maxim osipov - big data in mental health - 23rd july 2014
DESCRIPTION
Organised by the Bioinformatics group at the BRCMH, IoP, SLaM and Maudsley Digital, this symposium showcased talks regarding the important roles of big data in mental health biomedical research and treatments.TRANSCRIPT
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DEPARTMENT OF ENGINEERING SCIENCEINSTITUTE OF BIOMEDICAL ENGINEERINGCENTRE FOR DOCTORAL TRAINING IN HEALTHCARE INNOVATION
July 23, 2014
FROM QUESTIONNAIRES TO OBJECTIVE DATA
CONTINUOUS MONITORING OF MANIA AND DEPRESSION SYMPTOMS USING MOBILE PHONE SENSORS
Maxim Osipovsupervised by Prof. Gari Cliffordand Dr. David Clifton
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Problem
* WHO. The global burden of disease: 2004 update.
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Symptoms
Dimensions ofPsychopathology*
Reality distortionHallucinations, Delusions
PovertyFlat affect, Poverty of speech*,Decreased voluntary motor activity*
DepressionLow mood, Low self-esteem, Hopelessness, Suicidality, Somatic symptoms*
DisorganizationFormal thought disorder, Inappropriate affect, Disorganized or bizarre behavior*
AnxietyFeelings of unease, fear* or dread, Overactivity of the sympathetic nervous system*
* Symptoms can be detected using activity, cardiovascular or electrodermal monitoring
PsychomotorExcitation
Labile affect, Pressure of speech*,Motor agitation*
MoodElation
Elevated mood, Elevated self-esteem, Decreased need for sleep*
* P. F. Liddle, Disordered mind and brain: The neural basis of mental symptoms.
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Bipolar disorder
Bipolar Disorder
Lifetime prevalence of ~1.5%
Peak age of first episode onset is in the teens or twenties
20x increase in risk of suicide
“Cyclical” illness, ~10% have 4 or more episodes per year
* DSM-IV
Management
Medication to prevent episodes of mania and depression
Medication to treat the main symptoms
Psychological treatment
Detecting warning signs helps with better treatment
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Bipolar disorder - Management
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Depression and Mania (QIDS & ASRM)
1. Falling Asleep *2. Sleep During the Night *3. Waking Up Too Early *4. Sleeping Too Much *5. Feeling Sad6,7. Increased / Decreased Appetite8,9. Increased / Decreased Weight10. Concentration / Decision Making11. View of Myself12. Thoughts of Death or Suicide13. General Interest14. Energy Level *15. Feeling Slowed Down *16. Feeling Restless *
1. Happiness2. Self-confidence3. Need for Sleep *4. Talk More *5. Being More Active *
* Can be measured objectively, using mobile or wearable devices.
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Automated Monitoring of Symptom Severity (AmoSS) – PI Prof. Gari Clifford
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Physical activity
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Light exposure
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Battery level
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Geolocation
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Mobile phone data limitations
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Integration with self-management platform
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Acknowledgments
Hill Foundation Scholarship
RCUK Digital Economy Programme grant number EP/G036861/1 (Oxford Centre for Doctoral Training in Healthcare Innovation)
Wellcome Trust Centre Grant No. 098461/Z/12/Z (Sleep, Circadian Rhythms and Neuroscience Institute)
EPSRC grant EP/K020161/1 (Multiscale markers of circadian rhythm changes for monitoring of mental health)
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Acknowledgments - AmoSS Team
Prof. Gari Clifford
Prof. Guy Goodwin
Dr. Athanasios Tsanas
Dr. Amy Bilderbeck
Dr. Kate Saunders
Niclas Palmius
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Thank you!