Biochemistry Ph.D. program, as an interdisciplinary, cross-department program, will be administered through the Graduate School. Participating faculty will elect a three-member steering committee. The committee will elect a Graduate Program Director who will work closely with the Dean of the Graduate School and will be assisted by a staff member. The Graduate Program Director will be invited to attend all meetings of the Graduate Faculty Council.

IV.a. None expected. Faculty listed in Table 1 of the proposal have fully functioning laboratories with the necessary equipment and computers. No new equipment is required to start up this program.

IV.b. The program builds on existing resources, so it is not anticipated that new library or other learning resources will be required.

V.a. No new resources are requested, and costs associated with recruiting and other program administration will be handled through the Graduate School and the departments of member faculty (currently; Biological Sciences, Chemistry, and Forestry Resources and Environmental Sciences).

VI. Yes, The Department of Chemistry has initiated three new programs: Biochemistry and Molecular Biology B.S., Pharmaceutical Chemistry B.S. and Cheminformatics

VI.a.1. In the BS in Biochemistry and Molecular biology proposal the goal was to double the number of students in the program. In 2003-4, the number of students in the program was 6; this

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number included students in BL and CH interested in biochemistry and molecular biology. Currently the number of students in the two departments total 50 (CH-19; BL 31). In addition, there are 27 students in the closely related Pharmaceutical Chemistry program in Chemistry; the goal was 32 students by 2015. In Cheminformatics the number of students is 5; the goal is 20.

VI.a.2. Significant new resources were generated from external and internal sources in the Department of Chemistry, including cost share for CH4721: Research Methods in Biochemistry. This lab was funded by the NSF ($150,000) and Departmental resources ($100,000). CH3540: Biophysical Chemistry and CH3541: Biophysical Chemistry Lab are new offerings and a faculty member was hired to teach these courses. CH4222: Bioanalytical Chemistry was adapted from a five credit Intro Quant & Instrumental Analysis, specifically designed for the Biochemistry and Molecular Biology and the Pharmaceutical Chemistry degrees. Additional costs are incurred by the Department (via student fees) for supplies used for CH4995. The Department of Biological Sciences had preexisting courses in place before the start of the Biochemistry and Molecular Biology B.S. program. The biochemistry and molecular biology laboratories were upgraded with departmental resources. VI.a.3. Since the Biochemistry and Molecular Biology B.S. was implemented, two new faculty members have been hired in the Dept. of Chemistry. One is an SFHI hire and the other is attributable to the new degree program and teaches Biophysical Chemistry/Lab. The Dept. of Biological Sciences has hired six new faculty members in this area in the last five years. Two of these are SFHI hires.

VI.a.4. Instrumentation in support of new lab courses in the Dept. of Chemistry is from the National Science Foundation, student laboratory fees, department budget and as described in VI.a.2. (above).

VI.b. Enrollment has doubled in the Dept. of Chemistry. All growth has been in the three new degrees without decreasing the existing Chemistry B.S.

Enrollment in other undergraduate degree programs increased from 261 to 266 in the last five years in the Dept. of Biological Sciences. In the same period, graduate student enrollment increased from 24 to 38.

VII.a. Total general fund budget: Biological Sciences: $2,363,600 (this is slightly different than compendium which has 2,374,801 for 2010-2011); Total general fund budget: Chemistry: 2,390,227; Total general fund budget: School of Forest Resources and Environmental Science: $3,578,444 (data from Compendium 2011)

VII.b. This number is impossible to get because Institutional Analysis does not track tuition revenue at the unit level. Tuition at the University is charged based on student type rather than course level and some students receive some sort of financial aid that reduces their net tuition revenue that is received by the University.

VIII. The other programs currently under consideration or development as proposals include Master's Biomedical Engineering, Accelerated Master's Biomedical Engineering, Master's

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Program Security and Medical Informatics. Since there is no request for additional resources for this program and it does not overlap with the other programs under consideration, there will be no effect on these programs.

Comment [j1]: These are now approved and in place.

