medical chemistry introduction
TRANSCRIPT
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Medical Chemistry
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Medical Chemistry
Chemistry in its relation to pharmacy, physiology, or any science connected with medicine.
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Introduction
Medical chemistry is based on General chemistry (physical chemistry)Inorganic chemistry, Organic chemistry, Analytical chemistryIt supports several basic medical disciplines, asmedical biochemistry, physiology, pathophysiology, pharmacology, etc. -
Organization of the first semester I
Textbooks required
General chemistryTextbook: Mc Murry Fay : Chemistry, 4th Edition
(Ebbing: General Chemistry, last Edition)
or other kinds of textbooks
Organic chemistryTextbook: P.Gergely: Organic and bioorganic chemistry for medical students (3rd edition)
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Recommended literature:
McMurry, Fay: Chemistry
4th ed.
P. Gergely: Organic and bioorganic chemistry 3rd ed.
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Organization of the first semester II
Inorganic chemistryTextbook: Experiments in medical chemistry (Laboratory manual) edited by V. Nagy
Analytical chemistryTextbook: Experiments in medical chemistry (Laboratory manual) edited by V. Nagy
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Syllabi are avaible at:
www.pote.hu ETR CooSpace Medical Chemistry
or
www.pote.hu Departments Biochem. and Med. Chem. Educational Materials Medical Chemistry
Laboratory experiments in medical chemistry
ed. Veronika Nagy
Available only on internet!
Laboratory experiments in medical chemistry
Written by
Attila Agcs, Zoltn Berente, Gergely Gulys, Pter Jakus, Tams Lrnd, Veronika Nagy, Erika Rad-Turcsi, Anik Taktsy
Edited by
Veronika Nagy
University of Pcs
Department of Biochemistry and Medical Chemistry
- Bioorganic chemistry
Textbook see above P. Gergely: Organic and bioorganic chemistry for medical students (3rd edition)
Bioinorganic chemistryTextbook: P. Gergely: Introduction to bioinorganic chemistry (3rd, revised edition)
Organization of the second semester
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Practices I
Form: simple experiments performed by the students themselves
and a few demonstrations (done by the staff)
Topics in the first semester
Basics of inorganic and general and analytical chemistry
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Practices II
Topics in the second semesterBasics of complex chemistry, organic chemistry and modern separation methods -
Practices III
Laboratory SafetyChemical laboratory is a hazardous place.The students are obliged to wear a lab coat and approved safety glasses or goggles. These are to provided by the students.Packbacks, coats and other belongings should be left in the students locker or the cloakroom before practices. -
Practices IV
Other rules will be discussed on the first meeting with your practice leader. -
Seminars
Topics in the first semester.They cover the main parts of general and organic chemistryForm: short revision of a chapter of general chemistry + practicing chemical calculations revision of the essentials of organic chemistry(Calculation exercises, educational material on the internet!) -
Attendance
Attendance at lecturesAttendance at seminars and practices is obligatory.Criteria of accepted semester -
Examination I
First semesterSemester exam: written exam
Topics: cover general and inorganic and organic chemistry
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Examination II
Results of the academic year 2009-2010 /first semester
Total number of students:
230 persons (100%)
failed: 90 persons (39%)
passed: 108 persons (47%)
disappeared: 32 persons (14%)
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http://aok.pte.hu/index.php?page=egyseg&egy_id=20&nyelv=eng&menu=okt_anyag
Use the material under
Medical Chemistry 2010/2011
Educational materials, as sample tests, lectures, etc. are available here.
Web site of the Biochemistry and Medical Chemistry
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Criterion Discipline: General Chemistry I
Time frame: 2 hours / week, 28 hours / semester
Subject of General chemistry: calculation exercises
Requirements: the students are obliged to write two midterm test papers on the 6th and 13th weeks.
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Criterion Discipline: General Chemistry II
On these test 2x8, i.e. 16 points can be gathered, which is counted into the final mark of Medical Chemistry.
One should reach at least the 30% (5 points) on the two test altogether and should participate on the 75% of the classes.
To fulfil the requirements of General Chemistry is a prerequisite for the valid semester in Medical Chemistry.
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What is the subject of chemistry?
Chemistry is a branch of science discussing the matter, dealing with its composition, structure, behaviour, in addition with its chemical reactions.
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Short History of Chemistry I
Practical arts (Egypt and Mesopotamia, to 600 BC)manufacturing of perfumessmelting of metalsmanufacturing of drugsbrewing (preparation of beer) -
Short History of Chemistry II
Greek period (600 BC-300 BC)Developing the idea of atomThe concept of the four elements: earth, air, fire, water -
Short History of Chemistry III
Alchemy, Alexandrian and the Muslim world (300 BC to 1650 AD )Invention of processes as distillation, sublimation, crystallization, oxidationDiscovery of several elementsConcepts as acid-base and alkali originated from the Arabic word al-kiliIndustrial chemistry: production of paper -
Short History of Chemistry IV
Iatrochemistry - chemical discipline connected to medicine. Paracelsus: The true use of chemistry is not to make gold but to prepare medicines.Mercury unites with sulphur
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Short History of Chemistry V
Phlogiston theoryThe chemists tried to explain different phenomena as burning, rusting and metabolism on a common base.Theory: the combustible objects contain a fire-like element, phlogiston, it is liberated during combustion. -
Short History of Chemistry VI
Modern chemistry, Antoine Lavoisier, the father of the modern chemistryLaws of chemistryChemical nomenclature and pioneer in stoichiometry, etc.A. Lavoisier
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Importance of chemistry for medical students I
General chemistryBasic principles and facts used by biology, physiology, etcE.g.: term of pH - importance of pH regarding the body fluids, enzymatic performance, etc. -
Importance of chemistry for medical students II
E. g. Distribution law of Nernst absorption of lipid soluble drugs, mechanism of action of anaesthetics, etc.E. g. Intermolecular forces - mechanism of action of some medicinesprotein binding of medicines -
Organic and bioorganic chemistry I
E. g. Hydroxylation of aromatic compounds- metabolism and changes in renal excretionE. g. Similarity of molecule structure similarity of pharmacological actionE. g. Cis-trans isomerism of substances varying toxicity of cis-trans isomeric compounds -
Organic and bioorganic chemistry II
E.g. acetylene groups (triple bond)- role in drugs (in steroid contraceptive agents)E.g. reaction of thiols with heavy metals toxicity of heavy metals (possible targets: thiol enzymes)