mendelelian genetics
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Mendelelian Genetics. Gregor Mendel (1822-1884). Responsible for the Laws governing Inheritance of Traits. Gregor Johann Mendel. Austrian monk Studied the inheritance of traits in pea plants Developed the laws of inheritance - PowerPoint PPT PresentationTRANSCRIPT
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Mendelelian Mendelelian GeneticsGenetics
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Gregor Gregor MendelMendel
(1822-1884)(1822-1884)
Responsible Responsible for the Laws for the Laws governing governing
Inheritance Inheritance of Traitsof Traits
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Gregor Johann Gregor Johann MendelMendel
Austrian monkAustrian monk Studied the Studied the inheritanceinheritance
of traits in of traits in pea plantspea plants Developed the Developed the laws of laws of
inheritanceinheritance Mendel's work was not Mendel's work was not
recognized until the turn recognized until the turn of theof the 20th century 20th century
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Gregor Johann MendelGregor Johann Mendel Between Between 1856 and 1863,1856 and 1863, Mendel Mendel
cultivated and tested some cultivated and tested some 28,000 28,000 pea plantspea plants
He found that the plants' offspring He found that the plants' offspring retained retained traits of the parentstraits of the parents
Called theCalled the “Father of Genetics" “Father of Genetics"
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Site of Site of Gregor Gregor
Mendel’s Mendel’s experimeexperime
ntal ntal garden in garden in the Czech the Czech RepublicRepublic
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Mendel stated that Mendel stated that physical traits are physical traits are inherited as inherited as “particles”“particles”Mendel did not know Mendel did not know that the “particles” that the “particles” were actually were actually Chromosomes & DNAChromosomes & DNA
Particulate InheritanceParticulate Inheritance
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Genetic TerminologyGenetic Terminology
TraitTrait - any characteristic that - any characteristic that can be passed from parent to can be passed from parent to offspring offspring
HeredityHeredity - passing of traits - passing of traits from parent to offspring from parent to offspring
GeneticsGenetics - study of heredity - study of heredity
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Types of Genetic Types of Genetic CrossesCrosses
Monohybrid cross Monohybrid cross - - cross involving a cross involving a single traitsingle traite.g. flower color e.g. flower color
Dihybrid crossDihybrid cross - - cross involving two cross involving two traits traits e.g. flower color & plant heighte.g. flower color & plant height
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Punnett SquarePunnett SquareUsed to help Used to help solve genetics solve genetics problemsproblems
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Designer Designer “Genes”“Genes” AllelesAlleles - - two forms of a two forms of a gene gene
(dominant & recessive)(dominant & recessive) DominantDominant - - stronger of two genes stronger of two genes
expressed in the hybrid; represented expressed in the hybrid; represented byby aa capital letter (R)capital letter (R)
RecessiveRecessive - - gene that shows up less gene that shows up less often in a cross; represented by aoften in a cross; represented by a lowercase letter (r)lowercase letter (r)
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More More TerminologyTerminology
GenotypeGenotype - - gene combination for gene combination for a traita trait (e.g. RR, Rr, rr) (e.g. RR, Rr, rr)
PhenotypePhenotype - - the physical feature the physical feature resulting from a genotyperesulting from a genotype (e.g. (e.g. red, white) red, white)
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Genotype & Phenotype in Genotype & Phenotype in FlowersFlowers