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Master’s Program in Biomedical Engineering Department of Biomedical Engineering

College of Engineering and the Graduate School Michigan Technological University

August 2011 1. Introduction This is a proposal to formally establish a Master’s degree program in Biomedical Engineering (BME) within MTU’s Department of Biomedical Engineering. This proposal will establish Plan A, Plan B and Plan D MS degree options. The mission of the proposed program is to create a pathway for students to further enhance their engineering and life science knowledge, gaining a competitive edge in an increasingly demanding job market. The proposed Master’s degree program in BME will be fully administered and maintained by the Department of Biomedical Engineering. The scope of the proposed program is similar to many existing programs at MTU as well as at other institutions. Engineering students with high academic standing can apply and be accepted for the program. Students without a Biomedical Engineering undergraduate degree are welcome into the program, but may be required to take additional life science courses to make up for deficiencies in life science training. Highly qualified non-engineering students are also welcome to apply, however, these individuals may be required to complete additional mathematical and/or engineering courses to make up for perceived deficiencies. Participating students are also required to maintain good standing after acceptance into the program. Our specific objectives are to:

1) Offer a Master’s degree beginning in the fall of 2012. 2) Initiate a recruiting effort to publicize the expanded graduate opportunities in BME at MTU. 3) Establish initial MS student enrollment at a level of 15 (including an estimated 12 from the

accompanying proposal for an accelerated MS program). 4) Contribute to MTU’s mission to be a nationally prominent and internationally recognized

technological university that bridges technology and business and meets the needs of a global and technologically rich society through excellence in undergraduate and graduate education, scholarship, and research.

2. Rationale Biomedical Engineering is one of the fastest growing engineering specialties in the United States. The bachelor’s degree program in biomedical engineering at Michigan Technological University reflects this trend and has experienced steady growth in student numbers since the program was initiated in 1997. BME at MTU currently enrolls approximately 235 undergraduate students. To prepare students for careers in biomedical engineering requiring advanced education beyond the bachelor’s degree, the BME department established and offered a doctoral program in biomedical engineering starting 2005. BME currently has 15 doctoral students enrolled in the program. At present, MTU has programs in biomedical engineering aimed at preparing students for both entry level (bachelor’s degree) terminal level (Ph.D. degrees) positions. Nevertheless, there is still a strong need for master’s program that can provide training to students who are interested in mid-level entry positions, or who desire to have a competitive edge compared to students with a standard 4-year BME bachelor’s degree.

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There are many reasons to establish a master’s program in biomedical engineering at MTU. First, at the national level, there is an increasing demand for master’s degree level biomedical engineers. Without a master’s degree program at MTU, MTU graduates will be forced to attend competitor institutions if they wish to continue beyond a 4-year bachelor’s degree but do not want to commit at least 4 more years towards a Ph.D. degree. Second, a master’s program in biomedical engineering is a natural progression for the Biomedical Engineering Department at MTU. To be competitive nationally, the university recognizes that it is important to have strong graduate programs, in addition to undergraduate programs, to achieve the highest quality education at all levels. The small size of the BME graduate student population has restricted the department’s efforts towards developing highly focused, advanced graduate-level courses. The establishment of a master’s program is expected to increase the size of the graduate program and provide a large number of self-supporting students. This will allow the department to engage in activities that strengthen the overall graduate mission of the department and the university. Third, a master’s program in biomedical engineering will both directly and indirectly enhance the research efforts in the department. The proposed Plan A master’s program is a traditional, hands-on master’s degree that requires research leading to a thesis. The proposed Plan B requires a smaller project that results in a research paper. Finally the Plan D master’s degree is purely didactic in nature preparing students to further continue their education, if desired. As a result, the Plan D master’s program will allow the department to identify and recruit highly motivated and better prepared students into the department’s Ph.D. program. 3. Related Programs Related Programs at MTU Currently, the BME department at MTU has an undergraduate program that awards graduating students a bachelor’s of science in biomedical engineering, and a graduate program that awards students a Ph.D. in biomedical engineering. There are no master’s programs in BME. Students who wish to pursue a master’s degree in a biomedical engineering –related field at Michigan Technological University must pursue their degree from another engineering department, such as electrical, mechanical, materials science or chemical engineering. Equivalent/Competitive Programs in the State of Michigan University of Michigan The Biomedical Engineering Department at the University of Michigan has a graduate program in the Horace Rackham School of Graduate Studies that grants M.S. and Ph.D. degrees in Biomedical Engineering. The department is jointly supported by the College of Engineering and the Medical School. In order to obtain an M.S. degree in Biomedical Engineering, students must satisfactorily complete (B or better for courses that are issued letter grades, and S for courses that are graded S/U) a minimum of 30 credits of graduate study beyond the bachelor's degree. Within this requirement, a group of core courses, or their equivalents in the biological sciences, as well as several graduate-level engineering and physical science courses, must be completed. Directed research work is required to familiarize the student with the unique problems associated with biological systems research.

