AccreditationMount Sinai Medical Center isaccredited by the AccreditationCouncil for Continuing MedicalEducation (ACCME) to sponsorcontinuing medical educationfor physicians. Mount Sinaidesignates this educationalactivity for a maximum of 14AMA PRA Category 1 Credit(s)Physicians should only claimcredit commensurate with theextent of their participation inthe activity.

Psychology CreditThe University of MiamiLeonard M. Miller School ofMedicine is approved by theAmerican PsychologicalAssociation to sponsorcontinuing education forpsychologists. The Universityof Miami Miller School ofMedicine maintainsresponsibility for thisprogram and its content.

14 CE credits will be awardedto psychologists for attendanceat this conference.

Disclosure StatementFaculty relationship(s) with industry will be disclosed and available in theSymposium Syllabus and at the meeting site. Disclosure to the audience will bemade by the Faculty prior to their presentations by the Activity Director.

As a provider accredited by the Accreditation Council for Continuing MedicalEducation, Mount Sinai Medical Center requires its staff, and CME Committeemembers (i.e. Planners) to disclose to all stakeholders and learners that theindividual either has or does not have Relevant Financial Relationship(s) with acommercial interest. Therefore, anyone in a position to control CME content mustcomplete a Disclosure of Financial Relationship form. Planner relationship(s) withindustry will be disclosed and available in the Symposium Syllabus.

Corporate SupportThis symposium is made possible by unrestricted educational grants fromindustry; our appreciation is expressed for their support of this program.Sponsors will be listed in our Symposium Syllabus and on the Symposium Web-Site.

AcknowledgmentThis symposium is being supported by the Florida Alzheimer’s Disease ResearchCenter (ADRC).

Symposium InformationPlease contact: Warren Barker

MCI Symposium CoordinatorWien Center for Alzheimer’s Disease & Memory DisordersMount Sinai Medical CenterPhone: 305-674-2592 – Fax: 305-674-2996E-mail: mcisymposium@msmc.comWeb: www.mcisymposium.org

Wien Center4300 Alton Road

Miami Beach, FL 33140

www.mcisymposium.org

Presented By:The Wien Center for Alzheimer’s Disease and Memory DisordersMount Sinai Medical Center, Miami Beach, Florida

and

The Johnnie B. Byrd, Sr. Alzheimer’s Center & Research InstituteTampa, Florida

FFrr iiddaayy -- SSaattuu rrddaayy,, MMaarrcchh 77-- 88,, 22000088Symposium Location:MMiiaammii BBeeaacchh RReessoorrtt && SSppaa4833 Collins Ave., Miami Beach, FL 33140

Program Director:RRaannjjaann DDuuaarraa,, MMDDMedical DirectorWien Center for Alzheimer’s Disease & Memory DisordersMount Sinai Medical Center, Miami Beach, FLDepartments of Medicine and PsychiatryMiller School of Medicine, University of Miami, Miami, FL

Sponsored By:The Behrman Center for Medical Education at Mount Sinai Medical center

MILD COGNITIVE IMPAIRMENT (MCI) SYMPOSIUM“Theme for 2008: The Basis for Disease Modifying Treatments of Alzheimer's Disease”

Needs AssessmentUnless ways are found to prevent

Alzheimer’s Disease (AD) or delay its

onset, it is projected that over 13 million

people in the United States will be living

with AD by 2050. Individuals with AD

suffer from cognitive and functional

impairment, loss of productivity and

significant deterioration in over-all quality

of life. Most will develop problematic

behaviors, such as agitation and

aggression, and many will need long-term

care. In addition, caregivers of the

patients are adversely affected by

physical burden, emotional stress and

financial hardship.

In the last two decades, significant

progress has been made in understanding

the pathogenesis of AD and the risk

factors associated with the development

of the clinical illness. This progress has

stimulated the development of several

potential disease modifying treatments for

Alzheimer’s disease. Advances in clinical

neuropsychological assessment, brain

imaging and biological markers have

improved our ability to detect the disease

earlier and monitor its progression with

regards to treatment. Earlier detection

and improved monitoring will become

even more important as treatment

options improve.