Genotype of alleles:Genotype of alleles:RR = red flower= red flowerrr = yellow flower= yellow flower
All genes occur in pairs, so All genes occur in pairs, so 22 allelesalleles affect a characteristic affect a characteristic
Possible combinations are:Possible combinations are:
GenotypesGenotypes RRRR RRrr rrrr
PhenotypesPhenotypesRED RED RED RED YELLOWYELLOW
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GenotypesGenotypes HomozygousHomozygous genotype - gene combination genotype - gene combination
involving 2 dominant or 2 recessive genes involving 2 dominant or 2 recessive genes (e.g. RR or rr);(e.g. RR or rr); also called also called pure pure
HeterozygousHeterozygous genotype - gene genotype - gene combination of one dominant & one combination of one dominant & one recessive allele (recessive allele (e.g. Rr);e.g. Rr); also called also called hybridhybrid
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Genes and Environment Determine Genes and Environment Determine CharacteristicsCharacteristics
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Mendel’s Pea Mendel’s Pea Plant Plant
ExperimentsExperiments
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Why peas,Why peas, Pisum Pisum sativumsativum?? Can be grown in a Can be grown in a small small
areaarea Produce Produce lots of offspring lots of offspring Produce Produce purepure plants when plants when
allowed to allowed to self-pollinateself-pollinate several generations several generations
Can be Can be artificially cross-artificially cross-pollinatedpollinated
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Reproduction in Reproduction in Flowering PlantsFlowering Plants
• Pollen contains spermPollen contains sperm– Produced by the stamenProduced by the stamen
• Ovary contains eggsOvary contains eggs– Found inside the flowerFound inside the flower
Pollen carries sperm to Pollen carries sperm to the eggs for fertilizationthe eggs for fertilization
Self-fertilizationSelf-fertilization can can occur in the same occur in the same flowerflower
Cross-fertilizationCross-fertilization can can occur between occur between flowersflowers
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Mendel’s Experimental Mendel’s Experimental MethodsMethods
• Mendel hand-pollinated Mendel hand-pollinated flowers using a paintbrushflowers using a paintbrush– He could snip the stamens He could snip the stamens
to prevent self-pollinationto prevent self-pollination– Covered each flower with Covered each flower with
a cloth baga cloth bag• He traced traits through the He traced traits through the
several generationsseveral generations
•
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How Mendel BeganHow Mendel BeganMendel Mendel produced produced purepure strains by strains by allowing allowing the plants the plants to to self-self-pollinatepollinate for for several several generatiogenerationsns
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Eight Pea Plant Eight Pea Plant TraitsTraits
• Seed shapeSeed shape --- Round --- Round (R)(R) or Wrinkled or Wrinkled (r)(r)• Seed ColorSeed Color ---- Yellow ---- Yellow (Y)(Y) or Green or Green ((yy))• Pod ShapePod Shape --- Smooth --- Smooth (S)(S) or wrinkled or wrinkled ((ss))• Pod ColorPod Color --- Green --- Green (G)(G) or Yellow or Yellow (g)(g)• Seed Coat ColorSeed Coat Color ---Gray ---Gray (G)(G) or White or White (g)(g)• Flower positionFlower position---Axial ---Axial (A)(A) or Terminal or Terminal (a)(a)• Plant HeightPlant Height --- Tall --- Tall (T)(T) or Short or Short (t)(t)• Flower color Flower color --- --- Purple Purple (P)(P) or white or white ((pp))
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Mendel’s Experimental Mendel’s Experimental ResultsResults
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• Did the observed ratio match the theoretical ratio?Did the observed ratio match the theoretical ratio?