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Wayne State University Wayne State University offers both the MS and Ph.D. degrees in Biomedical Engineering. The master’s degree is offered in two options: Plan A, which requires a minimum of 34 credit hours in course-work including an eight-credit thesis and Plan C, which requires a minimum of 34 credits in course work. Wayne State does not offer an accelerated BS/MS program. Michigan State University Biomedical Engineering is not available as a major at Michigan State, but several MSU degree programs include an optional concentration for biomedical-related focused study, including Biosystems Engineering, Chemical Engineering, Materials Science and Engineering, and Mechanical Engineering. The Electrical Engineering major includes a Biomedical Engineering major track. Equivalent Programs Nationally Nationally, master’s programs in biomedical engineering at research-oriented universities are the norm. Certain BME programs, notably the Georgia Institute of Technology/Emory program restrict awarding MS degrees to those doctoral students who have met the minimum requirements for a MS degree, but fail to complete the Ph.D. program. The table below lists a few of the top rated biomedical engineering programs, and their MS programs (if offered).

Top national undergraduate biomedical (bioengineering) programs

MS or equivalent program?

Johns Hopkins University Yes Georgia Institute of Technology/Emory M.S. only for failing Ph.D.

students University of California – San Diego Yes Duke University (Pratt) Yes University of Washington Yes Massachusetts Institute of Technology Yes University of Pennsylvania Yes Boston University Yes Rice University Yes (Master of

Bioengineering – non-thesis) Stanford University Yes University of Arizona Yes

4. Projected Enrollment We project our initial master’s graduate enrollment to be 3, plus an additional 12 from the proposed accelerated program for a total of 15. Our goal is to increase this number to 25 master’s students (combined accelerated program and this program) in 5 years. The estimation is based on exit interviews and alumni surveys from past years. Recruitment plans include (1) advising our BME undergraduate majors of the potential for continuing at MTU obtain a master’s degree in BME following one additional year of study, (2) working with MTU’s Undergraduate Admissions/Recruitment Office along with the Graduate School to develop a BME brochure and a focused marketing plan, (3) updating the BME Department web page highlight the master’s program.

5. Scheduling Plans The master’s program in BME will be offered at the beginning of Fall Semester 2012.

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6. Curriculum Design Admission Requirements:

1) Only students with a cumulative GPA of 3.0 or above are eligible to enter the BME master’s program.

2) In general, all students who have a BS in an engineering discipline are eligible to apply. However, those students lacking undergraduate courses in the life sciences may be required to complete additional courses in the life sciences to correct for this deficiency.

3) Exceptional students with non-engineering BS degrees are also eligible to apply. However, these students may be required to complete additional courses in engineering and or mathematics to correct for this deficiency.

4) General GRE exam results are required to be submitted as part of the admissions process. 5) The standard Graduate School admissions process applies.

Program Requirements:

1) The number of credits required for the Master’s degree is 30 credits 2) Students who are accepted into the program will not be allowed to continue if their cumulative

GPA falls below a 3.0. A cumulative GPA of 3.0 will be required for graduation. 3) Due to the interdisciplinary nature of the biomedical engineering program, courses also will be

taken outside of the Biomedical Engineering Department as determined by the student and his/her advisory committee and dependent on the student’s area of emphasis. However, the students will need at least 12 credit hours (in addition to the 2, 1 cr seminar requirement – see #6, below) from the BME department.

4) Each student will have an academic/research advisor who is a member of the Biomedical Engineering faculty. The Advisor’s primary responsibility will be supervising the student’s academic and professional growth, as well as working with the student to develop an academic plan for enrolling in the appropriate courses for the student and program.

5) The academic plan developed by the student and academic advisor will need written approval from the faculty advisor and the departmental graduate coordinator.

6) Throughout their degree program, the graduate students will be required to attend the Graduate Seminar. During the first year of study, the students will receive one credit for each semester for participation. After the first year, attendance will still be mandatory, but the students will not receive credit.

7) All Graduate School residency and credit requirements must be met.

