ANSYS, Inc. Proprietary

Medical Device Simulation Using ANSYS

Derek SweeneyIDAC Ireland Ltd

IDAC Company Background

• CAE Consultants• Established in 1997• 4 Employees

o Derek Sweeneyo Dr. Paul Fanningo Bob Mooreo Barbara Leichtenstern

• ANSYS Channel Partner in Ireland• Members of Technology Network Alliance

(www.technet-alliance.com)

IDAC Company Activities

• Consultancy• Training• Software Sales• European Projects• Customisation

European Projects

• BLOODSIMo Simulation of cardiovascular and other biomedical problemso Provided simulation tools and methods to clinicians and medical device manufacturers

• GEMSSo Grid Enabled Medical Simulation Serviceso As the Internet revolutionised access to information, the Grid will revolutionise

accessibility to applications. GEMSS demonstrates how Grid technologies can be used

to transform healthcare and enable Europe to lead that transformation. • @neurIST

o @neurIST is focussed on cerebral aneurysms and intends to provide an integrated decision support system to assess the risk of aneurysm rupture in patients and to optimize their treatments.

Why Use Simulation?

• Competitive World• R&D and Innovation is Key to Success• Design Cycle must be Compressed• Simulation to Design

o Bettero Cheapero Faster

Why Use Simulation?

“Novate are developing an innovative vena cava filter for treatment of patients who are at risk of deep vein thrombosis. The device must conform closely to the vena cava wall, but still provide sufficient stiffness and fatigue strength. “To help to achieve this design balance, Novate have used IDAC’s services at each design iteration, to simulate deployment of the device inside the vessel and calculate fatigue life. Novate plans to commence a clinical trial in 2009.”

'At Abbott, we use simulations from the concept stage of stent design right through to finalization. At the concept stage, it is used for feasibility studies, sensitivity studies and design optimization. These allow us to better understand the behavior of different stent geometries and rapidly provide us with the information needed to make sound design decisions early in the design process.' says Erik Eli, Abbott Vascular, Santa Clara.

Medical Device Applications

• Transcatheter Devices

• Web Enabled Stent Applications

• Stent Optimisation – Novate Medical

• Knee Assist Device – Moximed

• Composite Wheelchair – I Imagine Design

• @neurIST – Role of Haemodynamics in Vascular Disease

• @neurIST – Virtual Stenting

Transcatheter Devices

• Balloon Expanded & Self Expanding• Recoil• Shortening• Fatigue• Radial Strength/Stiffness• Bending (crimped and expanded)• Flat Plate Test• Flow Simulations of Stented Vessels

Web Enabled Stent Applications

Stent Optimisation – Novate Medical

Stent Optimisation – Novate Medical

Stent Optimisation – Novate Medical

Knee Assist Device - Moximed

Knee Assist Device - Moximed

Knee Assist Device - Moximed

Composite Wheelchair – I Imagine Design

@neurIST – Role of Haemodynamics in Vascular Disease

surface reconstruction 3 computer model flow prediction

medical image surface reconstruction 1 surface reconstruction 2

@neurIST – Role of Haemodynamics in Vascular Disease

Accepted “wisdom” Predicted the SAH patients?

• Size matters (7mm) 3/7

Proposed indices

• Aspect ratio (1.6) 5/7

• Size ratio (3) 1/7

• WSS 4/7

• Oscillatory shear index (0.40) 6/7

• Non-sphericity index (0.183) 6/7

• The software is easy to use by clinicians

• Results were interchangeable with Dr Marzo’s within 5 cases.

• 45 minutes clinician time + 2-3 hours computation

@neurIST – Role of Haemodynamics in Vascular Disease

Size is not the best predictor of aneurysm’s rupture potential

Haemodynamic and shape indices may have greater influence on

rupture potential

Strongest correlations found for Oscillatory Shear Index and Non-

sphericity index

@neurIST – Virtual Stenting

ComparisonIn-vitro vs. Virtual stent release

@neurIST – Virtual Stenting

ValidationContrast fill-in/wash-out

Enterprise

Time density curves from the in-vitro experiment in the inlet (I, blue), in the aneurysm (A, pink) and in the aneurysm for the CFD simulation (A, green)

@neurIST – Virtual Stenting

Silk

Time density curves from the in-vitro experiment in the inlet (I, blue), in the aneurysm (A, pink) and in the aneurysm for the CFD simulation (A, green)

ValidationContrast fill-in/wash-out