"melting pot" of the sciences in interdisciplinary research
TRANSCRIPT
Stirring the melting pot of the sciences: Leading the way to interdisciplinary research
Mixing Social Science into Computer Science, Bioinformatics and more.
Natalie Jane de Vries
Introduction - The University of Newcastle and CIBM
• The Newcastle region is the second most populated area in the Australian state of New South Wales (approx 510,000)
• Situated 162 km (2 hours) North of Sydney in the Hunter Region
• University of Newcastle established: 1965• Directors of CIBM: Prof. Pablo Moscato and Co-director Prof. Rodney Scott
The Centre for Bioinformatics, Biomarker Discovery and Information-based Medicine – Background
• One of only 10 Priority Research Centres of The University of Newcastle.
• Origin: The Newcastle Bioinformatics Initiative (2002-2006) established by the work of Moscato and Berretta in Computer Science
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BioinformaticsThe application of Computer
Science and Information Technology to Biology/Life
Sciences
Information-based Medicineis a shift toward a future of
medicine that can become more personalized, more predictive,
and ultimately more preventative
“Melting pot” of the Sciences?
• Big Data• Data Analytics• Consumer Insights• Consumer Analytics• ‘Internet of things’• Social Media
Analysis• Clustering/
subtyping/segmenting
• Ordering• Ranking• Optimization
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• Community Detection• Graph analysis• Similarity Measures• Classification• Characterisation• Predictive Analytics• Etc..
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AgendaWhat will I talk about today?
• Part 1) General Introduction to the mixing of Computer Science, Social Science, Marketing and Consumer Behaviour at out Centre
• Part 2) Clustering and Segmentation– From Breast Cancer Subtypes to Consumer Behaviours to Social
Media Metrics data and more…
• Part 3) Reverse Engineering Consumer Behaviour Modelling Constructs from Data– We introduce the idea of functional constructs to model online
customer engagement behaviours through symbolic regression
• Part 4) Future Research Directions– Future Directions, Aims, Conclusions and time for questions
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Part 1: Computer Science and Consumer Behaviour Research
• Increase in amount and size of consumer-related data• Online technologies generate large datasets• Increase in online behaviours towards brands• Increasing importance of social media in marketing strategies• Need for greater understanding of consumers through e.g. clustering
consumers (or objects in general) into similar groups
Part 2: Clustering and Segmentation
Complete graph Minimum Spanning Tree Select and remove edges that are not k-Nearest Neigbors
Final forest (a forest is a set of trees) = clusters
Previous (large scale) applications of the MST-kNN method:• U.S. Stock market time series data (Inostroza-Ponta, Berretta, & Moscato, 2011)
• Yeast gene expression data (Inostroza-Ponta, Mendes, Berretta, & Moscato, 2007)
• Alzheimer’s disease data - in the order of 1 million data elements (Arefin, Mathieson, Johnstone, Berretta, & Moscato, 2012)
• Prostate cancer data (Capp et al., 2009)
• Social Media (Facebook) Metrics Data (Lucas et al. 2014)
These examples show the methodology proposed here has a proven scalability for larger datasets
Novel methodology of clustering by CIBM’s researchers: MST-kNN
Biomarker Discovery and Clustering in Breast Cancer
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• Incidence – In 2014, it is estimated that 15,270 women will be diagnosed with breast cancer in Australia.
• Luminal A• Luminal B• HER2-enriched• Normal-like• Basal-like
Molecular Subtypes
TreatmentNot all patients need the same treatment or respond to the same treatment
• Surgery• Radiotherapy• Hormonal therapy• Chemotherapy
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Luminal A
Luminal B
Her2
Normal-like
Basal
Controls
METABRIC data setPAM50 labels
Figure. MST-kNN clustering.
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The MST-kNN Clustering Method in Consumer Behaviour Research
Customer Engagement Behaviours- behavioural manifestations of Customer Engagement (CE) toward a firm after and beyond purchase (van Doorn et al. 2010)
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Online Customer Engagement Survey/Questionnaire Tool
Methodological Outline14Categor
y No. Explanation Percentage of sample
1 Fashion Brands 31.54%
2Community, Charities, Personality and Sports Fan Pages
23.99%
3 Other Services 19.68%
4 Other Consumer Goods 8.09%
5 Hospitality (Restaurants, Cafes, Bars) 7.28%
6 Consumer Electronics 7.01%
7 Automotive 2.43%
Respondents’ chosen brand categories
Methodology: Difference Meta-features
The difference of values between two measured features might be capable to distinguish between two given categories, even when those features are not able to do so alone (De Paula et al, 2011)
Previous successful application of difference meta-features in Alzheimer’s Disease biomarker detection (De Paula et al. 2011) and (Arefin et al. 2012), both in PLoS ONE.
Data collection and pre-
processing
Meta-features: Pair-wise
differences
Meta-features: Pair-wise products
Intra- and inter-construct relationships
Distance Computation
Data preparation
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Results: Clustering Highlights
Heterogeneous cluster?More homogenous cluster?