Typical Program of Study: There are no core required classes for the MS in Biomedical Engineering. Course plans will be developed by the student, the student’s advisor and the BME graduate program coordinator. A minimum of 12 credits (of the minimum 30) must be taken from the BME Department. Because of the breadth of the field of Biomedical Engineering, there is no single ‘typical’ program of study. However, Appendix II lists some appropriate existing courses that a BME MS student may take to fulfill course requirements. 7. New Course Descriptions Three new faculty hires (already hired; will begin Fall 2011) will develop new graduate level courses as part of their regular teaching duties to supplement existing graduate level courses (for our existing Ph.D. Program). However, these courses will not be required courses for the degree. 8. Library and Other Learning Resources No additional library or other learning resources are associated with this program.

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9. Faculty Resumes Biomedical Engineering faculty resumes can be found at http://www.biomed.mtu.edu/fac_CVs/ . Participating Biomedical Engineering Faculty include: Sean J. Kirkpatrick, Ph.D., Associate Professor & Chair Michael Neuman, MD, Ph.D., Full Professor Jeremy Goldman, Ph.D., Associate Professor Keat Ghee Ong, Ph.D., Associate Professor Megan Frost, Ph.D., Associate Professor Rupak Rajachar, Ph.D., Associate Professor Niloy Choudhury, Ph.D., Assistant Professor Feng Zhao, Ph.D., Assistant Professor Bruce Lee, Ph.D., Assistant Professor Martyn Smith, Ph.D., Adjunct Professor Qing-Hui Chen, Ph.D., Adjunct Assistant Professor Karen Roemer, Ph.D., Adjunct Assistant Professor 10. Description of Available/Needed Equipment Students will access the university-wide computing facilities already present. 11. Program Revenue & Costs Presented below is a quick summary of the financial assessment of the proposed program. A more complete evaluation is given in Appendix I. The appended evaluation conforms to the proposal 51-04 of the University Senate of Michigan Technological University. Revenue (Based on 2011-20112 Tuition & Student Voted Fees) Graduate Resident and Non-Resident Per Credit Rate: $702 Engineering tuition Fee Per Semester For Undergraduates Taking 6 Credits or more and Graduate Students Taking 5 Credits or More: $705 Student activity Fee: $44.30 Experience Tech Fee: $69.00 Per Student (30 credits* $702) $21,060 Engineering Tuition Semester Fee (4 semesters) $ 2,820 Fees (4 semesters) $ 453.20 Total per Student $24,333.20 Based on Initial Enrollment of 3 Students: $72,999.60 (Initial class) New Costs Student support: No financial support for MS students is required Lab space: No new laboratory space is needed

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New courses: BME already offers numerous graduate level courses as part of our Ph.D. degree program. We have also recently hired 3 new tenure-track faculty, each of whom will develop a graduate level course as part of their regular teaching assignment. Thus no new costs associated with new course development. Student offices: BME has sufficient space to house the expected enrollment. Student Advising: For the research MS students, much of the research advising will be completed during the usual weekly lab meetings that each of the BME faculty hold with their research groups. Course advising for the MS students will be minimal and the time required for this advising will be small as the BME faculty already perform these same advising tasks for BME Ph.D. students. 12. Space No additional space is required to support this proposed program. 13. Policies, regulations and rules Specific policies, regulations and rules for this program are stated in Section 6: Curriculum Design (above). 14. Accreditation Requirements There are no further accreditation requirements for this proposed Master’s program. 15. Internal Status of Proposal This proposal for a master’s program in Biomedical Engineering has been approved by the Faculty of the Department of Biomedical Engineering, by the Engineering Council, and by the Dean, College of Engineering. 16. Planned Implementation Date This proposed master’s program will be implemented in the Fall of 2012.

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Appendix I

Criteria for Financial Evaluation of proposed Academic Programs Senate proposal 51-04