Target AudienceThis activity is designed for:

– Neurologists

– Psychiatrists

– Geriatricians / Gerontologists

– Radiologists (neuroimaging specialists)

– Epidemiologists

– Neuropsychologists

– Psychologists

– Neuroscientists

Educational ObjectivesThe purpose of this series of symposia is to provide a forum for new information and for in-depth discussions about advances inAlzheimer’s Disease (AD) research, clinical diagnosis and treatment.The goals of the Mild Cognitive Impairment (MCI) Symposium seriesare to study the pathophysiology of AD and other causes ofdementia, and to explore possible methods of intervention in theearliest stages of these disorders, that is, in the MCI stage. In thecurrent symposium we will examine recent developments inunderstanding disease mechanisms which offer potential strategiesfor treating and preventing Alzheimer’s disease. We will also studymethodologies for identifying the earliest stages of the disease aswell as assessing the effects of treatment. Finally, we will presentresults from several studies on potential disease-modifying treatmentsfor Alzheimer’s disease that may become available in the future.

The symposium will include a keynote address, a panel discussion,and four individually themed symposia, each featuring national andinternational experts in the fields of neurology, neurobiology,psychiatry, geriatrics, neuropsychology, radiology, epidemiologyand pharmacology. Each mini-symposium will be followed by anextended discussion period, allowing active audience participationto promote a better understanding of the issues.

Upon completion of this symposium, the attendees should have abetter understanding of the following:

� Known Risk Factors for Alzheimer’s Disease (AD)

� Determinants of the Rate of Progression of AD

� Pathogenic Mechanisms for Cognitive Impairment in Animalsand Humans

� Measurement of the Progression and the Effects of Treatment in AD

� Why, When and How to Disclose the Diagnosis of AD

� Non-Pharmacological Treatment and Prevention of Early ADand other Dementias

� Potential Disease Modifying Agents for Treatment andPrevention of AD

Distinguished FacultyProgram DirectorRanjan Duara, MDMedical Director, Wien Center for Alzheimer’s Disease & Memory DisordersMount Sinai Medical Center, Miami Beach, FLDepartments of Medicine and Psychiatry, Miller School of MedicineUniversity of Miami, FL

Keynote Speaker:

Denis Evans, MDProfessor of Neurological SciencesRush University Medical CenterChicago, Illinois

Distinguished Faculty:

Paul Aisen, MDProfessor of Neurology and MedicineDirector, Memory Disorders ProgramGeorgetown University HospitalWashington, District of Columbia

Gary W. Arendash, PhDResearch Professor and Mouse Core DirectorJohnnie B. Byrd Sr., Alzheimer’s Center & Research InstituteTampa, Florida

Stephen Bondy, PhDProfessor, Department of Community and Environmental MedicineUniversity of CaliforniaIrvine, California

Soo Borson, MDProfessor of Psychiatry and BehavioralSciences, University of Washington School of MedicineDirector, Geriatric and Family ServicesClinic, University of Washington Medical CenterSeattle, Washington

Carl Cotman, PhDDirector of the Institute for Brain Aging and DementiaProfessor of Neurology and PsychobiologyUniversity of CaliforniaIrvine, California

Karen Duff, PhD Professor, Taub InstituteDepartment of Pathology (Columbia University) and Psychiatry (NYS Psychiatric Institute)New York, New York

Laura Fratiglioni, MD, PhDProfessor, Director of the Aging Research Center, Karolinska InstitutetStockholm, Sweden

Mary Ganguli, MD, MPHProfessor of Psychiatry and EpidemiologyUniversity of Pittsburgh School of MedicinePittsburgh, Pennsylvania

Todd E. Golde MD, PhDChair, Professor and ConsultantDepartment of NeuroscienceMayo Clinic JacksonvilleJacksonville, Florida

Michael Grundman, MD, MPHSenior Director of Clinical Development in the Alzheimer's Disease ProgramElan PharmaceuticalsSan Francisco, California

