Medical Applications of Molecular Nanotechnology

Nanomedicine

Group 7:Alex ShinBobby MartinBrian MaldonadoDenny WindgassenJohn MetcalfKenneth KrepsRoss Mathis

NANOMEDICINE

Def. Nanotechnology:• Describes creation of functional materials,

devices, and systems in nanometer scale length (1-100nm = 1-100 x 10 -9m)

Def. Nanomedicine:• Application of Nanotechnology in Medicine

NANOMEDICINEKey Goals:• Cure of traditionally incurable diseases (i.e. Cancer)• Providing more effective cure with fewer side

effects, and developing tools for more effective detection, diagnosis, and treatment

NANOROBOTS

• Microscopic devices ranging in size from 0.1-10 micrometers

- A human hair is typically 40 micrometers in diameter• Capable of navigating through the bloodstream

directly to the source

• Carry tools, medicines, lasers, etc.• Seems most fit to work in mass quantities

NANOROBOTS(cont’d)

• Designed to treat patients at the source• Precision• Microsurgery• Target drug delivery• Monitor your diabetes• …and more

NANOROBOTSThe Link

• Data Mining Monitor various patients with similar conditions, and find trends in the way they react to different treatments.• EHR Conditions can be automatically updated in your Electronic Health Record, via the nanorobots, eliminating the need for unnecessary follow up visits.

CELL REPAIR MACHINES

Small enough to fit inside of a cell or travel through the blood stream

Uses cilia for propulsion

Contains a memory of up to 1 GB

Contains a CPU with 10 MB of RAM

1000 extendable molecular manipulators, each controlled by the micro processor

CELL REPAIR MACHINESBefore treatment: Inject the CRMs to target the cancerous cells

1. Use the improved imaging in order to remove the cells by surgery

2. Use the CRMs to deliver medicines directly to the part of the body

3. Kill the cancer cells by the using methods such as Kanzius RF therapy

After treatment:Maintain the health of the patient

CELL REPAIR MACHINESOther medical applications of

CRMs:

Repair cellular injuries caused by hours of absent blood flow

Eliminate aging and increase the lifespan of a human to 600 years

Achieve “super human" strength by overlapping muscle tissue with fine diamond fiber

Revive cryogenically frozen patients

BIOMEDICALNANOTECHNOLOGY

BIOMEDICAL NANOTECHNOLOGY

• Diagnostics - Would help individuals with their PHR’s

• Prostheses and implants• Nanodrugs

Three Main Focuses

BIOMEDICAL NANOTECHNOLOGY

• Diagnostics - Would help individuals with their PHR’s

• Fairly new technology - Long term effects - Unforeseen Adverse effects

• Will be monitored closely into the future

Potential Problems

NANONEPHROLOGY

Nephrology• Study of the function and diseases of the

kidney

Nanonephrology• Branch of Nanomedicine that deals with

Nephrology

NANONEPHROLOGY

• Protein Structures

• Nano-Imaging

• Nanomedicine

Subfields

NANOBUBBLE TECHNOLOGYWhat is it?

• Bubbles that can be injected into the bloodstream to deliver oxygen to the body

• Can hold 400x more oxygen than the average red blood cell

• Breakdown of blood clots

Applications:• Hemorrhagic shock victims – rats kept alive with

only 50% normal quantity of blood• Carbon Monoxide poisoning – flood out the carbon

monoxide with oxygen saturation

NANOBUBBLE TECHNOLOGY

How this applies to HIT:• More efficient, more effective way to deliver oxygen• Costs less, no harmful chemicals that remain in the

body like competitors such as PolyHeme• In the future patients may be able to administer the

injections on their own and monitor their blood oxygen levels as well as their body’s circulation

NANOTECHNOLOGY IN DRUG DELIVERY

Controlled Release Systems - More efficient dosage - Reduced side effects

Vaccine Delivery Systems - Small size - Faster absorption

• Implanted Drug Release Systems,

NANOTECHNOLOGY IN DRUG DELIVERY

Increased effectiveness of medication - Controlled release

increases effective time

Targeted delivery of medication. - Absorbed by specific

tissue or cells

CONCLUSION• Introduction to various applications• Key Goals• Can bring advancements to three components of HIT

FUTURE:

CONCERNS:

• Promises better outcomes• Difficult to say when it is implemented

-> question of coordination and standardization

• Interaction between nanoparticles and living organisms should be fully evaluated first

• Cost

Questions?