I. Relation to University Strategic Plan a. Relation of program to the University’s educational and research goals: The University and the College of Engineering both are striving to increase graduate enrollment. In this regard, the proposed MS program aligns with the University’s research and educational goals. In addition, we expect the proposed MS Program to serve as a feeder program for the Department’s Ph.D. program and thereby increase both the numbers of students and the quality of students in the Ph.D. Program. b. Consistency with the University’s resource allocation criteria: No new resources are being requested at the Departmental level to support this proposed program. II. Impact on University Enrollment a. Projected number of students in the program: We project our initial master’s graduate enrollment to be 3, plus an additional 12 from the proposed accelerated program for a total of 15. Our goal is to increase this number to 25 master’s students (combined accelerated program and this program) in 5 years. The estimation is based on exit interviews and alumni surveys from past years. Recruitment plans include (1) advising our BME undergraduate majors of the potential for continuing at MTU obtain a master’s degree in BME following one additional year of study, (2) working with MTU’s Undergraduate Admissions/Recruitment Office along with the Graduate School to develop a BME brochure and a focused marketing plan, (3) updating the BME Department web page highlight the master’s program. b. Source of new students: Initially, we project that all new students will have earned their BS Degree from Michigan Tech. However, as the degree program matures, we project that we will draw students from other universities into the program. c. What is the likely correlation between demand for the new program and existing enrollment patterns at MTU?: We do not forsee any significant changes in the enrollment patterns at MTU as a result of this program. However, we do expect that students who are interested in obtaining an MS in BME will now do so through the Department of Biomedical Engineering as opposed to other Engineering Departments (e.g., MEEM, ECE). d. What is the current enrollment in the unit?: BME currently enrolls approximately 240 undergraduate students and 12 Ph.D. students. III. Impact on Resources Required by Department in which the program is Housed a. Faculty Lines: No new faculty lines are requested b. Faculty and Student Labs: No new Laboratory space is requested. All faculty maintain and active research lab as part of our Ph.D. Program. c. Advising: For the research MS students, much of the research advising will be completed during the usual weekly lab meetings that each of the BME faculty hold with their research groups. Course advising for the MS students will be minimal and the time required for this advising will be small as the BME faculty already perform these same advising tasks for BME Ph.D. students.

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d. Assessment: Faculty members will have to devote time to assessing the MS students. More students will enroll in our graduate courses and the work will need to be assessed. Faculty advisors and committee members will need to devote time to reviewing the student’s research and reading/assessing MS theses. IV. Impact on resources Required by Other Units Within the University a. Other academic units with regard to faculty, labs, and assessment: BME MS students may take courses from other Units on campus, if there is sufficient space in the courses. Faculty from other Units would have to assess the student’s performance in these courses just as they would for any other graduate student. b. Information Technology, Library, Central Administration etc.: New students will, of course, increase the demands on IT, the Library, etc. However, it is within the University’s goals to increase the number of graduate students enrolled. The students in the Program will pay the Engineering Tuition Fee which should, presumable, help to offset some of these costs. V. Assessement of the Ability to Obtain the Necessary Resources Assuming Requested Funds are Obtained: No new funds are requested; No new faculty lines are requested. VI. Past proposals: The Department has not initiated any other new degree programs in the past 5 years. VII. Departmental Budget Contribution a. What is the Department’s total general fund budget? $1,127,115 (2011-20112 Budget Year) b. How much tuition does the Department generate (approximate numbers)? 1. Credit hours taught by Department: 1321credit hours at $420.50/hour = $555,480.50 (+ fees) (Undergraduate in FY10) 157 credit hours at $702/hour = $110,214 (+fees) (Graduate in FY10) Total: ~$555,480.50+$110,214 = $665,649.50 Note that these values will increase slightly due to increased enrollment this academic year. 2. Number of credit hours taken by BME majors: Ave. of 16.38 cr hrs per student per semester * 240 students = 3,930 cr. hrs per semester (Undergraduate) 3,930cr hrs at $420.50/hr (in FY10) = $1,652,565 Ave of 9 cr hrs per student per semester * 12 Ph.D students = 108 cr. hrs per semester (Graduate) 108 cr hrs at $702/hr = $75,816 Total: $1,652,565+ $75,816 = $1,728,381 VIII. a. How do the benefits from this Program compare to other alternatives that are currently under consideration or development? No alternatives are currently under consideration or development. b. Will approval and allocation of resources to this program preclude the development of other programs? No allocation of new general fund resources or space is requested, so other programs will not be precluded from being developed based on these considerations.