The theoretical or expected ratio of The theoretical or expected ratio of plants producing round or wrinkled plants producing round or wrinkled seeds is seeds is 3 round :1 wrinkled3 round :1 wrinkled
Mendel’s observed ratio was 2.96:1Mendel’s observed ratio was 2.96:1
The discrepancy is due to The discrepancy is due to statistical statistical errorerror
The The larger the samplelarger the sample the more the more nearly the results approximate to nearly the results approximate to the theoretical ratiothe theoretical ratio
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Generation “Gap”Generation “Gap”• Parental PParental P11 Generation Generation = the parental generation in = the parental generation in
a breeding experimenta breeding experiment..• FF11 generation generation = the first-generation offspring in a = the first-generation offspring in a
breeding experiment. breeding experiment. (1st filial generation)(1st filial generation)– From breeding individuals from the PFrom breeding individuals from the P11 generation generation
• FF22 generation generation = the second-generation offspring in = the second-generation offspring in a breeding experiment. a breeding experiment. (2nd filial generation)(2nd filial generation)– From breeding individuals from the FFrom breeding individuals from the F11 generation generation
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Following the GenerationsFollowing the Generations
Cross 2 Cross 2 Pure Pure
PlantsPlantsTT x ttTT x tt
Results Results in all in all
HybridsHybridsTtTt
Cross 2 Cross 2 HybridsHybrids
getget3 Tall & 1 3 Tall & 1
ShortShortTT, Tt, ttTT, Tt, tt
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Monohybrid Monohybrid CrossesCrosses
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• Trait: Seed ShapeTrait: Seed Shape
• Alleles: Alleles: RR – Round – Round rr – Wrinkled – Wrinkled
• Cross: Cross: RoundRound seedsseeds xx Wrinkled Wrinkled seeds: Pseeds: P11 = = RRRR xx rr rr
PP11 Monohybrid Cross Monohybrid Cross
R
R
rr
Rr
RrRr
Rr
Genotype:Genotype: RrRr
PhenotypePhenotype: RoundRound
GenotypicGenotypicRatio:Ratio: All alikeAll alike
PhenotypicPhenotypicRatio:Ratio: All alike All alike
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PP11 Monohybrid Cross Monohybrid Cross
ReviewReview Homozygous dominant x Homozygous dominant x
Homozygous recessiveHomozygous recessive OffspringOffspring allall HeterozygousHeterozygous (hybrids)(hybrids) Offspring calledOffspring called FF11 generation generation
Genotypic & Phenotypic ratio isGenotypic & Phenotypic ratio is ALL ALL ALIKEALIKE
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• Trait: Seed ShapeTrait: Seed Shape
• Alleles: Alleles: RR – Round – Round rr – Wrinkled – Wrinkled
• Cross: Cross: RoundRound seeds seeds xx Round Round seeds: Pseeds: P1 1 == RrRr xx Rr Rr
FF11 Monohybrid Cross Monohybrid Cross
R
r
rR
RR
rrRr
RrGenotype:Genotype: RR, Rr, RR, Rr, rrrr
PhenotypePhenotype: Round Round && wrinkled wrinkled
G.Ratio:G.Ratio: 1:2:11:2:1
P.Ratio:P.Ratio: 3:1 3:1
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FF11 Monohybrid Cross Monohybrid Cross
ReviewReview Heterozygous x heterozygousHeterozygous x heterozygous Offspring:Offspring:
25% Homozygous dominant25% Homozygous dominant RRRR50% Heterozygous50% Heterozygous RrRr25% Homozygous Recessive25% Homozygous Recessive rrrr
Offspring calledOffspring called FF22 generation generation Genotypic ratio isGenotypic ratio is 1:2:11:2:1 Phenotypic RatioPhenotypic Ratio is 3:1 is 3:1
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What Do the Peas Look Like?What Do the Peas Look Like?