Clifford R Jack, Jr, MDProfessor of Radiology, The Alexander FamilyProfessor in Alzheimer’s Disease ResearchMayo Clinic and Foundation Rochester, Minnesota

Angela L. Jefferson, PhDAssistant Professor of MedicineCo-Director, Boston University Alzheimer'sDisease Center Education & InformationTransfer CoreBoston University School of MedicineBoston, Massachusetts

Arthur Kramer, PhDProfessor & Director of the BiomedicalImaging CenterUniversity of IllinoisUrbana, Illinois

David Loewenstein, PhDProfessor of Psychiatric & Behavioral SciencesUniversity of Miami and The Wien CenterMiami Beach, Florida

Jose A. Luchsinger, MD MPHFlorence Irving Assistant Professor ofMedicine and EpidemiologyColumbia UniversityNew York, New York

Professor Colin L. Masters, BMedSci(Hons),MBBS, MD, FRCPath, FRCPA, FAAExecutive Director and Laureate Professor, Mental Health Research Institute, University of MelbourneVictoria, Australia

JoAnne McLaurin, PhDProfessor, Centre for Research inNeurodegenerative Diseases andDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Canada

Mary Mittelman, DrPHDirector of Psychosocial Research andSupport Program, Silberstein InstituteResearch Professor, Department of Psychiatry,NYU School of MedicineNew York, New York

John Morris, MD Friedman Distinguished Professor ofNeurologyWashington University School of MedicineSt. Louis, Missouri

Ronald Petersen, MD, PhDProfessor of Neurology and AlzheimerDisease ResearchMayo Medical SchoolRochester, Minnesota

Michael J. Pontecorvo, PhDVice President, Clinical ResearchAvid RadiopharmaceuticalsPhiladelphia, Pennsylvania

Huntington Potter, PhDCEO and Scientific DirectorJohnnie B. Byrd Sr., Alzheimer’s Center & Research InstituteTampa, Florida

Orien Reid, MSWChairman, Alzheimer’s Disease InternationalLondon, United Kingdom

Norman Relkin, MD, PhDAssociate Professor of Clinical Neurology & NeuroscienceWeill Medical College of CornellNew York, New York

Eric Rodriguez MD, MPhilAssociate Professor, Department of MedicineUniversity of Pittsburgh School of MedicinePittsburgh, Pennsylvania

Juan Sanchez-Ramos, PhD, MDHelen E. Ellis Professor of NeurologyUniversity of South FloridaTampa, Florida

Eric Siemers, MD Medical Director, Alzheimer's Disease TeamLilly Corporate Center, Eli Lilly and CompanyIndianapolis, Indiana

Gary W. Small, MDParlow-Solomon Professor on Aging and Professor of PsychiatryDirector, UCLA Center on Aging Los Angeles, California

Mike Weiner, MDDirector, Center for Imaging ofNeurodegenerative Diseases, San Francisco VAMCProfessor of Medicine, Radiology, Psychiatry, and NeurologyUniversity of CaliforniaSan Francisco, California

Robert S. Wilson, PhDRush Alzheimer's Disease CenterRush University Medical CenterChicago, Illinois

Philip A. Wolf, MDProfessor of Neurology & PrincipalInvestigator, the Framingham Heart StudyBoston University School of MedicineBoston, Massachusetts

Kenton H. Zavitz, PhDSenior Director of Clinical AffairsMyriad Pharmaceuticals, Inc.Salt Lake City, Utah

PM

1:30-4:00 Mini-Symposium: Biomarkers for Measuring Progression and the Effects of Treatment in AD