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Appendix II List of Appropriate Existing Courses

(not necessarily all inclusive; does not include research credits or special topics courses)

Department of Biomedical Engineering Courses BE5100 Cell/Tissue mechanics BE5200 Biology for Engineers II BE5300 Polymeric Biomaterials BE5510 Cardiovascular Engineering BE5600 Active Implant. Dev. BE5700 Biosensors BE5940 Intro Tissue Eng. BE5550 Biostatistics for Health Sciences BE5990 Grad Seminar BE5800 Adv. Biomaterials Interfaces BE5880 Princ & Anal/Cell Proc. BE5900 Biomedical Optics (Note BME has recently hired 3 new faculty members into the Department. As part of their regularly assigned teaching duties, they will each develop a graduate-level course for the existing Ph.D. Program. These courses have yet to be defined, however, they will be added to this list as they are developed and offered.) Other College of Engineering Courses* EE5440 The Laser EE5522 Digital Image Processing EE5540 Statistical Optics EE5750 Dist Embedded Control Sys EE5940 Electrophysics Seminar EE5950 Signals and Systems Seminar EE5410 Engineering Electrodynamics EE5520 Fourier Optics EE5500 Prob & Stoch P rocesses MEEM5170 Finite Element Methods MEEM5210 Adv. Fluid Mech MEEM5650 Adv. Quality Eng CM5900 Nanobiosensors MEEM5240 Comp. Fluid Dynamics MEEM5150 Advanced Mechanics of Mats. MEEM5700 Dynamic Meas/Signal Analysis MEEM6110 Adv. Continuum Mech MY5260 Crystallography MY5580 Atomic force Microscopy Courses Offered in the College of Science and Arts* BL5340 General Immunology BL5502 Biological Sciences Seminar BL5030 Molecular Biology BL5025 The Scientific Profession BL4840 Mol. Biol. Tech CH5120 Pharm Chemistry: Drug Design CH6920 Adv. Mass Spectrometry PH5410 Quantum Mechanics CH6790 Protein Folding *Based on availability

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REVISED NAMING SCHEME FOR MEMBER OF THE GRADUATE FACULTY

This is a proposal to revise the terms applied to the different categories of Graduate Faculty at Michigan Technological University.

Currently there are two categories of Graduate Faculty: Graduate Faculty and ad hoc Graduate Faculty.

In addition there are people who are not members of the Graduate Faculty but who have received permission to teach graduate courses. These individuals are not allowed to supervise graduate students or serve on graduate committees (and have no special title at present).

The proposed new naming scheme separates members of the Graduate Faculty into different groups based on broad characteristics. This change will help students to understand that there are different categories of Graduate Faculty (including different terms of service). This change will also make it easier for the University to accurately communicate with external audiences about the number and type of faculty involved with our graduate programs. Finally this change will make it easier for individuals associated with our graduate programs to accurately communicate their level of involvement and privileges.

The proposed names and definitions for the Graduate Faculty are:

1) Full Members: Members of the academic faculty holding the rank of ASSISTANT PROFESSOR, ASSOCIATE PROFESSOR, or PROFESSOR.

2) Affiliated Members: Members holding the rank of LECTURER, ADJUNCT, and EMERITUS faculty and faculty holding a rank with a prefix of VISITING. Affiliated Members’ appointments are reviewed annually.

3) Contributing Members: Members with special technical expertise that are employees of Michigan Tech and have been nominated for membership in the Graduate Faculty by an academic department or school and have been appointed to the Graduate Faculty by the dean of the Graduate School. Contributing Members’ appointments are reviewed annually.

4) Temporary Members: Members with special technical expertise that are not employees of Michigan Tech. Temporary members must be nominated for membership in the Graduate Faculty by an academic department or school and must be appointed to the Graduate Faculty by the dean of the Graduate School. Temporary Members’ appointments are reviewed annually.

The proposed name and definition for individuals who are not members of the Graduate Faculty but who have received permission to teach graduate courses is:

Graduate Instructional Faculty: Individuals who are have been recommended by an academic department or school to teach one or more graduate courses and who have been approved by the dean of the Graduate School. These individuals may not supervise graduate students’ research or serve on graduate committees. Appointments are reviewed annually.

The attached sheets show how these names align with the text of the Faculty Handbook.

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Chapter 1. Mission, Vision, General Organization, and Governance Section 1.5 Faculty Status Definitions << previous :: next >>

1.5.3 Graduate Faculty Status

A. Membership

The Graduate Faculty consists of members of the academic faculty holding the rank of ASSISTANT PROFESSOR, ASSOCIATE PROFESSOR, or PROFESSOR who have been appointed by the Dean of the Graduate School.

The Dean of the Graduate School may also grant graduate faculty status to LECTURER, ADJUNCT, and EMERITUS faculty and faculty holding a rank with a prefix of VISITING, but these appointments are for one year and must be reviewed and reappointed on an annual basis.

Under special circumstances, the graduate dean may appoint individuals with special technical expertise to the graduate faculty for a specific term and purpose, such as serving as a member of a student's advisory committee.