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……And Now the Test And Now the Test CrossCross
• Mendel then crossed a Mendel then crossed a purepure & a & a hybridhybrid from his from his FF2 2 generationgeneration
• This is known as an This is known as an FF22 or test cross or test cross
• There are There are twotwo possible testcrosses: possible testcrosses:Homozygous dominant x HybridHomozygous dominant x HybridHomozygous recessive x HybridHomozygous recessive x Hybrid
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• Trait: Seed ShapeTrait: Seed Shape• Alleles: Alleles: RR – Round – Round rr – Wrinkled – Wrinkled• Cross: Cross: Pure Pure RoundRound seedsseeds xx Hybrid Hybrid Round Round seeds seeds • P =P =RRRR xx RrRr
FF22 Monohybrid Cross (1 Monohybrid Cross (1stst))
R
R
rR
RR
RrRR
Rr
Genotype:Genotype: RR, RR, RrRr
PhenotypePhenotype: RoundRound
GenotypicGenotypicRatio:Ratio: 1:11:1
PhenotypicPhenotypicRatio:Ratio: All alike All alike
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• Trait: Seed ShapeTrait: Seed Shape
• Alleles: Alleles: RR – Round – Round rr – Wrinkled – Wrinkled
• Cross: Cross: WrinkledWrinkled seedsseeds xx Hybrid Hybrid Round Round seeds seeds = = rrrr xx Rr Rr
FF22 Monohybrid Cross (2nd) Monohybrid Cross (2nd)
r
r
rR
Rr
rrRr
rr
Genotype:Genotype: Rr, rrRr, rr
PhenotypePhenotype: Round & Round & WrinkledWrinkled
G. Ratio:G. Ratio: 1:11:1
P.Ratio:P.Ratio: 1:1 1:1
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FF22 Monohybrid Cross Monohybrid Cross
ReviewReview Homozygous x heterozygous(hybrid)Homozygous x heterozygous(hybrid) Offspring:Offspring:
50% Homozygous 50% Homozygous RR or rrRR or rr50% Heterozygous50% Heterozygous RrRr
Phenotypic RatioPhenotypic Ratio is 1:1 is 1:1 Called Called Test CrossTest Cross because the offspring because the offspring
have have SAMESAME genotype as parents genotype as parents
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Mendel’s LawsMendel’s Laws
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Results of Monohybrid Results of Monohybrid CrossesCrosses
• InheritableInheritable factors or genesfactors or genes are are responsible for all heritable characteristics responsible for all heritable characteristics
• PhenotypePhenotype is based on is based on GenotypeGenotype • Each traitEach trait is based onis based on two genestwo genes, , one from one from
the mother and the other from the fatherthe mother and the other from the father • True-breeding individuals are True-breeding individuals are homozygous homozygous
( both alleles)( both alleles) are the same are the same
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Law of DominanceLaw of Dominance In a cross of parents that are In a cross of parents that are pure for contrasting traitspure for contrasting traits, , only one form of the trait will only one form of the trait will appear in the next generation.appear in the next generation.
All the offspring will be All the offspring will be heterozygous and express heterozygous and express only the only the dominant trait.dominant trait.
RR x rr RR x rr yieldsyields all Rr (round all Rr (round seeds)seeds)
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Law of DominanceLaw of Dominance
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Law of SegregationLaw of Segregation
• During the During the formation of gametesformation of gametes (eggs (eggs or sperm), the or sperm), the two allelestwo alleles responsible responsible for a trait for a trait separateseparate from each other. from each other.
• Alleles for a trait are then Alleles for a trait are then "recombined" at fertilization"recombined" at fertilization, , producing the genotype for the traits producing the genotype for the traits of the offspringof the offspring.
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Applying the Law of Applying the Law of SegregationSegregation
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Law of Independent Law of Independent AssortmentAssortment
• Alleles for Alleles for differentdifferent traits are traits are distributed to sex cells (& offspring) distributed to sex cells (& offspring) independently of one another.independently of one another.
• This law can be illustrated using This law can be illustrated using dihybrid crossesdihybrid crosses..
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Dihybrid CrossDihybrid Cross• A breeding experiment that tracks the A breeding experiment that tracks the
inheritance of two traitsinheritance of two traits..
• Mendel’s Mendel’s “Law of Independent “Law of Independent Assortment”Assortment”
• a. Each pair of alleles segregates a. Each pair of alleles segregates independentlyindependently during gamete formation during gamete formation
• b. Formula: 2b. Formula: 2nn (n = # of heterozygotes) (n = # of heterozygotes)
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Question:Question:How many gametes will be produced How many gametes will be produced for the following allele arrangements?for the following allele arrangements?