Results: Clustering and Significance Values
Data Rows selected Distance Metric
MST-kNN merged with the kNN cliques of
size
p-values
Wilcoxon’s Test Kruskal-Wallis
Original All
Robust 5NN 0.021187 0.042364
Spearman 6NN 0.025987 0.051962
Robust 6NN 0.028565 0.057117
Pearson 3NN 0.030232 0.060451
Spearman 3NN 0.040661 0.081306
Euclidean 6NN 0.041232 0.082448
Difference Metafeatures
‘Intra’ constructs
Robust 3NN 0.016551 0.033095
Robust 6NN 0.017177 0.03434
Pearson 3NN 0.018628 0.0372481
Pearson 6NN 0.019066 0.038124
Pearson 5NN 0.019656 0.039303
All Pearson 3NN 0.020594 0.041180
Product Metafeatures
‘Inter’ ConstructsSpearman 3NN 0.016949 0.033891
Pearson 4NN 0.01757 0.035132
All Pearson 4NN 0.017721 0.035433
‘Inter’ ConstructsPearson 6NN 0.01781 0.035611
Pearson 3NN 0.017816 0.035624
‘Inter’ Constructs Robust 4NN 0.017998 0.035988
Future Research Directions in this study
• Various domains and contexts to apply the novel process outlined in this study
• Combine a study using survey data as well as ‘live’ behaviour data from social networking sites (real-time interactions)
• Further exploration of meta-features in both survey data and ‘real’ online behaviour clustering studies; ‘differences’ meta-features in this study yielded better results
• This study guides the development of future feature selection models to identify group of consumers according to higher-order characteristics.
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The MST-kNN Method in Social Media Metrics Data
Engagement in Motion: Exploring Short Term Dynamics in Page-level Social Media Metrics
Benjamin Lucas1,2, Ahmed Shamsul Arefin1,3, Natalie de Vries1,3, Regina Berretta1,3, Jamie Carlson1,2, Pablo Moscato1,3
1 The University of Newcastle, Australia2 Newcastle Business School, Faculty of Business and Law3 The Priority Research Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine
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Part 3: Reverse Engineering Consumer Behaviour Modelling Constructs from Data
Consumer Behaviour Modelling is usually done by testing hypotheses that are generated from theory
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For example:
Source: de Vries & Carlson 2014 – Journal of Brand Management
Items (questions) make up one theoretical construct in Structural Equation Modelling (Hair et al. 2014). For example:
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Symbolic Regression Analysis27
Symbolic Regression Analysis 28
Figure 2. The Figure shows the items ‘used’ by Eureqa through symbolic regression setting each of the five ENG items as dependent variables (obtained using the whole data set).
de Vries NJ, Carlson J, Moscato P (2014) A Data-Driven Approach to Reverse Engineering Customer Engagement Models: Towards Functional Constructs. PLoS ONE 9(7): e102768. doi:10.1371/journal.pone.0102768http://127.0.0.1:8081/plosone/article?id=info:doi/10.1371/journal.pone.0102768
Figure 3. Data Set A – Network found as a result of the application of the model finding optimization software on each variable as a target.
de Vries NJ, Carlson J, Moscato P (2014) A Data-Driven Approach to Reverse Engineering Customer Engagement Models: Towards Functional Constructs. PLoS ONE 9(7): e102768. doi:10.1371/journal.pone.0102768http://127.0.0.1:8081/plosone/article?id=info:doi/10.1371/journal.pone.0102768
Inter-rater Agreement
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de Vries NJ, Carlson J, Moscato P (2014) A Data-Driven Approach to Reverse Engineering Customer Engagement Models: Towards Functional Constructs. PLoS ONE 9(7): e102768. doi:10.1371/journal.pone.0102768http://127.0.0.1:8081/plosone/article?id=info:doi/10.1371/journal.pone.0102768
Our Future research directions
• Work on scalability of methodologies• Improve optimisation algorithms (minimum distance, maximum
objectives, etc.)• Meta-heuristics (Memetic Algorithms) for applications on social
sciences• Network alignment (complex network analysis) of consumer
behaviour networks for uncovering structure in datasets• Proposal of edited book in large scale “Business and Consumer
Analytics” (Springer)• Smart Cities Network (sensor data, optimisation of cities and their
networks)• Digital Economy technologies
UoN and UKM
Things to remember:• UoN is always open for research collaborations (depending on funds – we operate on a project basis)• At CIBM we have supercomputing capacity available for large-scale projects• In our team we have particular strong expertise in operations research and management science• CIBM is open to diversify into new areas (e.g. computational social science as demonstrated today)• As Prof. Moscato says: “Do not hesitate to throw and ‘odd-ball’. Either we could be interested, or we
could put you in touch with other collaborators and colleagues”.
Terima Kasih
Questions?