Chair: Mike Weiner, MD

Cognitive MeasurementRobert Wilson, PhD

Volumetric MRI (the ADNI Experience)Clifford Jack, MD

4 Tesla MRI in MCI and Early ADMichael Weiner, MD

Amyloid Imaging with [C-11] PIB in Normal Aging, MCI and AD

Colin Masters, MD, PhD

Amyloid Imaging with [F-18] 1, 4-diphenyltriazoles

Mike Pontecorvo, PhD

PET FDG and Amyloid and Tau Imaging with [F-18] FDDNP in Early AD

Gary Small, MD

CSF Biomarkers in MCI and Early ADJohn Morris, MD

4:00-4:15 Break

4:15-5:00 Open Discussion

5:30-7:00 Panel Discussion: Disclosing the Diagnosis: Why, When and HowChair: Mary Ganguli, MD, MPHPanelists (Ronald Petersen, MD, PhD; Angela Jefferson, PhD; Mary Mittelman, DrPH; Soo Borson, MD; Eric Rodriguez, MD; Orien Reid, MSW)

7:00-9:00 WELCOME DINNER

Friday, March 7, 2008

AM

7:00-8:00 Breakfast Buffet

8:00-8:15 Welcome and IntroductionRanjan Duara MD

8:15-9:15 Keynote Address: What Determinesthe Risk of and Rate of Progression in Alzheimer‚s Disease: Mechanismsand Modifiers

Denis Evans, MD

9:15-11:15 Mini-Symposium: Pathogenic Mechanisms for Cognitive Impairment in Animals and Humans

Chair: Carl Cotman, PhD

Amyloid Metabolism and Cognitive Impairment in Animals and Humans

Todd Golde, PhD

Tau Pathology and Cognitive Impairment in Animals and Humans

Karen Duff, PhD

Protein Misfolding in the Pathogenesis of AD

JoAnne McLaurin, PhD

Inflammation and Brain AgingStephen Bondy, PhD

Inflammatory Cytokines and CognitiveImpairment in Aging

Philip Wolf, MD

Hypertension, Metabolic Syndrome and Cognitive Impairment

Jose Luchsinger, MD, MPH

11:15-11:30 Break

11:30-12:15 Open Discussion

12:15-1:30 LUNCH BREAK

Scientific Agenda

AM

7:30-8:30 Breakfast Buffet

8:30-8:45 Announcements and IntroductionsRanjan Duara, MD

8:45-10:30 Mini-Symposium: Non-Pharmacological Treatment and Prevention of Early AD and Other Dementias

Chair: Huntington Potter, PhD

Hematopoeitic Growth Factors for Brain Repair

Juan Sanchez-Ramos, MD, PhD

Risk Factors for Cognitive DeclineLaura Fratiglioni, MD, PhD

Cognitive and Environmental Stimulation for both Treatment and Prevention of Alzheimer’s Disease: Transgenic Mouse Studies

Gary Arendash, PhD

Cognitive Rehabilitation in MCI and Early AD

David Loewenstein, PhD

The Role of Exercise and Intellectual Engagement on AD and Cognition of older adults

Art Kramer, PhD

10:30-10:45 Break

10:45-11:30 Open Discussion

11:30-1:00 LUNCH BREAK

PM

1:00-3:00 Mini-Symposium: Potential DiseaseModifying Agents for Treatment andPrevention of AD

Chair: Paul Aisen, MD

Drug Development for AD and Prodromal AD: an Overview

Paul Aisen, MD

Clioquinol (Reformulated)Colin Masters, MD

Immunotherapy for AD (Immunoglobulin Infusion)

Norman Relkin, MD, PhD

Immunotherapy for AD (Antibody Infusion)Michael Grundman, MD

Flurizan: A Gamma Secretase Modulating Agent

Kenton Zavitz, PhD

LY450139: a Gamma secretase inhibitorEric Siemers, MD, PhD

3:00-3:15 Break

3:15-4:00 Open Discussion

4:00 Adjorn

Saturday, March 8, 2008

Method of Registration

To register by mail or fax: please complete

the registration form and send it with the

payment to the above mailing address or

fax number.

To register by internet:

www.mcisymposium.org

Registration confirmations will be issued.

Payment: Registration fees can be paid by

credit card or check, no cash is accepted.

Please make all checks payable to

MOUNT SINAI MEDICAL CENTER

Registration Fee Inclusions: Registration fees

include admittance to all the scientific

sessions, conferences, conference materials,

validated parking, breakfast, lunch,

refreshment breaks and welcome dinner as

specified in the program.