• Remember:Remember: 22nn (n = # of heterozygotes) (n = # of heterozygotes)
• 1.1. RrYyRrYy
• 2.2. AaBbCCDdAaBbCCDd
• 3.3. MmNnOoPPQQRrssTtQqMmNnOoPPQQRrssTtQq
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Answer:Answer:1. RrYy: 21. RrYy: 2nn = 2 = 222 = 4 gametes = 4 gametes
RY Ry rY ryRY Ry rY ry
2. AaBbCCDd: 22. AaBbCCDd: 2nn = 2 = 233 = 8 gametes = 8 gametes
ABCD ABCd AbCD AbCdABCD ABCd AbCD AbCd
aBCD aBCd abCD abCDaBCD aBCd abCD abCD
3. MmNnOoPPQQRrssTtQq: 23. MmNnOoPPQQRrssTtQq: 2nn = 2 = 266 = = 64 gametes64 gametes
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Dihybrid CrossDihybrid Cross
• Traits: Seed shape & Seed colorTraits: Seed shape & Seed color• Alleles:Alleles: R round
r wrinkled Y yellow y green
• RrYy x RrYy
RY Ry rY ryRY Ry rY ry RY Ry rY ryRY Ry rY ry
All possible gamete combinationsAll possible gamete combinations
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Dihybrid CrossDihybrid CrossRYRY RyRy rYrY ryry
RYRY
RyRy
rYrY
ryry
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Dihybrid CrossDihybrid Cross
RRYY
RRYy
RrYY
RrYy
RRYy
RRyy
RrYy
Rryy
RrYY
RrYy
rrYY
rrYy
RrYy
Rryy
rrYy
rryy
Round/Yellow: 9
Round/green: 3
wrinkled/Yellow: 3
wrinkled/green: 1
9:3:3:1 phenotypic ratio
RYRY RyRy rYrY ryry
RYRY
RyRy
rYrY
ryry
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Dihybrid CrossDihybrid Cross
Round/Yellow: 9Round/green: 3wrinkled/Yellow: 3wrinkled/green: 1
9:3:3:1
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Test CrossTest Cross• A mating between an individual of A mating between an individual of unknown genotype unknown genotype
and a and a homozygous recessivehomozygous recessive individual. individual.• Example:Example: bbC__ bbC__ x x bbccbbcc
• BB = brown eyesBB = brown eyes• Bb = brown eyesBb = brown eyes• bb = blue eyesbb = blue eyes
• CC = curly hairCC = curly hair• Cc = curly hairCc = curly hair• cc = straight haircc = straight hair
bCbC b___b___
bcbc
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Test CrossTest Cross
• Possible results:Possible results:bCbC b___b___
bcbc bbCc bbCc
C bCbC b___b___
bcbc bbCc bbccor
c
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Summary of Mendel’s lawsSummary of Mendel’s laws
LAWLAW PARENT PARENT CROSSCROSS OFFSPRINGOFFSPRING
DOMINANCEDOMINANCE TT x ttTT x tt tall x shorttall x short
100% Tt 100% Tt talltall
SEGREGATIONSEGREGATION Tt x TtTt x Tt tall x talltall x tall
75% tall 75% tall 25% short25% short
INDEPENDENT INDEPENDENT ASSORTMENTASSORTMENT
RrGg x RrGgRrGg x RrGg round & round & green x green x round & round & greengreen
9/16 round seeds & green 9/16 round seeds & green pods pods
3/16 round seeds & yellow 3/16 round seeds & yellow pods pods
3/16 wrinkled seeds & 3/16 wrinkled seeds & green pods green pods
1/16 wrinkled seeds & 1/16 wrinkled seeds & yellow podsyellow pods
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Sex-linked TraitsSex-linked Traits• Traits (genes) located on the Traits (genes) located on the sex sex
chromosomeschromosomes• Sex chromosomes are Sex chromosomes are X and YX and Y• XXXX genotype for females genotype for females• XYXY genotype for males genotype for males• Many Many sex-linked traitssex-linked traits carried on carried on XX
chromosomechromosome
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Sex-linked TraitsSex-linked Traits
Sex ChromosomesSex Chromosomes
XX chromosome - female Xy chromosome - male
fruit flyeye color
Example: Example: Eye color in fruit Eye color in fruit fliesflies
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Sex-linked Trait ProblemSex-linked Trait Problem• Example: Eye color in fruit flies• (red-eyed male) x (white-eyed female)
XRY x XrXr
• Remember: the Y chromosome in males does not carry traits.• RR = red eyed• Rr = red eyed• rr = white eyed• XY = male• XX = female
XR
Xr Xr
Y
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Sex-linked Trait Sex-linked Trait Solution:Solution:
XR Xr
Xr Y
XR Xr
Xr Y
50% red eyed female
50% white eyed male
XR
Xr Xr
Y
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Female CarriersFemale Carriers
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Incomplete Incomplete DominanceDominance
andandCodominanceCodominance
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Incomplete DominanceIncomplete Dominance
• F1 hybrids F1 hybrids have an appearance somewhat in in betweenbetween the phenotypes phenotypes of the two parental varieties.
