md , dnb neonatology consultant neonatology · regulation ot trophoblast proliferation and...
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Sterile Inflammation
Dr Nalinikant PanigrahyMD , DNB Neonatology
Consultant Neonatology
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Inflammation: What Is It?
An adaptive response to restore homeostasis
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Physiologic Inflammation is Central to Reproductive Success
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Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship Frontiers of pediatrics ,2018
Two summaries1. Respect Blood culture -
Negative report2. Robust definition of sepsis
INFLAMMATION is NOT INFECTION
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Chorioamnitis
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• Hypoxia –Ischemia • Preterm delivery • IUGR
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Placental swab negative Placenta biopsy – No infectionHigh TLC count Increased other inflammatory markers
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Blood Culture Negative High count TLC , Increased CRP = persistent high CRP even after antibiotics
107 VLBW cases = 15 babies CMV= 03 babies Fungal after 2nd Culture = 09 Babies CMPI
Unpublished Unit auditing
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Inflammasomes – Pandora Box ?
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DAMP PAMP
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Latest Research
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Summary
• Early suspicion of Sterile inflammation
• Respecting Blood culture negative Reports , Sepsis marker positive cases
• Prevention of inflammation if possible
• Newer treatment modalities