References• Arefin AS, A, Mathieson L, Johnston D, Berretta R, Moscato P (2012) Unveiling Clusters of RNA Transcript Pairs Associated with
Markers of Alzheimer’s Disease Progression, PLOS ONE, DOI: 10.1371/journal.pone.0045535• Capp et al. (2009) Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial, Radiotherapy
and Oncology, 90(3), 400-407• Hair, J. F., Hult, G. T. M., Ringle, C. M. and Sarstedt, M. (2014) A Primer on Partial Least Squares Structural Equation Modeling
(PLS-SEM) Los Angelos: Sage Publications Inc.• Inostroza-Ponta M, Mendes A, Berretta R, Moscato P (2007) An Integrated QAP-Based Approach to Visualize Patterns of Gene
Expression Similarity, Progress in Artificial Life, Lecture Notes in Computer Science, 4828, pp 156-167• Inostroza-Ponta M, Berretta R, Moscato P (2011) QAPgrid: A Two Level QAP-Based Approach for Large-Scale Data Analysis and
Visualization, PLOS ONE, DOI: 10.1371/journal.pone.0014468• Lucas B, Arefin AS, de Vries NJ, Berretta R, Carlson J, Moscato P (2014) Engagement in Motion: Exploring Short Term Dynamics
in Page-Level Social Media Metrics, IEEE Conference on Social Computing and Big Data and Cloud Computing (Sydney)• de Vries NJ, Carlson J (2014) Examining the drivers and brand performance implications of customer engagement with brands in
the social media environment, Journal of Brand Management, 21, 495-515• de Vries NJ, Carlson J, Moscato P (2014) A Data-Driven Approach to Reverse Engineering Customer Engagement Models:
Towards Functional Constructs, PLOS ONE, DOI: 10.1371/journal.pone.0102768• de Vries NJ, Arefin AS, Moscato P (2014) Gauging Heterogeneity in Online Consumer Behaviour Data: A Proximity Graph
Approach, IEEE Conference on Social Computing and Big Data and Cloud Computing (Sydney)• Marsden J, Budden D, Craig H, Moscato P (2013) Language Individuation and Marker Words: Shakespeare and His Maxwell's
Demon, PLOS ONE, DOI: 10.1371/journal.pone.0066813• Naeni LM, de Vries NJ, Reis R, Arefin AS, Berretta R, Moscato P (2014) Identifying Communities of Trust and Confidence in the
Charity and Not-for-Profit Sector: A Memetic Algorithm Approach, , IEEE Conference on Social Computing and Big Data and Cloud Computing (Sydney)
• van Doorn, J., Lemon, K. N., Mittal, V., Nass, S., Pick, D., Pirner, P. and Verhoef, P. C. (2010). Customer Engagement Behavior: Theoretical Foundations and Research Directions. Journal of Service Research, 13(3): 253-266.
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APPENDIX(Extra Slides)
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New Publication
Published 7th April 2015 in PLOS ONE
N J de Vries
R Reis
P Moscato
Clustering of consumers based on trust and donating behaviours in the not-for-profit sector
Including symbolic regression predictive modeling for consumer involvement with charities
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Resulting Segments of the Australian Market
1. Non-institutionalist charity supporters
2. Resource allocation critics
3. Information-seeking financial sceptics
4. Non-questioning charity supporters
5. Non-trusting sceptics
6. Charity management believers
7. Institutionalist charity believers
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0122133
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IEEE Conference paperMethodology: Product Meta-features
The product of values between two measured features might be capable to distinguish between two given categories, even when those features are not able to do so alone.
This study is the first to trial the application of this idea.
Left, the values of f1 (blue) and f2 (red) do not distinguish the classes well but their product (meta-feature in green) does.
Data collection and pre-
processing
Meta-features: Pair-wise
differences
Meta-features: Pair-wise products
Intra- and inter-construct relationships
Distance Computation
Data preparation
1 2 3 4 5 6 7 8 9 10 11 120
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My publications
• A Data-Driven Approach to Reverse Engineering Customer Engagement Models: Towards Functional Constructs (de Vries, Carlson and Moscato) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102768
• Examining the drivers and brand performance implications of customer engagement with brands in the social media environment (de Vries and Carlson): http://www.palgrave-journals.com/bm/journal/v21/n6/abs/bm201418a.html
• Gauging Heterogeneity in Online Consumer Behaviour Data: A Proximity Graph Approach (de Vries, Arefin and Moscato) http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7034833
• Engagement in Motion: Exploring Short Term Dynamics in Page-Level Social Media Metrics (Lucas et al) http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7034813&tag=1
• Identifying Communities of Trust and Confidence in the Charity and Not-for-Profit Sector: A Memetic Algorithm Approach (Moslemi et al) http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7034835&refinements%3D4251871666%26filter%3DAND%28p_IS_Number%3A7034739%29
Other SourcesFirst uses of ‘meta-features’:• Differences in Abundances of Cell-Signalling Proteins in Blood Reveal Novel
Biomarkers for Early Detection Of Clinical Alzheimer's Disease (De Paula et al) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017481
• Unveiling Clusters of RNA Transcript Pairs Associated with Markers of Alzheimer’s Disease Progression (Arefin et al) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045535
MST-kNN papers:• An Integrated QAP-Based Approach to Visualize Patterns of Gene Expression
Similarity (Inostroza Ponta et al) http://link.springer.com/chapter/10.1007/978-3-540-76931-6_14
• kNN-MST-Agglomerative: A fast and scalable graph-based data clustering approach on GPU (Arefin et al) http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6295143