metabolic disorder - courseware.cutm.ac.in
TRANSCRIPT
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METABOLIC DISORDER
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INBORN ERRORS OF METABOLISM
A group of diseases caused by
a defect in the activity of an enzyme that
affect a wide variety of metabolic processes;
defective processing or transport of amino acids,
fatty acids, sugars or metals
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INBORN ERRORS OF METABOLISM
• An inherited enzyme deficiency leading to the disruption
of normal bodily metabolism
• Impaired formation of a product normally produced by
the deficient enzyme
• Accumulation of a toxic substrate (compound acted upon
by an enzyme in a chemical reaction)
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What is a metabolic disease?
• Garrod’s hypothesis
A Bsubstrate excess
product deficiency
Dtoxic metabolite
C
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OUR GENETIC BACKGROUND
• Total genes 25000 in pairs
• Genetic disorders 7000
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GENETIC
BASIS OF
INHERITED
DISORDERS
Point mutations,
Insertions, Deletions,
Missense Mutations
and RearrangementsTotal slide. 13215 August 2019 6
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EPIDEMIOLOGY AND INHERITANCE
• Although each individual IEM is rare, cumulatively they occur~ 1:5000 live births
• Majority of IEM follow an autosomal recessive mode of inheritance
Total slide. 13215 August 2019 7
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Total slide. 13215 August 2019 8
CLASSIFICATION OF METABOLIC
DISEASES
Small molecule disease
– Carbohydrate
– Protein
– Lipid
– Nucleic Acids
– Minerals
– Vitamins
Organelle disease
– Lysosomes
– Mitochondria
– Peroxisomes
– Cytoplasm
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METOBOLIC DISORDERS
• Aminoacid Metabolim
• Lipid Metabolism
• Carbohydrate Metabolism
• Mitochondrial Energy Metabolism
• Vitamin Metabolism
• Metal Transport
• Nucleic acid and Heme Metabolism
• Organelles – lysosomes , peroxisomes
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Defects in Amino and Organic Acid Metabolism Defects in Carbohydrate MetabolismErrors in Fatty Acid MetabolismDefects in Cholesterol and Lipoprotein Metabolism Mucopolysaccharide and Glycolipid Disorders Defects in Nucleotide MetabolismDisorders in Metal Metabolism and Transport Porphyrias and BilirubinemiasDiseases Associated with Defective DNA Repair
METOBOLIC DISORDERS
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Categories of IEMs
Disorders of protein metabolism
(amino acidopathies, organic acidopathies,
and urea cycle defects)
Disorders of carbohydrate metabolism (eg, carbohydrate intolerance disorders, glycogen storage disorders, disorders of gluconeogenesis and glycogenolysis)
Fatty acid oxidation defects
Lysosomal storage disorders
Mitochondrial disorders
Peroxisomal disorders
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Protein metabolism disorders
Organic acidemias
Aminoacidurias
Urea cycle defects
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Carbohydrate metabolism disorders
Glycogen storage disease
Galactosemia
Fructose intolerance
Glucose malabsorption
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Fat metabolism disorders
Hypertriglyceridemia
Hyperlipidemia
Fatty acid oxidation defects
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VITAMIN DISORDERS
Biotinidase deficiency
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MINERAL
DISORDERS
Wilson disease
Menkes disease
Cystinosis