minority institution/ cancer center...
TRANSCRIPT
Dr. H. Nelson AguilaDr. H. Nelson AguilaCenter to Reduce Cancer Health DisparitiesCenter to Reduce Cancer Health Disparities
July 14, 2008July 14, 2008
Minority Institution/ Cancer Center Minority Institution/ Cancer Center PartnershipPartnership
Cancer Health Disparities Summit ’08
Eliminating Cancer Health Disparities Through
Science, Training and Community
Cancer Health Disparities Summit ’08
Eliminating Cancer Health Disparities Through
Science, Training and Community
MI/CCP Partnership Model
Reduce Cancer Health Disparities
• Build research capacity and training at MSIs• Create stable, long-term collaborations between MSIs and CCs in research, training, career
development, and outreach• Improve effectiveness of CC research, education and outreach for underserved
populations• Export successful approaches for addressing disparities to all CCs and other key networks
and consortiums
Education
Minority Training
Community Trust and Participation
MSICancer Research Expertise
State-of-the-Art Cancer Facilities
State-of-the-Art Cancer Treatments
CC
U54 - 7 partnershipsU56 - 10 partnershipsP20 - 9 partnerships
U54 - 7 partnershipsU56 - 10 partnershipsP20 - 9 partnerships
Current Distribution of NCI-Sponsored MI/CCPCurrent Distribution of NCI-Sponsored MI/CCP
GuamUniv. of Puerto Rico
Ponce School of Med
MI/CCP Partnership Program Structure
MI/CCP Program Structure
RESEARCH, TRAINING, OUTREACH, EDUCATION
MINORITYSERVINGINSTITUTION
CANCER CENTER
P20Feasibility Studies
F31, Career Awards, R03, R21,
R01, R25, T32, P01
U56Cooperative
Comprehensive Planning Grant
U54Comprehensive
Grant
F31/32/33, Career Awards, R03, R21,
R01, R25, T32, P01
MI/CCP P20 MechanismPAR-07-230
Next submission due date: April 15, 2009
Primary Objective: To provide support for cancer projects and Programs for a limited duration of time to perform feasibility studies/obtain preliminary data/submission of competitive grant applications.
Target Areas: Research; Training and Career Development; Education
Duration: Up to 4 years
Funding: Direct Cost up to $275K per partnership/year: Administrative and Developmental Costs planning; priority setting; implementation)
Final Objective: Submission of competitive grant applications (i.e. R series, K series, T32, R25T, F31, R25E) funded by NIH/NCI and/or comparable grant funding organizations.
0
3060
90120
150180
Num
ber o
f Can
cer
Res
earc
h St
udie
s
2001-2003 27 11
2004-2007 170 61
All Project Types
CHD Projects
Project Types Cancer Types Total
Breast Prostate Head & Neck Lung CRC Gynecologic
Pilot 31 23 19 16 19 15 123Full 15 10 3 5 6 5 47Total 46 33 22 21 25 20 170
U54/ U56 ResearchProjects
U54/U56 ResearchPublications
Aurora B Kinase Maintains Chromatin Organization During the Ml and Mll Transition in Surf Clam Oocytes
Cell Cycle 5:2648, 2006
BRCA1 Antitumor activity in breast, ovarian, and prostate cancers
Oncogene 26:6031, 2007
Breast Cancer Education for Native American Women
Clinical J Oncology Nursing 9(6): 689, 2005
Cispaltin and Fluoruracil Alone or with Docetaxel in Head and Neck Cancer
N Engl J Med 357:1705, 2007
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors
Science 315: 1133, 2007
U54/U56 ResearchCompetitive Grants
0
30
60
90
120
150N
umbe
r of G
rant
s
2001-2003 2 1 0
2004-2007 137 77 6
Submitted Funded Pending
U54/ U56 Training, Career Development and Education
21 Med Students25 Med Fellows
34 Post-Docs
72 Junior Faculty
21 High School Students
178 Master Students157 Pre-Docs
35 Post-Bac338 Undergrad
881 Trainees70 New MSI Faculty13 New CC Faculty
881 Trainees70 New MSI Faculty13 New CC Faculty
Education• Curricula to build critical mass of diverse investigators in cancer
research through competitive R25 grants, institutional support and leveraged funds
• New Mexico State University at Las Cruces and the Fred Hutchinson Cancer Research Center
• Biology 385: An Introduction to Cancer
• University of the District of Columbia and The Lombardi CCC (R25 grant)• Master’s Degree in Cancer Biology, Prevention, and Control
• Tuskegee University, University of AL at Birmingham CC, Morehouse School of Medicine
