MICROFLUIDIC PUMPSTO BE

PRESENTEDBY

UMAR ABDULLAHI ABDULHAMEED500612013

MAY,2013

OUTLINE

IntroductionMotivation Why microfluidic pumps? Definitions Types Applications Challenges References

INTRODUCTION A microfluidic devices was once only used

in the domain of inkjet printers and similarly-styled office equipment. Flash forward to today and you will see a microfluidic devices are employed in:

Biotechnologypharmaceuticallife science etc.

Microfluidic pumps are capable of achieving single digit pL per minute flow rate.

MOTIVATIONThe manipulation of fluid in channels with

dimensions of tens of micrometers-microfluidic pumping-has emerged as a distinct new field. Microfluidics has a potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology. But the field is still at an early stage of development.

To achieve these manipulations, the use of pump is earnestly needed in order to achieve miniaturization.

Why microfluidic pumps?

Mechanical pumps are not the best solution to overcome the viscous resistance of fluid flow in micro channels.

Large external pumps defies miniaturization

To allow implantation

DEFINATIONSMicrofluidics Microfluidics deals with the behavior, precise

control and manipulation of fluids that are geometrically constrained to a small volume typically microlitre,nanolitre picolitreor femtolitre.

Microfluidic is a science that deals with the flow of fluid in a channel of micrometer size.

What are microfluidic pumps? Microfluidic pumps are devices that are used to

pump or mix fluid in channels of micrometer size

in a microfluidic system.

BERNOULLI’S THEOREM

The Bernoulli equation is a special statement of the general energy equation

Work added to the system is referred to as pump head (hP)

Losses from the system are referred to as head loss (hL)

Pressure (lbf/in2) is a form of workStrictly Mechanical Energy so we get the

equation:P1 + PE1 + KE1 + WK = PE2 + KE2 + WKFRIC + P2

BERNOULLI’S Equation

Z1 + (P1/) + (V12/2g) = Z2 + (P2/) + (V2

2/2g) + hP - hL

Z : Elevation (ft)P : Pressure (lb/ft2) : Density (lb/ft3)V : Velocity (ft/sec)g : acceleration (32.2 ft/sec2)

Z : Elevation (ft)P : Pressure (lb/ft2) : Density (lb/ft3)V : Velocity (ft/sec)g : acceleration (32.2 ft/sec2)

Fluidic Design Equations – Bernoulli Again

Piezoelectric microfluidic pumps

Various Piezoelectric Pumps

TYPES OF MICROFLUIDIC PUMP

Different microfluidic pumps can be implement using:PiezoelectricElectrostatic effectThermo-pneumatic effectMagnetic effectElectrochemicalUltrasonic flow generationElectro-osmoticElectohydrodynamics principle

Types of microfluidic pumps

Microfluidic pump based on travelling waveThermal gradientCatalyticSurface tensionOptically actuated pumpsSelf-propelling semiconductor diode

Finger-powered pump

Finger –powered pump

FABRICATION OF THE DEVICE

ELECTRO-OSMOIC PUMPThe electro osmotic flow is generated in

the pump by applying a low voltage across the two electrodes.

This may be implemented using a battery or dc power supply unit.

For advance flow rate control a PWM power source can be supplied.

Provide excellent pumping performance in a

miniature package.It also provide smooth flow

ELECTRO-OSMOIC PUMP Ideal for integration into a microfluidic systems to its

reduced size and precise control that can be achieved in the low flow range.

The working liquid can be deionizer water but it is possible to pump any liquid including aggressive media and cell suspension. Thus it has application in life science .

AdvantagesNo pulsationNo moving part Small sizeHigh power performance.Easy operation

APPLICATIONSBiomedicalDrug deliveryFluid mixingParticle manipulationAdministering pharmaceutical productsLab –on-chipImplantation

Heart blood pumping implantation

APPLICATIONS Life science

DNA analysis Protein analysis Forensic test Lineage tracing Separation of mammalian cell

CHALLENGESDifficult to fabricate due to complex structureLimitation to specific fluidcost

REFERENCES

[1] D. D. Carlo and L. P. Lee, “Dynamic Single-Cell Analysis for 2009.[2] P. Yager, T. Edwards, E. Fu, K. Helton, K Nelson, M R. Tam, Quantitative Biology”, Anal. Chem., Vol. 78, pp. 7918-7925, and B. H. Weigl, “Microfluidic Diagnostic Technologies for Global Public Health”, Nature, Vol. 442, pp. 412-418, 2006.[3] G.-M. Walker and D. J. Beebe, “A Passive Pumping Method for Microfluidic Devices”, Lab Chip, Vol. 2, pp. 131-134, 2002.[4] I. Meyvantsson, J. W. Warrick, S. Hayes, A. Skoien, D. J. Beebe, “Automated Cell Culture in High Density Tubeless Microfluidic Device Arrays”, Lab Chip, Vol. 8, pp. 717-724, 2008.[5] A. W. Martinez, S. T. Phillips, and G. M. Whiteside's, “Three-Dimensional Microfluidic Devices Fabricated in Layered Paper and

Tape” Proc. Natl. Acad. Sci., Vol. 105, pp. 19606-19611, 2008.

THANKS FOR YOUR

AUDIENCE