• Example:Example: snapdragons (flower)snapdragons (flower)• red (RR) x white (rr)
• RR = red flowerRR = red flower• rr = white flower
R
R
r r
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Incomplete Incomplete DominanceDominance
RrRr
RrRr
RrRr
RrRr
RR
RR
rr
All Rr =All Rr = pink pink(heterozygous pink)(heterozygous pink)
produces theproduces theFF11 generation generation
r
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Incomplete DominanceIncomplete Dominance
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CodominanceCodominance• Two allelesTwo alleles are expressed ( are expressed (multiple allelesmultiple alleles) in ) in
heterozygous individualsheterozygous individuals..• Example:Example: blood type blood type
• 1.1. type Atype A = I= IAAIIAA or I or IAAii• 2.2. type Btype B = I= IBBIIBB or I or IBBii• 3.3. type ABtype AB = I= IAAIIBB
• 4.4. type Otype O = ii= ii
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Codominance Codominance ProblemProblem
• Example:homozygous male Type B (IBIB) x heterozygous female Type A (IAi)
IAIB IBi
IAIB IBi
1/2 = IAIB
1/2 = IBi
IB
IA i
IB
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Another Codominance Another Codominance ProblemProblem
• Example:Example: male Type O (ii) x female type AB (IAIB)
IAi IBi
IAi IBi
1/2 = IAi1/2 = IBi
i
IA IB
i
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CodominanceCodominance• QuestionQuestion::
If a boy has a blood type O and If a boy has a blood type O and his sister has blood type AB, his sister has blood type AB, what are the genotypes and what are the genotypes and phenotypes of their parents?phenotypes of their parents?
• boy - boy - type O (ii) type O (ii) X girl - X girl - type AB (Itype AB (IAAIIBB))
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CodominanceCodominance• Answer:Answer:
IAIB
ii
Parents:Parents:genotypesgenotypes = IAi and IBiphenotypesphenotypes = A and B
IB
IA i
i
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Genetic Practice Genetic Practice ProblemsProblems
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Breed the PBreed the P11 generation generation• tall (TT) x dwarf (tt) tall (TT) x dwarf (tt) pea plantspea plants
T
T
t t
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Solution:Solution:
T
T
t t
Tt
Tt
Tt
Tt All Tt = tall(heterozygous tall)
produces theFF11 generation generation
tall (TT) vs. dwarf (tt) pea tall (TT) vs. dwarf (tt) pea plantsplants
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Breed the FBreed the F11
generationgeneration• tall (Tt) vs. tall (Tt) pea tall (Tt) vs. tall (Tt) pea plantsplants
T
t
T t
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Solution:Solution:
TT
Tt
Tt
tt
T
t
T tproduces theFF22 generation generation
1/4 (25%) = TT1/2 (50%) = Tt1/4 (25%) = tt1:2:1 genotype1:2:1 genotype 3:1 phenotype3:1 phenotype
tall (Tt) x tall (Tt) pea tall (Tt) x tall (Tt) pea plantsplants
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