mdct in acute respiratory distress syndrome and multi-trauma
TRANSCRIPT
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MDCT in Acute Respiratory Distress Syndrome and Multi-trauma
Noah Stites-HallettAdvanced Radiology clerkship
Final presentation, 1/24/08
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Patient History
• 27 yo M presents as transfer from outside hospital (OSH) after crashing his moped
• Self-presented to OSH, was responsive, moving all 4 extremities
• CXR demonstrated bilateral pneumohemothoraceswas intubated and bilateral chest tubes placed
• CT demonstrated many injuries, including an aortic arch injury for which he was medflighted
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• PMH: None per OSH
• Meds: None per OSH
• Allergies: None per OSH
• Social Hx: Unattainable
• Family Hx: Unattainable
Additional Patient History
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• Vitals: T 100.1, HR 92, BP 102/45, MAP 6, CVP 16, Wt 120 kgs• Vent setting: PC 20/5, FIO2 0.7, RR 20, TV 521, last ABG
7.36/45/135• General: Intubated, sedated non-responsive• HEENT: NC, small facial contusion mid-upper lip• Neck: Supple, no JVD, no bruits, in Aspen collar• Pulm: Scattered rhonchi bilaterally, crackles lower lungs• Cardiac: RRR, nl S1 S2, no m/r/g• Abdomen: Soft, non-distended, no pulsatile masses, no
organomegaly• Extremities: WWP, no peripheral edema, 2+ pulses throughout
Physical Exam
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Labs
• No electrolyte abnormalities• BUN 18, Cr 1.2• CBC WBC 14.6, Hct 29.7 (Hgb 10.2),
Plt 209• INR 1.1
• Repeat CT performed (11 hours after accident)
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Axial Abdominal CT: Rib fracture
MGH AMICAS
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Axial Abdominal CT: Rib fracture
MGH AMICAS
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Comminuted Sternal Fracture
Coronal reconstruction Sagittal reconstruction
MGH AMICASMGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: T1 fracture
MGH AMICAS
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Axial Thoracic CT: Aortic Pseudoaneurysm
MGH AMICAS
Pseudoaneurysm
Normal aorticcontour
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Devascularized
Axial Abdominal CT: Splenic injury
MGH AMICAS
Spleen
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Chest tube
Contusion
Ground-glass NG tube
Endotracheal tube
MGH AMICAS
Axial Thoracic CT: Lung window
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Residual pneumothorax
Residual hemothorax
Contusion
MGH AMICAS
Chest tube
Axial Thoracic CT: Lung window
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ContusionChest tube
MGH AMICAS
Axial Thoracic CT: Lung window
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Chest tube
Contusion
Residual pneumothorax
Chest tube
MGH AMICAS
Axial Thoracic CT: Lung window
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Summary of Injuries
• Multiple rib fractures• Comminuted sternal fracture• T1 fracture (non-displaced)• Aortic pseudoaneurysm• Splenic devascularization
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Patient’s decline
• Over next week:– Increasing FIO2 requirement– Rising CO2
• Daily AP chest x-rays demonstrated worsening bilateral alveolar infiltrates – pulmonary contusions fully declare after about 6 hours so new
infiltrates had to be secondary to a new pathological process
• Chest CT repeated at day 6
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Septal thickening
Diffuse bilateral
ground glass infiltrate
Axial Thoracic CT ComparisonDay 1
Day 6MGH AMICAS
MGH AMICAS
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Air bronchograms
Day 6
Diffuse bilateral
ground glass infiltrate
Septal thickening
Day 1 Axial Thoracic CT Comparison
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Day 1
Day 6
Diffuse ground glass
infiltrate
Axial Thoracic CT Comparison
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ARDS pathophysiology
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Normal Alveolus
Ware LB, Matthay MA. The acute respiratory distress syndrome. NEJM. 2000;342:1334-49.
Ware LB, Matthay MA. The acute respiratory distress syndrome. NEJM. 2000;342:1334-49.M
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ARDS Alveolus
-Infection (pna, sepsis)
-Inhalation (toxic injury)
-Trauma (lung or extrathoracic injury)
-Hemodynamic (shock)
-Metabolic (pancreatitis)
-Others
Ware LB, Matthay MA. The acute respiratory distress syndrome. NEJM. 2000;342:1334-49.M
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ARDS Histology
Ware LB, Matthay MA. The acute respiratory distress syndrome. NEJM. 2000;342:1334-49.M
Hyaline membrane Overall
distortion/destruction of lung/alveolar architecture
Neutrophils
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• A clinical diagnosis:– PaO2:FiO2 <200, regardless of PEEP– Bilateral pulmonary infiltrates on CXR– Wedge pressure <18mm Hg or no clinical
evidence of elevated left atrial pressure
Diagnostic Criteria for ARDS
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Image Findings in ARDS
• CXR findings:– No initial findings wait 24 hours– Diffuse, bilateral pulmonary (alveolar) infiltrates
• CT findings:– Ground glass opacities patchy and diffuse– Consolidation mostly in dependent regions– Air bronchograms, bronchial dilation– Pleural effusions common but not necessary
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Treatment of ARDS
• Intubation– Lower lung volume ventilation (6cc/kg)– PEEP– Conservative fluid management (goal of near even
input and output)– Nitric oxide– Supportive therapy
• Treat initial cause (pneumonia, sepsis, etc)
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Patient follow up• Remained in ICU for 31 days for ARDS
– Rib/sternal fractures: Conservative management– T1 fracture: Deemed non-operable so patient placed
in halo– Aortic pseudoaneurysm: Endovascular stent placed– Splenic injury: Non-operable conservative
management
• Transferred to floor for 5 days then discharged
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References• Ware LB, Matthay MA. The acute respiratory distress syndrome. NEJM. 2000;342:1334-49.
• Kollef MH, Schuster DP. The acute respiratory distress syndrome. NEJM. 1995;332(1):27-37
• The Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. NEJM. 2006 Jun 15;354(24):2564-75.
• The Acute Respiratory Distress Syndrome (ARDS) Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. NEJM. 2000;342:1301- 8.
• The Acute Respiratory Distress Syndrome (ARDS) Network. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. NEJM. 2004;351(4):327-336
• Pesenti A, Tagliabue P, Patroniti N, Fumagalli R. Computerised tomography scan imaging in acute respiratory distress syndrome. Intensive Care Med. 2001;27:631-639
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Acknowledgements
• Luca Bigatello, M.D.• Karsten Bartels, M.D.• Bishr Haydar, M.D.• Scott Legrand, M.D.• Gillian Lieberman, M.D.• Maria Levanta