metabolic diseases. calcification. pigmentation.ustavpatologie.upol.cz/_data/section-1/154.pdf ·...
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METABOLIC DISEASES.
CALCIFICATION.
PIGMENTATION.
III. practical training
3rd year General Medicine
Atherosclerosis
calcification
fibrosis
Atherosclerosis Crystals of cholesterol in atheromatous plaque of arterial wall (negative
picture of washed up crystals)
Miliary tuberculosis – lung
Intradermal naevocellular naevus
Intradermal naevocellular naevus
Pathologic pigmentation of skin, defect of melanin-
vitiligo
1 normal distribution of melanin
in basal layer
2 defect of melanin in basal layer
2
1
Pathologic pigmentation of skin, defect of melanin-
vitiligo, impregnation of melanin by silver according to
Masson
1 normal distribution of melanin
in basal layer
2 defect of melanin in basal layer
1 2
Malignant melanoma
Malignant melanoma
Malignant melanoma
Malignant melanoma
Melanin in tumour cells
(lentigo maligna melanoma)
1
1
2
1 Melanin in tumour cells
2 Melanin fagocyted in
histiocytes (released from
tumour cells)
3 layer of keratinization in
epidermis
3
Nodular melanoma
Atrophy of the heart muscle
Haemosiderosis of liver
special staining of iron according Perls
Haemachromatosis of pancreas
special staining of iron according Perls
Biliary nephrosis
Biliary cirrhosis
Biliary cirrhosis (special staining of bile according Fouchet)
Antracosis of the lungs
1 antracotic pigment in
interalveolar septa indurated lung
2 clusters of siderophages
3 lumen of artery
1
2
2
3
Antracosis of the lungs
1 capsule of lymph node
2 lymphatic follicles
3 medullar sinus
4 antracophages in medulla of lymph node
5 lung tissue
1
2
2
3
4
5
Asbestosis of the lungs
copy
Silicosis of the lungs
1
1
1
1 fibrous centre of nodul
Silicosis of the lungs
kopie
1
1 fibrous centre of nodul
2 blending of alveoli (perifocal
emphysema)
2
2
2
Silicosis of the lungs
copy
Silicosis of the lungs– early stage (mostly in macrophages) silica crystals in polarized light
copy