Registration Hours: The conference

registration desk will be staffed:

Thursday, March 6 –

Mediterranean Foyer

4:00 pm – 7:00 pm

Friday, March 7 –

Meeting Room: Mediterranean East

7:00 am - 5:00 pm

Saturday, March 8 –

Meeting Room: Mediterranean East

7:00 am - 5:00 pm

Business casual attire is appropriate for all events. A light sweater or jacket is recommended in the meeting rooms.

Registration Information

Symposium Location

Miami Beach Resort and Spa: 4833 Collins Ave, Miami Beach, FL 33140 Phone: 1-866-767-6060Web-Site: www.miamibeachresortandspa.com

A historic masterpiece on the water, the Miami Beach Resort & Spa features luxuriousbeachfront accommodations, breathtaking oceanviews, and easy access to world-famousattractions, restaurants, and nightspots.With the spectacular Atlantic Ocean and its

beaches at your doorstep,enjoy the nearby world-classshopping and night lifedestinations of South Beach.

This distinctive hotel issurrounded by the AtlanticOcean and the IntracoastalWaterway, and boasts 424

elegant guest rooms and suites – each brimming withthoughtful amenities such as high-speed Internet accessand floor-to-ceiling oceanfront views. Visit ourBeachfront Aqua Sports Center to prepare for a day ofexciting jet skiing or parasailing. Drift to sleep under

the warm sunshine in a poolside cabana or on the white-sand beachnestled at your doorstep. If you can bear to leave our oceanfront MiamiBeach resort, spend a day exploring world-class museums and trendyboutiques and salons, and when eveningfalls, indulge in the sizzling restaurantsand nightclubs of South Beach, just downthe street. Our alluring resort offers theideal blend of South Beach sun andMiami cool, all in a picture perfect setting.

Hotel Reservations

For the convenience of the 6th Annual MCI Symposium attendees, a limitednumber of rooms have been reserved at the special daily rate of $229.00(single or double occupancy, plus resort fees, state and local taxes). Toreceive this conference rate, reservations must be made directly with theMiami Beach Resort and Spa and you must mention that you are a registrantof the 6th Annual MCI Symposium. Rooms will be held at the special rateuntil Monday, February 11, 2008. Rooms at the discounted rate will beallocated on a first-come, first-served basis. Reservations received after thecut-off date are subject to availability and prevailing rates.

FOR ROOM RESERVATIONS CALL: 1-866-767-6060 OR ACCESSTHE HOTEL WEB SITE VIA www.miamibeachresortandspa.com orVISIT THE MEETING WEBSITE VIA www.mcisymposium.org

MILD COGNITIVE IMPAIRMENT (MCI) SYMPOSIUM

Registration Form

THREE EASY WAYS TO REGISTERONLINE: FAX: MAIL:www.mcisymposium.org Attn: Warren Barker Warren Barker

(305) 674-2996 Mount Sinai4300 Alton RoadMiami Beach, FL 33140

REGISTRANT INFORMATION Please print:

_________________________________________________________________________________________LAST NAME FIRST NAME MI

DEGREE: MD DO PhD PsyD OTHER

__________________________________________________________________________________________________________________________________ADDRESS

________________________________________________________________________________________________________________________________CITY STATE ZIP CODE COUNTRY

________________________________________________________________________________________________________________________________E-MAIL FAX TELEPHONE

REGISTRATION FEES:Physicians: Discounted: $340.00 (if dated/postmarked by February 8)

$390.00 (if dated/postmarked after February 8)$440.00 (on site registration)

Non-Physicians: Discounted: $225.00 (if dated/postmarked by February 8)$275.00 (if dated/postmarked after February 8)$325.00 (on site registration)$100.00 (students)

PAYMENT METHOD:

American Express Master Card Visa Check in the amount of _____________

Card No. _______________________________________________ Expiration Date _____/_____

Cardholder’s Name _________________________________________________________________

Signature __________________________________________________________________________

Payment must accompany registration form

Refund Policy: Full refund will be given if written notice is received not later than February 8, 2008.

All refunds will be processed after the meeting.