Only graduate faculty members are eligible to teach graduate courses (500 level and above), serve as examining members on Masters and PhD committees, and supervise Masters and PhD students.

B. Qualifications of Graduate Faculty

1. Qualifications expected for graduate faculty appointment:

a. Experience and continued interest in the conduct of research. b. The necessary background for, and a continued interest in, teaching graduate

courses. c. Continued interest in serving as a graduate student advisor.

2. Evidence of Qualifications

Faculty may meet the qualification requirements if they:

a. Are currently involved in research work or graduate instruction or in advising graduate students.

Comment [j1]: “Full Members”

Comment [j2]: “Affiliated Members”

Comment [j3]: “Contributing Members” if employed by Michigan Tech (e.g., MITRI, research faculty, research scientists, etc.). Annual review. “Temporary Members” if not employed by Michigan Tech. These are only appointed to serve on the committee of a particular student or students. This is the old “ad hoc” category. Annual review.

Comment [j4]: “Graduate Instructional Faculty” can teach but not supervise graduate students or serve on graduate committees.

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b. Regularly publish articles in recognized journals having national distribution or books related to their field of study.

c. Have earned the terminal degree in their field.

C. Appointment Procedures

Graduate Faculty appointment and retention decisions are made by the Dean of the Graduate School with recommendations and advice from department chairs, deans of colleges and schools, and the Graduate Council.

Recommendation for Graduate Faculty status is made in writing by the department chair of the appropriate academic unit or by the deans of the Schools of Business and Forestryappropriate Schools. These recommendations are forwarded to the college dean, where appropriate, and then to the Graduate Dean.

D. Review of Graduate Faculty

It is expected that department chairs/school deans will continually review the performance of all individuals holding graduate faculty status in their respective units using criteria outlined in Section B above.

When, in a department chair/school dean's professional judgement, a faculty member holding a graduate faculty appointment is no longer satisfactorily functioning in this capacity, s/he must recommend that the individual in question be removed from graduate faculty status. The Dean of the Graduate School may also initiate the removal process in consultation with the appropriate chair/dean. The Dean of the Graduate School will act on recommendations with the advice and consent of the Graduate Council.

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Revised: 02/27/2007 - Format changes made. http://www.admin.mtu.edu/admin/prov/facbook/ch1/1chap-17.htm Copyright © 2007. Michigan Technological University. All Rights Reserved. Address web questions about this page to Ann Roth at aroth@mtu.edu.

Comment [j5]: Text to be updated during summer, 2011 to reflect University practice.

56

Changes to GACS (Graduate Assistant Cost Share)

The deans have had a lot of discussions lately about the University's need to promote (and reward) units that are effective at obtaining external support for graduate students. We all agree that we are going to need to increase the amount of external support for students significantly if we are going to meet our strategic plan goals in the graduate area.

In fall 2009, 178 students were funded by external sponsored accounts (these are students coded in Banner as FELE, GADE, and GRA). In fall 2010, 215 students were externally supported. In contrast, the number of internally funded lines was 318 in fall 2009 and fall 2010. The increase in number of externally supported students is very positive, and it is appropriate to begin to reward units that facilitating Michigan Tech’s progress toward its Strategic Plan goals. Together, the Graduate School and the academic deans have come up with a proposal (outlined below) that will reward units that obtain external support for graduate students. The goal of this new policy is to stimulate further growth in the number of students supported by sponsored projects. If this goal is not achieved, this new policy will be revised as appropriate.

We are still very early in the planning stages and there are many procedural issues that remain to be worked out. At this point the deans would appreciate receiving feedback about the proposed new policy. The existing policy is outlined directly below and the proposed new policy follows at the end of this document.

Current policy is that GACS is available in the following situations:

• When cost share is mandatory. o The Graduate School will provide up to a maximum of 50 percent of the total required

cost-share capped at the equivalent of the cost of nine credits per student (for a maximum of two students) per semester for academic year (two semesters) tuition at the time the proposal is submitted.

• When cost share is not mandatory (voluntary uncommitted) (for assistant professors only). o The Graduate School will provide partial funding for one graduate student per budget

year on proposals submitted by an assistant professor serving as lead PI. Cost-share support will be capped at the equivalent of the cost of nine credits of academic year tuition (two semesters) at the time the proposal is submitted. Documentation of the dollar amount of the GACS commitment will not be disclosed in the budget justification section of the proposal.