• Foundations of Cancer Biology (BIOL 0540)• Biosciences Research and Ethics (IBSC 0601)
• Northern Arizona University and Arizona Cancer Center• Chemical Carcinogenesis (MS level course)• Patient Navigation program for Native American students
• San Francisco State University and UCSF Hellen Diller Family CCC (state funding)
• Ph.D. Program for Nurses in clinical nursing oncology
Dr. Marcia Cruz-Correa (Assistant Professor) – UPRCC / MDACC • K22CA115193 – Clinicopathology of IGF2 Loss of Imprinting in Colon Neoplasia• R03CA130034 – Familial Colorectal Cancer in Puerto Rico: A Feasibility Study
Dr. James Lillard (Assistant Professor) – TU / MSM / UAB• DOD New Investigator Award – CCL25-CCR9 Prostate Cancer Cell Survival and Metastasis
Dr. Alecia Malin Fair (Assistant Professor) – MMC / VUCC• ACS Career Development Award (MRSGT-07-008-01-CPHPS) – Mammography Follow-up in Minority and Medically Underserved Women
Dr. Maribel Vazquez (Associate Professor) – CCNY / MSKCC•R21GM71703 – Mycrosystems to manipulate fibroblast chemotaxis•R21CA118255 – A mu migration assay for temporal protein localization
Training and Career DevelopmentMSI Junior Investigator Successes
MI/CCP- AACR ForumShowcased the Accomplishments of the MI/CCP Junior
Investigators April 14, 2008
• Basic Research - Dr. LaMonica V. Stewart, Meharry Medical College, Nashville, TN
• Clinical Research - Dr. Barbara H. Jung, University of California San Diego, La Jolla, CA
• Population Research - Dr. Gary Bennett, Harvard School of Public Health, Boston, MA
• Investing in the Future - Dr. Rachael Leon Guerrero, University of Guam, Mangilao, GU
• Using hypothesis driven interventions, Arizona CC and NAU are working with Native Americans, and the Hawaii CC and University of Guam are working with Pacific Islander populations, to increase cancer screenings through print and electronic mediums.
• Partnering with local community coalitions, MMC/VICC and TSU is reaching African American and Hispanic communities through cancer prevention workshops and symposiums. The purpose is to develop community-based participatory research.
U54/U56 Outreach
Next steps and challenges
• Increase publications and grant submissions • Evaluation of the impact of the MI/CCP program
(NCI and Partnerships)• Increase training and mentoring of students and
junior investigators• Tracking and evaluation of training and
educational programs• Improve communication among partnerships• Increasing outreach activities• Increasing clinical activities• Develop new funding mechanisms (NCI)
Selected MI/CCP Presentations
• July 141:00 – 2:30Session 6: Models of Training ProgramsDr. Marian Manciu – P20 UT El Paso/ UT Hlth. Sci. Ctr. San AntonioDr. Louis Canfield – U54 AZCC/ Northern Arizona UniversityDr. Christi Patten – P20 Mayo Clinic/ Dine College
• 2:45 – 4:00Session 2: Recruitment and Retention IssuesDr. Samuel Adunyah – U54 MMC/ VICCSession 3: Role of Physical Activity and Nutritional FactorsDr. Rachel Leon-Guerrero – U56 Univ. of Guam/ Hawaii CCSession 6: Cancer Health Disparities: Epidemiology & Risks FactorsDr. Pamela Hull – U54 MMC/ VICC (TSU)
Selected MI/CCP Presentations
• July 151:00 – 2:30Session 3: A Greater Understanding of Breast & Cervical CancerDr. Tu-Uyn Nguyen – U56 UCSF CC/ SFSUSession 5: Innovative Research MethodsDr. Alecia Fair (Malin) – U54 MMC/ VICC
• 2:45 – 4:00Session 1: Cancer Therapeutics & Radiopharmaceuticals Res.Dr. Marcia Cruz-Correa – U54 UPRCC/ MD Anderson
Contacts
Dr. Nelson Aguila Dr. Peter OgunbiyiProgram Director Program [email protected] [email protected]
Telephone301-496-7344
http://crchd.cancer.gov
P20 Program Accomplishments (FY01 – FY08)
P20 NumbersStudents trained 234Faculty career development 36Faculty hired 3Courses developed 9Publications 49Publications (under review) 20Applications submitted 23Grants awarded 12
Total of 17 Partnerships
P20 Accomplishments
• Students Trained• 146 Undergraduate• 65 Graduate• 23 Medical/ Dental
• New Courses • Cancer Biology 101• Cancer Causes & Prevention• Cancer Biology & Bioinformatics• Tumor Biology• Bioethics
• Cancers in Minority Populations– Breast– Prostate– Colorectal– Cervical
• Grants Awarded– R01– P20– U56– U54– DoD– Private Foundation