• When the proposal is large (>$500k/year) and interdisciplinary, multidisciplinary, or contribute significantly to the University’s mission.

(See: http://www.mtu.edu/gradschool/administration/academics/policies-procedures/gacs/ )

57

Proposed New Policy:

Recent developments have precipitated a review of the current GACS policy and development of some recommendations for change.

• Required cost-share will continue to be available as before for single investigators and large projects.

• Voluntary uncommitted GACS funds will not be committed (even internally) to projects at the proposal stage. This is an appropriate change because NSF has recently updated its stand on voluntary committed cost share (it is now prohibited).

• A GACS “incentive return” will be awarded to departments in an amount proportional to the amount expended on graduate student support from sponsored projects.

o The goal is to return a 1/3 the cost of graduate tuition for every student that receives full-time support (stipend plus tuition) from a sponsored project.

o The actual amount returned will be based on the availability of funds. o This new approach will be phased-in and the amount of funding to be made available

will increase as existing GACS commitments expire. o All existing commitments will be honored. o Returns will be based on actual expenditures (rather than budget) in graduate student

stipend, hourly, and tuition categories. o Funds will be returned the unit level (department chair or school dean). o Funds will be available for use to support graduate students *only*. o All support from sponsored projects will be considered (not just projects proposed by

assistant professors).

58

Page 1 of 2Modified 6/28/2011 ddcBanner Codes: M5, D7, TD-Publishing

Charlesworth, DebraExchange-Pro 9.302 8/15/11 02:23:32 PM

Michigan Technological University Graduate School

Pre-defense Form - Please type; handwritten forms are not acceptable

This form is required for the following degrees: PhD, MS (plan A, B, C) and Master of Forestry Off campus students should e-mail a completed form to their graduate program; they will print and submit.

Return this form to the Graduate School two weeks prior to the oral defense.

D7

Provide information about you and your program.

Last Name, First Name, MI Charlesworth, Debra

M Number (ex: M12345678) M12345678

Select Degree Type PhD MS MFor

Select Graduate Program Chemistry

Draft Due Date

10/03/2011A draft of your dissertation or thesis is due to your committee and the Graduate School two weeks prior to your defense.

Title of thesis, report, or dissertation The best dissertation ever!

Select your defense date, time, and place. Students make their own arrangements to reserve a room on campus and set a date and time for the defense. All information in this section must be provided when the form is submitted to the Graduate School.

Defense Date (M/D/YYYY) 10/17/2011 Start Time of Defense 2pm

Place - building and room number Admin 407A

Provide your committee members.The advisor and co-advisor (if applicable) serve as chairs of the committee. At least four members of the graduate faculty are required for doctoral candidates. At least one member will be from outside the student's administrative home department or school.

Jeremy Gilbert, Co-Chair

Eugene Lautenschlager, Co-Chair

Kathleen Faber

Wesley Burghardt

Sign the form. A graduate program director may sign for any advisor. Advisors should verify the ETD and

embargo options selected on the next page, and will ensure that the committee has received a draft of a

thesis, report, or dissertation two weeks before the defense date.

Jeremy Gilbert Date Eugene Lautenschlager Date

Graduate Program Director, Chemistry Date Assistant to the Dean of the Graduate School Date

59

Graduate Faculty Council—Draft Agenda GRADUATE SCHOOLSeptember 20, 2011 NOTE: (all handouts connected to a single pdf file)

1. Review minutes of 09/06/11 2. Committee Reports:

a. Call for volunteers to form a Thesis/Dissertation Guideline Review Committee (Dean Huntoon) 3. Old Business

a. Biochemistry & Molecular Biology PhD Proposal (P. Murthy) b. Biomedical Engineering MS Proposal (S. Kirkpatrick)

4. New Business a. Category Revisions for Graduate Faculty (Dean Huntoon) b. Changes to GACS (Dean Huntoon)

Graduate School > Graduate Faculty Council > Minutes

Graduate School Administration Building, 4th Floor

1400 Townsend Drive Houghton, Michigan 49931-1295

Ph. 906-487-2327 Fax: 906-487-2284

Email: gradadms@mtu.edu

Page 1 of 1GFC Meeting Draft Agenda | Graduate Faculty Council

9/21/2011http://www.mtu.edu/gradschool/administration/faculty-council/minutes/draft-agenda.html